ライフサイエンスコーパス: Langerhans

1 Langerhans cell (LC) networks play key roles in immunity

2 Langerhans cell histiocytosis (LCH) and Erdheim-Chester

3 Langerhans cell histiocytosis (LCH) and the non-LCH neop

4 Langerhans cell histiocytosis (LCH) combines in one noso

5 Langerhans cell histiocytosis (LCH) has a broad spectrum

6 Langerhans cell histiocytosis (LCH) is a clinically and

7 Langerhans cell histiocytosis (LCH) is a clonal disorder

8 Langerhans cell histiocytosis (LCH) is a myeloproliferat

9 Langerhans cell histiocytosis (LCH) is a rare disease af

10 Langerhans cell histiocytosis (LCH) is a rare disease wi

11 Langerhans cell histiocytosis (LCH) is a rare histiocyti

12 Langerhans cell histiocytosis (LCH) is an enigmatic dise

13 Langerhans cell histiocytosis (LCH) is an inflammatory m

14 Langerhans cell histiocytosis (LCH) is an inflammatory m

15 Langerhans cell histiocytosis (LCH) is characterized by

16 Langerhans cell histiocytosis (LCH) represents a clonal

17 Langerhans cell histiocytosis (LCH)-III tested risk-adju

18 "Langerhans cell histiocytosis" (LCH) describes a spectru

19 Langerhans cells (LC) are a subset of skin-resident dend

20 Langerhans cells (LC) in the epidermis of patients with

21 Langerhans cells (LC), the dendritic cells of the epider

22 Langerhans cells (LCs) and CD8(+) tissue-resident memory

23 Langerhans cells (LCs) and microglia develop from embryo

24 Langerhans cells (LCs) are a distinct population of dend

25 Langerhans cells (LCs) are able to orchestrate adaptive

26 Langerhans cells (LCs) are dendritic cells (DCs) localiz

27 Langerhans cells (LCs) are dendritic cells (DCs) residin

28 Langerhans cells (LCs) are distinct dendritic cells (DCs

29 Langerhans cells (LCs) are epidermis-resident antigen-pr

30 Langerhans cells (LCs) are epithelial APCs that sense da

31 Langerhans cells (LCs) are myeloid cells of the epidermi

32 Langerhans cells (LCs) are professional antigen-presenti

33 Langerhans cells (LCs) are self-renewing epidermal myelo

34 Langerhans cells (LCs) are self-renewing in the steady s

35 Langerhans cells (LCs) are skin-resident dendritic cells

36 Langerhans cells (LCs) are the dendritic cells (DCs) of

37 Langerhans cells (LCs) are the only DC subset in the hea

38 Langerhans cells (LCs) are the sole dendritic cell type

39 Langerhans cells (LCs) are the unique dendritic cells fo

40 Langerhans cells (LCs) comprise a dendritic network with

41 Langerhans cells (LCs) comprise a network of dendritic c

42 Langerhans cells (LCs) constitute a network of immune se

43 Langerhans cells (LCs) induce type 2 antibodies reactive

44 Langerhans cells participate in the immune response in l

45 Langerhans cells were required for eliciting immune resp

46 Langerhans cells, macrophages, and T lymphocytes were st

47 Langerhans' cells (LCs) are a subset of periphery reside

48 Langerhans-type dendritic cells (LC) are the most abunda

49 Langerhans-type dendritic cells (LC) are the only type o

50 Langerhans-type dendritic cells (LC) are the only type o

51 system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and

52 After activation, Langerhans cells (LC), a distinct subpopulation of epide

53 Although Langerhans cells (LCs) have been reported to express IL-

54 s; CD1c), plasmacytoid DCs (pDCs; CD303) and Langerhans cells (LCs; CD1a, CD207) in uncinate tissue (

55 IL-10 production by (regulatory) T cells and Langerhans cells in regulating CHS has been established

56 utrophils, macrophages, dendritic cells, and Langerhans cells remained in the tissue at least 1 wk.

57 utrophils, macrophages, dendritic cells, and Langerhans cells, and colocalization of vaccine Ag withi

58 epithelial, monocyte-derived dendritic, and Langerhans cells via direct cell-cell transmission.

