ライフサイエンスコーパス: Leishmania major

1 ry to treatment than leishmaniasis caused by Leishmania major.

2 uced by the obligate intracellular parasite, Leishmania major.

3 in Trypanosoma cruzi, Trypanosoma brucei and Leishmania major.

4 as been recently identified in the genome of Leishmania major.

5 acellular pathogens, including the parasite, Leishmania major.

6 es Trypanosoma brucei, Trypanosoma cruzi and Leishmania major.

7 on is decreased after an initial response to Leishmania major.

8 s: Trypanosoma brucei, Trypanosoma cruzi and Leishmania major.

9 ty against cutaneous leishmaniasis caused by Leishmania major.

10 l outcome in rhesus macaques challenged with Leishmania major.

11 ce to infections with the protozoan parasite Leishmania major.

12 ine transporter from the protozoan pathogen, Leishmania major.

13 rides and proteins in the protozoan parasite Leishmania major.

14 clone the gene for a homologue, LmACR2, from Leishmania major.

15 ility to infection by the protozoal parasite Leishmania major.

16 istant C3H mice 2 weeks after infection with Leishmania major.

17 mice after infection with different doses of Leishmania major.

18 panosoma brucei(TB), T. vivax, T. cruzi, and Leishmania major.

19 LAM(-/-) C57Bl/6 mice to remove the parasite Leishmania major.

20 on with the intracellular protozoan parasite Leishmania major.

21 t plays key roles in the infectious cycle of Leishmania major.

22 ses healing in CD40L(-/-) mice infected with Leishmania major.

23 hly resistant to the Th2-inducing protozoan, Leishmania major.

24 eatment of cutaneous leishmaniasis caused by Leishmania major.

25 istance to cutaneous leishmaniasis caused by Leishmania major.

26 to infection with the intracellular parasite Leishmania major.

27 teins of Phlebotomus papatasi, the vector of Leishmania major.

28 ed BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major.

29 stic of T(H)2 responses and are resistant to Leishmania major.

30 ity against intracellular pathogens, such as Leishmania major.

31 unization with protein Ags or infection with Leishmania major.

32 erimental parasitic cutaneous infection with Leishmania major.

33 e form of leishmaniasis after infection with Leishmania major.

34 xpressed, and characterized Ncb5or gene from Leishmania major.

35 t of leishmaniasis is the protozoan parasite Leishmania major.

36 against the intracellular protozoan parasite Leishmania major.

37 responses against the intracellular pathogen Leishmania major.

38 it were identified in Trypanosoma brucei and Leishmania major.

39 were evaluated for inhibition of recombinant Leishmania major 24-SMT and the effect of compounds on s

40 For the human pathogen Leishmania major, a key metabolic function is the synthe

41 was necessary for effective immunity against Leishmania major, a parasite whose clearance requires TL

42 hypothesis by expressing heterologous TS in Leishmania major, a protozoan parasite that causes cutan

43 nhibitors, whereas control of infection with Leishmania major, a Th1-dependent response, was enhanced

44 able produce NO or kill Trypanosoma cruzi or Leishmania major after priming with IFN-gamma.

45 control infection with Toxoplasma gondii and Leishmania major, agents that require highly activated m

46 We generated null mutants of the Leishmania major alkyldihydroxyacetonephosphate synthase

47 est the safety and efficacy of an autoclaved Leishmania major (ALM) promastigote vaccine (1 mg per do

48 cal grade of leishmanial antigen, autoclaved Leishmania major (ALM), or a recombinant leishmanial pro

49 That similar regions of Leishmania major also contain base J highlights the func

50 lin-specific T cell clones generated against Leishmania: major amastigotes responded to Leishmania:-i

51 , we infected IL-12 p40-/- C57BL/6 mice with Leishmania major, an intracellular protozoan parasite co

52 Cutaneous leishmaniasis, caused mainly by Leishmania major, an obligate intracellular parasite, is

53 To address this issue, we infected mice with Leishmania major and 2 wk later with lymphocytic choriom

54 Leishmania major and all other parasitic protozoa are un

55 exes 1-8 are active against promastigotes of Leishmania major and epimastigotes of Trypanosoma cruzi.

