ライフサイエンスコーパス: M. tuberculosis

1 M. tuberculosis (and M. marinum) PGL promotes bacterial

2 M. tuberculosis 6-kDa early secretory antigenic target (

3 M. tuberculosis complex was detected by the Genotype MTB

4 M. tuberculosis gyrase lacks a conserved serine that anc

5 M. tuberculosis imports these metabolites through its re

6 M. tuberculosis isolates can be categorised into differe

7 M. tuberculosis was identified in all 39 samples from wh

8 M. tuberculosis WhiB1 is a NO-responsive Wbl protein (ac

9 M. tuberculosis-infected IL-21R KO mice had enhanced bac

10 M. tuberculosis-specific CD4 T cells in HIV-infected ind

11 M. tuberculosis-specific CD4+ T-cell cytokine (interfero

12 the Netherlands, we identified a set of 100 M. tuberculosis strains either least or most likely to b

13 we sequenced and analyzed the genomes of 138 M. tuberculosis isolates from 97 patients sampled betwee

14 ata set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents.

15 osis to measure IgG antibody responses to 57 M. tuberculosis antigens using a field-based multiplexed

16 ion in vivo reduces protection and abrogates M. tuberculosis-specific immunoglobulin A (IgA) secretio

17 Additionally, M. tuberculosis cell wall lipids, particularly mycolic a

18 ntly enhanced protection against aerosolized M. tuberculosis (P < 0.01).

19 After M. tuberculosis infection, TOLLIP-deficient monocytes de

20 generated during host immune responses after M. tuberculosis infection of macrophages.

21 understand the basis of drug action against M. tuberculosis gyrase and how mutations in the enzyme c

22 ted excellent antibacterial activity against M. tuberculosis (MIC = 3.13 muM).

23 to have direct bactericidal activity against M. tuberculosis, the role of NO as a signaling molecule

24 at has potent, bactericidal activity against M. tuberculosis.

25 ine antibiotics enhanced the potency against M. tuberculosis by more than 100-fold, thus demonstratin

26 Although M. tuberculosis antigens were recognized by the IgG resp

27 An M. tuberculosis DeltaRv1258c mutant was constructed and

28 the mechanism of host lipid catabolism by an M. tuberculosis enzyme, augmenting our current understan

29 he robust T cell response observed during an M. tuberculosis infection.

30 nfluence of detergent in cultures of BCG and M. tuberculosis strains on the outcome of vaccination ex

31 ng the growth of Mycobacterium bovis BCG and M. tuberculosis.

32 In both E. coli and M. tuberculosis we find that four-gene LRCs are intimate

33 P-8, which was likely neutrophil derived and M. tuberculosis-antigen driven.

34 galactan biosynthesis in C. diphtheriae and M. tuberculosis In each species, the galactan is constru

35 LLIP variant on monocyte mRNA expression and M. tuberculosis-induced monocyte immune functions.

36 lymph nodes (LNs) from persons with HIV and M. tuberculosis coinfection, those with HIV monoinfectio

37 mulation with Toll-like receptor ligands and M. tuberculosis whole-cell lysate, increased M. tubercul

38 functions, including the production of anti-M. tuberculosis cytokines and inhibition of intracellula

39 While the removal of apoptotic M. tuberculosis (Mtb)-infected cells, or efferocytosis,

40 obacterial components to exosomes as well as M. tuberculosis strains that express recombinant protein

41 eviously uncharacterized membrane-associated M. tuberculosis protein encoded by Rv2672 is conserved e

42 s antigen transfer, antigen export, benefits M. tuberculosis by diverting bacterial proteins from the

43 etermine if there was an association between M. tuberculosis resistance mutations and patient mortali

44 ed by ambient conditions and crowding and by M. tuberculosis itself.

45 pporting the idea that they may be caused by M. tuberculosis cells with lipid inclusions.

