ライフサイエンスコーパス: LRP

1 LRP blockade and inhibition of PKA prevented uPA- and uP

2 LRP emerge through overlying root tissues by inducing au

3 LRP most efficiently neutralized the LPS-induced pro-inf

4 LRP-1 expression on peripheral blood DCs was quantified

5 LRP-1 is not known to modulate the pathogenesis of aller

6 LRP-1-deficient macrophages, isolated from mice, demonst

7 LRP-deficient macrophages were impaired in their ability

8 own to interact with LDLR-related protein 1 (LRP) through these clusters.

9 sity lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive i

10 sity lipoprotein receptor-related protein 1 (LRP-1) receptor with receptor-associated protein (RAP) o

11 sity Lipoprotein Receptor-Related Protein 1 (LRP-1) receptor.

12 eceptor, the LDL receptor-related protein 1 (LRP-1).

13 eceptor, the LDL receptor-related protein 1 (LRP-1).

14 sity lipoprotein receptor-related protein 1 (LRP/CD91), by defense collagens has been suggested as on

15 sity lipoprotein receptor-related protein-1 (LRP) antibody and an LRP antagonist, receptor-associated

16 sity lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (A

17 sity lipoprotein receptor-related protein-1 (LRP-1) plays a major role in TIMP-3 internalization.

18 ipoprotein (LDL) receptor-related protein-1 (LRP-1) to become enzymatically active.

19 kinase AXL, LDL receptor-related protein-1 (LRP-1), and RAN-binding protein 9 (RANBP9)--that mediate

20 ts receptor, LDL receptor-related protein-1 (LRP-1).

21 poprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/beta-catenin si

22 Here we develop a fast and accurate LRP method, Eagle, that extends this paradigm to populat

23 In addition, LRP-deficient and -expressing macrophages ingested equiv

24 In addition, LRPs induced improved cell-cycle progression and perfori

25 Although LRP-1 functions as an endocytic receptor for C1r and C1s

26 ptor-related protein-1 (LRP) antibody and an LRP antagonist, receptor-associated protein (RAP), and w

27 g Schwann cell signaling and migration by an LRP-1-dependent pathway.

28 cell survival, whereas re-introduction of an LRP-1 minigene in a mouse LRP-1-deficient fibroblast cel

29 ercapnic and hypotensive dilation through an LRP- and ERK MAPK dependent pathway.

30 al fibroblasts and myofibroblasts through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism.

31 that uPA is upregulated after H/I through an LRP-dependent process and that the released uPA impairs

32 their ability to ingest beads coated with an LRP ligand when compared with LRP-expressing macrophages

33 receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/beta-catenin signaling, e

34 kably similar to the time course of ADAN and LRP.

35 AXL and LRP-1 did not interact directly, but relied on RANBP9, w

36 t relied on RANBP9, which bound both AXL and LRP-1, to form the complex.

37 tantial binding to von Willebrand factor and LRP.

38 P(2)) production, signalosome formation, and LRP phosphorylation.

39 cs indicate that Glut4, the Tf receptor, and LRP-1 are differentially processed both within the cell

40 he role that the interaction between tPA and LRP plays on middle cerebral artery occlusion (MCAO)-ind

41 t receptor associated protein (RAP) and anti-LRP antibody blunted the increase in CSF uPA at 1 h (17+

42 e from healthy controls not affected by anti-LRP, suggesting that the LRP-CRT pathway was disturbed b

43 Pre-treatment of piglets with RAP, anti-LRP, and suPAR completely prevented, and the ERK MAPK an

44 athway includes the canonical elements arrow/LRP (low-density lipoprotein receptor-related protein),

45 The amplification function of Arrow/LRP appears to be particularly important for long-range

46 isms and that pharmacologic targets, such as LRP, might prove useful in restoring function in HAD pat

47 l and in vitro transmembrane invasion assay, LRP-deficient cells, which secreted high levels of uroki

48 lture model of antigen presentation, the AXL/LRP-1/RANBP9 complex was used by DCs to cross-present AC

49 es Abeta generation by scaffolding APP/BACE1/LRP complexes together.

50 interacted much more strongly with APP/BACE1/LRP than full-length RanBP9.

