ライフサイエンスコーパス: Langendorff

1 Langendorff LV performance was examined during isoproter

2 Langendorff perfused hearts were subjected to 20 minutes

3 Langendorff perfusion also indicated that mutant phospho

4 Langendorff perfusion indicated that the basal hyperdyna

5 Langendorff-perfused hearts from TG (n=6) and wild-type

6 Langendorff-perfused hearts underwent 1 h of regional is

7 Langendorff-perfused hearts were subjected to various pe

8 Langendorff-perfused isolated rat hearts were subjected

9 Langendorff-perfused isolated rat hearts were subjected

10 Langendorff-perfused mouse hearts were treated by triton

11 Langendorff-perfused mutant hearts also demonstrated dep

12 Langendorff-perfused rat hearts treated with EPO exhibit

13 Langendorff-perfused rat hearts were preconditioned with

14 Langendorff-perfused rat hearts were subjected to 40 min

15 Langendorff-perfused rat hearts were subjected to 40 min

16 Langendorff-perfused rat hearts were subjected to 40-min

17 Langendorff-perfused rat hearts were subjected to the Ca

18 In 10 Langendorff-perfused rabbit hearts, monophasic and bipha

19 -threshold atrial shocks was performed in 12 Langendorff-perfused sheep hearts.

20 In 13 Langendorff-perfused sheep hearts, AF was induced in the

21 empted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles.

22 during 6-ms MW and 3-ms/3-ms BW shocks in 19 Langendorff-perfused rabbit ventricles.

23 f this effect of defibrillation shocks in 23 Langendorff-perfused rabbit hearts by optically mapping

24 ular action potentials were recorded from 26 Langendorff-perfused guinea pig hearts in the absence (i

25 From 3 Langendorff-perfused pig hearts, 180 intramural unipolar

26 of propagation during 20 episodes of AF in 6 Langendorff-perfused sheep hearts.

27 of 0.1 to 0.5 micromol/L acetylcholine in 7 Langendorff-perfused sheep hearts.

28 Twenty-four VF episodes from 8 Langendorff-perfused rabbit hearts were studied using hi

29 ternans on the surface ECG was elicited in 8 Langendorff-perfused guinea pig hearts during fixed-rate

30 ed from 128 ventricular sites (1 cm(2)) in 8 Langendorff-perfused guinea pig hearts.

31 usly from 128 ventricular sites (1 cm2) in 8 Langendorff-perfused guinea pig hearts.

32 1-/- and wild-type hearts were perfused in a Langendorff apparatus in both the absence and presence o

33 Rabbit hearts were perfused in a Langendorff apparatus with full sympathetic and parasymp

34 emia/reperfusion, which was carried out in a Langendorff isolated perfused heart model (n=8 to 9 per

35 reperfusion reduced infarct size by 60% in a Langendorff isolated perfused rat heart model, and that

36 ed to hypoxia/reoxygenation, as well as in a Langendorff model of myocardial ischemia.

37 ischemia followed by 60 min reperfusion in a Langendorff model.

38 ro-flow global ischemia and reperfusion in a Langendorff model.

39 rom 4 (30-40 kg) pigs and were perfused in a Langendorff organ bath.

40 uction in cardiac function was observed in a Langendorff perfusion system.

41 mouse hearts were retrogradely perfused in a Langendorff preparation, and electrocardiograms were rec

42 d were subjected to I/R (25 min/60 min) in a Langendorff preparation.

43 h ethanol-free buffer prior to ischemia in a Langendorff preparation.

44 Six excised dog hearts were perfused in a Langendorff preparation.

45 tects the heart from reperfusion injury in a Langendorff setting.

46 rom the screen were subsequently tested in a Langendorff-perfused heart model of IR injury, revealing

47 or LC (100 microgram/mL) was infused into a Langendorff-perfused, isovolumically contracting mouse h

48 By use of a Langendorff preparation, hearts from transgenic mice sho

49 er surgery, hearts were either perfused on a Langendorff apparatus for 30 minutes at 37 degrees C (pr

50 rgery, transfected hearts were perfused on a Langendorff apparatus for 45 minutes, arrested with St T

51 Adult rat hearts perfused on a Langendorff apparatus were subjected to ischemia or isch

52 re perfused with Krebs-Henseleit buffer on a Langendorff apparatus.

53 5 minutes or 4 hours before reperfusion on a Langendorff apparatus.

54 blood flow in isolated hearts perfused on a Langendorff apparatus.

