ライフサイエンスコーパス: LPP

1 LPP and palladin expression was markedly decreased, in c

2 LPP expression in FAK-null fibroblasts enhanced cell spr

3 LPP expression was also markedly decreased in focal adhe

4 LPP silencing with short interfering RNA significantly d

5 inhibition of lipid phosphate phosphatase-1 (LPP-1) by propranolol or inhibition of the phosphatidylc

6 Positivity for GADA was associated with 3q28/LPP, for IA-2A with 1q23/FCRL3 and 11q13/RELA, and for P

7 es (P=4.50x10(-34)), PTPN22 (P=1.31x10(-7)), LPP (P=1.01x10(-11)), IL2RA (P=2.78x10(-9)), UBASH3A (P=

8 h as myosin, actin, caldesmon, calponin, and LPP, were down-regulated in embryoid bodies (EBs) derive

9 t expansion and proliferation of HPP-CFC and LPP-CFC.

10 FAP5), focal adhesion kinase (FAK), ERK, and LPP.

11 ive potential colony-forming cells (HPP- and LPP-CFCs) indicates an expansion of stem cells which wil

12 mily composed of zyxin, migfilin, TRIP6, and LPP.

13 Zyxin and LPP are implicated in cellular signaling and tumorigenes

14 cell adhesion, we demonstrate that zyxin and LPP function to increase the rate of early cell-cell jun

15 data implicate the LIM domains of zyxin and LPP in regulating cell-cell junction assembly through VA

16 We also identify the LIM region of zyxin and LPP to be a regulatory domain that blocks function of th

17 e direct peptide-protein association between LPP and BMP-RII.

18 Both LPP and palladin enhanced cell migration and spreading.

19 The expression of both LPP and palladin, like smooth muscle alpha-actin, was in

20 ex regulatory signaling cascade initiated by LPP and suggest that LPP may be a useful therapeutic sub

21 he conversion of extracellular S1P to Sph by LPP-1, which facilitates Sph uptake, followed by the int

22 es in syngeneic tumor-bearing FVB mice and C-LPP liposomes reduced doxorubicin accumulation in the sk

23 ockdown resulting from doxorubicin-loaded, C-LPP liposomes was similar to non-targeted liposomes in s

24 The binding of C-LPP liposomes conjugated with 0.63mol% of the peptide wa

25 carboxyl-terminated CRPPR peptide (termed C-LPP liposomes) bound to the NRP-positive primary prostat

26 Binding of the C-LPP liposomes was receptor-limited, with saturation obse

27 lar internalization was also enhanced with C-LPP liposomes, with 80% internalized following 3h incuba

28 cular and high molecular weight carbonylated LPP with 7-(diethylamino)coumarin-3-carbohydrazide (CHH)

29 Third, within each picture category, LPP-BOLD coupling revealed category-specific differences

30 In conclusion, LPP appears to be a myocardin-, RhoA/ROK-dependent SMC d

31 ion of FPPase activity for synthesis of CPP, LPP, and MPP.

32 l diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (M

33 here is no detectable upregulation of either LPP or TRIP6 expression in tissues derived from zyxin-nu

34 tudies showed that CAFs regulate endothelial LPP via a calcium-dependent signaling pathway involving

35 findings suggest that targeting endothelial LPP enhances the efficacy of chemotherapy in ovarian can

36 nt and unpleasant pictures elicited enhanced LPP, as well as heightened BOLD activity in both visual

37 VPP, 6.1 mg L(-1) for IPP, 0.8 mg L(-1) for LPP and 3.2 mg L(-1) for FP were determined.

38 We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocatio

39 ntaining IL2 and IL21, and at 3q28 harboring LPP.

40 o produce molecular constituents, the hybrid LPPs dissolve to produce NPs, with the drug release and

41 These hybrid LPPs exhibit much better flow and aerosolization propert

42 observed with CFHR1, CADM2, LOC730109/IL12A, LPP, LOC63920, SLU7, ADAMTSL1, C10orf64, OR8D4, FAM19A2,

43 C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B.

44 tic and cell biological evidence implicating LPPs as negative regulators of lysophospholipid signalin

45 TS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2

46 n PLCL1 (rs10497813, P=6.1x10(-10)), 3q28 in LPP (rs9860547, P=1.2x10(-9)); 20q13.2 in NFATC2 (rs6021

47 ese processes, is significantly decreased in LPP.

48 t of A404 cells induced a strong increase in LPP, as well as SM alpha-actin, SM myosin heavy chain, a

49 potentiation (LTP) had a higher threshold in LPP field potential studies but not in voltage clamped n

50 cardin in A404 cells significantly increased LPP mRNA expression.

