ライフサイエンスコーパス: Legionella pneumophila

1 LC4 is induced by the intracellular pathogen Legionella pneumophila.

2 n is critical to the growth and virulence of Legionella pneumophila.

3 respectively, from the pathogenic bacterium Legionella pneumophila.

4 R amplicons derived from genomic DNA of live Legionella pneumophila.

5 core components of an orthologous system in Legionella pneumophila.

6 for assembly of macromolecular structures in Legionella pneumophila.

7 competence in the freshwater living pathogen Legionella pneumophila.

8 of five F-box-domain-containing proteins of Legionella pneumophila.

9 d by caspase-1 after macrophage infection by Legionella pneumophila.

10 S) with homology to the Dot/Icm apparatus of Legionella pneumophila.

11 sponsive to heat-killed Escherichia coli and Legionella pneumophila.

12 ne in the facultative intracellular pathogen Legionella pneumophila.

13 eviously identified competence regulators in Legionella pneumophila.

14 intracellular respiratory bacterial pathogen Legionella pneumophila.

15 ene, sciS, found to be homologous to icmF in Legionella pneumophila.

16 on with the intracellular bacterial pathogen Legionella pneumophila.

17 racellular iron acquisition strategy used by Legionella pneumophila.

18 ubsequent infection with Escherichia coli or Legionella pneumophila.

19 re form of pneumonia caused by the bacterium Legionella pneumophila.

20 ed with the Gram-negative bacterial pathogen Legionella pneumophila.

21 cteria, including the opportunistic pathogen Legionella pneumophila.

22 tor protein SidM from the bacterial pathogen Legionella pneumophila.

23 Legionella pneumophila, a causative agent of bacterial p

24 s of 9 different serogroups of the bacterium Legionella pneumophila, a common human pathogen responsi

25 Legionella pneumophila, a motile opportunistic pathogen

26 Legionella pneumophila actively modulates host vesicle t

27 Typhimurium, Pectobacterium carotovorum and Legionella pneumophila, also include global regulators t

28 During its life cycle, Legionella pneumophila alternates between a replicative

29 During its life cycle, Legionella pneumophila alternates between at least two p

30 The opportunistic pathogen Legionella pneumophila alternates between two states: re

31 Legionella pneumophila, an intracellular pathogen respon

32 Legionella pneumophila, an intracellular pathogen that c

33 We show here that Legionella pneumophila, an intravacuolar pathogen that r

34 We characterized a DGR in Legionella pneumophila, an opportunistic human pathogen

35 ctivation of caspase-1 cleared unmanipulated Legionella pneumophila and Burkholderia thailandensis by

36 Legionella pneumophila and Coxiella burnetii are phyloge

37 We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type

38 eractions between the intracellular pathogen Legionella pneumophila and macrophages (Mphis), host and

39 inhibits axenic and intracellular growth of Legionella pneumophila and of 27 strains of wild-type an

40 eta induction by the intracellular bacterium Legionella pneumophila and promotes the bacterial growth

41 ssecting the interaction between a pathogen (Legionella pneumophila) and its host (cultured Drosophil

42 etecting and discriminating Legionella spp., Legionella pneumophila, and Legionella pneumophila serog

43 Coxiella burnetii and Legionella pneumophila are evolutionarily related pathog

44 most strains of the gram-negative bacterium Legionella pneumophila are not competent under normal la

45 hough most Dot/Icm-translocated effectors of Legionella pneumophila are not required for intracellula

46 e early stages of intracellular infection by Legionella pneumophila are well established at the ultra

47 Using the Gram-negative Legionella pneumophila as a model intracellular pathogen

48 ave been identified using bioinformatics and Legionella pneumophila as a surrogate type IV delivery s

49 The induction of virulence traits by Legionella pneumophila at the post-exponential phase has

50 The intracellular pathogen Legionella pneumophila avoids fusion with lysosomes and

51 onfronted with metabolic stress, replicative Legionella pneumophila bacteria convert to resilient, in

