ライフサイエンスコーパス: Leishmania donovani

1 moderate activity against the axenic form of Leishmania donovani .

2 mania braziliensis, Leishmania mexicana, and Leishmania donovani).

3 c protozoa Trypanosoma cruzi, T. brucei, and Leishmania donovani.

4 compound against the kinetoplastid parasite Leishmania donovani.

5 e isomerase gene from the protozoan parasite Leishmania donovani.

6 ADOMETDC has been cloned and sequenced from Leishmania donovani.

7 enetically deficient mice were infected with Leishmania donovani.

8 5, designated LdPEX5, has been isolated from Leishmania donovani.

9 lease (Ld3'NT/NU) of the parasitic protozoan Leishmania donovani.

10 we treated gene-deficient mice infected with Leishmania donovani.

11 to characterize lumenal uptake of GDP-Man in Leishmania donovani.

12 zation of selenocysteinyl-tRNA synthase from Leishmania donovani.

13 r human visceral leishmaniasis(VL) caused by Leishmania donovani.

14 s, which is caused by the protozoan parasite Leishmania donovani.

15 eral leishmaniasis in children infected with Leishmania donovani.

16 ty was detected against Trypanosoma cruzi or Leishmania donovani.

17 gainst the intracellular amastigotes form of Leishmania donovani.

18 n inoculation of the intracellular protozoan Leishmania donovani.

19 , including visceral leishmaniasis caused by Leishmania donovani.

20 xpression, and kinetic analysis of ASNA from Leishmania donovani.

21 s in the anthroponotic transmission cycle of Leishmania donovani.

22 fier 1 (Ufm1) and its conjugation pathway in Leishmania donovani.

23 MOs in visceral leishmaniasis (VL) caused by Leishmania donovani.

24 L-10 production by macrophages infected with Leishmania donovani.

25 vel of serine protease activity expressed by Leishmania donovani.

26 le for visceral leishmaniasis (VL) caused by Leishmania donovani.

27 C-terminal domain of the 3' nucleotidase of Leishmania donovani (33.7%).

28 ch as those caused by the protozoan parasite Leishmania donovani, a causative agent of visceral leish

29 r distribution of a K39 kinesin homologue in Leishmania donovani, a medically important parasite of h

30 Leishmania donovani, a protozoan parasite, causes viscer

31 ent in these mechanisms were challenged with Leishmania donovani, a protozoan that selectively parasi

32 aled its structural similarity to the LPG of Leishmania donovani, a species whose inability to bind t

33 Leishmania donovani AAH is 38 and 23% identical to Sacch

34 te to excellent activity when tested against Leishmania donovani amastigotes in vitro.

35 g T cell stimulation or after challenge with Leishmania donovani, an intracellular microbe whose cont

36 nutes after in vitro or in vivo contact with Leishmania donovani, an intracellular pathogen.

37 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and cytotoxicities for mammalian cel

38 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and cytotoxicity against mammalian c

39 ed by a myo-inositol transporter cloned from Leishmania donovani and expressed in Xenopus oocytes.

40 EM, we have determined the structures of the Leishmania donovani and human ribosomes at 2.9 A and 3.6

41 ines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular ama

42 Visceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum chagasi.

43 ections with intracellular pathogens such as Leishmania donovani and Mycobacterium tuberculosis pose

44 of an active cytochrome c oxidase complex in Leishmania donovani and that upon deletion of its gene t

45 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian

46 oma brucei rhodesiense , Trypanosoma cruzi , Leishmania donovani , and P. falciparum (K1 isolate).

47 a brucei rhodesiense, Trypanosoma cruzi, and Leishmania donovani), and several showed promising activ

48 a brucei rhodesiense, Trypanosoma cruzi, and Leishmania donovani), and two compounds (14 and 21) show

49 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for cytotoxicity against mammal

50 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for cytotoxicity against mammal

51 ap) were cloned from Leishmania amazonensis, Leishmania donovani, and Leishmania major, which encoded

52 st Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum, the caus

53 ied as vital components of purine salvage in Leishmania donovani, and therefore Deltaadss and Deltaas

54 n the parasitic protists Trypanosoma brucei, Leishmania donovani, and Trichomonas vaginalis.

55 Expression of Leishmania donovani APRT in transgenic T. gondii parasit

56 ucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, as well as cytotoxicity against mam

57 j (50 mg/kg/day) was further studied against Leishmania donovani/BALB/c mice via the intraperitoneal

58 stant tuberculosis, is a potent inhibitor of Leishmania donovani both in vitro and in vivo.