56 ected NF-kappa B2(-/-) and control mice with Leishmania major and followed disease progression.

57 -infection of C3HeB/FeJ (C3H) mice with both Leishmania major and Leishmania amazonensis leads to a h

58 -)also demonstrated cross-protection against Leishmania major and Leishmania braziliensis infection.

59 taneous and visceral leishmaniasis caused by Leishmania major and Leishmania donovani, respectively.

60 rious fragments of proteophosphoglycans from Leishmania major and Leishmania mexicana proteophosphogl

61 against an intradermal needle challenge with Leishmania major and sand fly saliva when vaccinated int

62 cgammaR(-/-) mice can control infection with Leishmania major and totally resolve cutaneous lesions.

63 nstrated that C57BL/6 mice coinoculated with Leishmania major and trimannose-coated beads produced si

64 netic deletions, we inhibited J synthesis in Leishmania major and Trypanosoma brucei using DMOG.

65 lymphocytic leukemia), parasitic infection (Leishmania major), and infectious disease (Listeria mono

66 -like sequences in Trypanosoma brucei, 27 in Leishmania major, and 24 in Trypanosoma cruzi.

67 Leishmania major aquaglyceroporin (LmjAQP1) adventitious

68 The Leishmania major aquaglyceroporin, LmAQP1, is responsibl

69 The Leishmania major aquaglyceroporin, LmAQP1, is responsibl

70 early IFN-gamma production and resistance to Leishmania major are impaired in the absence of WSX-1 si

71 anosoma brucei brucei, Trypanosoma cruzi and Leishmania major - are now complete, providing both a mi

72 the sandfly Phlebotomus papatasi, is used by Leishmania major as a receptor for mediating specific bi

73 parasite load upon secondary infection with Leishmania major as well as a reduction in DTH responses

74 e TOR kinases in the trypanosomatid parasite Leishmania major, as defined by homology to the phosphoi

75 TG mice mount impaired Th1 responses against Leishmania major, as manifested by increased parasitemia

76 coli monofunctional TS and in T. gondii and Leishmania major bifunctional TS-DHFR.

77 and fly infections by the protozoan parasite Leishmania major, binding of replicating promastigotes i

78 C3H and C57BL/6 mice are resistant to Leishmania major but develop chronic lesions with persis

79 nhanced resistance to the protozoan parasite Leishmania major but impaired immunity to the intestinal

80 the individual contributions of each ATG4 to Leishmania major by generating individual gene deletion

81 Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophi

82 gene, named Lmsp1, was cloned by screening a Leishmania major cDNA expression library using a rabbit

83 The potential of Leishmania major culture-derived soluble exogenous antig

84 rotozoal species: T. cruzi (Chagas disease), Leishmania major (cutaneous leishmaniasis), and Plasmodi

85 Previously, we showed that Leishmania major deletion mutants lacking the Golgi GDP-

86 hat results in ulcer-free protection against Leishmania major delivered by vector bites.

87 uclease/phosphatase (EEP) motif protein from Leishmania major, designated RNA editing exonuclease 1 (

88 C3HeB/FeJ mice challenged with Leishmania major develop a polarized Th1 response and su

89 BALB/c mice infected with Leishmania major developed a type 2 immune response whic

90 continuum modeling suggest that compared to Leishmania major DHFR-TS, P. falciparum DHFR-TS has a lo

91 was similar in the 2 strains, infectivity to Leishmania major differed, as did macrophage uptake of a

92 with protein or infection with the protozoon Leishmania major, draining lymph nodes (LNs) of IFN-regu

93 ng infection of susceptible BALB/c mice with Leishmania major, early production of interleukin-4 (IL-

94 In BALB/c mice infected with Leishmania major, early secretion of IL-4 leads to a Th2

95 In contrast, Leishmania major elicits a robust Th1 response that prom

96 Leishmania major encodes 2 orthologs of the cytokine mac

97 ion 3 days before and after a challenge with Leishmania major enhanced host resistance and reduced th

98 For example, the Leishmania major enzyme LmACR2 is both a phosphatase and

99 gondii growth inhibition and FPPS (human and Leishmania major) enzyme inhibition and by the fact that

100 gainst recombinant Plasmodium falciparum and Leishmania major enzymes and the human enzyme to give a

101 stimulation by microbial pathogens, such as Leishmania major, Escherichia coli, and Mycobacterium bo

102 worthily, UCNII killed the infective form of Leishmania major even inside the infected macrophages.

