ライフサイエンスコーパス: Lyme disease spirochete

1 CsrA in differential gene expression in the Lyme disease spirochete.

2 ular adaptation by Borrelia burgdorferi, the Lyme disease spirochete.

3 y that is essential to the life cycle of the Lyme disease spirochete.

4 gene deletion during murine infection by the Lyme disease spirochete.

5 tro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete.

6 tion suggests a role in transmission of this Lyme disease spirochete.

7 s OspC and OspA in Borrelia burgdorferi, the Lyme disease spirochete.

8 xpression in physiological adaptation by the Lyme disease spirochete.

9 biological and pathogenic properties of the Lyme disease spirochete.

10 ty in relapsing-fever spirochetes but not in Lyme disease spirochetes.

11 higher cell densities in blood than those of Lyme disease spirochetes.

12 tative lipoprotein genes was used to examine Lyme disease spirochetes.

13 rrelates with the loss of infectivity of the Lyme disease spirochetes.

14 ctions essential to both relapsing fever and Lyme disease spirochetes.

15 amily in the biology and pathogenesis of the Lyme disease spirochetes.

16 with the rep+ and ORF-E gene families of the Lyme disease spirochetes.

17 n of the cp32 circular plasmids found in the Lyme disease spirochetes.

18 logous sequences in the three genospecies of Lyme disease spirochetes.

19 nto the genetic regulatory mechanisms of the Lyme disease spirochetes.

20 izes to defend itself against infection with Lyme disease spirochetes.

21 r the outer surface protein C (OspC) gene in Lyme disease spirochetes.

22 se to this important virulence factor of the Lyme disease spirochetes.

23 tinct roles in cell type-specific binding by Lyme disease spirochetes.

24 Summary Borrelia burgdorferi, the Lyme disease spirochete, adapts as it moves between the

25 able surface Ag of Borrelia burgdorferi, the Lyme disease spirochete, also contains both variable and

26 MMPs may play a role in dissemination of the Lyme disease spirochete and in the pathogenesis of Borre

27 gnificant role in mammalian infection by the Lyme disease spirochete and is an important antigen for

28 binding preference varies with the strain of Lyme disease spirochete and that this variation influenc

29 Deer tick-transmitted pathogens such as Lyme disease spirochetes and babesiae appear to require

30 nces are present consistently in low-passage Lyme disease spirochetes and indicate that both highly c

31 as reservoirs for ehrlichiae as well as for Lyme disease spirochetes and the piroplasm that causes h

32 frastructure in both Borrelia burgdorferi (a Lyme disease spirochete) and B. turicatae (a relapsing f

33 revA genes are widely distributed among Lyme disease spirochetes, and the present studies determ

34 ubjects, 97 (8.4%) were seroreactive against Lyme disease spirochete antigen, of whom 14 (14%) also w

35 ins that are differentially expressed by the Lyme disease spirochete at various stages of its life cy

36 urface proteins and antigens shared with the Lyme disease spirochete (B. burgdorferi), may cause both

37 ified as a receptor for all three species of Lyme disease spirochetes (B. burgdorferi sensu stricto,

38 homologous to the cp32 plasmid family of the Lyme disease spirochete, B. burgdorferi.

39 The three major species of Lyme disease spirochete--B. burgdorferi sensu stricto, B

40 tebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi.

41 BBA68 (BbCRASP-1) of the Lyme disease spirochetes binds human factor H (FH) and F

42 Borrelia burgdorferi, the Lyme disease spirochete, binds the host complement inhib

43 Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a m

44 The Lyme disease spirochete Borrelia burgdorferi alters the

45 th either laboratory or field strains of the Lyme disease spirochete Borrelia burgdorferi and field s

46 tion by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the ric

47 orin-binding proteins (DbpA and DbpB) of the Lyme disease spirochete Borrelia burgdorferi bind decori

48 Infection of C57BL/6 (B6) mice with the Lyme disease spirochete Borrelia burgdorferi can result

49 the natural mammal-tick infection cycle, the Lyme disease spirochete Borrelia burgdorferi comes into

50 The genome of the Lyme disease spirochete Borrelia burgdorferi contains mu

51 Here we show that the Lyme disease spirochete Borrelia burgdorferi depends on

52 lycan cell-wall synthesis, we found that the Lyme disease spirochete Borrelia burgdorferi displays a

53 quirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a un

54 Outer surface protein A (OspA) from the Lyme disease spirochete Borrelia burgdorferi elicits pro

55 The Lyme disease spirochete Borrelia burgdorferi exists in n

56 The Lyme disease spirochete Borrelia burgdorferi expresses a

57 The Lyme disease spirochete Borrelia burgdorferi expresses d

58 aphy revealed that the chemoreceptors of the Lyme disease spirochete Borrelia burgdorferi form long,