51 N1 does not bind LRP or Kremen nor inhibit Wnt signaling and has had no k

52 Biochemically, LRP-6 interacts closely with PDGF receptor beta and TGF-

53 production of active heparanase by blocking LRP-1-mediated uptake of pro-heparanase and thereby decr

54 Both LRP-deficient and -expressing macrophages ingested fewer

55 ZIP1L suppression significantly delayed both LRP and LR formation.

56 e, the extract induced liver, but not brain, LRP and NEP and decreased plasma and brain Abeta, indica

57 This response was blocked by LRP-1 gene silencing or by co-incubation with the LRP-1

58 ke of the R2159N variant was reduced both by LRP-expressing U87-MG cells and by human monocyte-derive

59 with receptor-associated protein (RAP) or by LRP-1 gene silencing.

60 olved in inflammation, that are regulated by LRP-1.

61 e interactions as well as cellular uptake by LRP-expressing cells.

62 The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and

63 rimary root, plays a new role in controlling LRP development at later stages.

64 a high CACS considering that it is coronary LRP, rather than calcification, that underlies the major

65 nal-disrupting oncolytic adenovirus (oAd/DCN/LRP) to achieve a desirable therapeutic outcome against

66 d with a cognate control lacking NT (oAd/DCN/LRP-PEG).

67 The oAd/DCN/LRP-PEG-NT elicited increased NTR-selective cancer cell

68 ther, these results demonstrate that oAd/DCN/LRP-PEG-NT has strong therapeutic potential for systemic

69 thermore, systemic administration of oAd/DCN/LRP-PEG-NT significantly decreased induction of innate a

70 argeting and therapeutic efficacy of oAd/DCN/LRP-PEG-NT toward neurotensin receptor 1 (NTR)-overexpre

71 icantly enhanced antitumor effect of oAd/DCN/LRP-PEG-NT was mediated by active viral replication and

72 stemically injectable hybrid system, oAd/DCN/LRP-PEG-NT.

73 effect that is attenuated in LRP-deficient (LRP(-/-)) mouse embryonic fibroblasts.

74 anted 5.5+/-4.0 years earlier, NIRS detected LRP in 33%.

75 ase, then later at the flanks, of developing LRPs.

76 abundance in the tonoplast of the different LRP cells is pivotal to mediating this developmental pro

77 e properties of overlaying tissues disrupted LRP morphogenesis.

78 ion in the latter population of cells during LRP morphogenesis are not stereotypical.

79 role for MYB36 outside the endodermis during LRP development through a mechanism analogous to regulat

80 ression pattern of the NRT1.1 protein during LRP development and combined local transcript analysis w

81 Finally, inhibition of either LRP or gamma-secretase attenuated cerebral ischemia-indu

82 rference screen using Caenorhabditis elegans LRP-1/megalin as a model for LDLR transport.

83 AP-D3 interfere with transport of endogenous LRP-1 to the cell surface in a dominant negative fashion

84 These results establish LRP-1 as a cell-signaling receptor for MMP-9, which may

85 esponses in pericycle cells between existing LRP might restrict LRI near existing LRP and, when compr

86 xisting LRP might restrict LRI near existing LRP and, when compromised, ectopic LRI occurs.

87 ity to replicate in cancer cells and express LRP in vitro.

88 h the observation that Schwann cells express LRP-1 at significant levels only after nerve injury.

89 the low-density lipoprotein receptor family (LRPs) are complex, multimodular type I transmembrane rec

90 frared spectroscopy images were analyzed for LRP, defined as a bright yellow block on the near-infrar

91 In contrast, the k(ex) for LRP-1 was five times faster than Glut4 in basal cells, a

92 pattern of divisions, is most important for LRP morphogenesis and optimizes the process of lateral r

93 The potential for LRP-mediated chemoattraction to mediate axonal regenerat

94 This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive im

95 nophilic asthma suggests a possible role for LRP-1 in modulating type 2-high asthma.

96 is region of ApoE to a high-affinity CR from LRP (CR17) for structural elucidation of the complex.

97 Furthermore, LRP-1-silenced cells expressed decreased levels of vascu

98 G47Delta-LRP was then tested for its therapeutic effectiveness an

99 r therapeutic effectiveness between G47Delta-LRP and G47Delta-empty virus.

100 e and 8-10 hours after injection of G47Delta-LRP (n = 7) or G47Delta-empty virus (n = 6).

101 ability of CEST MR imaging to show G47Delta-LRP at acute stages of viral infection.

