ライフサイエンスコーパス: Leu residue

1 f protein substrates containing a C-terminal Leu residue.

2 peptide, and the addition of two hydrophobic Leu residues.

3 (protein C) containing poorly recognized P1' Leu residues.

4 sh between the bulky and hydrophobic Pro and Leu residues and the protruding -NH2 group of guanine is

5 l chemical shifts indicate that most Tyr and Leu residues are in beta-sheet conformation.

6 ands were conserved, with the exception of a Leu residue associated with the axial position of the Ty

7 on of these two complexes indicates that the Leu residue at the +3 position in the pT peptide and tha

8 an Ile residue, and the resistant one has a Leu residue at the putative herbicide-binding site.

9 etion derivatives of PY*LKTK reveal that the Leu residue at the Y+1 position and a substituent at the

10 is peptide has a heptad sequence repeat with Leu residues at a- and Ile at d-positions from residues

11 binant variant protein, in which the Phe-Arg-Leu residues (CadF AA 134-136) were altered to Ala-Ala-G

12 any Gua-containing basepair; 3) the Pro and Leu residues cannot selectively discriminate among TA, A

13 mutants with S/A insertions of three or four Leu residues differed from wild-type HN by having hetero

14 raging and supports a model with the Val and Leu residues embedded inside the lipid bilayer.

15 ion changed little with increasing number of Leu residues from 16 to 22 but increased with increasing

16 example of the substitution of a stabilizing Leu residue in a coiled-coil hydrophobic core position d

17 es, and moreover, mutation of the equivalent Leu residue in S6K1 or SGK1 prevented phosphorylation of

18 eated that align a set of l-Phe, d-Phe, or l-Leu residues in a parallel or an antiparallel arrangemen

19 Slo2 channels contain two conserved Leu residues in each of the four S6 segments that line t

20 Mutation of two inward-pointing Leu residues in edge beta-strand E to Lys increased mono

21 ion of the rotameric conformation of Val and Leu residues in proteins by solid-state NMR spectroscopy

22 ational studies revealed that at least three Leu residues in the conserved sequence are required for

23 One or two consecutive Leu residues in the hydrophobic core of the helix were s

24 The guinea pig enzyme autolyzes at Leu residues in the loop where human chymase autolyzes a

25 ggests that hydrophobic interactions between Leu residues in the upper region of the S6 segments cont

26 e chain rotameric states for several Val and Leu residues in this tetrameric helical bundle.

27 The native Leu residue inhibits distal coordination of diatomic lig

28 the N-terminal half of the polypeptide, that Leu residues may contribute to this function, and that s

29 regio- and stereospecificity and a conserved Leu residue near the catalytic non-heme iron.

30 single mutations, suggesting loss of Tyr and Leu residues of the 770YXXL773 motif enhances FGFR2 IIIb

31 a shallow groove formed by adjacent Tyr and Leu residues on the beta-sheet surface.

32 Substitution of two Leu residues on the nonpolar face (Leu(3) and Leu(14)) w

33 mino acids in the transmembrane domain to 17 Leu residues or replacement of the transmembrane and cyt

34 imately 0.5 nm from the next nearest Tyr and Leu residues, respectively.

35 nesis of both Leu147 and Leu148 or all three Leu residues resulted in a 85 or 94% decrease, respectiv

36 Substitution of these buried Asn residues by Leu residues results in a loss of structural uniqueness,

37 t the C(4) position to the backbone -NH of a Leu residue since this serves to drive the midpoint pote

38 ubunits were identified by mutating each non-Leu residue to Leu.

39 A Leu residue was found in ACCases from herbicide-resistan

40 -dependent manner in vivo, unless a critical Leu residue was mutated, supporting the view that a sequ

41 Peptides containing four Leu residues were destructive to mammalian model membran

42 omerization helix contains a stretch of four Leu residues, which appear to be essential for alpha-hel

43 deletion of hydrophobic residues (e.g., the Leu residues) will provide insight into the role the hyd

44 e in hydrophobic gating, replacement of both Leu residues with the isosteric but polar residue Asn (L

45 erase has been mutated to Gly, Ala, Val, and Leu, residues with aliphatic side chains.

46 ace of this complex is formed by hydrophobic Leu residues, with the exception of an Asn residue from

47 re formed from proteolytic hydrolysis of Leu-Leu residues within ELH and acidic peptide (AP).