103 that while normal BALB/c mice infected with Leishmania major exhibited a nonhealing phenotype, those

104 n, purification, and characterization of the Leishmania major exopolyphosphatase (LmPPX).

105 cutaneous compartment during infection with Leishmania major express P- and E-selectin ligands.

106 Leishmania major expresses two purine nucleobase transpo

107 e that the causative agent of leishmaniasis, Leishmania major, expresses an FMN-containing nitroreduc

108 ng infection with the intracellular parasite Leishmania major, expression of inducible NO synthase do

109 nds); R = 0.82, p < 0.0001, for an expressed Leishmania major FPPS (N = 45 compounds).

110 ptional analysis of chromosome 1 (chr1) from Leishmania major Friedlin (LmjF) which encodes the first

111 The complete nucleotide sequence of Leishmania major Friedlin chromosome 1 revealed 79 prote

112 A first generation cosmid contig map of the Leishmania major Friedlin genome has been constructed, a

113 e chromosomal sequence for chromosome 1 from LEISHMANIA: major Friedlin predicts that this chromosome

114 somes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA g

115 We examined the Leishmania major (Friedlin) and Trypanosoma cruzi (CL Br

116 A comparison of three crystal structures of Leishmania major fructose-1,6-bisphosphatase (LmFBPase)

117 Protective immunity against Leishmania major generated by DNA encoding the LACK (Lei

118 In our study, Leishmania major grew normally in RAW cells, RAW-express

119 om Trypanosoma brucei, Trypanosoma cruzi and Leishmania major identified protein motifs associated wi

120 n of macrophages with the protozoan parasite Leishmania major impairs PKCalpha, betaI, betaII, and ep

121 Infection with Leishmania major in BALB/c mice is accompanied by the de

122 s necessary for the long term maintenance of Leishmania major in genetically resistant C57BL/6 mice a

123 ccumulate at sites of chronic infection with Leishmania major in mice.

124 s disease following sand fly transmission of Leishmania major in susceptible BALB/c mice.

125 ave recently demonstrated protection against Leishmania major in the murine and nonhuman primate mode

126 Here we show that the persistence of Leishmania major in the skin after healing in resistant

127 micin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia.

128 ia-naive donors and cultured with or without Leishmania major in various combinations.

129 e been shown to be crucial for resistance to Leishmania major in vivo For example, mice in the resist

130 ted protective T-helper 1 (Th1) responses to Leishmania major in vivo, but were unable to support Th2

131 es (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide

132 high activity against an expressed FPPS from Leishmania major, in Dictyostelium discoideum growth inh

133 y important roles in the infectious cycle of Leishmania major, including the abundant lipophosphoglyc

134 We found that infection with Leishmania major increases the expression of vascular en

135 Infection with Leishmania major induces a protective immune response an

136 on with the intracellular protozoan parasite Leishmania major induces a state of concomitant immunity

137 Leishmania major-infected human dendritic cells (DCs) ex

138 In this study, we report that in Leishmania major-infected macrophages, the expression of

139 lls from the draining lymph nodes of treated Leishmania major-infected mice compared with cells from

140 pulation of central memory CD4(+) T cells in Leishmania major-infected mice that were capable of medi

141 Itgb2(-/-) mice were better able to resolve Leishmania major infection and generated a superior T(H)

142 CD40 plays dual immunoregulatory roles in Leishmania major infection and tumor regression.

143 In this article, we compared the outcome of Leishmania major infection in both CD40- and CD40L-defic

144 A model of Leishmania major infection in C57BL/6 mice has been esta

145 Experimental Leishmania major infection in mice has been of immense i

146 e show that the degree of protection against Leishmania major infection in mice is predicted by the f

147 During Leishmania major infection in mice, gamma interferon (IF

148 aniasis, we analyzed the course of cutaneous Leishmania major infection in MIF gene-deficient mice (M

149 with the spontaneous reactivation of chronic Leishmania major infection in old mice, likely because o

150 cells suppressed the disease development of Leishmania major infection in SCID mice reconstituted wi

151 ruct induce equally solid protection against Leishmania major infection in susceptible BALB/c mice.

