ライフサイエンスコーパス: Legionella

1 e between potential and confirmed sources of Legionella.

2 owledge about all the (potential) sources of Legionella.

3 could be classified as confirmed sources of Legionella.

4 res in other intracellular pathogens such as Legionella.

5 ce at the private nursery were infected with Legionella.

6 nd is caused by infection with the bacterium Legionella.

7 Legionella, a large group of environmental Gram-negative

8 Legionella activation of caspase-11 induced pyroptosis b

9 Legionella activation of caspase-11 stimulated activatio

10 However, in which manner Legionella actively exploits PI lipids to benefit its in

11 tified stagnant pipes, inhibiting culturable Legionella and biofilm formation, but promoted Legionell

12 Legionella and Coxiella are intracellular pathogens that

13 t is ideal for the growth and interaction of Legionella and free-living amoebae (FLA) due to biofilm

14 By using several species of Legionella and mice singly deficient for caspase-1 or ca

15 amines, on water chemistry and the growth of Legionella and mycobacteria across a transect of bench-

16 confirms prior reports of trade-offs between Legionella and mycobacteria if chloramines are applied a

17 aterborne pathogens were bacteria, including Legionella and other gram-negative bacteria, and nontube

18 Chloramines eliminated culturable Legionella and prevented L. pneumophila from recolonizin

19 (particularly Campylobacter, Norovirus, and Legionella) and exposure frequency.

20 egionella), decorative water wall fountains (Legionella), and heater-cooler devices used in cardiac s

21 curring HMA+ and HMA- strains of Toxoplasma, Legionella, and Chlamydia indicates the existence of evo

22 veral infectious agents, such as Toxoplasma, Legionella, and Chlamydia, have been reported to grow wi

23 th organisms such as Pneumocystis, Listeria, Legionella, and Salmonella.

24 Water is the major natural reservoir for Legionella, and the pathogen is found in many different

25 Legionella anisa was identified by 16S rRNA gene sequenc

26 ssed: blood cultures, urine pneumococcal and legionella antigens, Mycoplasma pneumoniae and Chlamydia

27 breaks within the last years have shown that Legionella are a growing challenge for public health.

28 ylococcus aureus, Chlamydia, Mycoplasma, and Legionella are each identified in 2%-5% of patients with

29 that novel exoproteins which are specific to Legionella are especially important for infection.

30 ethods capable of rapidly identifying viable Legionella are important for the control of engineered w

31 ntified in early 1977, bacteria of the genus Legionella are recognised as a common cause of community

32 Legionella bacteria are ubiquitous in natural matrices a

33 e pneumonia and systemic infection caused by Legionella bacteria is Legionnaires' disease.

34 Legionella bacteria multisystem manifestations mainly af

35 If humans inhale aerosols containing Legionella bacteria, Legionnaires' disease or Pontiac fe

36 rtant role in the transmission of infectious Legionella bacteria; they might not yet be considered in

37 le tertiary-level laboratory were tested for Legionella by PCR, whether requested or not.

38 between 6 and 10 mg/L, reducing the level of Legionella by three logarithmic unit by 2 months postins

39 using previously described agonists in that Legionella caspase-11 activation was rapid and required

40 ch is localized to the cytosolic side of the Legionella-containing vacuole (LCV) and is essential for

41 y hijacking endocytic pathways and forming a Legionella-containing vacuole (LCV) in which the bacteri

42 Within macrophages and amoeba, the Legionella-containing vacuole (LCV) membrane is derived

43 e AnkB effector enables its anchoring to the Legionella-containing vacuole (LCV) membrane.

44 pneumophila survives and replicates within a Legionella-containing vacuole (LCV) of amoebae and macro

45 ole for LidA in bridging the membrane of the Legionella-containing vacuole (LCV) with that of secreto

46 ostentry and to grow to large numbers in the Legionella-containing vacuole (LCV), as evident at 12 h.

47 pneumophila to establish a niche called the Legionella-containing vacuole (LCV), which is permissive

48 stablish a replication-permissive niche, the Legionella-containing vacuole (LCV).