46 r the direct regulation of CD4(+) T cells by M. tuberculosis lipoglycans conveyed by BVs that are pro

47 ta-lactamase) that is naturally expressed by M. tuberculosis.

48 TCR signaling is inhibited by M. tuberculosis cell envelope lipoglycans, such as lipoa

49 on biosynthetic transformations performed by M. tuberculosis while suggesting avenues for the evoluti

50 we found that membrane vesicles produced by M. tuberculosis and released from infected macrophages i

51 glycans conveyed by BVs that are produced by M. tuberculosis and released from infected macrophages.

52 ition of effector CD4(+) T cell responses by M. tuberculosis may contribute to immune evasion.

53 Th2, and Th17 cells following stimulation by M. tuberculosis antigen and enhanced frequencies of CD8(

54 talytic activities and could be supported by M. tuberculosis Pyc.

55 pe, were infected with a lower dose of 3 CFU M. tuberculosis All animals mounted similar T-cell respo

56 s at weeks 1 and 3 after high-dose (500 CFU) M. tuberculosis infection exhibited significantly lower

57 However, after challenging M. tuberculosis with nitric oxide we found that the rapi

58 opoietic cells in resistance against chronic M. tuberculosis infection in mice infected with M. tuber

59 ction in lung bacterial loads during chronic M. tuberculosis infection compared with fully IL-10-comp

60 ycobacterial persisters, and rapidly cleared M. tuberculosis infection in vivo.

61 geographically diverse set of 1,397 clinical M. tuberculosis isolates with known drug resistance phen

62 patient mortality as identified in clinical M. tuberculosis isolates from a diverse M/XDR-TB patient

63 A set of 296, mostly XDR, clinical M. tuberculosis isolates from four countries were subjec

64 has been poorly characterized in the context M. tuberculosis infection.

65 In contrast, M. tuberculosis populations subject to less drug pressur

66 s a consequence, DCIR-deficient mice control M. tuberculosis better than WT animals but also develop

67 rding the relationships between the detected M. tuberculosis resistance mutations and M/XDR-TB treatm

68 pe MTBDRplus version 2.0 assay, in detecting M. tuberculosis complex directly in respiratory specimen

69 TBDRplus 2.0 is highly accurate in detecting M. tuberculosis complex in respiratory specimens and is

70 In conclusion, direct M. tuberculosis antigen detection proved difficult even

71 tty acids, a pertinent question arises: does M. tuberculosis have the enzyme(s) for cleavage of fatty

72 the critical cellular source of IL-10 during M. tuberculosis infection is still unknown.

73 the multiple immune sources of IL-10 during M. tuberculosis infection, activated effector T cells ar

74 y player in establishing this balance during M. tuberculosis infection.

75 s leading to immune containment early during M. tuberculosis infection, and support the idea that imp

76 Furthermore, during M. tuberculosis infection, Il10 expression in CD4(+) T c

77 egulates the macrophage transcriptome during M. tuberculosis infection, activating antimicrobial path

78 lung CD4(+) T-cell responses and limit early M. tuberculosis growth.

79 The transcriptome of encapsulated M. tuberculosis was similar to that of starvation, hypox

80 y and resistance determinants within endemic M. tuberculosis populations.

81 red different proposed methods of estimating M. tuberculosis prevalence, including a method described

82 with fluorescein diacetate (FDA, evaluating M. tuberculosis metabolic activity) for predicting infec

83 For example, M. tuberculosis uses host-derived lipids/fatty acids as

84 In this study, we present the first M. tuberculosis Rv3802 X-ray crystal structure, solved t

85 paucity of variation means that the data for M. tuberculosis are more equivocal than for the other sp

86 s host macrophage apoptosis is essential for M. tuberculosis (Mtb) to replicate intracellularly while

87 in vitro, underscoring Msh1's importance for M. tuberculosis persistence in lipid-rich microenvironme

88 ogic interactions occurring in the lungs for M. tuberculosis and their impact on infection and persis

89 hages became necrotic, providing a niche for M. tuberculosis replication before escaping into the ext

90 suggest that hLECs are a potential niche for M. tuberculosis that allows establishment of persistent

91 lar macrophages, a major host cell niche for M. tuberculosis, are not only phagocytose inhaled microb

92 changes point to a hydrophobic phenotype for M. tuberculosis sensu stricto.