152 ype, TACI-KO Mvarphis were unable to control Leishmania major infection in vitro, and intradermal ino

153 is, we examined lesion development following Leishmania major infection of genetically susceptible BA

154 leukocytes were recruited into lesions after Leishmania major infection of mice.

155 benefit (detente cordiale) such as occurs in Leishmania major infection of resistant mouse strains, t

156 Here, we show that cutaneous Leishmania major infection stimulated expression of the

157 S IV-deficient mice were more susceptible to Leishmania major infection than were wild-type littermat

158 e we describe a reproducible murine model of Leishmania major infection transmitted by Phlebotomus pa

159 gene for CD40L (CD40L(-/-) mice) can control Leishmania major infection when they are infected with r

160 After Leishmania major infection, disease progression was dete

161 Here, we used a mouse model of Leishmania major infection, in which parasite persistenc

162 In Leishmania major infection, manipulating Pias1 expressio

163 or IEX-1 in control of the susceptibility to Leishmania major infection, the inflammatory response du

164 In a mouse model of Leishmania major infection, vaccination with heat-killed

165 Additionally, there was a block in the Leishmania major infection-induced relocalization of spl

166 or of the cutaneous inflammatory response to Leishmania major infection.

167 K1-deficient mice were highly susceptible to Leishmania major infection.

168 Genetic background influences the outcome of Leishmania major infection.

169 , regulates Ca2+ influx, and defends against Leishmania major infection.

170 from house dust mite (HDM)-induced asthma or Leishmania major infection.

171 ecessary for the homing of T(reg) at site of Leishmania major infection.

172 e Th1 cell responses and are able to control Leishmania major infection.

173 ce, something that conferred protection from Leishmania major infection.

174 ignaling were evaluated in a murine model of Leishmania major infection.

175 tokine Flt3L would protect against cutaneous Leishmania major infection.

176 enetic background, are highly susceptible to Leishmania major infection.

177 at LJM11 confers protective immunity against Leishmania major infection.

178 D4(+) T cell responses in the mouse model of Leishmania major infection.

179 is indispensable for host resistance against Leishmania major infection.

180 tion and analysis of an agent-based model of Leishmania major infection.

181 Since nonhealing Leishmania major infections in susceptible BALB/c mice h

182 site burden compared to wild-type mice after Leishmania major intradermal ear infection.

183 Leishmania major is a parasite that resides and replicat

184 Leishmania major is an obligately intracellular protozoa

185 ously shown that persistence of the parasite Leishmania major is controlled by endogenous CD4(+) CD25

186 Cure of infections with Leishmania major is critically dependent on the ability

187 Control of the protozoan parasite Leishmania major is dependent on establishing a robust T

188 Infection with Leishmania major is enhanced when the sand fly Lutzomyia

189 Protection from the parasite Leishmania major is mediated by CD4 T cells.

190 Protective immunity against Leishmania major is provided by s.c. immunization with a

191 nfection in C3H mice, whereas infection with Leishmania major is self-healing.

192 unity such as Mycobacterium tuberculosis and Leishmania major is the requirements to sustain memory/e

193 In particular, we have generated a Leishmania major iscl(-) mutant which is deficient in SL

194 In this paper, we show that a strain of Leishmania major (L. major Seidman [LmSd]) that produces

195 is associated with resistance to developing Leishmania major (L. major) infection.

196 Invading neutrophils efficiently captured Leishmania major (L.m.) parasites early after sand fly t

197 The Leishmania major LACK antigen contains an immunodominant

198 The Leishmania major LACK antigen is a key target of the imm

199 CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramer

200 Leishmania major lacking phosphoglycans (lpg2-) were una

201 o study truly lpg(-) parasites, we generated Leishmania major lacking the gene LPG1 [encoding a putat

202 and to phylogenetically distinct protozoan (Leishmania major, Leishmania donovani, Toxoplasma gondii

203 istance to intracellular organisms including Leishmania major, Leishmania mexicana, and Listeria mono

204 ut could not inhibit the growth of cutaneous Leishmania major lesions.