59 lt the visceral replication of intracellular Leishmania donovani but fail to properly resolve infecti

60 high levels in mice and humans infected with Leishmania donovani, but their contribution to host resi

61 Infection with the protozoan Leishmania donovani can cause serious visceral disease o

62 onic inflammation such as chronic infection (Leishmania donovani), cancer (melanoma and colorectal ca

63 Leishmania donovani cannot synthesize purines de novo an

64 Leishmania donovani cannot synthesize purines de novo an

65 oregulatory lipid, in successful survival of Leishmania donovani, causative agent of the fatal viscer

66 stages of the pathogenic protozoan parasite, Leishmania donovani, causative agent of the tropical inf

67 Leishmania donovani causes visceral leishmaniasis (VL),

68 udy, we show that in muMT mice infected with Leishmania donovani, CD8 T cells displayed a greater cyt

69 susceptible C57BL/6 (B6) mice infected with Leishmania donovani, CD8(+) T cell mechanisms are requir

70 ny species and subsepecies of such protozoa, Leishmania donovani chagasi causes visceral leishmaniasi

71 were less able to control hepatic growth of Leishmania donovani compared with wild-type mice.

72 ania chagasi are specific for members of the Leishmania donovani complex and have been shown to indic

73 annia subgenus in aggregate; the Leishmania (Leishmania) donovani complex in aggregate; the species L

74 primitive trypanosomatid pathogen of humans, Leishmania donovani, constitutively expresses a unique e

75 h the malarial cysteine proteases as well as Leishmania donovani cysteine protease.

76 Exploiting a mutant cell line (FBD5) of Leishmania donovani deficient in inosine and guanosine t

77 s on the LdNT1.1 nucleoside transporter from Leishmania donovani defined two amino acid residues in p

78 e causative agent of visceral leishmaniasis, Leishmania donovani, does not prime human DC for IL-12 p

79 Leishmania donovani express two members of the equilibra

80 that RAG-2 mice intravenously infected with Leishmania donovani form heterogeneous skin parasite pat

81 Metalloprotease gp63 (Leishmania donovani gp63 (Ldgp63)) is a critical virulen

82 the order Hs-SAHH > Tc-SAHH > Ld-SAHH (from Leishmania donovani) > Pf-SAHH (from Plasmodium falcipar

83 3.15 +/- 12.69% and 80.93 +/- 10.50% against Leishmania donovani /hamster model.

84 The protozoan Leishmania donovani has a myo-inositol/proton symporter

85 The protozoan flagellate Leishmania donovani has an active myo-inositol/proton sy

86 infection with antimony-resistant strains of Leishmania donovani has not been experimentally addresse

87 Studies of Leishmania donovani have shown that both ornithine decar

88 rified biochemically and genetically for the Leishmania donovani HGPRT employing a combination of pro

89 rhodesiense STIB900, T. cruzi Tulahuan, and Leishmania donovani HU3.

90 determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenin

91 enous protein, induces control over visceral Leishmania donovani in experimentally infected BALB/c mi

92 n B was used to kill approximately 90-95% of Leishmania donovani in livers of mice deficient in mecha

93 sue, and its role in preventing clearance of Leishmania donovani in murine models of VL.

94 eparately described the protozoan now called Leishmania donovani in splenic tissue from patients in I

95 o infection with the intracellular protozoan Leishmania donovani in this animal model.

96 overcome this obstacle to analyzing visceral Leishmania donovani in this relevant immunopathogenetic

97 s Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani in vitro, to identify the determinan

98 nosoma brucei brucei, Trypanosoma cruzi, and Leishmania donovani in vitro.Only monoesters 7-9 with a

99 We show that HSCs are infected with Leishmania donovani in vivo and in vitro and that this i

100 bosyltransferase (aprt) loci were created in Leishmania donovani in which both alleles were eliminate

101 r model of visceral leishmaniasis, caused by Leishmania donovani, in contrast to infection in mice, m

102 ine homeostasis in both life cycle stages of Leishmania donovani, individual mutant lines deficient i

103 okine-driven responses were characterized in Leishmania donovani-infected BALB/c mice in which IL-10

104 cytokines has similar therapeutic potential, Leishmania donovani-infected BALB/c mice were injected w

105 In nonvaccinated Leishmania donovani-infected BALB/c mice, HASPB- and KMP

106 Leishmania donovani-infected interleukin-13-/- BALB/c mi

107 We show that Leishmania donovani-infected macrophages (MPhis) are cap

108 Leishmania donovani-infected macrophages were much more

109 signal transduction pathway was analyzed in Leishmania donovani-infected phorbol-differentiated U937