59 terstitial dendritic cells of the dermis and Langerhans cells of the epidermis, in a dose- and time-d

60 ytic conditions, Erdheim-Chester disease and Langerhans cell histiocytosis.

61 ng cancer and in Erdheim-Chester disease and Langerhans'-cell histiocytosis.

62 elocalization toward the basal epidermis and Langerhans cells.

63 y an abnormality in corneal nerve fibers and Langerhans cells in patients with and without HIV-SN.

64 althy skin biopsies, human keratinocytes and Langerhans cells with IL-4.

65 of VIP on TLR regulation in macrophages and Langerhans cells.

66 Kupffer cells, microglia and Langerhans cells are only marginally replaced in one-yea

67 lymphomas, neuroblastoma, some sarcomas, and Langerhans cell histiocytosis.

68 dritic cells (DC) in the skin and mucosa are Langerhans cells (LC) and interstitial dermal DC (iDDC).

69 those of histiocytic human diseases, such as Langerhans cell histiocytosis.

70 The development of both Langerhans cells (LCs) and microglia is highly dependent

71 The latter also included CD1a(bright) Langerhans cells.

72 diated expression of interleukin-6 (IL-6) by Langerhans cells.

73 Presentation of foreign antigen by Langerhans cells (LC) in the absence of exogenous adjuva

74 These two markers are mainly expressed by Langerhans cells, which are one of several functionally

75 ency virus type 1 (HIV-1) is internalized by Langerhans cells (LCs) in stratified epithelia and trans

76 arbohydrate-dependent uptake of pathogens by Langerhans cells in the first step of antigen presentati

77 regulates the outcome of Ag presentation by Langerhans cells (LCs) to T cells through actions on mic

78 CD207+ Langerhans cells (LCs) and CD11c+ myeloid dendritic cell

79 led an increased number of epidermal CD83(+) Langerhans cells in FLG-null subjects.

80 tic cells: monocyte-derived dendritic cells, Langerhans cells, and interstitial dermal dendritic cell

81 o neutrophils, eosinophils, dendritic cells, Langerhans cells, macrophages and osteoclasts.

82 cytes, fibroblasts, melanocytes, mast cells, Langerhans cells, and Meissner's corpuscles, as well as

83 DCs were able to cross-prime CD8(+) T cells, Langerhans cells were unexpectedly found to potently cro

84 ll populations including endogenous T cells, Langerhans cells, and gammadelta T cells were not requir

85 heterogeneous diseases that mostly comprise Langerhans cell histiocytosis (LCH) and non-LCH.

86 ransit through the epidermis, which contains Langerhans cells (LC) and keratinocytes (KC), among othe

87 corneal nerve fiber tortuosity, and corneal Langerhans cell density between healthy controls and pat

88 No differences were identified in corneal Langerhans cell density (19.84 cells/mm2 for the control

89 ltrastructural features similar to cutaneous Langerhans cells (LCs).

90 There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), an

91 r with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRAFV600E mutation.

92 factor-alpha, IL-8, and CCL20, in dendritic/Langerhans-like cells and to a lesser extent in keratino

93 the effect of CHQ on human monocyte-derived Langerhans-like cells (MoLC) and dendritic cells (MoDC)

94 f langerin(high)-expressing monocyte-derived Langerhans-like cells.

95 Human CD34(+) progenitor-derived Langerhans-type dendritic cells (LCs) are more potent st

96 ection against HIV infection to skin-derived Langerhans cells in the ex vivo system, suggesting Marav

97 ify possible features that can differentiate Langerhans cells from malignant melanocytes to prevent t

98 Based on our ability to discriminate Langerhans cells (LCs), conventional DCs, monocytes, mon

99 Epidermal Langerhans cells (eLCs) uniquely express the C-type lect

100 Epidermal Langerhans cells (LC) expressing the high-affinity recep

101 Epidermal Langerhans cells (LCs) of the skin represent the prototy

102 Dermal dendritic cells and epidermal Langerhans cells are APCs that migrate from skin to drai

103 ered intradermally are taken up by epidermal Langerhans cells (LCs), dermal Langerin(neg) DCs, and de

104 he MCs was efficiently taken up by epidermal Langerhans cells and dermal dendritic cells in the vicin

105 conventional DC subsets and not by epidermal Langerhans cells.