205 pathogenesis of the human protozoan parasite Leishmania major, little is known about the enzymes and

206 une responses and the self-healing nature of Leishmania major (Lm) infection, we examined the interac

207 CD8+ T cells are generated in response to Leishmania major (Lm) or Toxoplasma gondii parasitic inf

208 d characterization of aquaglyceroporins from Leishmania major (LmAQP1) and Leishmania tarentolae (LtA

209 Here we used an Leishmania major lpg1- mutant, which lacks LPG alone and

210 model of cutaneous leishmaniasis using 10(2) Leishmania major metacyclic promastigotes inoculated int

211 sted of mice challenged in the ear with live Leishmania major metacyclic promastigotes.

212 s of 62 bisphosphonates as inhibitors of the Leishmania major mevalonate/isoprene biosynthesis pathwa

213 Using the Leishmania major mouse model of dermal infection, we obs

214 In contrast, L. donovani and Leishmania major mutants deficient solely in LPG express

215 Since Leishmania major mutants that lack lipophosphoglycan and

216 Crystal structures bound to Leishmania major NMT were obtained, and the active diast

217 oles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transporter gene

218 synthase-dihydrofolate reductase enzyme from Leishmania major occurs via electrostatic interactions b

219 ew virulence factors have been described for Leishmania major, one of the causative agents of cutaneo

220 We find two populations of persistent Leishmania major: one rapidly replicating, similar to pa

221 n this study we expressed active recombinant Leishmania major OPB and provide the first structure of

222 uction of genes encoding Ddi1 orthologs from Leishmania major or humans.

223 acute lymphocytic choriomeningitis virus and Leishmania major parasite infections, which were rescued

224 PCR-based method to determine the number of Leishmania major parasites inoculated into the ears of l

225 o for nitric oxide production and killing of Leishmania major parasites is dependent on tumor necrosi

226 ibutes to the innate immune response against Leishmania major parasites is unknown.

227 Leishmania major parasites lacking the GDP-mannose trans

228 ellular infection, we previously showed that Leishmania major parasites prime human DC for efficient

229 The glf homolog from the protozoan Leishmania major partially complements C. elegans glf-1.

230 specific P-pocket found in the structures of Leishmania major PDEB1 and Trypanosoma cruzi PDEC.

231 Leishmania major phosphodiesterases (LmjPDEs) have been

232 nses against neo and recall antigens using a Leishmania major polyprotein (MML) vaccine given with po

233 Leishmania major possesses single DHCH1 and FTL genes en

234 e wild-type BALB/c (H-2d) mice infected with Leishmania major predominantly recognize a single epitop

235 The parasitic protozoa Leishmania major produces a peroxidase (L. major peroxid

236 (DCs) of C57BL/6 mice with L. amazonensis or Leishmania major promastigotes and assessed the activati

237 In this study, we show that Leishmania major promastigotes express a single glycerol

238 have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of d

239 volving s.c. inoculation of large numbers of Leishmania major promastigotes, have not supported an es

240 s Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major provides an opportunity to determine th

241 ice, we report that cutaneous infection with Leishmania major provides heterologous protection agains

242 shares 50% amino acid sequence identity with Leishmania major PTR1 (LmPTR1) and comparisons show that

243 A series of crystallographic analyses of Leishmania major PTR1 are reported.

244 versed by expression of enzymatically active Leishmania major PTR1 in RNAi lines ((oe)RNAi) or by add

245 Here we characterize Leishmania major quinonoid-dihydropteridine reductase (L

246 Control of infection caused by Leishmania major requires the development of IFN-gamma+C

247 Control of the intracellular protozoan, Leishmania major, requires major histocompatibility comp

248 Infection of mice with Leishmania major results in disease progression or resol

249 these sequences with the published genome of Leishmania major reveals marked conservation of synteny

