ライフサイエンスコーパス: M. africanum

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1 tuberculosis complex, namely M. microti and M. africanum.

2 ng lineage, the Euro-American X lineage, and M. africanum.

3 s M. tuberculosis, 6 (1%) were identified as M. africanum, 8 (1%) were identified as M. bovis, and 13

4 T-6 and CFP-10, comparing M. tuberculosis to M. africanum and a strain of M. africanum complemented w

5 nd IFN-alphabeta receptor knockout mice with M. africanum and monitored bacterial growth, lung diseas

6 TB complex (354 cases of M. tuberculosis, 20 M. africanum and one case of M. bovis) and 69 (15%) were

7 ion apparatus member, Rv3879c, is mutated in M. africanum, and individuals infected with M. africanum

8 complex includes M. tuberculosis, M. bovis, M. africanum, and M. microti.

9 However, there is no simple definition of M. africanum, and some authors question the validity of

10 ally identified as M. bovis were shown to be M. africanum because they had a wild-type pncA sequence

11 l identifications for all TBC members except M. africanum, but further characterization resulted in p

12 an isolates from Sierra Leone, identified as M. africanum by biochemical and growth characteristics.

13 all strains, although these were enriched in M. africanum cell lysates, suggesting a modest ESX-1 sec

14 tuberculosis to M. africanum and a strain of M. africanum complemented with M. tuberculosis Rv3879c.

15 In mice, M. africanum demonstrated smaller bacterial population s

16 Genotypic analyses identified a cluster (M. africanum group A) which included M. africanumT and w

17 These results confirm impaired fitness of M. africanum in vivo and indicate that Rv3879c is not re

18 t IFN-alphabeta is pathogenic during chronic M. africanum infection and that the pathogenic effects m

19 Fourteen Sierra Leone M. africanum isolates (designated group A) had katG codo

20 Three M. africanum isolates (group B) had katG codon 203 ACT T

21 Drug-resistant M. africanum isolates had katG and rpoB mutations simila

22 All M. africanum isolates had the ancestral CTG Leu at katG

23 deletion, specific to the animal-adapted and M. africanum L6 lineages, that restores ESAT-6 secretion

24 M. africanum, and individuals infected with M. africanum less frequently demonstrate T-cell response

25 tuberculosis complex (TBC; M. tuberculosis, M. africanum, M. canettii, M. microti, M. bovis, and M.

26 of M. tuberculosis, M. bovis, M. bovis BCG, M. africanum, M. microti, and M. canettii was developed.

27 l-characterized isolates of M. tuberculosis, M. africanum, M. microti, M. bovis, and M. bovis BCG.

28 r-positive pulmonary tuberculosis exposed to M. africanum progress less frequently to active disease

29 Future studies of M. africanum should include both phenotypic and genotypi

30 These two M. africanum strains contain multiple (three and six) co

31 isingly, coincident polymorphisms linked one M. africanum subtype I genotype with the dassie bacillus

32 . tuberculosis (or M. africanum subtype II), M. africanum subtype I, M. bovis, M. bovis BCG, M. capra

33 ther as MtbC composed of M. tuberculosis (or M. africanum subtype II), M. africanum subtype I, M. bov

34 Phenotypic identification of M. africanum yielded a heterogeneous collection of strai

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