1  the behavioral symptoms associated with the Lesch-Nyhan syndrome.

2 act on the use of female hiPSCs for modeling Lesch-Nyhan syndrome.

3 me (DS)/trisomy 21, and the carrier state of Lesch-Nyhan syndrome.

4  pathological conditions such as cholera and Lesch-Nyhan syndrome.

5  of non-dopaminergic neuronal development in Lesch-Nyhan syndrome.

6 l to HPRT1, the housekeeping gene underlying Lesch-Nyhan syndrome, an X-linked recessive disorder.

7 behavioral abnormalities associated with the Lesch-Nyhan syndrome as previously suggested.

8  are unlikely to contribute substantially to Lesch-Nyhan syndrome burden.

9 rited mutations in the human HPRT leading to Lesch-Nyhan syndrome (D193N) or gout (S103R or S109L), a

10                                              Lesch-Nyhan syndrome encompasses a host of neurological

11 at directly contacts the Mg(2+) ions, causes Lesch-Nyhan syndrome (HGPRT(Kinston), D193N).

12  a disorder in the HPRT gene (leading to the Lesch-Nyhan syndrome) is unique to human, chimpanzee, an

13 s with 6-hydroxydopamine (6-OHDA; a model of Lesch-Nyhan syndrome (LNS)) or vehicle (unlesioned rats)

14 pectively model Parkinson's disease (PD) and Lesch-Nyhan syndrome (LNS).

15  from germ-line HPRT mutations identified in Lesch-Nyhan syndrome or hyperuricemia patients.

16 ibosyltransferase (HGPRTase) is the locus of Lesch-Nyhan syndrome, the activator of the prodrugs 6-me

17 e (HPRT) deficiency in humans results in the Lesch-Nyhan syndrome which is characterized, among other