102 served between tumors infected with G47Delta-LRP and G47Delta-empty virus.

103 0.3, P = .02) after infection with G47Delta-LRP but not G47Delta-empty viruses.

104 es derived from cells infected with G47Delta-LRP or the control G47Delta-empty virus.

105 activation, an effect that is attenuated in LRP-deficient (LRP(-/-)) mouse embryonic fibroblasts.

106 E-I demonstrated that there was no change in LRP mRNA expression upon ACE-I treatment.

107 rom transgenic mice genetically deficient in LRP resulting from tissue-specific loxP/Cre recombinatio

108 A substantial increase in LRP-1 expression was observed.

109 nt protease mRNA expression was increased in LRP-1-deficient cells, as was expression of inducible ni

110 rupting (or enhancing) expression of RBOH in LRP and/or overlying root tissues decelerates (or accele

111 inhibited NF-kappaB activity selectively in LRP-1-deficient cells.

112 siRNA, targeted against uPA in LRP-deficient clones, attenuated their invasive potentia

113 tability both in primary root tissues and in LRPs, it acts differentially on protein accumulation, de

114 n of AtTIP1;1 and AtTIP1;2 protein levels in LRPs, expression of AtTIP2;1 is specifically needed in a

115 bstitution rates were significantly lower in LRPs than HRPs, especially for sets of internal branches

116 on of NRT1.1, which is markedly repressed in LRPs in the absence of NO3(-) To explain this discrepanc

117 the primary root and a strong repression in LRPs and to a lower extent at the primary root tip.

118 e features of the CD8(+) T cell responses in LRPs toward emerging epitope variants provide insights i

119 iated protein that inhibits ischemia-induced LRP, a signaling receptor for t-PA.

120 These findings show that tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitate

121 The viral population infecting LRPs was also characterized by a slower increase in syno

122 ceptor responsible for ADAMTS-5 clearance is LRP-1.

123 Large LRP having a maximum LCBI in 4 mm >/=400 were infrequent

124 he lipid core burden index (LCBI), and large LRP were defined as a maximum LCBI in 4 mm >/=400.

125 tasis, has been shown to interact with LDLR, LRP, and VLDLR, through these clusters.

126 ties, four 15-residue peptides with leucine (LRP), phenylalanine (FRP), valine (VRP), and alanine (AR

127 However, significant increase in liver LRP and NEP occurred much earlier, at 7 d, and were acco

128 ain Abeta, indicating that increase in liver LRP and sLRP occurring independent of Abeta concentratio

129 fera mediated through up-regulation of liver LRP indicates that targeting the periphery offers a uniq

130 Selective down-regulation of liver LRP, but not NEP, abrogated the therapeutic effects of t

131 patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic su

132 Insulin increased k(en) for alpha-2-M/LRP-1 by 30%.

133 In basal cells, the k(en) for alpha-2-M/LRP-1 was similar to Glut4 but 5-fold slower than Tf.

134 (Tf) and alpha(2)-macroglobulin (alpha-2-M; LRP-1) were compared using quantitative flow cytometric

135 genic mice that specifically lack macrophage LRP through Cre/lox recombination.

136 Furthermore, deletion of macrophage LRP decreased uptake of (125)I-very-low-density lipoprot

137 to outline the recycling pathway of Megalin (LRP-2), an apical receptor with key developmental and re

138 the LDL receptor superfamily (LDLR, megalin, LRP).

139 introduction of an LRP-1 minigene in a mouse LRP-1-deficient fibroblast cell line (PEA-13) restored t

140 ion to two adjacent cell files overlying new LRP is crucial to ensure that auxin-regulated cell separ

141 analysis demonstrated that the shape of new LRPs is highly conserved.

142 Despite a high CACS, no LRP was detected in 8 (40.0%) subjects.

143 Notably, LRP-1-mediated endocytosis of ADAMTS-5 is impaired in ch

144 n the mutant primordia, rendering "PLT-null" LRP.

145 sites within the cluster and the ability of LRP to discriminate in vivo between uncomplexed and prot

146 ry mediators was explained by the ability of LRP-1 to suppress basal cell signaling through the I kap

147 studies demonstrate a direct contribution of LRP to phagocytosis and indicate that LRP is not require

148 isease was assessed in mice with deletion of LRP-1 in CD11c(+) cells (Lrp1(fl/fl); CD11c-Cre) and by

149 The detection of LRP in a pre-existing stent by NIRS alone is not reliabl

150 translocation of the intracellular domain of LRP in neurons within the area of ischemic penumbra, and

151 d states to (CR)(2) and (CR)(3) fragments of LRP cluster II.