93 ures previously confirmed to be positive for M. tuberculosis complex (MTBC) by qPCR.

94 extraction directly from patient samples for M. tuberculosis WGS.

95 on this premise, we have been searching for M. tuberculosis antigens specifically capable of inducin

96 rt of the Public Health England solution for M. tuberculosis genomic processing, they will have wide

97 where the proportion of T-bet(high)Foxp3(+) M. tuberculosis-specific CD4(+) T cells was significantl

98 T cells from M. tuberculosis-infected IL-21R KO mice were unable to i

99 rt as well as three chemotypes for DHFR from M. tuberculosis are reported.

100 tern blot demonstrated that lipoglycans from M. tuberculosis-derived bacterial vesicles (BVs) are tra

101 a mechanism for lipoglycans to traffic from M. tuberculosis within infected macrophages to reach T c

102 entify the cellular targets of 12 VapCs from M. tuberculosis by applying UV-crosslinking and deep seq

103 Thirty-one (52%) grew M. tuberculosis on blood culture.

104 .1% of participants harbored a heterogeneous M. tuberculosis infection; such heterogeneity was indepe

105 How M. tuberculosis alternates between host-imposed quiescen

106 augmenting our current understanding of how M. tuberculosis meets its nutrient requirements under hy

107 However, M. tuberculosis antigens are also exported from infected

108 recapitulates all clinical aspects of human M. tuberculosis infection, using a human microarray and

109 e comparable to those seen in cases of human M. tuberculosis infection.

110 The model comprises host immunity, M. tuberculosis metabolism, M. tuberculosis growth adapt

111 nor conditional depletion of wag31 impacted M. tuberculosis susceptibility to this compound.

112 In M. tuberculosis, these secretion systems have taken on r

113 replaced by an alanine (i.e., GyrA(A90)) in M. tuberculosis gyrase, the bridge still forms and plays

114 selective inhibition of PABA biosynthesis in M. tuberculosis using the small molecule MAC173979.

115 an anti-CD20 antibody, to deplete B cells in M. tuberculosis-infected macaques to examine the contrib

116 les to study epitope-specific CD4 T cells in M. tuberculosis-infected MCMs, which may guide future te

117 UGM and the galactan are essential in M. tuberculosis, but their importance in Corynebacterium

118 e of action and actual enzymatic function in M. tuberculosis have remained enigmatic.

119 However, in M. tuberculosis, the existing Streptococcus pyogenes Cas

120 tion, suggesting that Rv2633c is involved in M. tuberculosis pathogenesis.

121 e other iron-regulated genes such as mbtB In M. tuberculosis, both iron and zinc modestly repressed e

122 Gata3, RORgammat, and Foxp3 was measured in M. tuberculosis-specific CD4(+) T cells in HIV-uninfecte

123 eport, we characterize the role of MmpL11 in M. tuberculosis.

124 dentify the NTP binding proteome (NTPome) in M. tuberculosis (M.tb), a deadly pathogen.

125 most closely related sterol-binding P450s in M. tuberculosis, suggesting that further investigations

126 ation targeting oxidative phosphorylation in M. tuberculosis.

127 raction mapping and drug-target profiling in M. tuberculosis.

128 lear receptor, pregnane X receptor (PXR), in M. tuberculosis infection in human monocyte-derived macr

129 ) and both are synchronously up-regulated in M. tuberculosis during macrophage infection.

