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1 ium and is not present in M. tuberculosis or M. paratuberculosis.
2 the M. avium control has the DNA sequence of M. paratuberculosis.
3 ion of isolates of M. avium from isolates of M. paratuberculosis.
4 ty-six acid-fast isolates were identified as M. paratuberculosis, 15 were identified as belonging to
6 inguish between sheep and cattle isolates of M. paratuberculosis and easily and reproducibly differen
7 se drug susceptibility assay is reliable for M. paratuberculosis and gives results within 7 days, whe
9 M. avium-M. intracellulare complex (but not M. paratuberculosis), and the remaining 18 were identifi
10 cattle or humans, single-cell suspensions of M. paratuberculosis cells were adjusted to an optical de
11 udies requiring the quantification of viable M. paratuberculosis cells, such as drug susceptibility t
12 son with the previously described BACTEC 460 M. paratuberculosis counting method, quantification with
16 de repeat sequences dispersed throughout the M. paratuberculosis genome, of which 78 were perfect rep
19 d by exposure of PBMCs from clinical cows to M. paratuberculosis in vitro tended to be repression of
20 est up regulation following stimulation with M. paratuberculosis, including those encoding bovine CD4
21 similar (overall r = 0.84), suggesting that M. paratuberculosis-induced gene repression in clinicall
22 ost efficacious therapy for the treatment of M. paratuberculosis infections and that the use of fluor
23 avium) and M. avium subsp. paratuberculosis (M. paratuberculosis), intracellular bacteria that can ca
24 nd reproducible high-resolution subtyping of M. paratuberculosis isolates for molecular epidemiologic
25 ysis enables the genetic characterization of M. paratuberculosis isolates from different host species
26 nucleotide sequencing of the 78 loci of six M. paratuberculosis isolates from different host species
27 R) region enabled the differentiation of the M. paratuberculosis isolates in clade A18 into seven dis
29 loci was used to genotype a collection of 33 M. paratuberculosis isolates representing different mult
31 rates the isolation and/or identification of M. paratuberculosis or a closely related M. avium comple
33 antibody reactivities by immunoblotting with M. paratuberculosis recombinant clones expressing the 36
35 ed characterization of a recently identified M. paratuberculosis short sequence repeat (SSR) region e
37 Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis)-specific sequence (locus 251), and
39 de evidence for the host specificity of some M. paratuberculosis strains as well as sharing of strain
40 S900 integration loci clustered 67 of the 76 M. paratuberculosis strains into a single clade (designa
43 We employed reverse transcription PCR using M. paratuberculosis subspecies-specific primers (IS 900)
44 PBMCs from subclinically infected cows with M. paratuberculosis tended to up regulate expression of
45 Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis), the causative agent of Johne's dis
46 We conclude that clinical trials with anti-M. paratuberculosis therapy are indicated in patients wi
47 obial agents with potential activity against M. paratuberculosis, we have developed a firefly lucifer
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