49 the cytoplasmic face of the membrane of the Legionella-containing vacuole (LCV).

50 ages in a specialized compartment termed the Legionella-containing vacuole (LCV).

51 ocalization N) protein to the surface of the Legionella-containing vacuole where this putative transm

52 Rtn4 playing a role in the formation of the Legionella-containing vacuole, it was recruited to almos

53 oa and mammalian phagocytes within a unique "Legionella-containing vacuole." The bacteria govern host

54 We report that the delivery of GBP2 to Legionella-containing vacuoles is dependent on the bacte

55 Vs and that the delivery of GBP1 and GBP2 to Legionella-containing vacuoles or YCVs is substantially

56 on of endosomes thereby blocking fusion with Legionella-containing vacuoles.

57 e factors, become flagellated, and leave the Legionella-containing vacuoles.

58 hase, the bacteria grow within host cells in Legionella-containing vacuoles.

59 is a promising disinfectant that can prevent Legionella contamination of hospital water supplies.

60 ve the manufacturer's recommended target for Legionella control.

61 ospital, including collection of samples for Legionella culture.

62 ectronic faucets (Pseudomonas aeruginosa and Legionella), decorative water wall fountains (Legionella

63 this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to gen

64 Specifically, cytosolic sensing of Legionella-derived flagellin, inflammasome activation, a

65 que nucleotide sequences in its target gene, legionella determinent target A (ldtA), creating a reper

66 Activation by Legionella differed from caspase-11 activation using pre

67 ction than has been found in the comparative Legionella Dot/Icm model.

68 ial and temporal control of Rab1 function by Legionella during infection.

69 4SS-dependent interplay between Brucella and Legionella during macrophage coinfection.

70 vgA, and that this pentameric assembly binds Legionella effector proteins.

71 and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 by switch

72 uding a subset of previously uncharacterized Legionella effectors that appear to be able to regulate

73 Among these Legionella effectors, WipA has been primarily studied be

74 Thus, Legionella employs multiple sophisticated molecular mech

75 tein homology search revealed that the three Legionella enzymes and P. fluorescens PC-PLC share conse

76 ance during monochloramine treatment include Legionella, Escherichia, and Geobacter in the lab-scale

77 e show that three of these effectors [LegC2 (Legionella eukaryotic-like gene C2)/YlfB (yeast lethal f

78 Here we show that the Legionella export apparatus is localized to the bacteria

79 Gram-negative bacteria from the Legionella genus are intracellular pathogens that cause

80 gionella and biofilm formation, but promoted Legionella growth in pipes subject to convective mixing.

81 g copper-silver ionization for prevention of Legionella growth in water.

82 than Detroit water and exceeded the minimum Legionella growth temperature of 20 degrees C more frequ

83 regarding the variable effects of copper on Legionella growth, and confirms prior reports of trade-o

84 and silver concentrations were tested showed Legionella growth.

85 ver water that were potentially conducive to Legionella growth.

86 egionella-specific culture, all but 2 showed Legionella growth; 11 isolates were identical to 3 clini

87 the impact of monochloramine disinfection on Legionella, heterotrophic bacteria (36 degrees C), Pseud

88 must be avoided as the risk of disseminating Legionella in neonates is very high.

89 ation was consistent with proven or probable Legionella infection in 84% of the cases.

90 Emerging data suggest that Legionella infection involves the subversion of host pho

91 In December 2008, a large outbreak of Legionella infection occurred in term neonates in Cyprus

92 and the control of energy metabolism during Legionella infection.

93 ety for Clinical Microbiology Study Group on Legionella Infections (ESGLI), were tested together with

94 clinical features of 33 consecutive cases of Legionella infections that occurred at the University of

95 om advanced stage (IIIB, IV) patients, while Legionella is higher in patients who develop metastases.