106 sues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that a

107 In contrast, epidermal Langerhans cells and tissue macrophages were largely pre

108 RC1 but not mTORC2 is required for epidermal Langerhans cell (LC) homeostasis.

109 oid and myeloid DCs, but also from epidermal Langerhans cells, indicating a distinct DC entity.

110 We recently reported that human epidermal Langerhans cells (LCs) are more efficient than dermal CD

111 The precise role of human epidermal Langerhans cells (LCs) in immune response is highly cont

112 henotypic characteristics of human epidermal Langerhans cells (LCs).

113 ) mice contained normal numbers of epidermal Langerhans cells (eLC) and increased numbers of CD11b(+)

114 for maintaining the homeostasis of epidermal Langerhans cells (LCs).

115 ance in mice critically depends on epidermal Langerhans cells (LCs), which capture DNTB and migrate t

116 upffer cells), brain (microglia), epidermis (Langerhans cells) and lung (alveolar macrophages) origin

117 Increased numbers of CD1a-expressing Langerhans cells were detected both in the epithelium an

118 g cutaneous inflammation when it facilitates Langerhans cell egress from skin and enables the accumul

119 esident member of the dendritic cell family, Langerhans cells (LCs) are generally regarded to functio

120 Unconventional immune regulatory roles for Langerhans cells, mast cells, and natural killer T (NKT)

121 istically to fully block HIV-1 transfer from Langerhans to autologous CD4(+) T cells and to inhibit C

122 plasmacytoid DC (pDC) and in vitro-generated Langerhans cells (LC) obtained from AD patients with HSV

123 enesis of 2 of the most common histiocytoses-Langerhans cell histiocytosis (LCH) and Erdheim-Chester

124 Human Langerhans cell (LC) precursors populate the epidermis e

125 Human Langerhans cells (LCs) are highly efficient at priming c

126 s the only other cytokine expressed by human Langerhans cells.

127 nd T-helper type 1 skewing function in human Langerhans cell-like dendritic cells (LC-DCs).

128 We tested the capacity of human Langerhans cells (LCs) and dermal dendritic cells (DDCs)

129 of TGF-beta1 on the differentiation of human Langerhans cells (LCs) and identified Axl as a key TGF-b

130 The ontogeny of human Langerhans cells (LCs) remains poorly characterized, in

131 for all mouse DC subsets revealed that human Langerhans cells (LCs) and the mouse XCR1(+)CD8alpha(+)C

132 y factors (IRFs) as controllers of the human Langerhans cell response to epidermal cytokines was reve

133 The presence of hyperreflective Langerhans cells mimicking malignant melanocytes was the

134 ts of skin-resident DC have been identified: Langerhans cells (LCs), dermal Langerin+ DC (Lang+ dDC),

135 Following MN immunization, Langerhans cells (LCs) constituted the major skin DC sub

136 nase (ERK) signaling pathway is activated in Langerhans cell histiocytosis (LCH) histiocytes, but onl

137 eric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen rec

138 BRAF mutations have been observed in Langerhans cell histiocytosis (LCH).

139 of skin langerin-expressing cells (including Langerhans cells).

140 NV infected a wide range of cells, including Langerhans cells, macrophages, dermal dendritic cells, m

141 most common histiocytic disorders, including Langerhans cell histiocytosis, Erdheim-Chester disease,

142 Cs in SDLNs, and augmented TRITC/DBP-induced Langerhans cell (LC) migration 72 hours post TRITC treat

143 angerin and the ephrin A2 receptor to infect Langerhans cells, which support full HHV-8 lytic replica

144 DCs, including a population of inflammatory Langerhans cells.

145 al melanocyte hyperplasia and intraepidermal Langerhans cells.

146 MHD1 is also expressed in epidermis-isolated Langerhans cells (LC), but degradation of SAMHD1 does no

147 cluding ex vivo-generated DCs, skin-isolated Langerhans cells, and blood myeloid DCs and plasmacytoid

148 dly, huLangerin-DTA mice (DeltaLC) that lack Langerhans cells (LC) developed increased skin inflammat

149 Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic

150 fected HIV-susceptible CD4(+) T lymphocytes, Langerhans/dendritic cells, and macrophages.