55 Using a Langendorff perfused rat heart, we show that the acetylc

56 Using a Langendorff perfusion model and an intraventricular ball

57 osure, we assessed cardiac responses using a Langendorff preparation in a protocol consisting of 20 m

58 Using a Langendorff preparation, one group of isolated rabbit he

59 Using a Langendorff rat heart perfusion protocol, we observed ag

60 tile function in isolated cardiomyocytes and Langendorff-perfused hearts.

61 y internalized in cardiomyocyte cultures and Langendorff-perfused hearts.

62 Echocardiography and Langendorff perfusion demonstrated that cell implantatio

63 unction was examined by echocardiography and Langendorff-perfused isolated heart preparation, whereas

64 hearts were assessed under both Working and Langendorff preparations.

65 nhibitor (digoxin or acriflavine) 4 h before Langendorff perfusion resulted in loss of IPC, as did ad

66 For both Langendorff-perfused hearts, the calculated epicardial a

67 Endothelial function was assessed by Langendorff preparations at 1, 2, and 4 weeks.

68 splant recipients with DCM were supported by Langendorff perfusion and were mapped during VF.

69 ucose uptake using isometrically contracting Langendorff-perfused hearts from normal mice (C57BL/6J),

70 which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.

71 two-dimensional preparations of cryoablated Langendorff-perfused rabbit hearts.

72 -alpha (ELISA) and function were determined (Langendorff).

73 f constant flow) or decreased coronary flow (Langendorff constant pressure), which was also observed,

74 2SO4 saturation of perfusates collected from Langendorff rat heart preparations optimally precipitate

75 tly using mitochondria rapidly isolated from Langendorff-perfused hearts.

76 epicardial monophasic action potentials from Langendorff-perfused murine KCNE1-/- hearts for the firs

77 TMRM fluorescence (FTMRM) was recorded from Langendorff-perfused rabbit hearts immobilized with bleb

78 e in situ imaging of T-tubule structure from Langendorff-perfused intact hearts with laser scanning c

79 and preserved cardiac physiologic function (Langendorff preparation).

80 our hrs postburn, left ventricular function (Langendorff), cardiomyocyte [Ca2+]i and [Na+]i measured

81 ing a blood-perfused parabiotic rabbit heart Langendorff model, myocardial oxygen consumption (MVO2)

82 and developed pressure in isolated rat heart Langendorff preparations without affecting diastolic pre

83 n was determined in isolated beating hearts (Langendorff preparation).

84 into the left ventricles of isolated hearts (Langendorff model), and in vitro measurement of Ca2+ tra

85 murine cardiomyocytes and adult rat hearts (Langendorff preparation) mitochondrial fragmentation and

86 tolic pressure, 4+/-1 versus 23+/-1.6 mm Hg; Langendorff LV developed pressure, 105+/-4 versus 62+/-9

87 ath was not observed in young pigs; however, Langendorff-perfused SCN5A(E558X/+) hearts had an increa

88 In Langendorff hearts, Mdivi-1 reduced mitochondrial reacti

89 In Langendorff perfused hearts, atrial conduction was studi

90 In Langendorff-perfused guinea pig hearts, mast cell degran

91 In Langendorff-perfused hearts, the functional recovery dur

92 In Langendorff-perfused mouse heart preparations, Cx43/beta

93 In Langendorff-perfused rat hearts, both Ser(1674) and Ser(

94 f in vivo atrioventricular node ablation, in Langendorff-perfused porcine hearts, using a scanned 12C

95 pwise pacing was used to induce alternans in Langendorff-perfused guinea pig hearts from which optica

96 Left ventricular function analysis in Langendorff perfused hearts and closed-chest anesthetize

97 Titin properties were analyzed in Langendorff-perfused mouse hearts after 20-minute ischem

98 sion proteins for use in cell culture and in Langendorff perfusion of adult rat hearts.

99 l matrix of isolated cardiac myocytes and in Langendorff-perfused hearts based on the use of the redo

100 the EGSH in isolated cardiac myocytes and in Langendorff-perfused hearts.

101 peptide in isolated cardiac myocytes and in Langendorff-perfused mouse hearts.

102 the mechanism of ventricular arrhythmias in Langendorff-perfused whole heart preparations from homoz

103 nsmembrane potential and intracellular Ca in Langendorff-perfused canine AVJ preparations that did no

104 of flecainide and quinidine were compared in Langendorff-perfused wild-type (WT), and genetically mod

105 VFT was determined in Langendorff perfused rat hearts by burst pacing until su

106 activity of the compounds was determined in Langendorff preparations of guinea pig hearts to assess

107 schemia-reperfusion injury was determined in Langendorff-perfused hearts isolated from wild-type mice

108 of propranolol (0.3 mg/L) on VF dynamics in Langendorff-perfused rabbit hearts.