130 associated with low-level BDQ resistance in M. tuberculosis Both genes encode transcriptional regula

131 PZA-resistance in M. tuberculosis is increasing, especially among M/XDR ca

132 mal maturation arrest and acid resistance in M. tuberculosis.

133 modulate the local granulomatous response in M. tuberculosis-infected macaques during acute infection

134 rin subunits increased MMP-1/10 secretion in M. tuberculosis-stimulated monocytes.

135 t RNA polymerase, a validated drug target in M. tuberculosis.

136 independent of RpsA and trans-translation in M. tuberculosis.

137 fication, redox physiology, and virulence in M. tuberculosis and discovered WhiB3 as crucial mediator

138 1 exposure and genetic depletion of Wag31 in M. tuberculosis suggests that APYS1 might indirectly aff

139 lowing transcriptional silencing of wag31 in M. tuberculosis.

140 , more interleukin 10 (IL-10), and increased M. tuberculosis numbers.

141 M. tuberculosis whole-cell lysate, increased M. tuberculosis replication, and decreased selective aut

142 HIV infection was associated with increased M. tuberculosis Ag-induced CD4 T cell death ex vivo, ind

143 ) T-cell depletion correlated with increased M. tuberculosis presence, increased IL-10 production, an

144 rther analysis may provide new insights into M. tuberculosis metabolic processes and new targets for

145 crophages, leading to impaired intracellular M. tuberculosis survival.

146 ted CD4+ T-cell destruction, we investigated M. tuberculosis-specific responses in bronchoalveolar la

147 The experimental regimens kill M. tuberculosis much more rapidly than the standard regi

148 Representatives of the series kill M. tuberculosis within macrophages without toxicity to t

149 tion with live and gamma-irradiated (killed) M. tuberculosis.

150 dulates CD8(+) T-cell function during latent M. tuberculosis infection.

151 Gold-Plus (QFT-Plus) for diagnosis of latent M. tuberculosis infection (LTBI).

152 veolar lavage (BAL) from persons with latent M. tuberculosis infection and untreated HIV coinfection

153 Among individuals with latent M. tuberculosis infection, those with DM had diminished

154 Our findings show that for a pathogen like M. tuberculosis, which is well adapted to the human host

155 Many M. tuberculosis P450s remain uncharacterized, suggesting

156 Samples where many M. tuberculosis aptamers produced high signals were rare

157 icant (P < 0.0001) differences in the median M. tuberculosis signals and in specific pathogen markers

158 s host immunity, M. tuberculosis metabolism, M. tuberculosis growth adaptation to hypoxia, and nutrie

159 ted to "M. canettii" and M. kansasii, modern M. tuberculosis probably became more hydrophobic by incr

160 Moreover, M. tuberculosis MazF-mt6 cleaves 23S rRNA Helix 70 to in

161 ning, the hydrophobicity of rough morphology M. tuberculosis and Mycobacterium bovis strains was grea

162 served that exosomes released during a mouse M. tuberculosis infection contribute significantly to it

163 ressing carbenicillin resistance in multiple M. tuberculosis strains (including multidrug-resistant s

164 Binding to native M. tuberculosis proteins was confirmed by using M. tuber

165 ree mRNA after encountering stress, and nine M. tuberculosis MazF family members cleave mRNA, tRNA, o

166 We too find ESX-1 of M. tuberculosis and M. marinum lyses host cell membranes

167 A total of 50% of M. tuberculosis H37Rv-infected IL-21R KO mice died in 6

168 g Msh1 expression compromised the ability of M. tuberculosis to proliferate inside lipid-rich foamy m

169 lution to the problem of variable amounts of M. tuberculosis DNA in direct samples.

170 lineages 1 and 3, sequencing and analysis of M. tuberculosis whole genomes from Southern India highli

171 of which are critically important aspects of M. tuberculosis pathogenicity.