151 cts with FLG-null mutations have more mature Langerhans cells in nonlesional skin irrespective of whe

152 ecause oral antigen-presenting cells (mostly Langerhans and myeloid dendritic cells) exhibit a tolero

153 Human epidermal and mucosal Langerhans cells (LCs) express the C-type lectin recepto

154 We tested the contribution of mucosal Langerhans cells (LCs) to alveolar bone homeostasis in m

155 with monocyte-derived DCs (MDDCs) and MUTZ3 Langerhans cells (LCs) to investigate their relevance as

156 Skin-resident DCs, namely, Langerhans cells (LCs), have been implicated in regulati

157 langerin (Lang; CD207)(neg) DCs, but neither Langerhans cells nor Lang(+) DCs were required for CD8(+

158 Juvenile xanthogranuloma (JXG) is a non-Langerhans histiocytic cell disorder in children which m

159 Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that most commonly affects

160 d eruptive histiocytosis (GEH) is a rare non-Langerhans cell histiocytosis with a benign, self-healin

161 Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, to whose pathogenesis neo

162 Erdheim-Chester disease (ECD) is a rare, non-Langerhans histiocytosis.

163 In vivo studies questioned the ability of Langerhans cells (LCs) to mediate CD8(+) T cell priming.

164 nfection, we showed that in vivo ablation of Langerhans cells (LCs) resulted in enhanced bone loss.

165 lation by UVB radiation, because ablation of Langerhans cells abolished the UVB-induced phenotype.

166 matic disease defined by the accumulation of Langerhans cell-like dendritic cells (DCs).

167 oinflammatory cytokines, and accumulation of Langerhans cells and macrophages within 3 days of tamoxi

168 ations have been observed in 57% of cases of Langerhans cell histiocytosis (LCH) and 54% of cases of

169 logical heterogeneity and differentiation of Langerhans cells, delineate the signaling pathways respo

170 d TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo.

171 ology of the skin, including the function of Langerhans cells, the migration of immune cells in skin,

172 assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis have undergone c

173 This infection of Langerhans cells and interstitial dermal dendritic cells

174 -derived IL-1beta alone reduced infection of Langerhans cells, macrophages, and dermal dendritic cell

175 culation led to recruitment and infection of Langerhans cells, macrophages, and dermal dendritic cell

176 ited in recent years, and the involvement of Langerhans cells (LCs), a population of epidermal dendri

177 ng beta cells within the pancreatic islet of Langerhans are responsible for maintaining glucose homeo

178 egulated hormone secretion from the islet of Langerhans is central to the pathophysiology of diabetes

179 Cell-cell communication in the islet of Langerhans is important for the regulation of insulin se

180 ce EXOs, we isolated cells from the islet of Langerhans of NOD mice and cultured them in vitro.

181 Thus, the anatomy of the islet of Langerhans permits the specific localization of diabetog

182 eleased from the alpha-cells of the islet of Langerhans, which has a key role in glucose homeostasis.

183 Macrophages in islets of Langerhans and in the interacinar stroma are distinct in

184 nly expressed on beta-cells in the islets of Langerhans and is therefore an attractive target for ima

185 tructural changes were observed in islets of Langerhans and livers of mutant animals, as well as alte

186 e focus on the resident APC of the islets of Langerhans and their role in autoimmune diabetes.

187 ecific T cells from reentering the islets of Langerhans and thereby blocked the autodestructive proce

188 The islets of Langerhans are endocrine organs characteristically dispe

189 The pancreatic islets of Langerhans are multicellular micro-organs integral to ma

190 Thus, the macrophages of the islets of Langerhans are poised to mount an immune response even a

191 Islets of Langerhans are the regulators of in vivo blood glucose l

192 Also, the islets of Langerhans attracted polymorphonuclear cells, possibly v

193 s beyond the pancreatic lymph node-islets of Langerhans axis and indicates that circulating insulin,

194 on of diabetogenic T cells only to islets of Langerhans bearing the specific antigen.