152 small interfering RNA-mediated knockdown of LRP, mannose receptor, or DC-SIGN expression in monocyte

153 Deletion or knockdown of LRP-1 abolished tPA-mediated cell survival, whereas re-i

154 oximately 90% reduction in protein levels of LRP-1 without changes in its mRNA levels.

155 and for the analysis of the oncogenicity of LRP receptors that are often overexpressed in breast tum

156 aurora1 (aur1) aur2 disrupts the pattern of LRP cell divisions and impacts its growth dynamics, yet

157 nisms controlling proliferation potential of LRP cells remains poorly understood.

158 uired during the highly regulated process of LRP morphogenesis and emergence.

159 duces regulated intramembrane proteolysis of LRP and whether this process is related to cell death.

160 iated regulated intramembrane proteolysis of LRP results in cell death under ischemic conditions.

161 The ligand binding regions of LRP consist of clusters of cysteine-rich approximately 4

162 PI3K signaling pathways in the regulation of LRP-mediated astrocytoma invasion.

163 This phenotype was due to the retardation of LRP emergence.

164 In this study we investigated the role of LRP in cell death.

165 The role of LRP-1 in modulating HDM-induced airways disease was asse

166 ly slowed down after 10 h due to shedding of LRP-1 from the cell surface and formation of soluble LRP

167 At the site of LRP detected by NIRS in a cohort of pre-existing stents,

168 absence of neointimal tissue at the site of LRP detected by NIRS, intravascular ultrasound may provi

169 At the site of LRP, intravascular ultrasound found no neointimal tissue

170 ration/activation by mechanisms dependent on LRP-6 and WNT ligands but not the downstream beta-cateni

171 re expression of normal RAP has no effect on LRP-1 transport.

172 sion, organ shape, and overlaying tissues on LRP morphogenesis by exploiting recent advances in live

173 ivision pattern versus overlaying tissues on LRP morphogenesis using mutant and transgenic approaches

174 Conversely, only one LRP ligand, metallothionein II, was found to be chemoatt

175 rt that inhibition of either tPA activity or LRP or genetic deficiency of tPA resulted in a significa

176 Upon treatment of DCs with mannan or LRP ligand alpha2-macroglobulin, we observed only a mino

177 or with receptor-associated protein (RAP) or LRP-1 siRNA abolished the ApoE effects.

178 concentrating this signal in cells overlying LRP.

179 ic population to perform long-range phasing (LRP), enabling accurate imputation and association analy

180 e the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high c

181 ging phenomenon in which lipid-rich plaques (LRPs) develop within pre-existing stents.

182 In the peripheral nervous system (PNS), LRP-1 is robustly expressed by Schwann cells only after

183 rise in the lateralized readiness potential (LRP) on a subset of biased payoff trials contralateral t

184 The lateralized readiness potential (LRP) was used for indexing motor preparation.

185 The lateralized readiness potential (LRP), an electrophysiological index of response preparat

186 AN) and the lateralized readiness potential (LRP).

187 nse-locked lateralized readiness potentials (LRPs).

188 ing Lys(1370) and Lys(1374), which precludes LRP-1 binding.

189 s overexpressing PtabZIP1L showed precocious LRP and LR development, while PtabZIP1L suppression sign

190 ion of LR pre-branch sites and LR primordia (LRP).

191 larly in zones where lateral root primordia (LRP) initiate and LR differentiate and emerge.

192 Lateral root primordia (LRP) originate from pericycle stem cells located deep wi

193 s, the morphology of lateral root primordia (LRP), the auxin response gradient, and the expression of

194 roper development of lateral root primordia (LRP).

195 isions that generate lateral root primordia (LRP).

196 presses emergence of lateral root primordia (LRPs) at low concentration or absence of NO3(-) through

197 In Arabidopsis, lateral root primordia (LRPs) originate from pericycle cells located deep within

198 the emergence of new lateral root primordia (LRPs).

199 uently purified to a lactulose-rich product (LRP; approximately 70% lactulose content to total sugar)

200 gressors (HRPs) versus low-risk progressors (LRPs).

