ライフサイエンスコーパス: LLE

1 LLE and SPE were employed for sample clean-up and enrich

2 LLE is sensible for the development stages but does not

3 LLE using di-(2-ethylhexyl)phosphoric acid (D2EHPA) extr

4 LLE using dichloromethane as organic phase was combined

5 the method employing florosil column after a LLE procedure was applied for wine samples with satisfac

6 In this study the feasibility of a LLE-GC-EI-MS method for the analysis of 43 phenolic acid

7 electron microscopy studies revealed that Ac-LLE formed bead-like microstructures, Ac-LVE and Ac-YYD

8 ly predicted tripeptides (Ac-LVE, Ac-YYD, Ac-LLE, Ac-YLD, Ac-MYD, Ac-VIE) were chosen for experimenta

9 f LLVY-methylcoumaryl-7-amide (LLVY-MCA) and LLE-beta-nitroanilide (LLE-betaNA) more than REGalpha or

10 enrichment of N-glycans, permethylation, and LLE.

11 ction ability of SPE with the diol phase and LLE were similar.

12 n of extraction efficiencies between SPE and LLE.

13 bination of solid phase extraction (SPE) and LLE to produce a cleaner extract that can be easily conc

14 HS-SPME and LLE-GC/MS analyses revealed that metabolism of the compo

15 Lipophilic efficiency indices such as LLE and LELP were suggested to support balanced optimiza

16 This fully automated LLE methodology avoids several disjointed steps involved

17 miniaturized LLE procedures, fully automated LLE techniques allowing high-throughput bioanalytical st

18 bioanalytical method, based on the automated LLE and fast gradient LC-MS/MS, was validated and succes

19 The automated LLE methodology is universal and can be employed for sam

20 Both LLE and LELP have significant impact on ADME and safety

21 d binding thermodynamics, we found that both LLE and LELP help identifying better quality compounds.

22 A combination of SPE (OasisHLB) followed by LLE was shown to maximize compound identification and qu

23 p to 51%) vs. its non-sonicated counterpart (LLE-agitation) and n-hexane washing.

24 with improved lipophilic ligand efficiency (LLE) consistent with the reduction of clogP.

25 on of cellular lipophilic ligand efficiency (LLE) in a series of 2-anilino-pyrimidine IGF-1R kinase i

26 d or increased ligand lipophilic efficiency (LLE) compared to previously reported compounds led to th

27 ioactivity and ligand lipophilic efficiency (LLE) parameter were the principal guidelines in the lead

28 ponse weighted ligand lipophilic efficiency (LLE) termed AgLLE is discussed along with the issues of

29 Here, we introduce locally linear embedding (LLE), an unsupervised learning algorithm that computes l

30 In this work, liquid-liquid extraction (LLE) and solid phase extraction (SPE), of polyphenols fr

31 ng method based on liquid-liquid extraction (LLE) followed by ultra performance liquid chromatography

32 SERS) coupled with liquid-liquid extraction (LLE) for quantification of p-coumaric acid (pHCA) in the

33 deconjugation and liquid-liquid extraction (LLE) for the determination of total BPA, and the results

34 ng the semirobotic liquid-liquid extraction (LLE) in deep-well 96-well plates was developed for the q

35 Liquid-Liquid extraction (LLE) is a common sample pretreatment technique often use

36 Additionally, a liquid-liquid extraction (LLE) method was developed for comparison of extraction e

37 ed high-throughput liquid-liquid extraction (LLE) methodology has been developed and utilized for the

38 ed high-throughput liquid-liquid extraction (LLE) methodology has been developed for preparation of b

39 Liquid-liquid extraction (LLE) of a 200 mL effluent sample showed the best perform

40 lues observed with liquid-liquid extraction (LLE) of a venipuncture sample.

41 We modified our liquid-liquid extraction (LLE) procedure for F(2)-isoprostane analysis to use a co

42 permethylation and liquid-liquid extraction (LLE) steps are labor intensive and are thus not practica

43 eviously published liquid-liquid extraction (LLE) techniques using bis(2-ethylhexyl) phosphate as the

44 rmining PAHs using liquid-liquid extraction (LLE), clean-up and detection by liquid chromatography wi

45 vaporation (SAFE), liquid-liquid extraction (LLE), solid phase extraction (SPE), and simultaneous dis

46 niscale version of liquid-liquid extraction (LLE), termed miniscale-LLE (msLLE), with automated full

47 further selective liquid-liquid extraction (LLE).

48 mization effort using 9, we further improved LLE as exemplified by a much more druglike analog 26.

49 was confirmed in positive ionisation mode in LLE extract, whereas in the SPE extract they were not pr

50 re, we introduce a new fully automated micro-LLE technique based on gas-pressure assisted mixing foll

51 have been made in automated and miniaturized LLE procedures, fully automated LLE techniques allowing

52 id-liquid extraction (LLE), termed miniscale-LLE (msLLE), with automated full evaporation dynamic hea

53 Results showed that the modified LLE was robust to a range of salinity, Fe, and DOC conce

54 -amide (LLVY-MCA) and LLE-beta-nitroanilide (LLE-betaNA) more than REGalpha or REGbeta alone.

55 solubility, and the composite parameters of LLE and pIC50-pSolubility were used to assess compound q

56 Here we investigated the performance of LLE and LELP on multiple data sets representing differen

57 mparable or better than conventional offline LLE, in which the handling of small volumes remains chal

58 In the optimized LLE method, a formate buffer solution was first loaded i

59 In the optimized LLE method, crude combinatorial library samples were dis

60 y modestly activates cleavage of LLVY-MCA or LLE-betaNA by the proteasome.

61 d safety profiles; however, LELP outperforms LLE in risk assessment at least on the present data set.

62 local symmetries of linear reconstructions, LLE is able to learn the global structure of nonlinear m

63 methods for local dimensionality reduction, LLE maps its inputs into a single global coordinate syst

64 steps involved in a manual or semiautomated LLE method, leading to significantly reduced sample prep

65 Conclusions indicate that LLE gives better recoveries for highly polar, non-polar,

66 sequentially added to the LLE plate so that LLE would occur in the interface between the two liquid

67 The LLE extracts of the plasma samples of the two compounds

68 The LLE method was automated using 96-well-format plates and

69 iazole) to 6.4 ng/mL (benzothiazole) for the LLE method.

70 ethyl ketone, were sequentially added to the LLE plate so that LLE would occur in the interface betwe

71 application of the automated high-throughput LLE method should greatly reduce the labor, time, and co

72 probe assisted liquid-liquid extraction (US-LLE) combined with a freeze-based fat precipitation clea

73 ration of biological samples using a 96-well LLE plate and a 96-channel robotic liquid handling works

74 The 96-well LLE plate is made of a 96-well filter plate filled with