ライフサイエンスコーパス: LVM

1 LVM and relative wall thickness increased, whereas preva

2 LVM regressed in both groups but with no significant dif

3 LVM was measured by echocardiography, and measurements o

4 LVM was obtained with 2D M-mode echocardiography in a co

5 LVM was quantified by AS and MP in 126 consecutive patie

6 LVM was similar in individuals predisposed to hypertensi

7 0.001) and electrocardiographic (p < 0.001) LVM remained associated with development of depressed LV

8 n LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.9 g/m(2); 95% CI, 2.4-11.3 g/m(2); P=0.003)

9 In regression models, year 25 LVM or relative wall thickness was the dependent variabl

10 Significant determinants of year 25 LVM/m(2.7) were year 5 LVM, year 5 and change in body ma

11 terminants of year 25 LVM/m(2.7) were year 5 LVM, year 5 and change in body mass index, year 5 and ch

12 Allopurinol significantly reduced absolute LVM (-2.65 +/- 5.91 g vs. placebo group +1.21 +/- 5.10 g

13 st correlation was found between RI and age, LVM, LVMI, and plasma parathormone concentration and was

14 vs. placebo -1.3 +/- 4.48 g; p = 0.007) and LVM index (LVMI) (allopurinol -2.2 +/- 2.78 g/m(2) vs. p

15 cebo group +1.21 +/- 5.10 g [p = 0.012]) and LVM indexed to body surface area (-1.32 +/- 2.84 g/m(2)

16 ion existed between sympathetic activity and LVM index in the LVH[-] and LVH[+] groups (at least r=0.

17 Comparable hemodynamics and LVM regression can be achieved using a second-generation

18 e velocity, left ventricular mass (LVM), and LVM index (LVMI) increased in subsequent RI quartile sub

19 rmined LVM was indexed to body surface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1

20 of 50 patients, MRI was also used to assess LVM regression, and again there was no significant diffe

21 cardiovascular magnetic resonance to assess LVM, and positron emission tomography to quantify restin

22 <55%, was analyzed by quartiles of baseline LVM.

23 coronary artery bypass surgery, or baseline LVM.

24 sional echocardiograms obtained to determine LVM.

25 ardiac magnetic resonance imaging-determined LVM was indexed to body surface area (LVM index); in the

26 Baseline quartile of echocardiographic LVM indexed to body surface area was associated with dev

27 Elevated LVM index, concentric LVH, altered diastolic function, a

28 protein expression associated with elevated LVM.

29 rtial voxels, but this has not been used for LVM quantification.

30 Compared with whites, blacks had greater LVM (indexed to height(2.7); P<0.05).

31 rface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1 g/m2, a value between those of th

32 were on dialysis had greater cIMT and higher LVM index than those with CRI (P < 0.001) and greater ar

33 and dialysis groups had greater cIMT, higher LVM index, and poorer diastolic function than the contro

34 Both groups had higher LVM index compared with controls (22.2+/-6.1 g/m(2.7), P

35 The dialysis group had higher LVM index than the group with CRI (42.9+/-10.3 versus 29

36 al voxel segmentation, AS(PV) yielded higher LVM (159+/-38 g) than MP (Delta=20+/-10 g) and AS(FV) (D

37 0th percentile), and concentric hypertrophy (LVM and RWT >or=80th percentile).

38 >or=80th percentile), eccentric hypertrophy (LVM >or=80th percentile but RWT <80th percentile), and c

39 In patients without baseline hypertrophy, LVM index and MFS remained stable.

40 mean difference between groups for change in LVM and LVMI was -3.89 g (95% confidence interval: -1.1

41 Change in LVM index (54 +/- 13 g/m(2.7) to 42 +/- 10 g/m(2.7), p <

42 The primary outcome measure was change in LVM, assessed by cardiac magnetic resonance imaging (CMR

43 main cardiac secondary outcome was change in LVM.

44 Changes in LVM were associated with changes in blood pressure (conv

45 l partial voxels yields a 14-17% increase in LVM versus full voxel segmentation, with increased diffe

46 lysis resulted in a significant reduction in LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.

47 The primary outcome was reduction in LVM as calculated by cardiac magnetic resonance imaging

48 Increased LVM as assessed by electrocardiography or echocardiograp

49 Increased LVM is associated with an increased risk for stroke.

50 Increased LVM is associated with an increased risk of stroke, espe

51 d undergoing chronic dialysis have increased LVM, LV performance, and contractility at rest.

52 thyroid hormone was a predictor of increased LVM index and poor diastolic function.

53 ltivariate analysis, the effect of increased LVM on the risk of stroke was significantly decreased by

54 Prior studies have shown that increased LVM is a risk factor for heart failure but not whether i

55 Thus, increased LVM was defined by the highest quartile of LVM.

56 n in Endog that is associated with increased LVM and impaired cardiac function.

57 fect was stronger in subjects with increased LVM than among those without increased LVM (p = 0.033).

58 risk of stroke among patients with increased LVM to a level comparable to that of patients without in

59 sk, especially among patients with increased LVM.

60 eased LVM than among those without increased LVM (p = 0.033).

61 arable to that of patients without increased LVM.

62 ighly replicated, blood-pressure-independent LVM locus on rat chromosome 3p.

