ライフサイエンスコーパス: Lys residue

1 and general derivatizing agents for the 38C2 Lys residue.

2 rization switch moderated by a single buried Lys residue.

3 hich Glu at position 13 was substituted by a Lys residue.

4 sidue capable of interacting with a cationic Lys residue.

5 many instances, this motif is followed by a Lys residue.

6 contain an average of nine Arg residues per Lys residue.

7 which recognizes LLO through its N-terminal Lys residue.

8 endent ubiquitination on the pex12-1 ectopic Lys residue.

9 he N-terminal domain of CtBP2 contains three Lys residues.

10 es isopeptide bond formation between Gln and Lys residues.

11 e beta-hairpin consisting of two Trp and two Lys residues.

12 ntification of factor XIIIa-reactive Gln and Lys residues.

13 to result from deprotonation of the flanking Lys residues.

14 nonalkaliphiles but contained fewer Arg and Lys residues.

15 n exhibits a high S1 specificity for Arg and Lys residues.

16 ne isopeptide bonds between specific Gln and Lys residues.

17 e by this enzyme can occur at a lone pair of Lys residues.

18 of modified peptides and assigning glycated Lys residues.

19 though salt bridge interactions with surface Lys residues.

20 anes of cells despite eight cationic Arg and Lys residues.

21 tra-GP(1) disulfide bonds, and four critical Lys residues.

22 um albumin (BSA) molecules by conjugation to Lys residues.

23 , which forms a Michael-type adduct with the Lys residues.

24 rnative mechanism, which depends on internal Lys residues.

25 s both amine acceptor (Gln) and amine donor (Lys) residues.

26 a lesser extent, including ubiquitination at Lys residues 12, 21, and 23 and specific truncations at

27 Alanine substitutions of Lys residues 165 and 166 in human TF have been shown pre

28 greatest with peptides containing an Arg or Lys residue 5 positions downstream (P+5) from the Ser.

29 NH2-terminal region of the fragment and four Lys residues (539, 556, 580, 601) located in the COOH-te

30 was significantly reduced by substitution of Lys residues 642-645, indicating that these residues may

31 A Lys residue (679 in human POLN) of particular interest w

32 Replacement of the lactococcal DpsA Lys residues 9, 15 and 16 by Glu did not inhibit DNA bin

33 esidue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise

34 of HERG channels to neutral (Ala) or basic (Lys) residues accelerated the rate of channel deactivati

35 being buried in the protein interior, these Lys residues acquired pK(a) values comparable to those o

36 Ala residues were substituted for the Arg/Lys residues (ACSANA-HY1), and these substitutions did n

37 of the changes in cleavage of progastrin at Lys residues after omeprazole.

38 backbone by N(6) acylation of the central l-Lys residue and subsequent N(6)-hydroxylation of the cen

39 he CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this resid

40 ultiple amyloidogenic proteins by binding to Lys residues and disrupting hydrophobic and electrostati

41 es isopeptide bond formation between Gln and Lys residues and is allosterically regulated by GTP.

42 ed through isopeptide bonds between internal Lys residues and the C-terminus of Ub, can be assembled

43 The use of Arg, rather than Lys residues, and the inclusion of Tyr or Phe residues i

44 Our results show that these Lys residues are acetylated by the nuclear acetylase p30

45 queous phase only occurs at high pH when the Lys residues are de-protonated.

46 the IE promoter, indicating that the Gln and Lys residues are important for the DNA binding activity.

47 and Thr3 show reduced activity when adjacent Lys residues are modified.

48 m activation revealed that histone H3 and H4 Lys residues are not globally hyperacetylated during pha

49 Several surface-exposed Lys residues are present in IL-1beta, but not in IL1RN.

50 Ts) demonstrates that three highly conserved Lys residues are present in the catalytic domain of FucT

51 lysines from peptides containing up to three Lys residues are readily quantified using this method.

52 analysis was carried out to determine which Lys residues are sentrinized.