195 Pancreatic islets of Langerhans consist of endocrine cells, primarily alpha,

196 The islets of Langerhans constitute the endocrine part of the pancreas

197 Islets of Langerhans contain antigen-presenting cells that capture

198 Human pancreatic islets of Langerhans contain five distinct endocrine cell types, e

199 m the beta-cells of the pancreatic islets of Langerhans controls energy homeostasis in vertebrates, a

200 from beta cells of the pancreatic islets of Langerhans controls metabolic homeostasis and is impaire

201 insulin pathway genes in isolated islets of Langerhans from these patients.

202 dynamics of multiple peptides from islets of Langerhans in a highly automated fashion is expected to

203 n Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and examined the m

204 oactive spots colocalized with the islets of Langerhans in clorgyline-treated animals.

205 Insulin is secreted from the islets of Langerhans in coordinated pulses.

206 Insulin is released from the islets of Langerhans in discrete pulses that are linked to synchro

207 ncerning the lymph drainage of the islets of Langerhans in the human pancreas.

208 cells in the intestine and in the islets of Langerhans in the pancreas.

209 We found that the islets of Langerhans in young nonobese diabetic (NOD) mice contain

210 We engrafted human pancreatic islets of Langerhans into the renal subcapsular space of immunodef

211 ulin secretion from the pancreatic islets of Langerhans is enhanced by the intestinal hormone glucago

212 e endocrine pancreas, of which the islets of Langerhans is the major constituent, has been implicated

213 Encapsulation of islets of Langerhans may represent a way to transplant islets in t

214 The islets of Langerhans normally contain resident antigen presenting

215 of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag

216 gen presenting cells (APCs) in the islets of Langerhans of the non-obese diabetic (NOD) mouse.

217 from pancreatic beta-cells within islets of Langerhans plays a critical role in maintaining glucose

218 Pancreatic islets of Langerhans regulate blood glucose homeostasis by the sec

219 n of diabetogenic CD4 T cells into islets of Langerhans resulting in diabetes were examined.

220 resident macrophages of pancreatic islets of Langerhans that lasted for several weeks.

221 ics and islet mass of transplanted islets of Langerhans throughout diet-induced progression from norm

222 What coordinates the many islets of Langerhans throughout the pancreas to produce unified os

223 Allogeneic islets of Langerhans transplantation is hampered in its success as

224 diators that are secreted by human islets of Langerhans upon CVB infection and may shed light on the

225 , we studied the response of human islets of Langerhans upon mock or CVB3 infection.

226 et amyloid polypeptide (IAPP) from islets of Langerhans using a microfluidic system with two-color de

227 e problem is the reinfiltration of islets of Langerhans with regenerated, autoaggressive lymphocytes.

228 tein synthesis in freshly isolated islets of Langerhans, across a range of glucose concentrations.

229 rat pituitary, the rat pancreatic islets of Langerhans, and from the Aplysia californica nervous sys

230 se levels, preserves beta-cells in islets of Langerhans, and improves insulin action.

231 ntransparent nanoneedle arrays, of islets of Langerhans, and of hippocampal neurons under upright opt

232 bility of paracrine factors in the islets of Langerhans, and the constitution of the beta cell baseme

233 eta-cells, found in the pancreatic islets of Langerhans, are destroyed by infiltrating T cells.

234 s patches, lymph nodes, pancreatic islets of Langerhans, bone marrow, and salivary glands of preclini

235 y dysfunction to beta-cells in the islets of Langerhans, disrupting insulin secretion and glucose hom

236 ) peptide and protein profiling of Islets of Langerhans, for future type 2 diabetes (T2D) studies.

237 ion of the endocrine pancreas, the islets of Langerhans, has been shown to provide cholinergic input

238 A primary insult to the pancreatic islets of Langerhans, leading to the activation of innate immunity

239 The islets of Langerhans, micro-organs for maintaining glucose homeost

240 ocrine compartment, organized into islets of Langerhans, produces hormones that regulate blood glucos

241 cells were directly recruited into islets of Langerhans, where they established contact with resident

242 f the transporter localized in the islets of Langerhans.

243 usters of the type found in normal islets of Langerhans.

244 insulin secretion dynamics of the islets of Langerhans.