51 In this study we investigated LPP action in rabbit primary intervertebral disc cells c

52 positive feedback generally induced a larger LPP.

53 nction of context, eliciting somewhat larger LPPs when presented in blocks, and prompting smaller slo

54 Importantly, later (LPP), but not early (EPN), waveforms predicted actual ge

55 Like LPP, palladin, is highly expressed in differentiated smo

56 3C/C2CD4A, FAF1, PTPRD, AP3S2, KCNK16, MAEA, LPP, WFS1, and TMPRSS6 loci.

57 y different and divergent from the mammalian LPPs.

58 Mechanistically, LPP increased focal adhesion and stress fiber formation

59 siRNA-mediated LPP silencing in ovarian tumor-bearing mice improved pac

60 Three-week immunotherapy with 170 mug LPP reduced CPT reactivity significantly and increased p

61 bo or cumulative doses of 70, 170 or 370 mug LPP.

62 (EPN) and later cognitively controlled (N2, LPP) patterns of neural response while viewing character

63 In neither experiment were there effects of LPP.

64 al adhesion kinase upregulated expression of LPP(2) and now show upregulation of palladin, and paired

65 erall, the data suggest that the function of LPP and palladin is context dependent, that they play a

66 stically bound to chromatin for induction of LPP/miR-28 transcription.

67 , the decrease in lymphatic flow and loss of LPP during PLN collapse are consistent with decreased dr

68 ntribute to the generation and modulation of LPP are not well understood.

69 AECs expressed LPP1-3, and overexpression of LPP-1 enhanced the hydrolysis of exogenous [(3)H]S1P to

70 s function that triggers the pathogenesis of LPP.

71 The palladin interacting region of LPP was mapped to the first and second LIM domains.

72 Down-regulation of LPP-1 by siRNA decreased intracellular S1P production fr

73 oth muscle cells.(1) Using the C-terminus of LPP as bait in a yeast two hybrid system, palladin, an a

74 This shows the ability of LPPs to accurately preserve a sample's genome informatio

75 s only modestly effective as an inhibitor of LPPs, is a potent inhibitor of SPP1; the activity was pa

76 d this was blocked by XY-14, an inhibitor of LPPs.

77 One LPP was sufficient to capture sequences from <100-500 bp

78 Similar to other LPPs, SPP1 activity was also independent of any cation r

79 lization potential of large porous particle (LPP) systems by spray drying solutions of polymeric and

80 also includes the lipoma preferred partner (LPP) and thyroid receptor-interacting protein 6 (TRIP6).

81 Fs upregulated the lipoma-preferred partner (LPP) gene in microvascular endothelial cells (MECs) and

82 Lipoma preferred partner (LPP) has been identified as a protein highly expressed i

83 Lipoma preferred partner (LPP) is a proline rich LIM domain family protein highly

84 tein 6 (TRIP6) and lipoma-preferred partner (LPP), but not to zyxin itself.

85 in, zyxin, and the lipoma preferred partner (LPP).

86 gion, which we term the lateral place patch (LPP), contained a large concentration of scene-selective

87 jections than in the lateral perforant path (LPP), an effect associated with distinctions in transmit

88 he structure via the lateral perforant path (LPP).

89 Link protein N-terminal peptide (LPP) is a proteolytic fragment of link protein, an impor

90 gpASIT+) containing Lolium perenne peptides (LPP) and having a short up-dosing phase has been develop

91 lamellar phases: the long periodicity phase (LPP) and the short periodicity phase (SPP).

92 ned the role of lipid phosphate phosphatase (LPP)-1 and sphingosine kinase1 (SphK1) in converting exo

93 trolled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2).

94 gulated by the lipid phosphate phosphatases (LPPs).

95 wn type 2 lipid phosphate phosphohydrolases (LPPs), but similar to the yeast orthologs, mammalian SPP

96 of the lymphocytic CA, Lichen planopilaris (LPP), compared to normal scalp biopsies identified decre

97 t frequent form of PCA, lichen planopilaris (LPP).

98 ng a highly brilliant laser produced plasma (LPP) source with a scanning-free GEXRF setup, providing

99 The late positive potential (LPP) is a commonly used event-related potential (ERP) in

100 The late positive potential (LPP) is a reliable electrophysiological index of emotion

101 The late positive potential (LPP) is an event-related potential that is enhanced when

102 nt images while the late positive potential (LPP), an event-related potential component that reflects

103 (EPN), P3, and the late positive potential (LPP).

104 s prompted a larger late positive potential (LPP, 400-700 ms) and a larger positive slow wave (1-6 s)

105 Late positive potentials (LPPs) for 'to-be-remembered' (TBR) relative to 'to-be-fo

106 ference test and the Lateral Paw Preference (LPP) test.