96 -based typing of Legionella pneumophila, the Legionella laboratory at the Centers for Disease Control

97 In summary, diverse Legionella LD-causing species share a conserved core-gen

98 tive aerobic bacteria belonging to the genus Legionella; Legionella pneumophila serogroup 1 is the ca

99 tive distribution: 38%), while environmental Legionella-like phylotypes peaked (19%) during Period II

100 Legionella longbeachae (Llo) and Legionella pneumophila

101 Crystal structure of SidP orthologue from Legionella longbeachae reveals that this unique PI-3-pho

102 of 20 effectors from Legionella pneumophila, Legionella longbeachae, and Coxiella burnetii.

103 ding) plumbing systems, including strains of Legionella, Mycobacterium, Acanthamoeba, and Pseudomonas

104 testing, releasing more iron, which is a key Legionella nutrient, while also directly causing disinfe

105 viability haRPA, is able to identify viable Legionella on DNA microarrays.

106 the growth of opportunistic pathogens (e.g., Legionella) or other nuisance organisms (e.g., nitrifier

107 Legionella pathogenicity is mediated by specific virulen

108 ormation exists regarding effectors in other Legionella pathogens.

109 er, our identification of a unique family of Legionella PI phosphatases highlights a common scheme of

110 zed in the United States with a diagnosis of Legionella pneumonia in the Premier Perspectives databas

111 Two proven nosocomial cases of Legionella pneumonia occurred at the Wesley Hospital (Br

112 alone or a quinolone alone for treatment of Legionella pneumonia was associated with similar hospita

113 Legionella pneumonia was diagnosed in 3152 adults across

114 n or a quinolone antibiotic for treatment of Legionella pneumonia.

115 rsistence and associated risks of pathogenic Legionella pneumophila (L. pneumophila), thus raising hu

116 model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (

117 Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumon

118 dentify amoeba isolates, and the presence of Legionella pneumophila , Mycobacterium spp., Pseudomonas

119 uring infection of macrophages, the pathogen Legionella pneumophila bypasses the microbicidal endosom

120 femtomole levels of 16s rRNA from pathogenic Legionella pneumophila can be timely and effectively det

121 at a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubi

122 tion, the intracellular pathogenic bacterium Legionella pneumophila causes an extensive remodeling of

123 The quantification of RNA from Legionella pneumophila cellular lysates was successfully

124 he intracellularly replicating lung pathogen Legionella pneumophila consists of an extraordinary vari

125 The intracellular pathogen Legionella pneumophila converts from a noninfectious rep

126 The gram-negative bacterial pathogen Legionella pneumophila creates a novel organelle inside

127 The structure of Legionella pneumophila Cu(+)-ATPase shows that a kinked

128 Importantly, Legionella spp. and Legionella pneumophila decreased after switching back to

129 The Legionella pneumophila Dot/Icm T4SS injects approximatel

130 The Legionella pneumophila effector vacuolar protein sorting

131 The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host s

132 wed the phagocytosis of both viable and dead Legionella pneumophila filaments.

133 he transition state mimetic structure of the Legionella pneumophila GAP LepB in complex with Rab1 and

134 irulence factors from the bacterial pathogen Legionella pneumophila has been discovered to modify hum

135 Legionella pneumophila has been shown to secrete a prote

136 igation of legionellosis outbreaks caused by Legionella pneumophila However, as common sequence types

137 le and non-viable Legionella spp. as well as Legionella pneumophila in one hour.

138 at2, effectively suppress the replication of Legionella pneumophila in primary murine macrophages.

139 es intracellular infection of macrophages by Legionella pneumophila In the present study, we identifi

140 infection mouse model of influenza virus and Legionella pneumophila in which we can separate resistan