53 for 18C6, suggesting that the side chains of Lys residues are the preferred binding site for 18C6 com

54 Since lysine (Lys) residues are a major target for ubiquitination, we

55 One class utilizes an internal Lys residue as the active site nucleophile, and includes

56 caldarius adenylate kinase has the invariant Lys residue as well as the two Arg residues, its phospha

57 A Lys residue at P3' of Pro-sigma(K) could not be replaced

58 Substitution of a Lys residue at position 68 with Asn in MUG not only acce

59 NK1 killers depended on the presence of the Lys residue at position 80, an upward pointing residue n

60 Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 t

61 ibution of positive charges by placing three Lys residues at both termini while maintaining identical

62 a subset that consists of Asp, Glu, His, and Lys residues at eight of the nine contiguous P6-P3' posi

63 Docking simulation predicted that three Lys residues at positions 180, 184, and 186 of the EGF-l

64 follow the N-end rule but depends on the two Lys residues at positions 4 and 17 of the native A1-chai

65 rometry of MDA-modified apoA-I revealed that Lys residues at specific sites had been modified.

66 d to be dependent on the number of L-lysine (Lys) residues at the C-terminus.

67 placement of Gln(881) with Asn, Glu, Asp, or Lys residues augmented the homolytic cleavage of 8R-HPOD

68 ith pKA values of about 5.9 and 8.4 (His and Lys residues?) but do not support a function for the pho

69 We mapped the acetylated Lys residues by tandem mass spectrometry and determined

70 chains (linked through different Ub lysine (Lys) residues) can confer different fates on target prot

71 ICA complexed with CH3NH3+ as a mimic of the Lys residue confirmed that such an interaction lowered t

72 contains the sequence Lys-Pro-Glu where the Lys residue contacts the gamma-phosphate of ATP and the

73 s also consistent with the pKa values of the Lys residues determined previously.

74 The position-a Lys residues do not, however, confer a single preference

75 Here we show that modulating the number of Lys residues does not affect recognition events within t

76 i) on-resin incorporation of the linker at a Lys residue epsilon-amine, (ii) Fmoc-SPPS elongation of

77 sing on the Ub molecule that contributes the Lys residue for chain formation, we found that specific

78 possessing a diketone linker reacts with the Lys residues forming an enaminone derivative.

79 other PLP-dependent enzymes, an active site Lys residue forms a Schiff base with PLP in the absence

80 The conserved Lys residue found adjacent to the axial ligand in the se

81 in must proceed in a way that protects these Lys residues from attack by E3 ligases.

82 omponent of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradation of fibrin

83 Nineteen of the Lys residues have depressed pK(a) values, some as low as

84 ch as histone acetylation and methylation on Lys residues-have been linked to these lasting actions o

85 tion of pro-KLK6 requires hydrolysis after a Lys residue; however, KLK6 exhibits 2 order of magnitude

86 urements on OspA specifically 15N-labeled at Lys residues identified the locations of the two folding

87 hat several conserved motifs consisting of a Lys residue immediately followed by a Ser residue are pr

88 e of L-lysine complexed with E. coli LysRS2 (lysS), residues implicated in amino acid recognition and

89 A juxtamembrane Lys residue in beta also has an important role in the in

90 e of R3.29 in TM3 seems to be fulfilled by a Lys residue in EL2, whereas the R7.39 in TM7 seems to be

91 her the probes were covalently attached to a Lys residue in Gag or to residues specifically within th

92 emical data, the unusual conformation of the Lys residue in S.acidocaldarius adenylate kinase is expl

93 The Lys residue in the conserved DEK motif coordinates the n

94 o investigate the function of this conserved Lys residue in the large and small subunits of the heter

95 ptor fold and a highly conserved active-site Lys residue in the seventh transmembrane segment of the

96 ydrophobic patch is interrupted by a charged Lys residue in the T1-SP10RF(A) peptide.

97 Acetylation of the Lys residue in this motif, demonstrated in vivo by using

98 ate NMR demonstrated binding of CLR01 to the Lys residues in Abeta at the earliest stages of assembly

99 The microenvironments (pKa) of Lys residues in apo B-100 in small, dense, intermediate,

100 e NCX1-CBD1 structure are neutralized by two Lys residues in CALX1.1-CBD2.

101 are critical for the usage of the respective Lys residues in chain synthesis.

102 Mutations of Walker A Ser and Lys residues in combination with E552A/E1197A had the sa

103 Furthermore, three Lys residues in DbpA appear to be critical for the bindi

104 tion was also prevented by altering the four Lys residues in its cytosolic domain to Arg, suggesting

105 pid proteasome-mediated degradation required Lys residues in MHCI heavy chain ectodomain.

106 L-lysine (Bz-Gly-Lys) as a model compound of Lys residues in protein and 13-hydroperoxyoctadecadienoi

107 the emerging role of acetylation of critical Lys residues in regulating APE1 functions.