245 ecreting cells and isolated rodent islets of Langerhans.

246 population of nonbeta cells in the islets of Langerhans.

247 ne cell activity in the pancreatic islets of Langerhans.

248 pancreas and complete loss of the islets of Langerhans.

249 ed in pancreatic insulin-producing islets of Langerhans.

250 ressed in adult tissues, including islets of Langerhans.

251 nsulin-secreting beta-cells in the islets of Langerhans.

252 the thymus but is activated in the islets of Langerhans.

253 autoaggressive lymphocytes to the islets of Langerhans.

254 l lining of the ducts and form the islets of Langerhans.

255 in the extracellular space of the islets of Langerhans.

256 multiple micro-organs known as the islets of Langerhans.

257 rne factors dynamically access the islets of Langerhans.

258 nsulin-producing beta cells in the islets of Langerhans.

259 angerin, the distinguishing C-type lectin of Langerhans cells, would recognize the highly mannosylate

260 in regulates the maturation and migration of Langerhans cells, and its ligation prevents the inductio

261 ts internalization in specific organelles of Langerhans cells.

262 s (LCH) represents a clonal proliferation of Langerhans cells.

263 Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunode

264 dent manner, suggesting an essential role of Langerhans cells and dendritic cells in CHQ-provoked pso

265 f Th1 and Th2 polarization in the setting of Langerhans cell (LC) Ag presentation to responsive T cel

266 There is little data on treatment of Langerhans cell histiocytosis (LCH) in adults.

267 ing molecule that is abundantly expressed on Langerhans cells.

268 interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific inte

269 Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake

270 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a

271 n the cohort with Erdheim-Chester disease or Langerhans'-cell histiocytosis, the response rate was 43

272 nces in the numbers of T or B lymphocytes or Langerhans cells present in StrataGraft skin substitute

273 migratory dendritic cells and in particular Langerhans cells at governing T follicular helper and ge

274 Precursors of pathological Langerhans cells have yet to be defined.

275 tion of the epidermal mononuclear phagocytes Langerhans cells (LCs) to this phenomenon because of the

276 S-100-positive cells included CD1a-positive Langerhans cells, while CK20 did not identify any Merkel

277 atients with refractory, risk-organ-positive Langerhans cell histiocytosis (LCH) in 2005.

278 Antigen-presenting Langerhans cells show a differential migration phenotype

279 Activation via RANKL prevents Langerhans cell apoptosis, thus leading to enhanced anti

280 hough lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are perhaps more frequentl

281 us on lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis.

282 is functional, resulting in slightly reduced Langerhans cell numbers.

283 However, Flt3L-dependent DCs and resident Langerhans cells are dispensable for the inflammation.

284 However, the roles of skin-resident Langerhans cells (LCs) in eliciting immune responses hav

285 s highly expressed by DC purified from skin (Langerhans cells) and bone marrow, and has been shown to

286 At steady state, Langerhans cells (LCs) were lineage traced but also expr

287 dermally delivered TLR agonists to stimulate Langerhans cells and dermal DCs in their natural complex

288 Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate i

289 cific pattern recognition receptor TLR7, the Langerhans cell chemoattractant CCL20, and proinflammato

290 isrupted, allowing easier access of HIV-1 to Langerhans cells (LC) in the epidermis and perhaps even

291 In addition to Langerhans cells (LCs), other dendritic cells (CD11c(+))

292 uman immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective rol

293 Strikingly, using Langerhans cells model systems (mutz-3-derived LC, monoc

294 okine for mature DCs) in vitro, and in vivo, Langerhans cells show reduced emigration into draining l

295 novel somatic ARAF mutation in a child with Langerhans cell histiocytosis (LCH) and demonstrate that

296 During infection, HPV16 also interacts with Langerhans cells (LC), the APC of the epithelium, induci

297 facilitate the interaction of M. leprae with Langerhans cells.

298 9 patients with ECD and ECD overlapping with Langerhans cell histiocytosis (so-called mixed histiocyt

299 have been observed in half of patients with Langerhans cell histiocytosis (LCH) and in 50% to 100% o

300 ing data to date on a group of patients with Langerhans cell histiocytosis (LCH), which historically