ライフサイエンスコーパス: M1 muscarinic receptor

1 s transiently transfected with TRPC5 and the M1 muscarinic receptor.

2 are conserved, including suppression by the M1 muscarinic receptor.

3 tivation through cAMP-responsive element via M1 muscarinic receptor.

4 from the beta(2)-adrenergic receptor or the m1 muscarinic receptor.

5 omes that contain both heterotrimeric Gq and m1 muscarinic receptor.

6 cells is mediated by the genetically defined m1 muscarinic receptor.

7 activation in response to stimulation of the m1 muscarinic receptor.

8 coordinate both processes for the Gq-coupled M1 muscarinic receptor.

9 y cells after activation of the metabotropic m1-muscarinic receptor.

10 pruning was prevented by genetic deletion of M1 muscarinic receptors.

11 alpha subunits to the endothelin B (ETB) and M1 muscarinic receptors.

12 cted acetylcholine release via activation of M1 muscarinic receptors.

13 ation of mouse eggs overexpressing the human m1 muscarinic receptor, a G protein-coupled receptor.

14 We tested whether M1 muscarinic receptor activation enhances glutamatergic

15 M1 muscarinic receptor activation of IP production was n

16 y carbachol in Xenopus oocytes co-expressing M1 muscarinic receptors also causes inhibition of the ch

17 to phospholipid vesicles that contain m2 or m1 muscarinic receptor and G(i), G(z), or G(q), GAP acti

18 phaq-protein coupled receptors (GqPCRs) (the M1 muscarinic receptor and the mGluR1 metabotropic gluta

19 re, we demonstrate the colocalization of the m1 muscarinic receptor and the NR1a NMDA receptor subuni

20 GABAA-LTP requires the activation of M1-muscarinic receptors and an increase in cytosolic Ca(

21 current that develops during stimulation of M1 muscarinic receptors, and the currents activated by a

22 The M1 muscarinic receptor antagonist pirenzepine dose depen

23 Because M1 muscarinic receptors are typically coupled with G-alp

24 ents in these cells were potently reduced by M1 muscarinic receptors, because the effects of carbacho

25 Activation of M1 muscarinic receptors, but not nicotinic receptors, si

26 Activation of m1 muscarinic receptors by carbachol relaxed this inhibi

27 oupled receptors (GPCRs), represented by the m1 muscarinic receptor, can initiate intracellular signa

28 en added to proteoliposomes containing M2 or M1 muscarinic receptor-coupled G-protein heterotrimers.

29 These data suggest that activation of M1 muscarinic receptors during an ischemic event may con

30 of either the human P2Y2 (P2U-purinergic) or M1 muscarinic receptor expressed in oocytes resulted in

31 us orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations i

32 ospholipase Cbeta1 (PLCbeta1) signaling, the m1 muscarinic receptor, Galphaq, and PLCbeta1 were expre

33 This work demonstrates that the m1-muscarinic receptor gene product modulates excitatory

34 After transfection with IRK1 and m1 muscarinic receptor genes, tsA cells expressed a cesi

35 ase and establish PYK2 as an effector of the m1 muscarinic receptor in the regulation of multiple cel

36 haX, inhibited the activation of transfected m1 muscarinic receptor in these cells.

37 This indicates involvement of the M1 muscarinic receptor in this response.

38 els is potently reduced by signaling through M1 muscarinic receptors in striatopallidal neurons, but

39 ad weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl benzilat

40 e that the small GTPase, Rho, transduces the m1 muscarinic receptor-induced inhibition of Kir2.1 via

41 e second messengers were not involved in the m1 muscarinic receptor-induced response.

42 Stimulation of the m1 muscarinic receptor inhibited Kir2.1, when both recep

43 Therefore, the data indicate that the m1 muscarinic receptor inhibits IRK1, presumably via sti

44 The M1 muscarinic receptor is excitatory, and facilitates ne

45 n in the striatum as a result of stimulating m1 muscarinic receptors located within this structure an

46 ffect the PM localization or function of the M1 muscarinic receptor (M1R)/Gq signaling cascade.

47 ma mutants, however, showed little effect on m1-muscarinic receptor-mediated PLC activation, which is

48 Most striatal projection neurons express m1 muscarinic receptor mRNA with m4 mRNA found in 40-50%

49 Activation of M1 muscarinic receptors occurs through orthosteric and a

50 sing through the thalamic radiation activate M1 muscarinic receptors on TC projections and sustain gl

51 lation in RBL2H3 cells stably expressing the M1 muscarinic receptor (RBL-2H3-M1 cells).

52 ng M current inhibition by B2 bradykinin and M1 muscarinic receptors respond very differently to inhi

53 We show that D2 dopaminergic and M1 muscarinic receptors selectively modulate a biophysic

54 ing; and (c) a requirement for hVPS34 during M1 muscarinic receptor signaling.

55 otein kinase c (PKC), mimicked the effect of m1 muscarinic receptor stimulation by inhibiting the IRK

56 lts delineate molecular events attending the m1 muscarinic receptor stimulation of this tyrosine kina

57 l, fully prevented the inhibition of IRK1 by m1 muscarinic receptor stimulation.

58 aM kinase II inhibitors, KN-93 and KN-62, on M1-muscarinic receptor stimulation of inositol phosphate

59 CaM inhibitors reduced M1-muscarinic receptor stimulation of inositol phospholi

60 First, we used cell lines with M1 (muscarinic) receptors that couple to phospholipase C

61 platelet-derived growth factor receptors and m1 muscarinic receptors that selectively stimulate the E

62 We expressed in COS-7 cells m1 muscarinic receptors that were mutated at Asp122 and

63 e Gq family couple ligand stimulation of the m1 muscarinic receptor to activation of phospholipase C,

64 beta1 gamma2HF dimers supported coupling of M1 muscarinic receptors to the Gq alpha subunit.

65 In m1 muscarinic receptor transfected HEK-293 cells, carbac

66 (M,ng)) by acetylcholine was investigated in m1 muscarinic receptor-transformed mouse neuroblastoma-r

67 rivatives display functional selectivity for m1 muscarinic receptors, warranting further evaluation a

68 y rectifying potassium channel (IRK1) by the m1 muscarinic receptor was studied with the whole-cell p

69 eceptors were found in goblet cells, whereas M1-muscarinic receptors were in stratified squamous cell

70 N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC50 of 55 nM and was a