110 ity of NK T cell-deficient CD1d(-/-) mice to Leishmania donovani infection and Leishmania-induced CD1

111 nterferon (IFN-gamma) controls intracellular Leishmania donovani infection and the efficacy of antimo

112 but self-curing C57BL/6 mice, intracellular Leishmania donovani infection enhanced Toll-like recepto

113 Here we show that DCs from mice with chronic Leishmania donovani infection fail to migrate from the m

114 ing marginal zone macrophages resulting from Leishmania donovani infection have increased resistance

115 strates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gam

116 role of IL-6, responses to an intracellular Leishmania donovani infection in the livers of IL-6(-/-)

117 We have recently reported that Leishmania donovani infection results in a remarkably se

118 tment of euthymic BALB/c mice with quiescent Leishmania donovani infection with T cell-depleting or a

119 nduction of an efficient Th1 response during Leishmania donovani infection, but they play distinct ro

120 Upon evaluation in a mouse model of acute Leishmania donovani infection, one phenylpyridine deriva

121 the interrelationship of Wnt5a signaling and Leishmania donovani infection.

122 immunity and early visceralization following Leishmania donovani infection.

123 uces leishmanicidal activity in experimental Leishmania donovani infection; therefore, BALB/c mice we

124 Leishmania donovani infects macrophages, disrupting immu

125 We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents

126 The initial macrophage-Leishmania donovani interaction results in the formation

127 Leishmania donovani is a protozoan parasite.

128 aniasis caused by the intracellular parasite Leishmania donovani is a significant public health probl

129 nthine phosphoribosyltransferase (XPRT) from Leishmania donovani is a unique enzyme that lacks a mamm

130 Leishmania donovani is an intracellular parasite that in

131 The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidin

132 East Africa, where Leishmania donovani is prevalent, faces the highest burd

133 niasis, acquired resistance to intracellular Leishmania donovani is Th1 cell cytokine dependent and l

134 nfection of mice with the protozoan parasite Leishmania donovani, is characterized by focal accumulat

135 and transfected into a Deltaldnt1/Deltaldnt2 Leishmania donovani knockout.

136 A knockout strain of Leishmania donovani lacking both ornithine decarboxylase

137 aromyces cerevisiae, Caenorhabditis elegans, Leishmania donovani, Lactococcus lactis, and Bacillus su

138 ode of gene regulation in which the parasite Leishmania donovani (Ld) causes mitochondrial depolariza

139 l structures of the dimeric APRT enzyme from Leishmania donovani (LdAPRT) bear many similarities to o

140 role of live attenuated centrin gene-deleted Leishmania donovani (LdCen(-/-) ) parasites through indu

141 By screening Leishmania donovani libraries with polyclonal antibodies

142 ut not AMB solution significantly suppressed Leishmania donovani liver parasite burdens (p<0.05) but

143 MTP1 by inflammation was also observed in a Leishmania donovani model of chronic infection.

144 However, in the Leishmania donovani model of pathogen persistence, Il10(

145 In this study, we showed that Leishmania donovani modulates the TLR2-mediated pathway

146 rmore, stromal cells from mice infected with Leishmania donovani more effectively supported different

147 In a Leishmania donovani mouse model, two racemic phenylpyrid

148 ransporter, which was classified as ABCC2 or Leishmania donovani multidrug resistance protein 2 (LdMR

149 ing modes, resulting in novel, highly potent Leishmania donovani NMT inhibitors with good selectivity

150 es we generated a computational model of the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

151 ithin predicted transmembrane domains of the Leishmania donovani nucleoside transporter 1.1, LdNT1.1,

152 d adenosine kinase (AK) to purine salvage in Leishmania donovani, null mutants genetically deficient

153 nhibition is distinct from that reported for Leishmania donovani or CMV, in that it targets the inter

154 ed that genetically modified live-attenuated Leishmania donovani parasite cell lines (LdCen(-/-) and

155 on of the four PfCENs in a centrin knock-out Leishmania donovani parasite line that exhibited a sever

156 Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen (-/-)) showed prote

157 Leishmania donovani parasites are the cause of visceral

158 Starvation of Leishmania donovani parasites for purines leads to a rap

159 sly, we have shown that genetically modified Leishmania donovani parasites, here described as live at

160 sed by infection with the protozoan parasite Leishmania donovani, parasites persist in the spleen and

161 Leishmania donovani possess two closely related genes th

162 amma) gene knockout (GKO) mice infected with Leishmania donovani proceeded to reduce liver parasite b