141 Legionella pneumophila infects human alveolar macrophage

142 Legionella pneumophila infects lung macrophages and inje

143 The intracellular pathogen Legionella pneumophila interferes with autophagy by deli

144 Upon entry of Legionella pneumophila into amoebas and macrophages, hos

145 Legionella pneumophila is a bacterial pathogen that thri

146 AnkB effector of the intravacuolar pathogen Legionella pneumophila is a bona fide F-box protein, whi

147 Legionella pneumophila is a causative agent of a severe

148 Legionella pneumophila is a causative agent of severe pn

149 Legionella pneumophila is a facultative intracellular hu

150 Legionella pneumophila is a water-borne bacterium that c

151 Legionella pneumophila is an environmental bacterium and

152 Legionella pneumophila is an intracellular bacterial pat

153 Legionella pneumophila is an intracellular bacterial pat

154 Legionella pneumophila is an intracellular bacterium tha

155 Legionella pneumophila is an intravacuolar pathogen that

156 Legionella pneumophila is auxotrophic for several amino

157 evious studies established that the pathogen Legionella pneumophila is capable of hijacking Rab1 func

158 e Dot/Icm type IV secretion system (T4SS) of Legionella pneumophila is crucial for the pathogen to su

159 Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide

160 Type II protein secretion (T2S) by Legionella pneumophila is required for intracellular inf

161 Legionella pneumophila is the causative agent of a sever

162 Bacterial pathogen Legionella pneumophila is the causative agent of Legionn

163 le genome sequence analysis was performed on Legionella pneumophila isolates from the infected patien

164 Previously, we reported that mutants of Legionella pneumophila lacking a type II secretion (T2S)

165 Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, s

166 Intracellular growth of Legionella pneumophila occurs in a replication vacuole c

167 rulent strain of the intracellular bacterium Legionella pneumophila or a nonpathogenic mutant of L. p

168 nnaires' disease in a clinical setting where Legionella pneumophila PCR had been introduced.

169 lination of Rab35, which is catalyzed by the Legionella pneumophila protein AnkX, interferes with the

170 study provides detailed understanding of the Legionella pneumophila protein DrrA and of AMP-transfer

171 resses translation of the hupA mRNA, and the Legionella pneumophila protein RocC binds the RocR sRNA,

172 sional structure of the protein lpg2210 from Legionella pneumophila provides the first structural inf

173 Infection by the human pathogen Legionella pneumophila relies on the translocation of ap

174 se-11 was dispensable for the restriction of Legionella pneumophila replication in macrophages and in

175 ion of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that i

176 ted that 84% are caused by the microorganism Legionella pneumophila Serogroup (Sg) 1.

177 Legionella spp., Legionella pneumophila, and Legionella pneumophila serogroup 1 in primary specimens.

178 bacteria belonging to the genus Legionella; Legionella pneumophila serogroup 1 is the causative agen

179 Legionella pneumophila serogroup 1 isolates were culture

180 t the genomic sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H (ATC

181 Legionella pneumophila serogroup 3 was recovered in neon

182 In this report, we found that members of the Legionella pneumophila SidE effector family harbor a DUB

183 m type IV secretion system (T4SS) of several Legionella pneumophila strains.

184 The intracellular bacterial pathogen Legionella pneumophila subverts host membrane transport

185 Legionella pneumophila survives and replicates within a

186 for translocation using the well-established Legionella pneumophila T4SS secretion model.

187 ls by the Dot/Icm injection apparatus allows Legionella pneumophila to establish a niche called the L

188 Here, we used the bacterial pathogen Legionella pneumophila to understand how the immune syst

189 al host organism Acanthamoeba castellanii to Legionella pneumophila under in vivo (LCV) conditions.

190 Legionella pneumophila uses a single homodimeric disulfi

191 Legionella pneumophila uses a type IVB secretion system

192 Legionella pneumophila uses the Icm/Dot type 4B secretio

193 The bacterial pathogen Legionella pneumophila utilizes approximately 300 effect

194 Legionella pneumophila utilizes the Dot/Icm type IV tran

195 inic acid from the lipopolysaccharide of the Legionella pneumophila virulence factor.