172 uency, phenotype, and functional capacity of M. tuberculosis-specific CD4 T cells in HIV-infected and

173 buting to impaired proliferative capacity of M. tuberculosis-specific CD4 T cells in HIV-infected ind

174 The ex vivo proliferative capacity of M. tuberculosis-specific CD4 T cells was markedly impair

175 unctional capacity of Ag-specific T cells of M. tuberculosis-infected mice.

176 mpedes successful T cell-mediated control of M. tuberculosis have not been well defined.

177 ted sanroque mice showed enhanced control of M. tuberculosis infection associated with delayed bacter

178 e critical for IFN-gamma-mediated control of M. tuberculosis infection.

179 ling is essential for the optimal control of M. tuberculosis infection.

180 N-gamma target genes required for control of M. tuberculosis is inducible NO synthase (iNOS).

181 n this article that during the first 14 d of M. tuberculosis infection, the predominant cells express

182 zymes allows rapid and specific detection of M. tuberculosis in live animals.

183 xcellent substrate for accurate detection of M. tuberculosis rapidly and specifically in animals, fac

184 oved signal to noise ratios for detection of M. tuberculosis.

185 tion, an essential pathogenic determinant of M. tuberculosis Together, these results have significant

186 To define the diversity of M. tuberculosis-specific CD4(+) Th subsets and determine

187 relevant to understanding the environment of M. tuberculosis replication in the host.

188 n serum and urine, but further evaluation of M. tuberculosis SOMAmers using other platforms and sampl

189 d genetic markers in convergent evolution of M. tuberculosis toward enhanced transmissibility in vivo

190 s surrogate model, suggests the existence of M. tuberculosis mutator strains.

191 47 (Rv2741) gene led to attenuated growth of M. tuberculosis in vitro and in vivo, and a PE_PGRS47 mu

192 The estimated incidence of M. tuberculosis infection in adults was 1.5-6 times high

193 We modeled the incidence of M. tuberculosis infection in all age groups using these

194 tterns, as well as the observed incidence of M. tuberculosis infection in children and the prevalence

195 e to these metals altered the interaction of M. tuberculosis with macrophages, leading to impaired in

196 ible and drug-resistant clinical isolates of M. tuberculosis.

197 The enhanced killing of M. tuberculosis in macrophages in vivo by CD4(+) T cells

198 tion exhibited significantly lower levels of M. tuberculosis infection burdens in lung lobes and extr

199 s of CD44TA-SMP were recorded in the lung of M. tuberculosis infected mice as compared to controls.

200 Ag-specific T cells from the lungs of M. tuberculosis-infected IL-21R KO mice had increased ex

201 and when T cells were isolated from lungs of M. tuberculosis-infected mice, confirming the occurrence

202 d with Ag-specific T cells from the lungs of M. tuberculosis-infected WT mice.

203 fection time points during the first 6 mo of M. tuberculosis infection.

204 olgus macaque (Macaca fascicularis) model of M. tuberculosis infection closely mirrors the infection

205 el of hypoxic stress and in a mouse model of M. tuberculosis infection, suggesting that the pathogen

206 g of the cell surface trehalose mycolates of M. tuberculosis specifically generates metabolic interme

207 ikely HLA restriction, and a large number of M. tuberculosis T cell epitopes enabled us to identify p

208 ed persons resulted in the overall number of M. tuberculosis-specific CD4+ T cells in BAL being simil

209 The numbers of M. tuberculosis-specific tetramer(+)CD4(+) T cells were

210 acillus (AFB) smear-positive sediments or of M. tuberculosis isolates from AFB smear-negative samples

211 provide new insights into the parameters of M. tuberculosis-specific CD4 T cell immunity that are im

212 acrophages exhibited reduced phagocytosis of M. tuberculosis or TDM-coated latex beads.

213 bacterial growth during the chronic phase of M. tuberculosis infection.

214 caused gross malformation of the old pole of M. tuberculosis, with eventual lysis.

215 pecially in settings where the prevalence of M. tuberculosis infection is low and environmental sensi

216 on the mechanism of virulence regulation of M. tuberculosis.