109 Long-duration VF was induced electrically in Langendorff-perfused rabbit hearts (n=22) and terminated

110 ophasic action potential (MAP) electrodes in Langendorff-perfused murine hearts whether under normoka

111 ks were delivered from a bipolar ICD lead in Langendorff-perfused rabbit hearts.

112 We conducted epicardial mapping in Langendorff-perfused hearts, patch-clamp studies, gene e

113 on in vivo and epicardial voltage mapping in Langendorff-perfused hearts, we demonstrated that focal

114 electric measurements and optical mapping in Langendorff-perfused hearts.

115 ance and calcium transients were measured in Langendorff-perfused hearts and isolated cardiac myocyte

116 alcium pool, were performed using 19F NMR in Langendorff perfused rabbit hearts loaded with acetoxyme

117 Coronary artery occlusion in Langendorff perfused hearts from transgenic mice resulte

118 MPTP opening in Langendorff-perfused rat hearts was determined by perfus

119 formed during sustained AF (burst pacing) in Langendorff-perfused HF (n=7, 4 micromol/L acetylcholine

120 depressed cardiac contractile parameters in Langendorff-perfused hearts or in vivo.

121 al and intracellular Ca(2+) was performed in Langendorff-perfused rabbit hearts (n = 15).

122 Ca(2+)]SR (with Fluo-5N AM) was performed in Langendorff-perfused rabbit hearts.

123 om 8- and 24-month-old rats were perfused in Langendorff fashion and subjected to periods of ischemia

124 Rat hearts were perfused in Langendorff fashion for 60 min (control) or for 30 min f

125 our hours later, the hearts were perfused in Langendorff mode and subjected to 30 minutes of global i

126 ty-four hours later, hearts were perfused in Langendorff mode and subjected to 30 minutes of ischemia

127 0-day-old) rats were aerobically perfused in Langendorff mode before a PC stimulus of either (1) 3-mi

128 of Cys-119/Cys-162 by NO2-OA pretreatment in Langendorff-perfused murine hearts prevented the p38-MKK

129 eloped pressure and rate pressure product in Langendorff mode.

130 in the antiarrhythmic concentration range in Langendorff hearts and isolated rat ventricular myocytes

131 assess wavelength changes with heart rate in Langendorff-perfused wild-type (WT) and Scn5a(+/-) heart

132 s rhythm was similar to patterns recorded in Langendorff-perfused hearts.

133 re, intra-coronary infusion of sildenafil in Langendorff-isolated mouse hearts prior to ischemia-repe

134 simultaneously from 128 ventricular sites in Langendorff-perfused hearts (n = 15) in which propagatio

135 technique in establishing single-cell SL in Langendorff-perfused hearts loaded with the membrane dye

136 cardiac myofibrillar proteins was studied in Langendorff-perfused hearts.

137 Studies in Langendorff heart preparations from mutant TR-beta(1) tr

138 S) technique assessed arrhythmic tendency in Langendorff-perfused wild-type (WT) and genetically modi

139 ed in situ myocyte Ca(2+) dynamics in intact Langendorff-perfused hearts (ex vivo) from wild-type and

140 icardial and endocardial surfaces of intact, Langendorff-perfused Scn5a+/Delta hearts.

141 pecies-matched cells directly delivered into Langendorff-perfused porcine hearts or administered perc

142 Before 20 minutes of global ischemia, Langendorff-perfused rat hearts were perfused for 20 min

143 posome (CSIL) treatment of globally ischemic Langendorff instrumented hearts and a time response to t

144 Isolated Langendorff-perfused hearts from these myopathic animals

145 Isolated Langendorff-perfused rat hearts were subjected to perfus

146 In 11 isolated Langendorff-perfused rabbit hearts, monophasic action po

147 In 16 isolated Langendorff-perfused rabbit hearts, the interatrial sept

148 f episodes of global ischemia in an isolated Langendorff heart.

149 Using an isolated Langendorff perfused rabbit heart model, we subjected he

150 d by echocardiographic analyses and isolated Langendorff heart preparations.

151 rite as a cardioprotective agent in isolated Langendorff mouse heart preparations exposed to I/R.

152 Similarly, in isolated Langendorff perfused hearts of HSP70-positive and transg

153 pped using voltage-sensitive dye in isolated Langendorff-perfused hearts along with single glass-micr

154 development and pressure decline in isolated Langendorff-perfused hearts compared with saline-treated

155 rmed optical mapping experiments in isolated Langendorff-perfused rabbit hearts in which alternans wa

156 ation experiments were conducted in isolated Langendorff-perfused rat hearts and coronary-perfused pi

157 In isolated Langendorff-perfused rat hearts, CK inhibition increased

158 Treatment of isolated Langendorff rat hearts with a 12-LOX/AA cocktail signifi

159 right and left atrial appendages of isolated Langendorff-perfused murine hearts.

