ライフサイエンスコーパス: Lck kinase

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1 ptor desensitization through inactivation of Lck kinase.

2 1 cells, suggesting the critical role of p56(lck) kinase.

3 We and others have found that the Lck kinase, a member of the Src family of PTKs, binds th

4 Further, we present data indicating that the Lck kinase activates the guanine nucleotide exchange fac

5 signaling, concomitant to suppression of p56(lck) kinase activation.

6 Coexpression in 293T cells demonstrated that Lck kinase activity and Cbl ubiquitin ligase activity we

7 role in both enhancing CD8 alpha-associated Lck kinase activity and promoting the development of CD8

8 everalfold reduction in CD8 alpha-associated Lck kinase activity compared with that observed with cel

9 Dysregulation of Lck expression or Lck kinase activity has been implicated in T cell leukem

10 eage cells, we assessed CD8 alpha-associated Lck kinase activity in both T cell hybridomas and thymoc

11 mediated enhancement of CD8 alpha-associated Lck kinase activity in the differentiation of CD8 single

12 mice and human mutations, demonstrates that Lck kinase activity is critical for normal T cell develo

13 ce in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated b

14 t mice and human mutations demonstrates that Lck kinase activity is critical for T-cell receptor-medi

15 Therefore, Lck kinase activity is determined by the balance of acti

16 teracted with Lck, was capable of activating Lck kinase activity strongly and was multiply phosphoryl

17 ft also correlated, to a lesser extent, with Lck kinase activity that was down-regulated with Th1 dev

18 glucose deprivation (OGD) exhibited enhanced Lck kinase activity, and were resistant to injury on sub

19 ionship between tyrosine phosphorylation and Lck kinase activity, CD45- YAC-1 cells were transfected

20 in the BI-141 T cell hybridoma leads to the Lck kinase activity-dependent enhancement of TCR-mediate

21 SP development may not necessarily depend on Lck kinase activity.

22 sses Lck protein and exhibits high levels of Lck kinase activity.

23 H)-one ( 25), exhibits potent inhibition of Lck kinase activity.

24 This TCR signal may be independent of Lck kinase and SH2 activities, or may require lower thre

25 scious rabbit model, suggesting that Src and Lck kinases are essential for the development of ischemi

26 es as a lymphocyte-specific protein tyrosine Lck kinase binding site in the CD28 cytosolic tail.

27 A CD8alpha/Lck kinase-dead chimera also resulted in reconstitution

28 ugh src tyrosine kinases because eliminating lck kinase expression, coexpressing fyn kinase dead, or

29 horylation of the CD3epsilon ITAM by Fyn and Lck kinases in vitro.

30 f p34cdc2 kinase, which is phosphorylated by lck kinase (lymphocyte-specific tyrosine kinase, p56lck)

31 acologic inhibition or genetic disruption of Lck kinase, PLC-gamma1 or the T cell receptor complex in

32 opments include the finding that much of the Lck kinase (required to initiate T cell signaling) is al

33 Mutations in the Lck kinase, Src homology 2 or 3 domains, or the myristoy

34 into the active site of the closely related Lck kinase strongly favors ITAM binding in an orientatio

35 arallel recruitment of coreceptor-associated Lck kinase to the TCR ensured Zap70 phosphorylation and

36 as been proposed that the interaction of the Lck kinase with CD4 or CD8 coreceptors is critical for g

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