ライフサイエンスコーパス: M2 muscarinic receptor

1 ty in response to agonist stimulation of the M2 muscarinic receptor.

2 ) into HEK 293 cells that stably express the M2 muscarinic receptor.

3 beta2-adrenergic receptor (beta2AR) and the M2 muscarinic receptor.

4 ntagonists, we identified these receptors as M2 muscarinic receptors.

5 secretory response is regulated by neuronal M2 muscarinic receptors.

6 The X-ray crystal structure of the M2 muscarinic receptor, a key GPCR that regulates human

7 oupling selectivity was studied by using the m2 muscarinic receptor, a prototypical G(i/o)-coupled re

8 (AAbeta1AR) and activating autoantibodies to M2 muscarinic receptors (AAM2R) in the genesis of atrial

9 used as a test system the activation of the M2 muscarinic receptor activated K+ channels in HEK 293

10 effect of the Ca2+ channel beta3 subunit on M2 muscarinic receptor-activated G-protein inhibition an

11 al receptor type contributions, we find that m2 muscarinic receptor activation increases glomerular s

12 Cotransfection of the mutant blocked m2 muscarinic receptor activation of PLC by a pertussis

13 Thus, interference with morphine-induced M2 muscarinic receptor adaptation in critical brain regi

14 rior to behavioral testing, oxotremorine, an M2 muscarinic receptor agonist that reduces cholinergic

15 rdings from oocytes coexpressing D2DR or the m2 muscarinic receptor and G-protein-gated inward rectif

16 timulatory effect of ACh is mediated through M2 muscarinic receptors and a PTX-sensitive G-protein, b

17 gnificant increase in both the expression of M2 muscarinic receptors and its corresponding mRNA withi

18 Expression of recombinant M2-muscarinic receptors and N-type channels in HEK 293 c

19 flux into the lungs protects the function of M2 muscarinic receptors, and in so doing, prevents hyper

20 of acetylcholine is controlled by inhibitory M2 muscarinic receptors, and it appears that it is these

21 more, ACh-induced rebound was blocked by the M2 muscarinic receptor antagonist methoctramine but not

22 of baogongteng A had only weak affinity for M2-muscarinic receptors, as did 6beta-carbomethoxynortro

23 sitive for neuronal nitric oxide synthase or m2 muscarinic receptor, but only 23% were also positive

24 hese results suggest that transregulation of M2 muscarinic receptors by beta2-adrenoceptor stimulatio

25 In controls, blockade of neuronal M2 muscarinic receptors by gallamine potentiated vagally

26 quences, the 5-HT1A and 5-HT1B serotonin and M2 muscarinic receptors can couple with Gi1 but not Gt.

27 In PC12 cells expressing a Gi-coupled m2 muscarinic receptor, carbachol induces NFAT-mediated

28 (2) was stimulated significantly more by the M2 muscarinic receptor compared with alpha(o)beta(1)gamm

29 that a four-amino acid epitope (VTIL) on the m2 muscarinic receptor (corresponding to Val385, Thr386,

30 he molecular basis for selectivity of M1 and M2 muscarinic receptor coupling to heterotrimeric G prot

31 ggested for cAMP-dependent kinase and PKC in M2 muscarinic receptor down-regulation and their functio

32 de, implicating both of these kinases in the M2 muscarinic receptor down-regulation.

33 basic protein was used to determine whether M2 muscarinic receptor dysfunction, and the subsequent h

34 igh affinity (Ki 2.6 nM) and selectivity for M2-muscarinic receptors expressed in CHO cells.

35 This is associated with reduced M2 muscarinic receptor expression and function in the lu

36 M2 muscarinic receptor expression was assessed by Wester

37 nterleukin 1beta (IL-1beta) had no effect on M2 muscarinic receptor expression.

38 veness is a result of inhibition of neuronal M2 muscarinic receptor function by eosinophil major basi

39 pine, thus in pathogen free animals neuronal M2 muscarinic receptors function independently of cycloo

40 -GalphaiR) had no effect on agonist-mediated M2 muscarinic receptor GIRK response.

41 o phospholipid vesicles with trimeric Gz and m2 muscarinic receptor, Gz GAP accelerates agonist-stimu

42 it type inhibits G protein activation by the M2 muscarinic receptor in a reconstitution assay.

43 ric and wild-type subunits together with the m2 muscarinic receptor in Xenopus oocytes.