201 progressors (HRPs) and low-risk progressors (LRPs).

202 e parts of MESD in its function of promoting LRP maturation.

203 38B treatment, the receptor guidance protein LRP-1, which is required for endosomal recycling of the

204 tor, the laminin receptor precursor protein (LRP), a series of CNF1 truncated toxins were characteriz

205 ensity lipoprotein receptor-related protein (LRP) 5/6 is unknown.

206 ensity lipoprotein receptor-related protein (LRP) and cell surface glucose-regulated protein [Mr appr

207 th the lipoprotein receptor-related protein (LRP) and its ligand, calreticulin (CRT), because the LRP

208 ensity lipoprotein receptor-related protein (LRP) because the specific LRP blocker, receptor associat

209 nt/Fzd/lipoprotein receptor-related protein (LRP) complex and the associated beta-catenin signaling b

210 ensity lipoprotein receptor-related protein (LRP) in brain microvessels and the Abeta-degrading prote

211 Erk1/2, and lung resistance-related protein (LRP) in tumors were analyzed by Western blot analaysis,

212 ensity lipoprotein receptor-related protein (LRP) is a multifunctional endocytic receptor implicated

213 ensity lipoprotein receptor-related protein (LRP) is the principal clearance receptor for serpins and

214 of low-density lipoprotein-related protein (LRP) receptor and the ERK isoform of mitogen activated p

215 ids of lipoprotein receptor-related protein (LRP) robustly promoted Abeta generation independent of F

216 ocking lipoprotein receptor-related protein (LRP), a CRT receptor on macrophages.

217 ensity lipoprotein receptor-related protein (LRP), a member of the low-density lipoprotein receptor g

218 ensity lipoprotein receptor-related protein (LRP), amyloid precursor protein (APP), and BACE1 and rob

219 ensity lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), N-methyl

220 ensity lipoprotein receptor-related protein (LRP).

221 aling pathway: LDL receptor-related protein (LRP-1) and decorin.

222 ensity lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling di

223 ensity lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, in

224 ensity lipoprotein receptor-related protein (LRP-1), an endocytic receptor with cell signaling activi

225 s, low-density lipoprotein receptor protein [LRP] and apolipoprotein E [apoE]).

226 D] and lipoprotein receptor-related protein [LRP] family members) and the downstream beta-catenin eff

227 nsity lipoprotein receptor-related proteins (LRPs), and siRNA-mediated gene silencing revealed that t

228 The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b(+) DCs into WT mice generated a si

229 ion of the Abeta vascular clearance receptor LRP-1, and protection from the deleterious effects of Ab

230 M1 macrophage survival through its receptor LRP-1-mediated novel signaling cascade involving Erk1/2,

231 cell migration through the surface receptor LRP-1 (LDL receptor-related protein 1)/CD91.

232 he low-density lipoprotein-related receptor (LRP) is required for nuclear targeting.

233 Low-density lipoprotein receptors (LRPs) are present extensively on cells outside of the ne

234 Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients

235 These activities require LRP-1.

236 We found that AXL bound ACs, but required LRP-1 to trigger internalization, in murine CD8alpha+ DC

237 transfer living radical polymerization (SET-LRP) in water is described.

238 also conducted as a comparison with the SET-LRP system.

239 Similarly, LRP-1 expression by CD11b(+) lung DCs was significantly

240 om the cell surface and formation of soluble LRP-1 (sLRP-1)-TIMP-3 complexes.

241 virus-1 infection, mice lacking DC-specific LRP-1, AXL, or RANBP9 had increased AC accumulation, def

242 r-related protein (LRP) because the specific LRP blocker, receptor associated protein (RAP), prevente

243 /4D image analysis revealed that early stage LRPs exhibit tangential divisions that create a ring of

244 alpha action, or removal of the cell surface LRP-1 receptor for secreted Hsp90alpha reduces the tumor

245 MYB36 was expressed in the cells surrounding LRP where it controls a set of peroxidase genes, which m

246 ights to block Abeta generation by targeting LRP-mediated delivery of APP to raft microdomains.

247 howed significantly lesser cytotoxicity than LRP and FRP; further, the replacement of leucines with v

248 was found that lactose is more reactive than LRP for Maillard conjugation with both WPI and WPH.