196 Legionella pneumophila was found in the sedimentation po

197 Label-free detection of Legionella pneumophila was performed using a PC platform

198 the DNA uptake system in the human pathogen Legionella pneumophila We found that a repressor of this

199 ologs encoded by the Philadelphia isolate of Legionella pneumophila were toxic to yeast, and SidJ sup

200 ssecting the interaction between a pathogen (Legionella pneumophila) and its host (cultured Drosophil

201 s of 9 different serogroups of the bacterium Legionella pneumophila, a common human pathogen responsi

202 Typhimurium, Pectobacterium carotovorum and Legionella pneumophila, also include global regulators t

203 Legionella pneumophila, an intracellular pathogen respon

204 Legionella pneumophila, an intracellular pathogen that c

205 We show here that Legionella pneumophila, an intravacuolar pathogen that r

206 We characterized a DGR in Legionella pneumophila, an opportunistic human pathogen

207 etecting and discriminating Legionella spp., Legionella pneumophila, and Legionella pneumophila serog

208 causative agent of Legionnaires' pneumonia, Legionella pneumophila, colonizes diverse environmental

209 experimental validation of 20 effectors from Legionella pneumophila, Legionella longbeachae, and Coxi

210 Legionella pneumophila, Mycobacterium avium, and Pseudom

211 tive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium avium, Mycobacteri

212 mon lung pathogens Streptococcus pneumoniae, Legionella pneumophila, or Mycobacterium tuberculosis-in

213 her lethal (Yersinia pestis) and non-lethal (Legionella pneumophila, Pseudomonas aeruginosa) pulmonar

214 lytes of three pathogenic bacterial strains: Legionella pneumophila, Pseudomonas aeruginosa, and Salm

215 is, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Stenotro

216 Many bacteria, including Legionella pneumophila, rely on the type IV secretion sy

217 ) and 26GUmicroL(-1) for Legionella spp. and Legionella pneumophila, respectively, were achieved.

218 oazide (PMA) to simultaneously detect viable Legionella pneumophila, Salmonella typhimurium, and Stap

219 The intracellular pathogen, Legionella pneumophila, secretes approximately 300 effec

220 Proteases from Mycoplasma hyorhinis, Legionella pneumophila, Streptococcus pneumonia and Cand

221 Enzymes secreted by Legionella pneumophila, such as phospholipases A (PLAs)

222 Legionella pneumophila, the agent of Legionnaires' disea

223 For Legionella pneumophila, the bacterium translocates prote

224 cal protection from pulmonary infection with Legionella pneumophila, the causative agent of a severe

225 is a previously uncharacterized effector of Legionella pneumophila, the causative agent of Legionnai

226 mune response to bacterial pathogens such as Legionella pneumophila, the causative agent of Legionnai

227 The facultative intracellular pathogen Legionella pneumophila, the causative agent of Legionnai

228 Legionella pneumophila, the causative agent of Legionnai

229 When the bacterium Legionella pneumophila, the causative agent of Legionnai

230 Legionella pneumophila, the causative agent of Legionnai

231 Legionella pneumophila, the causative agent of Legionnai

232 The genome of the Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

233 The Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

234 Legionella pneumophila, the etiological agent of Legionn

235 Legionella pneumophila, the Gram-negative pathogen causi

236 as the gold standard for DNA-based typing of Legionella pneumophila, the Legionella laboratory at the

237 scovery protocol by targeting this enzyme in Legionella pneumophila, the major causative agent of Leg

238 Legionella pneumophila, the most commonly identified cau

239 Legionella pneumophila, the primary agent of Legionnaire

240 In Legionella pneumophila, the two-component system (TCS) P

241 ddition, during coinfection experiments with Legionella pneumophila, we found that defective intracel

242 racellular iron acquisition strategy used by Legionella pneumophila.

243 on with the intracellular bacterial pathogen Legionella pneumophila.

244 ubsequent infection with Escherichia coli or Legionella pneumophila.

245 ed with the Gram-negative bacterial pathogen Legionella pneumophila.

246 re form of pneumonia caused by the bacterium Legionella pneumophila.

247 cteria, including the opportunistic pathogen Legionella pneumophila.

248 tor protein SidM from the bacterial pathogen Legionella pneumophila.

249 LC4 is induced by the intracellular pathogen Legionella pneumophila.

250 n is critical to the growth and virulence of Legionella pneumophila.

251 respectively, from the pathogenic bacterium Legionella pneumophila.