160 ty at discrete epicardial layers of isolated Langendorff-perfused rabbit hearts to a depth of 500 mum

161 ration, hearts were perfused in the isolated Langendorff mode.

162 locked by Ba(2+) and ouabain in the isolated Langendorff rat heart.

163 as a mechanism of VF and VT in the isolated Langendorff-perfused rabbit heart in the absence of an e

164 METHODS AND We used isolated Langendorff-perfused hearts from control (CTL) and heart

165 We studied 7 isolated, Langendorff-perfused canine left atrial (LA) and PV prep

166 ing of the epicardial surface in 8 isolated, Langendorff-perfused rabbit hearts.

167 In isolated, Langendorff-perfused rabbit hearts, optical mapping reve

168 Studies were performed with isolated, Langendorff-perfused rabbit hearts.

169 lume relationship measured by the isovolumic Langendorff technique showed a progressive rightward shi

170 tabolite profiles obtained from ex vivo mice Langendorff-heart preparations perfused with glucose.

171 In modified Langendorff perfusions, ERAs (BQ-123 and bosentan 10(-7,

172 dtype and M2 or M1/3-receptor knockout mouse Langendorff hearts, atropine led to increased contractil

173 This study used a novel Langendorff, biventricular, ovine fetal heart preparatio

174 a-reperfusion, but not by ischemia alone, of Langendorff-perfused hearts from wild-type and p53 knock

175 ischemic myocardium, the glycogen content of Langendorff-perfused rat hearts was either depleted or e

176 tial duration from ventricular epicardium of Langendorff-perfused guinea pig hearts at baseline (pH 7

177 ultaneous voltage-calcium optical mapping of Langendorff-perfused SHR hearts revealed that H2 O2 -ind

178 Pretreatment of Langendorff perfused transgenic hearts with the iPLA2 me

179 d to measure the ionized [Ca2+] in the SR of Langendorff-perfused rabbit hearts.

180 al activity from the entire outer surface of Langendorff-perfused hearts.

181 ial (n=14) or endocardial (n=14) surfaces of Langendorff-perfused rabbit ventricles.

182 the surface of the left ventricular wall of Langendorff-perfused isolated rabbit hearts.

183 Animal experiments on Langendorff-perfused rabbit hearts demonstrate the key f

184 e right and left ventricles was performed on Langendorff perfused hearts.

185 ptical mapping experiments were performed on Langendorff rabbit hearts stained with ICG and perfused

186 est left ventricular (LV) catheterization or Langendorff perfusion studies.

187 ffects of Ang II in isolated buffer-perfused Langendorff feline hearts.

188 tyl penicillamine (SNAP), in buffer-perfused Langendorff hearts.

189 from ischemia-reperfusion (isolated perfused Langendorff model) were measured.

190 f myocardial stretch in an isolated perfused Langendorff preparation by inflation of an intraventricu

191 PCR, patch clamp, ex vivo coronary perfusion Langendorff heart experiments, and endothelial cell Ca(2

192 were preceded by increased aortic pressure (Langendorff constant flow) or decreased coronary flow (L

193 with yields comparable to those in published Langendorff-based methods, using direct needle perfusion

194 cells isolated from an ischemia/reperfusion Langendorff model perfused with oxygenated blood from an

195 Rat hearts were perfused in a retrograde Langendorff system, and the changes in extracellular Mg(

196 the heart was rapidly excised for retrograde Langendorff perfusion.

197 Similarly, Langendorff perfused hearts indicated exacerbated postis

198 etrograde aortic perfusion using specialized Langendorff apparatus, which poses considerable logistic

199 ventricular (LV) working hearts (LWHs) than Langendorff (LANG) perfused hearts.

200 es (WP), muscle myograph baths (MB), and the Langendorff perfused heart apparatus (LPH).

201 ns in primary cardiac myocytes (CMs) and the Langendorff-perfused intact heart.

202 Isolated hearts were perfused by the Langendorff method and were exposed to ischemia, hypoxia

203 ed rat hearts were perfused initially by the Langendorff mode with Krebs-Henseleit buffer (KHB) for 1

204 Hearts were perfused by the Langendorff mode, and after 20 minutes of stabilization

205 ock in the human fetal heart perfused by the Langendorff technique and inhibit L-type Ca2+ currents a

206 Combining the Langendorff method of isolated rat heart perfusion with

207 mals before the removal of the heart for the Langendorff procedure.

