ライフサイエンスコーパス: Leu-enkephalin

1 the natively electroinactive peptide des-Tyr-Leu-enkephalin.

2 odel, the endogenous antinociceptive peptide Leu-enkephalin.

3 ubstrates smaller than hexapeptides, such as Leu-enkephalin.

4 ,129 prevented the cardiovascular effects of Leu-enkephalin.

5 synthesis of an azaphenylalanine analogue of Leu-enkephalin 40.

6 Extension to the syntheses of Leu-enkephalin (9) and amyloid-beta (34-42) (10) demonst

7 this study was to develop an immunoassay for Leu-enkephalin, a mammalian opioid peptide, using a C-te

8 be critical for the hydrolysis of exogenous Leu-enkephalin, a neuropeptide present in the CA3 region

9 ransfected HeLa cells did not accumulate [3H]Leu-enkephalin above background levels, demonstrating th

10 The delta-selective glycosylated Leu-enkephalin amide 2, H(2)N-Tyr-D-Thr-Gly-Phe-Leu-Ser(

11 retrometabolic drug design was applied to a Leu-enkephalin analogue, Try-D-Ala-Gly-Phe-D-Leu (DADLE)

12 The Leu-enkephalin analogues were tested in a panel of bindi

13 cation (LOQ) by analyzing targeted peptides, leu-enkephalin and angiotensin II, spiked in a BSA trypt

14 don) dramatically increased the potencies of Leu-enkephalin and dynorphin A to produce MOR-1 internal

15 teins, including PSD-95, and opioid peptides leu-enkephalin and dynorphin in the hippocampus of young

16 With age, females showed opposing changes in leu-enkephalin and dynorphin levels in the mossy fiber p

17 ion-phase- and gas-phase deuterium uptake of Leu-Enkephalin and Glu-Fibrinopeptide B, confirmed that

18 Fmoc-based solid-phase peptide synthesis of Leu-enkephalin and in microwave-assisted automated synth

19 ned effects on memory formation produced by [Leu]enkephalin and [Met]enkephalin administration in 2 r

20 Basal concentrations of endogenous [Leu]enkephalin and [Met]enkephalin were determined for 5

21 containing more neurons heavily labeled for leu-enkephalin, and the main olfactory bulb, where only

22 d simultaneous monitoring of Met-enkephalin, Leu-enkephalin, and unknown peptides.

23 to be processed by CPA6, including Met- and Leu-enkephalin, angiotensin I, and neurotensin.

24 ectron microscopy using substance P and Met-/Leu-enkephalin antibodies to label GABAergic terminals f

25 Leu-enkephalin-Arg and Leu-enkephalin-Arg-Arg were gener

26 Leu-enkephalin-Arg and Leu-enkephalin-Arg-Arg were generated from dynorphin A a

27 he endogenous peptide opioid receptor ligand Leu-enkephalin as a model compound.

28 ain the sequences of both Met-enkephalin and Leu-enkephalin as seen for mammalian proenkephalin.

29 halin, met-enkephalin was more abundant than leu-enkephalin both within individual cells (darker stai

30 of the Australian lungfish indicates that a Leu-enkephalin-coding gene, distinct from proenkephalin,

31 Training had no effect on [Leu]enkephalin concentration in either the IMHV or the L

32 The results demonstrate that leu-enkephalin-containing terminals have a different ana

33 method was used to determine met-enkephalin, leu-enkephalin, dynorphin A(1-8), and beta-endorphin in

34 ntitative peroxidase immunohistochemistry of leu-enkephalin, dynorphin, synaptophysin, and PSD-95.

35 Des-tyrosyl-Leu-enkephalin elevated the apparent K(m) of L-proline t

36 Met/Leu-enkephalin expression was altered in pathological sk

37 phalin was then developed using the aequorin-Leu-enkephalin fusion protein as a labeled analyte in a

38 Des-Tyr-Leu-enkephalin (GGFL), a competitive peptide inhibitor o

39 y(3) and Phe(4)-Leu(5) dipeptide subunits in Leu-enkephalin (H(2)N-Tyr-Gly-Gly-Phe-Leu-OH), which is

40 The fact that Leu-enkephalin has been identified by radioimmunoassay a

41 r the accurate and precise quantification of Leu-enkephalin in a complex mixture using multiple-react

42 Levels of Leu-enkephalin in Cpefat/Cpefat mouse brain are approxim

43 The previous detection of Met-enkephalin and Leu-enkephalin in the CNS of the Australian lungfish, Ne

44 The omission of any one inhibitor abolished Leu-enkephalin-induced internalization, indicating that

45 Microinjections of Leu-enkephalin into the dorsal vagal complex induced hyp

46 These results suggest that Leu-enkephalin is involved in cardiovascular regulation

47 sought to determine the relationship between leu-enkephalin (LE)-containing axon terminals and GABAer

48 Within the HF, leu-enkephalin (LENK) is most prominent in the mossy fib

49 ine acetyltransferase plus substance P-, and Leu-enkephalin (Leu-enk)-containing extrinsic afferents

50 adiol, with or without progesterone, altered leu-enkephalin levels in the dentate gyrus and synaptoph

51 Additionally, met- and leu-enkephalin localization patterns largely overlap.

52 high potency and specificity of des-tyrosyl-Leu-enkephalin make this compound a useful tool for eluc

53 will be presented for [(eta(6)-Cp*Rh-Tyr(1))-leu-enkephalin](OTf)(2) and [(eta(6)-Cp*Rh-Tyr(3))-octre

54 In situ Met/Leu-enkephalin peptides were expressed in differentiatin

55 Furthermore, the absence of a Leu-enkephalin sequence in lungfish and amphibian proenk

56 As seen for amphibians, no Leu-enkephalin sequence was detected in the Australian l

57 and/or efficacy of the orthosteric agonists leu-enkephalin, SNC80 and TAN67, as measured by receptor

58 approach, we have electroosmotically pulled Leu-enkephalin through OHSCs to identify ectopeptidase a

59 ith carboxypeptidase B restores the level of Leu-enkephalin to the level in control brain.

60 ee important GPCR peptides; namely, [Tyr(1)]-leu-enkephalin, [Tyr(4)]-neurotensin(8-13), and [Tyr(3)]

61 Quantitative determination of leu-enkephalin using external calibration was verified b

62 For that, the N-terminus of Leu-enkephalin was genetically fused to the C-terminus o

63 A standard curve of Leu-enkephalin was performed in the presence of a backgr

64 An immunoassay for Leu-enkephalin was then developed using the aequorin-Leu

65 of 125I-Tyr-MIF-1 to 84.4% of total, whereas Leu-enkephalin was without effect.

66 [Leu]enkephalin was amnestic when administered in the IMH

67 alin (met-enkephalin) or leucine enkephalin (leu-enkephalin), we observed enkephalin localization con

68 Basal dialysate levels of Met-enkephalin and Leu-enkephalin were 60 +/- 30 and 70 +/- 20 pM while K+-

69 In tyrosyl-glycine and Leu-enkephalin, which have N-terminal tyrosines, bicycli