108 , and selectively react through the reactive Lys residues in the Ab binding sites to form 38C2 conjug

109 Human hemoglobin contains 11 Lys residues in the alpha chain and 10 Lys residues in t

110 ns 11 Lys residues in the alpha chain and 10 Lys residues in the beta chain.

111 Lys residues in the C terminus of apoA-I were targeted f

112 conjugation sites in the cytoplasmic tail or Lys residues in the ectodomain.

113 SRCR domains 2 and 3 with the two basic Arg/Lys residues in the Hp loop.

114 pH could not be resolved from those of other Lys residues in the molecule.

115 Two conserved Lys residues in the N-terminal domain of human immunodef

116 ide substrates with a preference for Arg and Lys residues in the P-1 position.

117 nd K483, and at least two other unidentified Lys residues in the surface loops of the outer membrane

118 n of the relative reactivities of respective Lys residues in the ubiquitin.

119 tionicity, manifested by abundant Arg and/or Lys residues in their sequences.

120 minal sequencing demonstrated that, of the 7 Lys residues in ubiquitin, Lys(6) was the most readily l

121 chiff-base and Michael-addition adducts with Lys residues, in addition to causing oxidation of Met re

122 gen-bonded network that positions the acidic Lys residue; in the active site of KGPDC, the homologous

123 gy modeling and suggested that a pro-peptide Lys residue intrudes into the S2 pocket, which is more s

124 ars lining the walls of the groove while the Lys residue is able to form a salt bridge with a proxima

125 This Lys residue is adjacent to the consensus CtBP binding mo

126 ently edits Cys-tRNAPro and that a conserved Lys residue is essential for this activity.

127 Protein acetylation on Lys residues is recognized as a significant post-transla

128 the ability of SacAcuA to acetylate multiple Lys residues is unique among AcuA-type acetyltransferase

129 we demonstrate that mutations at a different Lys residue, K294, may modulate the fidelity of Tth DNA

130 3A-APC (Lys191-193Ala) mutant in which three Lys residues (KKK191-193) were replaced with alanine, an

131 th an intramolecular crosslink to a proximal Lys residue, leading to increased thermal stability.

132 nge columbic interactions between basic (Arg/Lys) residues located N-terminally to the phosphorylated

133 os coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide cor

134 Mutation of any one of the HAH1p C-terminal Lys residues (Lys(56), Lys(57), or Lys(60)) to Gly does

135 CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that rea

136 binds to a pocket formed by three conserved Lys residues (Lys314, Lys326, and Lys328) on the surface

137 SUMOylation occurred at a single Lys residue, Lys428, of CtBP1.

138 mprised of 11 amino acids and flanked by two Lys residues, Lys573 and Lys583, that are located at the

139 e active site of KGPDC contains a homologous Lys residue (Lys64).

140 nding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.

141 APE1 ubiquitination occurred specifically at Lys residues near the N-terminus, and was markedly enhan

142 itute Ala and Gln residues for the conserved Lys residue of the Walker A box for nucleotide binding.

143 crosslinks could be formed between FPheK and Lys residue of two interacting proteins, including the h

144 L31C-PLB failed to cross-link to any Cys or Lys residue of wild-type SERCA2a, L31C did cross-link wi

145 We show that although the C'-terminal Lys residue of Wnt3a is critical for its activity and is

146 he existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, wh

147 Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear

148 The N-terminal Lys residues of Escherichia coli Dps have been implicate

149 Alanine scanning mutagenesis of 12 Arg/Lys residues of exosite 2 revealed a defect in 9a potenc

150 hrough ionic interactions formed between the Lys residues of FPR and Asp/Glu residues of FdI.

151 ribed genes are typically hyperacetylated at Lys residues of histones H3 and H4 and hypermethylated a

152 void of SacAcuA, none of the above-mentioned Lys residues of SacAcsA was acetylated.

153 geted agent by conjugating folic acid to the Lys residues of the apolipoprotein B (apoB)-100 protein.

154 ing site on ROMK1, all intracellular lysine (Lys) residues of ROMK1 were individually mutated to argi

155 When lysine (Lys) residues of the hD4R are substituted with arginine

156 lation and activation, and ubiquitylation of Lys residues on a cohort of MOM proteins, occur similarl

157 ow that (i) the effects of buried position a Lys residues on coiled-coil oligomerization are context

158 Mutation of the two Lys residues on the binding face of the beta-hairpin res

159 The SUMOylation sites included three Lys residues on the bipartite nuclear localization seque

160 umber of targets, including six of the seven Lys residues on Ub itself with a Lys-48>Lys-63>Lys-11>>>

161 peat (of seven) either with a bulky, charged Lys residue or with a Ser residue (sometimes found in th

162 nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and the

163 Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDal

164 ificity appears to be determined by a single Lys residue present in a sequence motif conserved in all

165 While the substitution of the two Lys residues present in ricin A chain with arginine slow

166 tion is required for enzyme activity, with a Lys residue providing higher intrinsic activity.