107 Lymphatic pumping pressure (LPP), measured indirectly by slowly releasing a pressuri

108 o-Pro (VPP), Ile-Pro-Pro (IPP), Leu-Pro-Pro (LPP) and Phe-Pro (FP) were separated on a C18-column cou

109 We used long padlock probes (LPPs) >300 bases in length for the assay, and the increa

110 present the utility of long padlock probes (LPPs) for targeted exon capture followed by array-based

111 oducts, such as lipid peroxidation products (LPP).

112 g), and 38.6% (70 mug) of patients receiving LPP vs 25.6% of patients receiving placebo (modified per

113 dy was to determine mechanisms that regulate LPP expression in an in vitro model of SM cell (SMC) dif

114 xamine how domains in zyxin and its relative LPP contribute to cell-cell junction assembly.

115 um generates a skin pathology that resembles LPP, and that LPP patients show gene expression changes

116 PINB6, P=1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 x 10(-8)), as well as a new independent SNP

117 whereas for unpleasant pictures significant LPP-BOLD correlation was observed in ventrolateral prefr

118 many trials are necessary to obtain a stable LPP?

119 re (mLPP) testing and electrical stimulation LPP (eLPP) testing in female rats to quantify the contri

120 rovascular endothelial cells (MECs) and that LPP expression levels in intratumoral MECs correlated wi

121 skin pathology that resembles LPP, and that LPP patients show gene expression changes that indicate

122 further demonstrate by microstimulation that LPP is connected with extrastriate visual areas V4V and

123 Our data reveal that LPP promotes disc matrix production, which was evidenced

124 These results suggest that LPP is generated and modulated by an extensive brain net

125 ng cascade initiated by LPP and suggest that LPP may be a useful therapeutic substitute for direct BM

126 The LPP has also been evaluated as a neural marker of affect

127 The LPP predicted both internalizing and externalizing sympt

128 Moreover, interactions between the LPP and stress continued to predict externalizing sympto

129 t episodic encoding is dependent on both the LPP and the endocannabinoid receptor CB1, and is strikin

130 form of synaptic plasticity expressed by the LPP (lppLTP) was profoundly impaired in Fmr1-KOs relativ

131 d unpleasant information, as measured by the LPP, predispose children to psychiatric symptoms when ex

132 activity were substantially reversed by the LPP-resistant LPA analogue, O-methylphosphothionate.

133 lit-half reliabilities were computed for the LPP and for difference waves revealing emotion effects (

134 iriform cortex were similar to those for the LPP, whereas adenosine modulation again correlated with

135 from the lavandulyl carbocation to form the LPP product.

136 Furthermore, the LPP varies little after 8 trials are added to the averag

137 However, the LPP component associated with the cognitive evaluation o

138 This arrangement of lipids in the LPP unit cell corresponds with the location of their lip

139 questions: how internally consistent is the LPP, and how many trials are necessary to obtain a stabl

140 (performing mathematics) would modulate the LPP while participants viewed emotionally arousing stimu

141 The affective modulation of the LPP is believed to reflect the increased attention to, a

142 esults are further discussed in terms of the LPP's role in motivated attention and implications for r

143 ormation on the molecular arrangement of the LPP.

144 For pleasant pictures, the LPP amplitude was coupled with BOLD in occipitotemporal

145 Second, the LPP amplitude across three picture categories was signif

146 ndings of the current study suggest that the LPP demonstrates good internal consistency and can be ad

147 Results indicated that the LPP was larger following pleasant and unpleasant stimuli

148 tribution by each of these structures to the LPP modulation is valence specific.

149 ls nine diffraction orders attributed to the LPP with a repeating unit of 129.4 +/- 0.5 A.

150 To engineer the LPPs, we developed a method that generates ssDNA molecul

151 different enzymological properties than the LPPs: the aliphatic cation propanolol, which is an effec

152 ion properties than the NPs; yet, unlike the LPPs, which dissolve in physiological conditions to prod

153 on of two dimethylallyl diphosphate units to LPP in vitro with apparent Km and kcat values of 208 +/-

154 the problem by correlating the single-trial LPP amplitude evoked by affective pictures with the bloo

155 d demonstrate the improved efficacy of using LPP-targeting siRNA in combination with cytotoxic drugs.

156 In stented pig coronary vessels, LPP was expressed in the neointima of cells lacking smoo

157 The N-terminus of palladin interacted with LPP both in vitro and in vivo, but not solely through it

158 Dominant-negative zyxin/LPP mutants reduce the rate of adhesion, lower VASP leve