52 uring infection of macrophages, the pathogen Legionella pneumophila bypasses the microbicidal endosom

53 femtomole levels of 16s rRNA from pathogenic Legionella pneumophila can be timely and effectively det

54 The intracellular pathogen Legionella pneumophila can infect and replicate within m

55 at a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubi

56 The gram-negative bacterium Legionella pneumophila causes a severe form of pneumonia

57 tion, the intracellular pathogenic bacterium Legionella pneumophila causes an extensive remodeling of

58 The quantification of RNA from Legionella pneumophila cellular lysates was successfully

59 cleotides (oligos) generate mutations on the Legionella pneumophila chromosome by a mechanism that re

60 Legionella pneumophila colonizes freshwater amoebae and

61 causative agent of Legionnaires' pneumonia, Legionella pneumophila, colonizes diverse environmental

62 he intracellularly replicating lung pathogen Legionella pneumophila consists of an extraordinary vari

63 The Legionella pneumophila-containing phagosome evades endoc

64 The intracellular pathogen Legionella pneumophila converts from a noninfectious rep

65 one B are active against bacteria, including Legionella pneumophila Corby, algae, and fungi.

66 Here, we found that SidM from Legionella pneumophila could act as both GEF and GDI-dis

67 re, we found that the intracellular pathogen Legionella pneumophila could interfere with autophagy by

68 The gram-negative bacterial pathogen Legionella pneumophila creates a novel organelle inside

69 The structure of Legionella pneumophila Cu(+)-ATPase shows that a kinked

70 Importantly, Legionella spp. and Legionella pneumophila decreased after switching back to

71 Our previous mutational analysis of Legionella pneumophila demonstrated a role for type II p

72 Legionella pneumophila directs the formation of a specia

73 The Legionella pneumophila Dot/Icm system is a type IV secre

74 The Legionella pneumophila Dot/Icm T4SS injects approximatel

75 VceC could also be translocated by the Legionella pneumophila Dot/Icm T4SS into host cells.

76 egions, were secreted by the closely related Legionella pneumophila Dot/Icm T4SS.

77 Effectors delivered into host cells by the Legionella pneumophila Dot/Icm type IV transporter are e

78 f the Dot/Icm type IV protein transporter of Legionella pneumophila during infection.

79 The Legionella pneumophila effector vacuolar protein sorting

80 The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host s

81 cm-translocated ankyrin B (AnkB) effector of Legionella pneumophila exhibits molecular mimicry of euk

82 Legionella pneumophila exhibits surface translocation wh

83 The bacterial pathogen Legionella pneumophila exploits host cell vesicle transp

84 (29%) of 14 case patients showed evidence of Legionella pneumophila exposure, according to serologic

85 n of the 528-bp gene immediately upstream of Legionella pneumophila F2310 ptsP (enzyme I(Ntr)).

86 wed the phagocytosis of both viable and dead Legionella pneumophila filaments.

87 ria monocytogenes that ectopically expresses Legionella pneumophila flagellin, a potent activator of

88 he transition state mimetic structure of the Legionella pneumophila GAP LepB in complex with Rab1 and

89 The gram-negative bacterium Legionella pneumophila grows in both natural and man-mad

90 When Legionella pneumophila grows on agar plates, it secretes

91 irulence factors from the bacterial pathogen Legionella pneumophila has been discovered to modify hum

92 Legionella pneumophila has been shown to secrete a prote

93 igation of legionellosis outbreaks caused by Legionella pneumophila However, as common sequence types

94 the PmrA/PmrB two-component system (TCS) of Legionella pneumophila in global gene regulation and in

95 ed replication of the intracellular pathogen Legionella pneumophila in mouse macrophages.

96 le and non-viable Legionella spp. as well as Legionella pneumophila in one hour.

97 at2, effectively suppress the replication of Legionella pneumophila in primary murine macrophages.