59 As an obligate pathogen, the Lyme disease spirochete Borrelia burgdorferi has a strea

60 Outer surface protein A (OspA) from the Lyme disease spirochete Borrelia burgdorferi has been a

61 The Lyme disease spirochete Borrelia burgdorferi has bundles

62 The Lyme disease spirochete Borrelia burgdorferi has two pla

63 ogens, promotes vascular interactions of the Lyme disease spirochete Borrelia burgdorferi Here, we in

64 etect heterogeneity of ospC genotypes of the Lyme disease spirochete Borrelia burgdorferi in the tick

65 The Lyme disease spirochete Borrelia burgdorferi is dependen

66 The Lyme disease spirochete Borrelia burgdorferi is the only

67 is paper, we show that the morphology of the Lyme disease spirochete Borrelia burgdorferi is the resu

68 The Lyme disease spirochete Borrelia burgdorferi lacks endog

69 The Lyme disease spirochete Borrelia burgdorferi lacks the t

70 The Lyme disease spirochete Borrelia burgdorferi possesses 1

71 The Lyme disease spirochete Borrelia burgdorferi reduces the

72 The Lyme disease spirochete Borrelia burgdorferi sensu stric

73 acterized an elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promot

74 The Lyme disease spirochete Borrelia burgdorferi undergoes s

75 In this report, the Lyme disease spirochete Borrelia burgdorferi was used as

76 of the antigenic variation vlsE gene of the Lyme disease spirochete Borrelia burgdorferi were analyz

77 Two motility genes (fliH and fliI) of the Lyme disease spirochete Borrelia burgdorferi were cloned

78 cell depletion on the immune response to the Lyme disease spirochete Borrelia burgdorferi, an extrace

79 iota of I. scapularis, a major vector of the Lyme disease spirochete Borrelia burgdorferi, influence

80 To enhance genetic manipulation of the Lyme disease spirochete Borrelia burgdorferi, we assayed

81 markable case of displacement is seen in the Lyme disease spirochete Borrelia burgdorferi, which does

82 dified lipoproteins, including OspA from the Lyme disease spirochete Borrelia burgdorferi.

83 ever agent Borrelia hermsii, and OspC of the Lyme disease spirochete Borrelia burgdorferi.

84 ding protein with an HU-like activity in the Lyme disease spirochete Borrelia burgdorferi.

85 s an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi.

86 , motility, and infectious life cycle of the Lyme disease spirochete Borrelia burgdorferi.

87 ssed elements of the segmented genome of the Lyme disease spirochete Borrelia burgdorferi.

88 n FlgJ homolog (FlgJ(Bb)) was studied in the Lyme disease spirochete Borrelia burgdorferi.

89 d for gene regulation and infectivity in the Lyme disease spirochete Borrelia burgdorferi.

90 t a number of human pathogens, including the Lyme disease spirochete Borrelia burgdorferi.

91 abolism and salvage compared to those in the Lyme disease spirochete Borrelia burgdorferi.

92 s crucial for the pathogenic strategy of the Lyme disease spirochete Borrelia burgdorferi.

93 amino acid sequences that were absent in the Lyme disease spirochete Borrelia burgdorferi.

94 The genetic structure of the Lyme disease spirochete (Borrelia burgdorferi) and its m

95 Outer surface proteins (Osp) A and C of the Lyme disease spirochete (Borrelia burgdorferi) are selec

96 A prime example is the Lyme disease spirochete, Borrelia burgdorferi (B. burgdo

97 of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an o

98 After transmission by an infected tick, the Lyme disease spirochete, Borrelia burgdorferi sensu lato

99 The Lyme disease spirochete, Borrelia burgdorferi, causes a

100 The Lyme disease spirochete, Borrelia burgdorferi, causes pe

101 VlsE, the variable surface antigen of the Lyme disease spirochete, Borrelia burgdorferi, contains

102 The Lyme disease spirochete, Borrelia burgdorferi, controls

103 The Lyme disease spirochete, Borrelia burgdorferi, encodes a

104 The Lyme disease spirochete, Borrelia burgdorferi, encounter

105 ed glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited

106 The Lyme disease spirochete, Borrelia burgdorferi, exists in

107 The Lyme disease spirochete, Borrelia burgdorferi, exists in

108 ous immunological studies indicated that the Lyme disease spirochete, Borrelia burgdorferi, expresses

109 The Lyme disease spirochete, Borrelia burgdorferi, expresses

110 Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have stro

111 protein B (OspB), a major lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi, have the

112 Persistence of the Lyme disease spirochete, Borrelia burgdorferi, in the pr

113 surface protein loci (ospA and ospC) of the Lyme disease spirochete, Borrelia burgdorferi, infecting

114 The Lyme disease spirochete, Borrelia burgdorferi, infects m

115 The Lyme disease spirochete, Borrelia burgdorferi, inhabits

116 Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi, is a dumb

117 The Lyme disease spirochete, Borrelia burgdorferi, is an ext

118 The Lyme disease spirochete, Borrelia burgdorferi, is capabl

119 The Lyme disease spirochete, Borrelia burgdorferi, is ingest

120 The Lyme disease spirochete, Borrelia burgdorferi, is introd

121 The Lyme disease spirochete, Borrelia burgdorferi, is largel

122 ponses and disease during infection with the Lyme disease spirochete, Borrelia burgdorferi, is not we

123 All examined isolates of the Lyme disease spirochete, Borrelia burgdorferi, naturally

124 The Lyme disease spirochete, Borrelia burgdorferi, occupies

125 A Lyme disease spirochete, Borrelia burgdorferi, that was

126 ion between arthropod and mammals forces the Lyme disease spirochete, Borrelia burgdorferi, to adapt

127 pC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it i

128 phy was used to analyze the structure of the Lyme disease spirochete, Borrelia burgdorferi.