250 es of DHFR-TS from Plasmodium falciparum and Leishmania major reveals that the linker domain primaril

251 d by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic cap

252 The Leishmania major RNA ligase-containing complex protein 2

253 Here we show that Leishmania major SAS-6 crystallizes as a 9-fold symmetri

254 In Leishmania major strain Friedlin, this is controlled by

255 Using a Leishmania major strain that produces nonhealing dermal

256 Genetic exchange between Leishmania major strains during their development in the

257 proteins, thiol-specific antioxidant (TSA), Leishmania major stress-inducible protein 1 (LmSTI1), an

258 Th2 responses, remain highly susceptible to Leishmania major substain LV39 due exclusively to residu

259 ated to TbMSP-B, a trypanosomal homologue of Leishmania major surface protease (MSP) described in the

260 e immunity after adoptive transfer in naive, Leishmania major susceptible BALB/c mice.

261 endent effects were evident in DCs from both Leishmania major-susceptible (BALB/c) and -resistant (C3

262 by prior infection or live vaccination with Leishmania major, termed leishmanization.

263 locus, were more resistant to infection with Leishmania major than were normal BALB/c mice.

264 flies conferred powerful protection against Leishmania major that was associated with a strong delay

265 s for representatives of the Kinetoplastida (Leishmania major), the Parabasalia (Trichomonas vaginali

266 f Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, the causative agents of African sleepi

267 Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2

268 In Leishmania major, the first step in methylglyoxal detoxi

269 aryotes, but in the trypanosomatid protozoan Leishmania major their functions differ significantly.

270 f Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different

271 am-negative bacteria as well as the parasite Leishmania major through a mechanism that depends on the

272 d a SL null mutant in the protozoan parasite Leishmania major through targeted deletion of the key de

273 we investigated the role of PME synthesis in Leishmania major through the characterization of an etha

274 is most often caused by the transmission of Leishmania major to humans by female phlebotomine sand f

275 The inoculation of live, nonattenuated Leishmania major to produce a lesion in a selected site

276 nses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed t

277 Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences fro

278 bacterial and parasitic pathogens including Leishmania major, Trypanosoma cruzi, and Neisseria gonor

279 deletion of the analogous N-terminal tail in Leishmania major TS-DHFR causes a 3-fold enhancement of

280 is a 100 microm non-active site inhibitor of Leishmania major TS-DHFR identified by molecular docking

281 Furthermore, whereas with Leishmania major TS-DHFR there are multiple lines of evi

282 c expression of TS in an unrelated parasite, Leishmania major, turned those parasites into activators

283 However, crystal structures of Leishmania major TyrRS show that, instead, the two halve

284 e development of protective immunity against Leishmania major, we have analyzed the course of cutaneo

285 CK1alpha and L-CK1 produced by the protozoan Leishmania major were also capable of increasing IFNAR1

286 cines against cutaneous leishmaniasis due to Leishmania major were evaluated using a challenge model

287 nt MP90 proteins from Trypanosoma brucei and Leishmania major were expressed in insect cells and cyto

288 f Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major were identified.

289 nt lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear los

290 an keratinocytes with Leishmania infantum or Leishmania major, which cause visceral or cutaneous leis

291 hmania amazonensis, Leishmania donovani, and Leishmania major, which encoded 60-kDa proteins that dis

292 ion of the obligately intracellular parasite Leishmania major, which is transmitted in nature followi

293 cture of a class I FH, the cytosolic FH from Leishmania major, which reveals a previously undiscovere

294 ote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the intes

295 with an IC(50) of 15.4 microM and inhibited Leishmania major with an IC(50) of 12.5 microM.

296 wed a significant cytotoxic activity against Leishmania major with IC50 values of 26.2, 20.2, 12.1, a

297 eath of the intracellular protozoan parasite Leishmania major with no host cell toxicity.

298 dentified by targeting the LACK antigen from Leishmania major within an antibody to CD205 (DEC-205),

299 To determine whether an ongoing response to Leishmania major would affect the response to a non-cros

300 unity to the obligate intracellular parasite Leishmania major, yet inoculation with live, wild-type L