98 r the recovery of a standardized inoculum of Legionella pneumophila in respiratory specimens (sputum

99 Based on the crystal structure of LapG of Legionella pneumophila in the accompanying report by Cha

100 es intracellular infection of macrophages by Legionella pneumophila In the present study, we identifi

101 infection mouse model of influenza virus and Legionella pneumophila in which we can separate resistan

102 The progression of Legionella pneumophila infection in macrophages is contr

103 TLR2 in mediating resistance to aerosolized Legionella pneumophila infection in vivo.

104 Type II protein secretion is critical for Legionella pneumophila infection of amoebae, macrophages

105 Upon Legionella pneumophila infection of macrophages, the cyt

106 the present study, we examined the effect of Legionella pneumophila infection on the expression of th

107 5 amino acids of flagellin or in response to Legionella pneumophila infection.

108 Legionella pneumophila infects human alveolar macrophage

109 Legionella pneumophila infects lung macrophages and inje

110 cultured in broth to the transmissive phase, Legionella pneumophila infects macrophages by inhibiting

111 The Dot/Icm type IV secretion system of Legionella pneumophila injects into host cells the F-box

112 The intracellular pathogen Legionella pneumophila interferes with autophagy by deli

113 Upon entry of Legionella pneumophila into amoebas and macrophages, hos

114 ave the unique ability to restrict or permit Legionella pneumophila intracellular growth.

115 Legionella pneumophila invades and replicates intracellu

116 Legionella pneumophila is a bacterial pathogen of amoeba

117 Legionella pneumophila is a bacterial pathogen that infe

118 Legionella pneumophila is a bacterial pathogen that thri

119 AnkB effector of the intravacuolar pathogen Legionella pneumophila is a bona fide F-box protein, whi

120 Legionella pneumophila is a causative agent of a severe

121 Legionella pneumophila is a causative agent of severe pn

122 Legionella pneumophila is a facultative intracellular hu

123 Legionella pneumophila is a gram-negative facultative in

124 Legionella pneumophila is a gram-negative facultative in

125 Legionella pneumophila is a Gram-negative opportunistic

126 Legionella pneumophila is a motile intracellular pathoge

127 The Gram-negative bacterium Legionella pneumophila is a parasite of eukaryotic cells

128 Legionella pneumophila is a water-borne bacterium that c

129 Legionella pneumophila is able to survive inside phagocy

130 Legionella pneumophila is an environmental bacterium and

131 Legionella pneumophila is an intracellular bacterial pat

132 Legionella pneumophila is an intracellular bacterial pat

133 Legionella pneumophila is an intracellular bacterial pat

134 Legionella pneumophila is an intracellular bacterium tha

135 Legionella pneumophila is an intracellular bacterium tha

136 Legionella pneumophila is an intracellular pathogen of f

137 Legionella pneumophila is an intracellular pathogen that

138 Legionella pneumophila is an intracellular pathogen that

139 Legionella pneumophila is an intracellular pathogen that

140 Legionella pneumophila is an intravacuolar pathogen that

141 Legionella pneumophila is an opportunistic intracellular

142 Legionella pneumophila is auxotrophic for several amino

143 evious studies established that the pathogen Legionella pneumophila is capable of hijacking Rab1 func

144 e Dot/Icm type IV secretion system (T4SS) of Legionella pneumophila is crucial for the pathogen to su

145 Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide

146 The virulence of Legionella pneumophila is dependent on the Dot/Icm type

147 The virulence of Legionella pneumophila is dependent upon its capacity to

148 After the pathogenic bacterium Legionella pneumophila is phagocytosed, it injects more

149 owth of Chlamydia psittaci, trachomatis, and Legionella pneumophila is regulated by the levels of int