167 Inclusion of exon 16 introduces a pair of Lys residues, providing a site for controlled endoproteo

168 We also found that a conserved Lys residue required for PP5 binding to hsp90 was critic

169 ngly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surfac

170 valent neutralization of the unpaired Asp or Lys residue, respectively, with n-alkylsulfonates or n-a

171 roduction in position 204(C+6) of a Glu or a Lys residue, respectively.

172 events, initiated by acetylation of a single Lys residue, results in proteolysis of RNase R in expone

173 hesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by

174 th nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)/K(32)/K(35)) ma

175 A binding were abrogated by mutation of both Lys residues, suggesting that either one can bind ATP.

176 was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.

177 eling and identification of reactive Gln and Lys residues targeted by factor XIIIa in rFnbA.

178 A Lys residue that is critical for this step is located in

179 lar interactions involving buried position-a Lys residues that can interact favorably only with surfa

180 he cytoplasmic tail of IFNAR1 contains seven Lys residues that could function as potential ubiquitin

181 s, nor does it associate with methylated Arg/Lys residues through its aromatic cage.

182 ns, little is known about how E3s select the Lys residue to be used in chain synthesis.

183 Mutation of the Lys residue to Gln resulted in a decrease in CtBP bindin

184 Mutating all three Lys residues to Glu (the 3KE mutation) did not affect th

185 Substitution of the Lys residues to Glu markedly reduced integrin binding of

186 occur within the subunits, exposing Arg and Lys residues to negatively charged binding sites of P-tR

187 Mutation of these Lys residues to neutral residues decreased PAK binding t

188 ets for ubiquitination since mutation of all Lys residues, to which the ubiquitin moiety is conjugate

189 lly coupled to surface exposed Cyt c lysine (Lys) residues using succinimidyl chemistry via amide bon

190 quence was either scrambled or if a critical Lys residue was chemically modified.

191 Lys-gingipain to cleave human hemoglobin at Lys residues was confirmed by electrospray ionization Fo

192 or its cytoplasmically exposed Ser, Thr, and Lys residues was still down-regulated, ubiquitinated, an

193 oint mutants, each lacking a single Walker A Lys residue, was generated to study the effects of aboli

194 The pK(a) values of some of the internal Lys residues were affected by interactions with surface

195 eversing mutant of the pro peptide where Arg/Lys residues were changed to Asp, and Asp/Glu residues t

196 Several acetylated Lys residues were mapped by tandem mass spectrometry, an

197 id (PNA) anti-miRs containing a few attached Lys residues were potent miRNA inhibitors.

198 Cyt c2 molecules in which positively charged Lys residues were replaced with Glu.

199 (hBD1) and (Lys-->Arg)hBD1 in which all four Lys residues were substituted for Arg.

200 uto-ubiquitination site of TRAF6 to a single Lys residue, which if mutated renders TRAF6 unable to ac

201 20 amino acids each that is rich in Gln and Lys residues, which are potential transglutaminase subst

202 lectropositive surface with six Arg and five Lys residues, which presumably interacts with the negati

203 vity toward DNA with an increasing number of Lys residues, while a corresponding decrease in complex

204 Chymotrypsin prefers P1' Arg/Lys residues, while trypsin prefers hydrophobic P1' resi

205 ution of the Ca(2+)-coordinating Asp310 by a Lys residue, whose side-chain amine may have functionall

206 y that the replacement of a partially buried Lys residue with Glu at position 49 in E.coli HPr increa

207 unit was altered by replacing the C-terminal Lys residue with three Asp residues.

208 edundant nature of interaction of P1 Arg and Lys residues with Asp129, Tyr150 and Ser163 of the enzym

209 ith respect to their lack of the "invariant" Lys residue within the phosphate-binding loop, and two A

210 Here, we show that a Lys residue within the pilin-like motif of the EbpC subu

211 position favorable to form salt bridges with Lys residues within the EH-domain.

212 nteractions and acetylation of some internal Lys residues within the N-terminal segments of the histo