44 to determine whether the adaptive changes to M2 muscarinic receptors in autonomic centers are linked

45 lts suggest that the increased expression of M2 muscarinic receptors in this region represents one ne

46 the cytoplasm, we created a series of mutant m2 muscarinic receptors in which one to four extra Ala r

47 The M2 muscarinic receptor is the prototypic model of allost

48 with a model in which agonist binding to the m2 muscarinic receptor leads to a relative movement of T

49 When reconstituted with M2 muscarinic receptors (M2) plus either Gi or Go, RGS4

50 terized the oligomeric status of eGFP-tagged M2 muscarinic receptor (M2R) and Gi1 by single-particle

51 miR-2 regulates expression of the C. elegans M2 muscarinic receptor (m2R) ortholog, GAR-2.

52 eta-adrenergic receptors) and the Gi-coupled M2 muscarinic receptor (M2R) were expressed transiently

53 thetic regulation of HR and the prototypical M2 muscarinic receptor (M2R)-dependent signaling pathway

54 e receptor that activates KACh channels, the M2 muscarinic receptor (M2R).

55 Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basol

56 major basic protein, which blocks inhibitory M2 muscarinic receptors (M2Rs) on nerves, increasing ace

57 In the airways, inhibitory M2 muscarinic receptors (M2Rs) on parasympathetic nerves

58 ransient expression in COS-7 cells of m1 and m2 muscarinic receptors (mAChRs) as a model system to st

59 ion of the Ca2+ channel beta3 subunit causes M2 muscarinic receptor-mediated inhibition of alpha1B Ca

60 that autoinhibition of release results from M2 muscarinic receptor-mediated inhibition of these pres

61 rom the third intracellular loop (i3) of the M2-muscarinic receptor (MR) (His208-Arg387), M3-MR (Gly3

62 s no effect of TNF-alpha and IL-1beta on the m2 muscarinic receptor mRNA stability, and nuclear run-o

63 ment with 8-bromo-cAMP also had no effect on m2 muscarinic receptor mRNA, whereas forskolin caused a

64 l caused a biphasic decrease in cell surface M2 muscarinic receptor number in human embryonic lung 29

65 Inhibitory M2 muscarinic receptors on parasympathetic nerve endings

66 n conclusion, loss of function of inhibitory M2 muscarinic receptors on the airway parasympathetic ne

67 Decreased function of inhibitory M2 muscarinic receptors on the parasympathetic nerve end

68 S16 underwent phosphorylation in response to m2 muscarinic receptor or EGFR stimulation in HEK 293T o

69 Ectopic expression of m2 muscarinic receptors or Kir3.2c channels was unable t

70 e arrestin2 target, phosphorylated activated m2 muscarinic receptor (P-m2 mAChR*), we identified the

71 of the third cytoplasmic loop of the porcine m2 muscarinic receptor plays an important role in recept

72 gnificantly upregulated mRNA and protein for m2 muscarinic receptors, PTX-sensitive G alpha(o) G-prot

73 over, the majority of the VF neurons express M2 muscarinic receptors, raising the possibility that th

74 The mutation in the m2 muscarinic receptor reduced absolute agonist affiniti

75 ently transfected with beta(2)-adrenergic or m2 muscarinic receptors, respectively, treatment with ag

76 tuted into phospholipid vesicles with Gz and m2 muscarinic receptors, RGSZ1 increased agonist-stimula

77 ors (i.e. the beta2-adrenergic receptor, the m2 muscarinic receptor, rhodopsin, and the type 1A angio

78 minus of Galphaq or Galphas had no effect on M2 muscarinic receptor stimulation of the K+ channel.

79 nwardly rectifying K+ currents responsive to m2-muscarinic receptor stimulation.

80 These studies showed that the M2 muscarinic receptor subtype, besides its well documen

81 Here we examine the localization of m1 and m2 muscarinic receptor subtypes across subpopulations of

82 In the Y403F m2 muscarinic receptor, the difference between the two a

83 e parasympathetic response of the heart (the M2 muscarinic receptor; the alpha-subunit of the heterot

84 Monomers and oligomers of the M2 muscarinic receptor therefore have been compared to i

85 results indicate that acetylcholine acts at M2 muscarinic receptors to mediate the estrogen-induced

86 We report a novel signaling pathway linking M2 muscarinic receptors to metabotropic ion channels.

87 To explore the physiological roles of the M2 muscarinic receptor, we have generated mice lacking f

88 tuted monomers and tetramers of the purified M2 muscarinic receptor were compared with muscarinic rec

89 Conversely, stimulation of the m2 muscarinic receptor, when coexpressed with IRK1, resu

90 nduce transcriptional down-regulation of the M2 muscarinic receptor, which seems to be mediated throu

91 everal GPCRs, including beta2-adrenergic and M2 muscarinic receptors, which are commonly used as repr