249 ion of LRP to phagocytosis and indicate that LRP is not required for the C1q-triggered enhancement of

250 We propose that LRP-1 suppresses expression of inflammatory mediators in

251 ding studies using Fc chimeras revealed that LRP, DC-SIGN, and mannose receptor can bind to FVIII; ho

252 We show that LRP-1 is associated with endothelial transcytosis that d

253 cause recent studies in rodents suggest that LRP-1 inhibits inflammation, we conducted activity-based

254 Furthermore, the data suggest that LRP-mediated chemoattraction represents a novel, non-cla

255 rophages, confirming for the first time that LRP participates in phagocytosis.

256 The LRP and lactose were then conjugated with either whey pr

257 The LRP antagonist receptor associated protein (RAP) and ant

258 The LRP gene was detected through CEST imaging of lysates de

259 The LRP size and shape depends on the balance between positi

260 essed the growth factor carrier site and the LRP-1 recognition domain (RBD) as separate GST fusion pr

261 its ligand, calreticulin (CRT), because the LRP-mediated increase in phagocytosis of viable neutroph

262 Both apoE and pro-heparanase bind the LRP-1.

263 with LRP1 is direct, and is modulated by the LRP chaperone, Receptor-Associated Protein (RAP).

264 es simplex virus G47Delta, which carried the LRP gene, was constructed and tested for its capacity to

265 osphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstr

266 her beta-propeller containing protein in the LRP family).

267 s before stimulus information influenced the LRP.

268 proliferating and arrested cells inside the LRP, coinciding with the change from flat to dome-shaped

269 Interestingly, the LRP emergence phenotype of the triple tip mutants could

270 TMS also only modulated the LRP on incongruent trials, causing an increased positive

271 ximately 400 ms) and the peak latency of the LRP (approximately 1200 ms).

272 usion (MCAO) in mice induces shedding of the LRP ectodomain, we investigated here whether cerebral is

273 This can aid in development of the LRP gene as a reporter for the real-time detection of vi

274 The introduction of the LRP transgene had no effect on the viral replication or

275 radient ultracentrifugation to show that the LRP cytoplasmic domain-mediated effect was accompanied b

276 ot affected by anti-LRP, suggesting that the LRP-CRT pathway was disturbed by PR3-CRT association.

277 surrounding normal brain tissue, whereas the LRP-overexpressing and uPA-deficient cells did not invad

278 gene silencing or by co-incubation with the LRP-1 antagonist, receptor-associated protein.

279 ssues place biomechanical constraints on the LRPs that are likely to impact their morphogenesis.

280 mainly drove these differences, whereas the LRPs maintained a directed and maintained functional res

281 Thus, LRP-1 dictates physiological and pathological catabolism

282 utant that binds to GRP78 but cannot bind to LRP regulates DNA and protein synthesis by human prostat

283 acids, is responsible for decorin binding to LRP-1 and subsequent TGF-beta-dependent signaling.

284 were blocked by inhibiting MMP-9-binding to LRP-1 with receptor-associated protein (RAP) or by LRP-1

285 The ability of FP6 to trigger LRP-1-dependent cell signaling in PC12 cells was reprodu

286 MAPK and JNK signaling cascades, acting via LRP-6 with associated WNT ligand.

287 When LRP-deficient and -expressing macrophages were plated on

288 roteases accumulate at increased levels when LRP-1 is absent.

289 ingle ligand binding repeat cluster, whereas LRP contains three large clusters of ligand binding repe

290 We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adap

291 The mechanism by which LRP-1 inhibits NF-kappaB activity involves down-regulati

292 coated with an LRP ligand when compared with LRP-expressing macrophages, confirming for the first tim

293 on and clarified the interaction of Dkk with LRP.

294 g SPRY-LisH domains not only interacted with LRP but also with APP and BACE1.

295 in that are responsible for interaction with LRP-1 and are involved in TGF-beta-dependent binding and

296 and LRR5 participate in the interaction with LRP-1 and TGF-beta as well as in its dependent signaling

297 f MMP-9, which mediates the interaction with LRP-1, blocked MMP-9-induced cell signaling and migratio

298 in the enhancement of APP interactions with LRP and BACE1 and increased lipid raft association of AP

299 ndependently of C1 and its interactions with LRP.

300 thermore, our results demonstrate that young LRP are more sensitive to perturbations in the cytokinin