163 Adaptation of the glucose metabolism of Leishmania donovani promastigotes (insect stage) was inv

164 Leishmania donovani promastigotes constitutively secrete

165 Leishmania donovani promastigotes deficient in both LPG

166 more than 70 artemisinin derivatives against Leishmania donovani promastigotes is described for the f

167 Leishmania donovani promastigotes were shown to release

168 itor cell-derived dendritic cells (DCs) with Leishmania donovani promastigotes, Histoplasma capsulatu

169 Leishmania donovani protozoan parasites, the causative a

170 The primitive protozoan pathogen of humans, Leishmania donovani, resides and multiplies in highly re

171 leishmaniasis caused by Leishmania major and Leishmania donovani, respectively.

172 Infection with antimony-resistant Leishmania donovani (Sb(R)LD) induces aggressive patholo

173 he molecular mechanism of antimony-resistant Leishmania donovani (Sb(R)LD)-driven up-regulation of IL

174 ar patients infected with antimony-resistant Leishmania donovani (Sb(R)LD).

175 that supports extensive skin infection with Leishmania donovani, spatial analyses at macro-(quantita

176 es (in North Dakota) and infection caused by Leishmania donovani species complex.

177 e (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resi

178 ed infection with the intracellular parasite Leishmania donovani suggests that vaccination could prev

179 of the intracellular replication of residual Leishmania donovani that escape chemotherapy evolves to

180 We have used a mutant line (TUBA5) of Leishmania donovani that is deficient in adenosine/pyrim

181 ons in the polyamine biosynthetic pathway of Leishmania donovani, the causal agent of visceral leishm

182 panothione reductase (TR) activity levels in Leishmania donovani, the causative agent of visceral lei

183 In this study the interactions of Leishmania donovani, the causative agent of visceral Lei

184 entary screens against the tropical parasite Leishmania donovani, the causative agent of visceral lei

185 However, for Leishmania donovani, the DNA-binding activity and the ma

186 within the polyamine biosynthetic pathway of Leishmania donovani, the etiological agent of visceral l

187 We provided a proof-of-concept of SL-seq in Leishmania donovani, the main causative agent of viscera

188 re, we investigated the interactions between Leishmania donovani, the main etiological agent of visce

189 re we demonstrate that during infection with Leishmania donovani, the marginal zone of mice undergoes

190 In contrast, mice infected with Leishmania donovani, the most commonly studied model of

191 or (TNF)-deficient mice were challenged with Leishmania donovani to characterize TNF in the response

192 Here we have engineered Leishmania donovani to express high levels of an active

193 ngipalpis to transmit Leishmania infantum or Leishmania donovani to hamsters.

194 s exploited by the intra-macrophage parasite Leishmania donovani to protect their "home" from actinom

195 ically distinct protozoan (Leishmania major, Leishmania donovani, Toxoplasma gondii) and helminth (Br

196 osoma cruzi, Trypanosoma brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, and Plasmodium f

197 Precise replacement of the Leishmania donovani tryA gene encoding TR was only possi

198 lastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma b

199 sess antiprotozoal activity in vitro against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma

200 7BL/6 mice involving Schistosoma mansoni and Leishmania donovani, two important human pathogens affec

201 eoside permease from the parasitic protozoan Leishmania donovani, using ab initio computation.

202 , interleukin (IL)-12 initiates control over Leishmania donovani via Th1 cell activation, interferon

203 In established Leishmania donovani visceral infection in normal mice, a

204 C57BL/6 mice failed to control intracellular Leishmania donovani visceral infection, indicating that

205 ilisin protease (SUB; Clan SB, family S8) of Leishmania donovani was cloned and found to possess a un

206 serum to the purified recombinant HGPRT from Leishmania donovani was generated in rabbits, and confoc

207 eoside permease from the parasitic protozoan Leishmania donovani was modeled using ab initio computat

208 To test this hypothesis, Leishmania donovani was serially passaged in mice expose

209 er cells) in mice infected with the parasite Leishmania donovani, we identified a transcriptomic netw

210 within the LdNT2 nucleoside transporter from Leishmania donovani were mutated and the resultant pheno

211 cids, but the only crystal structure is from Leishmania donovani, which expresses a long form of the

212 wed obvious antileishmanial activity against Leishmania donovani with an IC50 value of 9.22 muM.

213 , and 24l, exhibited potent activity against Leishmania donovani with IC(50) values ranging from 3.75

214 parasites Trypanosoma brucei rhodesiense and Leishmania donovani with IC50 values of 1.55 and 0.22 mu