150 Type II protein secretion (T2S) by Legionella pneumophila is required for intracellular inf

151 The type II secretion (T2S) system of Legionella pneumophila is required for the ability of th

152 Legionella pneumophila is the causative agent of a sever

153 Bacterial pathogen Legionella pneumophila is the causative agent of Legionn

154 Legionella pneumophila is the causative agent of the sev

155 One effector of Legionella pneumophila is the glucosyltransferase Lgt1,

156 Legionella pneumophila is the only prokaryote found, thu

157 Legionella pneumophila is the predominant cause of Legio

158 le genome sequence analysis was performed on Legionella pneumophila isolates from the infected patien

159 he performance of laboratories in genotyping Legionella pneumophila isolates using the standard Europ

160 rsistence and associated risks of pathogenic Legionella pneumophila (L. pneumophila), thus raising hu

161 cloned and characterized, two proteins from Legionella pneumophila (L1 H-NOX and L2 H-NOX) and one f

162 Previously, we reported that mutants of Legionella pneumophila lacking a type II secretion (T2S)

163 experimental validation of 20 effectors from Legionella pneumophila, Legionella longbeachae, and Coxi

164 plasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, Legionella micdadei, Bordetella

165 Legionella pneumophila (Lp), an important cause of morbi

166 model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (

167 from Escherichia coli (EcFAAL) and FAAL from Legionella pneumophila (LpFAAL) bound to acyl adenylate,

168 The L-serine dehydratase from Legionella pneumophila (lpLSD) has recently been shown t

169 s from Bacillus subtilis (bsLSD, type 1) and Legionella pneumophila (lpLSD, type 2).

170 Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumon

171 The intracellular bacterial pathogen Legionella pneumophila modulates a number of host proces

172 The intracellular pathogen Legionella pneumophila modulates the activity of host GT

173 To restrict infection by Legionella pneumophila, mouse macrophages require Naip5,

174 By characterizing a Legionella pneumophila mutant defective for differentiat

175 dentify amoeba isolates, and the presence of Legionella pneumophila , Mycobacterium spp., Pseudomonas

176 ersistence of three opportunistic pathogens (Legionella pneumophila, Mycobacterium avium, and Pseudom

177 Legionella pneumophila, Mycobacterium avium, and Pseudom

178 tive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium avium, Mycobacteri

179 Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, s

180 Intracellular growth of Legionella pneumophila occurs in a replication vacuole c

181 tospira interrogans, Mesorhizobium loti, and Legionella pneumophila, one or both glucosamine residues

182 rulent strain of the intracellular bacterium Legionella pneumophila or a nonpathogenic mutant of L. p

183 Bartonella henselae, Listeria monocytogenes, Legionella pneumophila, or adenovirus type 5, promoted a

184 mon lung pathogens Streptococcus pneumoniae, Legionella pneumophila, or Mycobacterium tuberculosis-in

185 nnaires' disease in a clinical setting where Legionella pneumophila PCR had been introduced.

186 in strains, in H. pylori 26695 strain and in Legionella pneumophila Philadelphia 1 strain.

187 Gram-negative Legionella pneumophila produces a siderophore (legiobact

188 Legionella pneumophila proliferates in environmental amo

189 Legionella pneumophila proliferates within various proti

190 The type II secretion system of Legionella pneumophila promotes pathogenesis.

191 lination of Rab35, which is catalyzed by the Legionella pneumophila protein AnkX, interferes with the

192 study provides detailed understanding of the Legionella pneumophila protein DrrA and of AMP-transfer

193 The Legionella pneumophila protein RalF is secreted into hos

194 resses translation of the hupA mRNA, and the Legionella pneumophila protein RocC binds the RocR sRNA,

195 gen testing for Streptococcus pneumoniae and Legionella pneumophila provide direction for the clinici

196 sional structure of the protein lpg2210 from Legionella pneumophila provides the first structural inf

197 her lethal (Yersinia pestis) and non-lethal (Legionella pneumophila, Pseudomonas aeruginosa) pulmonar

198 lytes of three pathogenic bacterial strains: Legionella pneumophila, Pseudomonas aeruginosa, and Salm