63 Patients with LVH (LVM/body surface area >/=116 and >/=96 g/m(2) in men and

64 is of sex-specific distributions of LV mass (LVM) and relative wall thickness (RWT): normal (LVM and

65 esonance (CMR) typically quantifies LV mass (LVM) by means of manual planimetry (MP), but this approa

66 between sympathetic activation and LV mass (LVM) has not been clearly defined across a range of arte

67 meter, LV posterior wall thickness, LV mass (LVM), and LV mass index (LVMI), compared to participants

68 0-year change in left ventricular (LV) mass (LVM) and LV geometry in black and white young adults in

69 Left ventricular mass (LVM) and cardiac gene expression are complex traits regu

70 ies such as increased left ventricular mass (LVM) and diastolic dysfunction develop at the time of mi

71 ied the correlates of left ventricular mass (LVM) in 84 healthy young adults aged 16 to 24 years from

72 relationship between left ventricular mass (LVM) in adults and longitudinal measurements of CV risk

73 allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD).

74 causes regression of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM).

75 ustained reduction in left ventricular mass (LVM) index after 5 years (from 71.4 [SD 22.5] g/m(2.7) t

76 Left ventricular mass (LVM) is a highly heritable trait and an independent risk

77 ine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced l

78 An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular mor

79 Left ventricular mass (LVM) is correlated with body composition and central hem

80 ciated with increased left ventricular mass (LVM) is modified by physical activity (PA).

81 We assessed left ventricular mass (LVM) regression with transthoracic echocardiography (TTE

82 ative contribution of left ventricular mass (LVM) regression, change in aortic valve area (AVA), and

83 pulse wave velocity, left ventricular mass (LVM), and LVM index (LVMI) increased in subsequent RI qu

84 resonance to measure left ventricular mass (LVM), and PET to quantify resting and hyperemic (dipyrid

85 Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diast

86 ventricular hypertrophy (LVH; high LV mass [LVM]) is traditionally classified as concentric or eccen

87 y, 939 hypertensive patients with measurable LVM at baseline were randomized to a mean of 4.8 years o

88 nil at this time, lunar vertical migration (LVM) may facilitate monthly pulses of carbon remineraliz

89 n 29%, concentric dilated in 14%, and normal LVM in 25%.

90 roups to 23%, 4%, 5%, and 7%; 62% had normal LVM after 4 years.

91 ts because hypertensive patients with normal LVM seem to be a low-risk group.

92 e-varying Cox analyses, compared with normal LVM, those with eccentric dilated and both concentric no

93 EDV)-and compared with patients with normal LVM.

94 ) and relative wall thickness (RWT): normal (LVM and RWT <80th percentile), concentric remodeling (LV

95 baseline a normal LVEF and an assessment of LVM (either by electrocardiogram or echocardiogram), and

96 To dissect the major determinants of LVM, we combined expression quantitative trait locus1 an

97 The extent of LVM during the winter suggests that the behavior is high

98 03), and percent change in geometric mean of LVM (7.0%; 95% CI, 1.0%-12.6; P=0.02).

99 ng in childhood is a consistent predictor of LVM in young adults, underscore the importance of obesit

100 to adulthood were significant predictors of LVM index in young adults.

101 uence of partial voxels on quantification of LVM.

102 c stroke was seen in the highest quartile of LVM (odds ratio [OR]: 6.14 [95% confidence interval [CI]

103 d LVM was defined by the highest quartile of LVM.

104 Allopurinol causes regression of LVM in patients with T2DM and LVH.

105 Regression of LVM occurred in all patients (from 129+/-30 to 94+/-24 g

106 Regression of LVM was linearly related to change in resting total LV b

107 are not directly dependent on regression of LVM.

108 a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice.

109 ese data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modif

110 rdiography (echo) and an ex vivo standard of LVM at necropsy.

111 k of stroke and may have variable effects on LVM.

112 The benefit of frequent hemodialysis on LVM may be mediated by salutary effects on blood pressur

113 ronounced effect of frequent hemodialysis on LVM was evident among patients with left ventricular hyp

114 enced the effect of frequent hemodialysis on LVM.

115 l blood pressure and sympathetic activity or LVM index.

116 AS quantified LVM in all patients, yielding a 12-fold decrease in proc

117 tic resonance imaging to accurately quantify LVM, in hypertensive patients with and without LVH and i

118 (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated wi

119 o placebo, allopurinol significantly reduced LVM (allopurinol -5.2 +/- 5.8 g vs. placebo -1.3 +/- 4.4

120 Frequent in-center hemodialysis reduces LVM.

121 WT <80th percentile), concentric remodeling (LVM <80th percentile but RWT >or=80th percentile), eccen

122 al hour of sleep was associated with smaller LVM (beta: -3.483, P < 0.0001) and LVMI (beta: -0.815, P

123 analysis of the combined groups showed that LVM correlated closely with body size, particularly lean

124 total LV blood flow was linearly related to LVM, whereas CVR was not.

125 osed, and diastolic perfusion rather than to LVM.

126 V chamber volume (r=0.28, P=0.002) and total LVM (r=0.19, P=0.03).

127 identified the genetic factors that underlie LVM variation, and the regulatory mechanisms for blood-p

128 MR agreement with echo and necropsy-verified LVM.

129 Multivariable regression determined whether LVM was independently associated with the development of

130 Methods were independently compared with LVM quantified on echocardiography (echo) and an ex vivo

131 nsidered to be more strongly correlated with LVM in comparison to other descriptors of fatness.

132 , P<.05) showed significant correlation with LVM.

133 t abundance had the highest correlation with LVM.

134 elded small but significant differences with LVM at necropsy.