217 cterium marinum, a close genetic relative of M. tuberculosis used to model tuberculosis.

218 Longitudinal sampling of M. tuberculosis from 34 patients with treatment failure

219 Genomic sequences of M. tuberculosis isolates displayed significant variation

220 iously characterized PAS resistant strain of M. tuberculosis.

221 wall lipids in rifampin-resistant strains of M. tuberculosis The specific links between rifampin resi

222 e whole-genome sequences from 498 strains of M. tuberculosis to identify new resistance-conferring ge

223 eferential depletion of a discrete subset of M. tuberculosis-specific IFN-gamma(+)IL-2(-)TNF-alpha(+)

224 ic oxide stress, suggesting that survival of M. tuberculosis under acute stress is contingent on mech

225 dicator of ongoing community transmission of M. tuberculosis.

226 Chemical treatments of M. tuberculosis whole-cell lysates (MtbWL) ruled out pro

227 as a first-line method for routine typing of M. tuberculosis isolates, especially where Beijing strai

228 nts on mice and transcriptional responses on M. tuberculosis RESULTS: Vaccination of mice with encaps

229 One M. tuberculosis and three M. bovis strains were recovere

230 cterize Mycobacterium tuberculosis and other M. tuberculosis complex (MTBC) strains, composed of a no

231 acrophages from diabetic mice to phagocytose M. tuberculosis ex vivo and promote T-cell activation in

232 ian concentration of FDA microscopy-positive M. tuberculosis, 10% of their contacts developed tubercu

233 lower total frequency of cytokine-producing M. tuberculosis-specific CD4 T cells, and preferential d

234 wherein expression of hPXR in mice promotes M. tuberculosis survival.

235 synthesis at a level high enough to protect M. tuberculosis from Q203-induced bacterial death.

236 vitro trans-translation assay with purified M. tuberculosis ribosomes we find that an interfering ol

237 Protein-DNA interaction assays with purified M. tuberculosis RuvC (MtRuvC) and YqgF (MtRuvX) revealed

238 More recently, M. tuberculosis whole-genome sequencing has been used to

239 viability of replicating and non-replicating M. tuberculosis in vitro and during acute and chronic in

240 the recent transmission of already-resistant M. tuberculosis strains rather than repeated de novo evo

241 Mutations in APYS1-resistant M. tuberculosis mapped exclusively to wag31, a gene that

242 wildtype allele of wag31 in APYS1-resistant M. tuberculosis was dominant and restored susceptibility

243 f patients infected with isoniazid-resistant M. tuberculosis.

244 , and are active against multidrug-resistant M. tuberculosis strains, indicating a distinct mode of a

245 Whereas phylogenetic analysis has revealed M. tuberculosis spread throughout history and in local o

246 A rough M. tuberculosis H37Rv DeltapapA1 sulfoglycolipid-deficie

247 whole genome sequenced 223 randomly selected M. tuberculosis strains from 196 patients within the Tir

248 totoxicity and good activity against several M. tuberculosis clinical isolates, including four that a

249 inst the nonreplicating streptomycin-starved M. tuberculosis 18b-Lux strain, and therefore, these der

250 the important insights gained from studying M. tuberculosis immunity at the site of disease during H

251 rates a nutrient-replete niche that supports M. tuberculosis growth.