199 is, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Stenotro

200 Infection by the human pathogen Legionella pneumophila relies on the translocation of ap

201 Many bacteria, including Legionella pneumophila, rely on the type IV secretion sy

202 Legionella pneumophila remains an important opportunisti

203 The intracellular pathogen Legionella pneumophila replicates in a vacuole that recr

204 Legionella pneumophila replicates inside alveolar macrop

205 Legionella pneumophila replicates within alveolar macrop

206 se-11 was dispensable for the restriction of Legionella pneumophila replication in macrophages and in

207 Legionella pneumophila requires the Dot/Icm protein tran

208 onnaires' disease, the gamma-proteobacterium Legionella pneumophila, resides and replicates within a

209 ) and 26GUmicroL(-1) for Legionella spp. and Legionella pneumophila, respectively, were achieved.

210 oazide (PMA) to simultaneously detect viable Legionella pneumophila, Salmonella typhimurium, and Stap

211 When cultured in a low-iron medium, Legionella pneumophila secretes a siderophore (legiobact

212 ion of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that i

213 Under iron stress, Legionella pneumophila secretes legiobactin, a nonclassi

214 The intracellular pathogen, Legionella pneumophila, secretes approximately 300 effec

215 ted that 84% are caused by the microorganism Legionella pneumophila Serogroup (Sg) 1.

216 Legionella spp., Legionella pneumophila, and Legionella pneumophila serogroup 1 in primary specimens.

217 bacteria belonging to the genus Legionella; Legionella pneumophila serogroup 1 is the causative agen

218 Legionella pneumophila serogroup 1 isolates were culture

219 mately 84% of legionellosis cases are due to Legionella pneumophila serogroup 1.

220 t the genomic sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H (ATC

221 Legionella pneumophila serogroup 3 was recovered in neon

222 We report the isolation of Legionella pneumophila serogroup 4 from synovial tissue

223 ows: for Bordetella pertussis, 2 CFU/ml; for Legionella pneumophila (serotypes 1 to 15) and Legionell

224 In this report, we found that members of the Legionella pneumophila SidE effector family harbor a DUB

225 m type IV secretion system (T4SS) of several Legionella pneumophila strains.

226 Proteases from Mycoplasma hyorhinis, Legionella pneumophila, Streptococcus pneumonia and Cand

227 The intracellular bacterial pathogen Legionella pneumophila subverts host membrane transport

228 The intracellular pathogen Legionella pneumophila subverts Rab1 function to create

229 Enzymes secreted by Legionella pneumophila, such as phospholipases A (PLAs)

230 Legionella pneumophila survives and replicates within a

231 for translocation using the well-established Legionella pneumophila T4SS secretion model.

232 stem (T4SS) highly similar to the Dot/Icm of Legionella pneumophila that is believed to be essential

233 In some instances, such as infection with Legionella pneumophila, the activation of the NLRC4 infl

234 Legionella pneumophila, the agent of Legionnaires' disea

235 Legionella pneumophila, the bacterial agent of legionnai

236 For Legionella pneumophila, the bacterium translocates prote

237 Legionella pneumophila, the causative agent of a severe

238 fer protection from secondary infection with Legionella pneumophila, the causative agent of a severe

239 thal infection by the intracellular pathogen Legionella pneumophila, the causative agent of a severe

240 ip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe

241 cal protection from pulmonary infection with Legionella pneumophila, the causative agent of a severe

242 When the bacterium Legionella pneumophila, the causative agent of Legionnai

243 Legionella pneumophila, the causative agent of Legionnai

244 Legionella pneumophila, the causative agent of Legionnai

245 Legionella pneumophila, the causative agent of Legionnai

246 Legionella pneumophila, the causative agent of Legionnai

247 Legionella pneumophila, the causative agent of Legionnai

248 Legionella pneumophila, the causative agent of Legionnai

249 is a previously uncharacterized effector of Legionella pneumophila, the causative agent of Legionnai