252 R amplicons derived from genomic DNA of live Legionella pneumophila.

253 ing form of pneumonia caused by the bacteria Legionella pneumophilia.

254 In addition, Legionella provides the protein SidD that hydrolytically

255 novel Zn(2+)-dependent PLC family present in Legionella, Pseudomonas, and fungi with broad substrate

256 re formation, pyroptosis, and restriction of Legionella replication in macrophages and in vivo.

257 he NLRC4 inflammasome and the restriction of Legionella replication in macrophages and in vivo.

258 related to the NLRC4-mediated restriction of Legionella replication were performed using mice double

259 review provides an overview of reservoirs of Legionella reported in the literature, other than drinki

260 ination of hot water distribution systems by Legionella represents a great challenge due to difficult

261 ion of substrates is critically required for Legionella's alteration of the host endocytic pathway, a

262 s positive, increasing to 1 in 9 during peak Legionella season (November to January).

263 be easily adapted for the monitoring of all Legionella serogroups in clinical and environmental samp

264 fferent proportions of viable and non-viable Legionella, shown with the example of L. pneumophila, ra

265 cases of pneumonia due to L. donaldsonii and Legionella sp. D5382 are likely the first reports of hum

266 hernii, L. parisiensis, L. sainthelensi, and Legionella sp. strain D5382.

267 p serogroups 1-17 and 17 emergent LD-causing Legionella species (of which 33 were sequenced in this s

268 ssembled and characterized the genomes of 38 Legionella species and predicted their effector repertoi

269 Together, these results suggest that diverse Legionella species infect patients with cancer in the Ho

270 Legionella species inhabit freshwater and soil ecosystem

271 The 33 strains involved 12 Legionella species or subspecies: 15 strains of L. pneum

272 The effector repertoires of different Legionella species were found to be largely non-overlapp

273 -negative bacteria, Mycobacterium species or Legionella species.

274 splant, with their infections caused by five Legionella species.

275 differences in virulence between strains of Legionella species.

276 here environmental samples were obtained for Legionella-specific culture, all but 2 showed Legionella

277 pt initiation of appropriate antibiotics for Legionella spp in all patients with community-acquired o

278 Importantly, Legionella spp. and Legionella pneumophila decreased aft

279 units (GU) microL(-1) and 26GUmicroL(-1) for Legionella spp. and Legionella pneumophila, respectively

280 es, biosensors for the on-field detection of Legionella spp. are highly in demand.

281 at is able to quantify viable and non-viable Legionella spp. as well as Legionella pneumophila in one

282 Legionella spp. densities (likely including pathogenic L

283 etween Vermamoebae vermiformis densities and Legionella spp. densities (r = 0.83, p < 0.028).

284 Here we present data on FLA and Legionella spp. detected in water and biofilm from two t

285 Legionella spp. have been isolated and recovered from a

286 The densities of Legionella spp. identified in the hoses were similar to

287 gger flagellin/NLRC4-mediated restriction of Legionella spp. infection in macrophages and in vivo.

288 Recovery values for viable Legionella spp. were found between 81% and 133%.

289 Legionella spp., another genus containing potential oppo

290 simultaneously detecting and discriminating Legionella spp., Legionella pneumophila, and Legionella

291 events were positive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium a

292 However, concentrations of Legionella spp., M. intracellulare, Acanthamoeba spp., a

293 a high correlation coefficient (R=0.994) for Legionella spp., with a detection limit of 0.1 ng of the

294 The Legionella strains were isolated from bronchoscopy speci

295 LegC3 is likely utilized by Legionella to modulate eukaryotic membrane fusion events

296 ility of L. pneumophila and other species of Legionella to take up radiolabeled iron.

297 ds at the Cleveland Clinic were searched for Legionella urinary antigen (UAG), culture, and PCR tests

298 ecular mechanisms of an effector involved in Legionella virulence and may inform approaches to elucid

299 teraction between the two T4SSs in producing Legionella virulence phenotypes.

300 e, crucial for elucidating the mechanisms of Legionella virulence.