208 matched control rabbits were perfused in the Langendorff mode and subjected to 45 minutes of ischemia

209 arts from C57BL/6J mice were perfused in the Langendorff mode and subjected to the following conditio

210 th bicarbonate buffer at 39 degrees C in the Langendorff mode at a constant pressure.

211 from Sprague-Dawley rats and perfused in the Langendorff mode with Krebs-Henseleit solution under the

212 mg/kg IP) 24 hours before global I-R in the Langendorff mode.

213 In the Langendorff model sulindac provided significant protecti

214 Ang-(1-9) increased contraction in the Langendorff model through a protein kinase A-dependent m

215 atine kinase release and infarct size in the Langendorff model.

216 r(tm1Unc)-TgN 1Jaw) mice and perfused in the Langendorff or working-heart mode.

217 tes compared with untreated cells and in the Langendorff perfused ex vivo heart.

218 activation of PKCepsilon in vitro and in the Langendorff perfused ex vivo heart.

219 naesthesia, fetal hearts were mounted in the Langendorff preparation, allowing measurement of left ve

220 d rat hearts were perfused for 10 min in the Langendorff-mode with Krebs-Henseleit buffer in the abse

221 ata derived from a model of stable VF in the Langendorff-perfused guinea pig heart that demonstrates

222 xperiments using a potentiometric dye in the Langendorff-perfused guinea pig heart.

223 Activation patterns of VF in the Langendorff-perfused rabbit heart were studied with the

224 pathways involved in this activation in the Langendorff-perfused rat heart.

225 tion on the surface of the ventricles in the Langendorff-perfused sheep heart.

226 ctivation on the surface of the atria in the Langendorff-perfused sheep heart.

227 al activity on the epicardial surface of the Langendorff-perfused adult mouse heart.

228 he epicardial and endocardial surface of the Langendorff-perfused rabbit heart.

229 on on the surface of the right atrium of the Langendorff-perfused sheep heart during pacing, atrial f

230 f nonarrested hearts acutely perfused on the Langendorff apparatus.

231 ardial surface in ventricles showed that the Langendorff-perfused TG hearts were able to sustain stab

232 oncentrated in the myocardium and, using the Langendorff model, to be effective in improving both car

233 -flow I/R (45 minutes/120 minutes) using the Langendorff preparation.

234 Isolated rat hearts were perfused via the Langendorff method under a constant flow of Krebs-Hensel

235 mice and wild-type controls perfused via the Langendorff mode were subjected to 30 minutes of ischemi

236 y of the left ventricles determined with the Langendorff ex vivo model of ischemia/reperfusion.

237 at hearts were crystalloid perfused with the Langendorff method and subjected to global, normothermic

238 ere subjected to global no-flow I/R with the Langendorff system.

239 Thirty Langendorff-perfused sheep hearts were exposed to acute

240 gf-1(+/-)) transgenic mice were subjected to Langendorff perfusions and progressive periods of ischem

241 Compared with control hearts, transgenic Langendorff-perfused hearts had a significantly lower in

242 Four weeks after transplantation, Langendorff perfusion demonstrated that both maximum dP/

243 Functional assessments using Langendorff preparations and (13)C nuclear magnetic reso

244 s were studied in the absence of blood using Langendorff preparations.

245 gram data from 7 isolated human hearts using Langendorff setup and intraoperative clinical data from

246 mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant m

247 In 2 models of ischemia/reperfusion using Langendorff-perfused guinea pig and mouse hearts, a sign

248 rve was assessed in RV- and left ventricular-Langendorff models and in vivo.

249 d in vivo by echocardiography and in ex vivo Langendorff perfused hearts.

250 nd 120 min of reperfusion, either as ex vivo Langendorff preparations or by in situ occlusion of the

251 e and human cardiomyocytes and in an ex vivo Langendorff-perfused whole-heart model.

252 Isolated hearts were Langendorff perfused and subjected to ischemia and reper

253 Nine pig hearts were Langendorff-perfused (atrial pacing, cycle length 650 ms

254 METHODS AND Isolated rat hearts were Langendorff-perfused and exposed to 40-minute normotherm

255 Rat hearts were Langendorff-perfused, subjected to 35 minutes of regiona

256 -type (WT) and NOX-2 knockout (KO) mice were Langendorff perfused and subjected to 35 min ischemia/re

257 ene, hearts from 14 New Zealand rabbits were Langendorff-perfused.

258 earts from male (M) and female (F) rats were Langendorff-perfused for 30 min prior to either regional

259 Cardiac function was assessed with Langendorff perfusion and echocardiography.

260 Results obtained with Langendorff-perfused hearts showed that this difference