129 s crucial for the pathogenic strategy of the Lyme disease spirochete, Borrelia burgdorferi.

130 The Lyme disease spirochetes, Borrelia burgdorferi (sensu la

131 In the Lyme disease spirochetes, both the ospE and vlsE gene fa

132 Infection with Lyme disease spirochetes can be chronic.

133 The Lyme disease spirochetes, comprised of at least three cl

134 s been postulated that the vls system of the Lyme disease spirochetes contributes to immune evasion t

135 The Lyme disease spirochete controls production of its OspC

136 investigations into mechanisms by which the Lyme disease spirochete controls synthesis of its Erp su

137 Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing a

138 Southern blot analyses of Lyme disease spirochetes cultured from 16 of the patient

139 ies (>10(8)/ml) in their host's blood, while Lyme disease spirochetes do not (<10(5)/ml).

140 Taken together, our data demonstrate the Lyme disease spirochete encodes a manganese-dependent SO

141 The ospE gene family of the Lyme disease spirochetes encodes a polymorphic group of

142 The genome of Borrelia burgdorferi, the Lyme disease spirochete, encodes a homolog (the bb0184 g

143 The Lyme disease spirochete expresses several plasminogen-bi

144 the first report and characterization of the Lyme disease spirochete from that state.

145 to immunological pressures suggests that the Lyme disease spirochete has exploited recombinatorial pr

146 Borrelia burgdorferi, the Lyme disease spirochete, has a genome comprised of a lin

147 oglycans (GAGs) by Borrelia burgdorferi, the Lyme disease spirochete, has the potential to promote th

148 lants represents a novel system for studying Lyme disease spirochetes in a mammalian host-adapted sta

149 expressed dbpA alleles derived from diverse Lyme disease spirochetes in B. burgdorferi strain B314,

150 nce of large-scale genetic exchanges between Lyme disease spirochetes in nature, including the appare

151 us genes are important to the maintenance of Lyme disease spirochetes in one or more of their hosts.

152 ification of several mammalian receptors for Lyme disease spirochetes, including glycosaminoglycans,

153 omologic index based on density estimates of Lyme disease spirochete-infected nymphal deer ticks (lxo

154 Outer surface protein A (OspA) of the Lyme disease spirochete is primarily produced in the tic

155 Outer surface protein C (OspC) of the Lyme disease spirochetes is an important virulence facto

156 Some Lyme disease spirochete isolates can bind complement reg

157 basis of how Borrelia burgdorferi (Bb), the Lyme disease spirochete, maintains itself in nature via

158 Through this mechanism, a population of Lyme disease spirochetes may synchronize production of s

159 ces in our ability to genetically manipulate Lyme disease spirochetes, particularly B. burgdorferi, a

160 Borrelia burgdorferi, the Lyme disease spirochete, persistently infects mammalian

161 Lyme disease spirochetes possess a single HtrA protease

162 Borrelia burgdorferi, the Lyme disease spirochete, possesses a surface protein, Vl

163 The Lyme disease spirochetes produce several factor H bindin

164 borrelial isolates in order to elucidate the Lyme disease spirochete's complex parasitic strategies.

165 In human Lyme disease, spirochetes spread from the site of a tick

166 None of the Lyme disease spirochetes tested possessed catalase or pe

167 ortant in the pathogenesis or biology of the Lyme disease spirochetes, then a wide distribution among

168 at additional mechanisms are employed by the Lyme disease spirochete to evade complement-mediated kil

169 hat multiple integrins mediate attachment of Lyme disease spirochetes to host cells.

170 Borrelia burgdorferi, the Lyme disease spirochete, undergoes dramatic changes in a

171 tial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in

172 y the ability to bind to target tissues, and Lyme disease spirochetes utilize multiple adhesive molec

173 Plasmin stabilized on the surface of the Lyme disease spirochete was shown to activate pro-MMP-9

174 proteins (Hsps) by Borrelia burgdorferi, the Lyme disease spirochete, was investigated by radiolabeli

175 Three representatives of each species of Lyme disease spirochete were tested for the ability to b

176 Lyme disease spirochetes were previously shown to bind g

177 ponses of Borrelia burgdorferi (Bb) B31, the Lyme disease spirochete, when grown under conditions ana

178 variable metabolic requirements of different Lyme disease spirochetes within tick vectors could poten