252 high inhibitory activity toward susceptible M. tuberculosis strains, with an MIC90 of 0.125-0.25 mug

253 human tuberculosis lesions in vivo, and that M. tuberculosis induces and colocalizes with HO1 during

254 In summary, we demonstrate that M. tuberculosis EsxL inhibits antigen presentation by en

255 Here, we demonstrate that M. tuberculosis RpsA interacts with single stranded RNA,

256 In summary, our data demonstrate that M. tuberculosis stimulation upregulates integrin alphaVb

257 We herein report that M. tuberculosis and M. bovis bacillus Calmette-Guerin in

258 We further report that M. tuberculosis esxL induced the expression of nitric-ox

259 g affinities and activity kinetics show that M. tuberculosis CtpD has higher affinity for Fe(2+) and

260 Here, we show that M. tuberculosis induced the expression of indoleamine 2,

261 In this article, we show that M. tuberculosis induces and colocalizes with HO1 in both

262 Further, we showed that M. tuberculosis ESAT-6 family protein EsxL, encoded by R

263 ng of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and t

264 These data suggest that M. tuberculosis exploits neutrophilic inflammation to pr

265 The M. tuberculosis genome encodes 23 such ESAT-6 family pro

266 strict CLSI criteria, QC ranges against the M. tuberculosis H37Rv reference strain were established

267 in, nucleic acid, and nonpolar lipids as the M. tuberculosis antigens inducing protective gamma9delta

268 variation, a C. diphtheriae ortholog of the M. tuberculosis carbohydrate polymerase responsible for

269 ronchoscopically infected with 41 CFU of the M. tuberculosis Erdman strain.

270 nt with previous studies indicating that the M. tuberculosis orthologue, Rv0227c, is an essential gen

271 polysaccharides than those obtained with the M. tuberculosis GlfT2.

272 the 2 vaccines yielded stronger immunity to M. tuberculosis infection.

273 regulation; however, its role in immunity to M. tuberculosis is unknown.

274 s whereby HIV impairs protective immunity to M. tuberculosis, we evaluated the frequency, phenotype,

275 ig-I, whose potential roles in resistance to M. tuberculosis infection have not yet been investigated

276 ected ART-treated individuals in response to M. tuberculosis antigen stimulation.

277 mics of two macrophage models in response to M. tuberculosis infection.

278 stigate this pathway in the host response to M. tuberculosis, we performed metabolic and functional s

279 ction during the cellular immune response to M. tuberculosis.

280 nic targets for adaptive immune responses to M. tuberculosis and may help to inform the design of mor

281 ng excessively robust cytolytic responses to M. tuberculosis in vitro, at the time of diagnosis, comp

282 s been shown to dampen Th1 cell responses to M. tuberculosis infection impairing bacterial clearance.

283 le to induce optimal macrophage responses to M. tuberculosis.

284 Activity also translates to M. tuberculosis, with a lead compound from this study po

285 Infected dendritic cells (DCs) transport M. tuberculosis to local lymph nodes but activate CD4 T

286 mpL11 mutant is similar to that of wild-type M. tuberculosis in macrophages, the mutant exhibits impa

287 Understanding M. tuberculosis metabolism within granulomas could contr

288 Using M. tuberculosis mutants as indicators of the pathogen's

289 tuberculosis proteins was confirmed by using M. tuberculosis culture filtrate proteins and fractions

290 ce following aerosol challenge with virulent M. tuberculosis, consistent with a role for these T cell

291 TB and/or HIV infection, circulating ex vivo M. tuberculosis-specific CD4(+) T cells did not display

292 s with latent TB infection exhibited ex vivo M. tuberculosis-specific CD4(+) T cells predominantly of

293 the phenotype as well as function of ex vivo M. tuberculosis-specific tetramer(+)CD4(+) T cells using

294 by LAM may represent one mechanism by which M. tuberculosis evades T cell recognition.

295 es, such as Prevotella in the lung, and with M. tuberculosis antigen-induced Tregs.

296 f Ag-specific T cells in lungs compared with M. tuberculosis-infected WT mice.

297 tuberculosis infection in mice infected with M. tuberculosis Erdman.

298 ted methylome changes in cells infected with M. tuberculosis revealed commonality of differentially m

299 t MHC-identical animals can be infected with M. tuberculosis Two MCMs homozygous for the relatively c

300 those with HIV monoinfection, and those with M. tuberculosis monoinfection with a spectrum of periphe