250 mune response to bacterial pathogens such as Legionella pneumophila, the causative agent of Legionnai

251 The facultative intracellular pathogen Legionella pneumophila, the causative agent of Legionnai

252 Legionella pneumophila, the causative agent of Legionnai

253 The genome of the Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

254 The Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

255 Legionella pneumophila, the causative organism of Legion

256 Legionella pneumophila, the etiological agent of Legionn

257 Legionella pneumophila, the Gram-negative pathogen causi

258 as the gold standard for DNA-based typing of Legionella pneumophila, the Legionella laboratory at the

259 scovery protocol by targeting this enzyme in Legionella pneumophila, the major causative agent of Leg

260 Legionella pneumophila, the most commonly identified cau

261 Legionella pneumophila, the primary agent of Legionnaire

262 In Legionella pneumophila, the two-component system (TCS) P

263 Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanism

264 The ability of the intracellular bacterium Legionella pneumophila to cause disease is totally depen

265 The ability of Legionella pneumophila to cause pneumonia is determined

266 ls by the Dot/Icm injection apparatus allows Legionella pneumophila to establish a niche called the L

267 The ability of Legionella pneumophila to grow and cause disease in the

268 ystem is a type IVb secretion system used by Legionella pneumophila to modulate vesicular transport i

269 etwork of proteins secreted by the bacterium Legionella pneumophila to promote intracellular growth,

270 Here, we used the bacterial pathogen Legionella pneumophila to understand how the immune syst

271 To transit between hosts, intracellular Legionella pneumophila transform into a motile, infectio

272 vacuole that supports bacterial replication, Legionella pneumophila translocates a large number of ba

273 The intracellular human pathogen Legionella pneumophila translocates multiple proteins in

274 The Dot/Icm type IV secretion system of Legionella pneumophila translocates numerous bacterial e

275 The Dot/Icm system of Legionella pneumophila triggers activation of caspase-3

276 The noninvasive Legionella pneumophila triggers an identical response th

277 al host organism Acanthamoeba castellanii to Legionella pneumophila under in vivo (LCV) conditions.

278 igated the role of RNase R in the biology of Legionella pneumophila under various conditions and perf

279 Legionella pneumophila uses a single homodimeric disulfi

280 Legionella pneumophila uses a type IV secretion system t

281 Legionella pneumophila uses a type IVB secretion system

282 The pulmonary pathogen Legionella pneumophila uses the Dot/Icm type IV secretio

283 Legionella pneumophila uses the Icm/Dot type 4B secretio

284 Legionella pneumophila utilizes a type IV secretion syst

285 The bacterial pathogen Legionella pneumophila utilizes approximately 300 effect

286 Legionella pneumophila utilizes the Dot/Icm type IV tran

287 Legionella pneumophila vacuole biogenesis was analyzed b

288 this list are the sialylated human pathogens Legionella pneumophila, Vibrio parahemeolyticus, Pseudom

289 inic acid from the lipopolysaccharide of the Legionella pneumophila virulence factor.

290 Legionella pneumophila was found in the sedimentation po

291 bone marrow-derived murine Mphi (BMphi) with Legionella pneumophila was investigated.

292 Label-free detection of Legionella pneumophila was performed using a PC platform

293 the DNA uptake system in the human pathogen Legionella pneumophila We found that a repressor of this

294 ddition, during coinfection experiments with Legionella pneumophila, we found that defective intracel

295 g homogenates from guinea pigs infected with Legionella pneumophila were plated monthly onto differen

296 ologs encoded by the Philadelphia isolate of Legionella pneumophila were toxic to yeast, and SidJ sup

297 increased survival of the bacterial pathogen Legionella pneumophila when present inside its protozoan

298 rucella melitensis, Bartonella henselae, and Legionella pneumophila, which are also able to persist w

299 In this study, we used Legionella pneumophila, which triggers membrane-bound an

300 n, and infection in mouse models compared to Legionella pneumophila, yet these two species have indis