ライフサイエンスコーパス: M3 muscarinic receptor

1 d the quaternary organization of the related M3 muscarinic receptor.

2 ted for the homologous Y506F mutation in the m3 muscarinic receptor.

3 ist affinities more dramatically than in the m3 muscarinic receptor.

4 ciferase reporter construct and a Gq-coupled m3 muscarinic receptor.

5 ry-m3 cells expressing the human recombinant m3-muscarinic receptor.

6 that involves direct antagonism of M1 and/or M3 muscarinic receptors.

7 rent evoked by activation of expressed m1 or m3 muscarinic receptors.

8 l in astrocytes was due to the activation of M3 muscarinic receptors.

9 ors that coupled selectively with the M2 and M3 muscarinic receptors.

10 zontal cells were labeled with antibodies to M3 muscarinic receptors.

11 cts were mediated by co-activation of M1 and M3 muscarinic receptors.

12 ts from any alterations in function of these M3 muscarinic receptors.

13 Recent studies demonstrate that m3 muscarinic receptor activation in SK-N-SH neuroblasto

14 in HEK293 cells stably transfected with the m3 muscarinic receptor and compared them with the corres

15 up-regulated lung expression of M1, M2, and M3 muscarinic receptors and phosphodiesterase (PDE)4D5 i

16 Cholinergic agonists, through M2 and/or M3 muscarinic receptors, and VIP, through VIPR2, regulat

17 The M3 muscarinic receptor antagonist 4-DAMP effectively rev

18 t therapy with tiotropium bromide, an M1 and M3 muscarinic receptor antagonist, will decrease the air

19 a disulfide cross-linking strategy using the m3 muscarinic receptor as a model system.

20 se hamster ovary cells stably expressing the M3 muscarinic receptor augmented receptor-mediated mobil

21 sent study, by expressing an arrestin-biased M3 muscarinic receptor-based DREADD (M3D-arr) in stable

22 ponse to activation of the G-protein coupled M3 muscarinic receptor by 10 microM acetylcholine (ACh).

23 Furthermore, we demonstrate that the M3-muscarinic receptor can be differentially phosphoryla

24 Stimulation of M1 and M3 muscarinic receptors causes bronchoconstriction.

25 residues C-terminal of the AALS motif in the m3 muscarinic receptor completely abolished functional a

26 ooth muscle cells, ACh activates both M2 and M3 muscarinic receptors coupled to Gai and Gaq, respecti

27 rtion of the third intracellular loop of the m3-muscarinic receptor downstream of glutathione S-trans

28 ical class I GPCRs, the beta2 adrenergic and M3 muscarinic receptors, enter cells constitutively by c

29 genous SET co-immunoprecipitates with intact M3 muscarinic receptor expressed in cells.

30 y of these agents depends on the blockade of M3 muscarinic receptors expressed on airway smooth muscl

31 the ability of coexpressed N- and C-terminal m3 muscarinic receptor fragments to form functional rece

32 tors that couple exclusively to Galphaq (the m3 muscarinic receptor), Galphai (the kappa-opioid recep

33 pallidal MSN activity via a Gq-coupled human M3 muscarinic receptor (hM3Dq), a type of designer recep

34 Using the activatory Gq-coupled human M3 muscarinic receptor (hM3Dq), we found that chemogenet

35 Antagonizing the human M3 muscarinic receptor (hM3R) over a long time is a key

36 SET binds the carboxyl region of the M3-muscarinic receptor i3 loop, and endogenous SET co-im

37 We show here that the native M3 muscarinic receptor in 1321N1 cells and an epitope-ta

38 rbachol was blocked by antagonists of M1 and M3 muscarinic receptors in two subpopulations of BF GABA

39 in the phosphorylation and regulation of the M3-muscarinic receptor in transfected cells and cerebell

40 gion within the short C-terminal tail of the M3-muscarinic receptor inhibited the ability of the rece

41 The M3 muscarinic receptor is a prototypical member of the c

42 r example, the effect of carbachol acting on M3 muscarinic receptors is blocked by wortmannin, sugges

43 emonstrated that the phospholipase C-coupled m3-muscarinic receptor is phosphorylated in an agonist-s

44 cts with the third intracellular loop of the M3 muscarinic receptor (M3-MR), and SET knockdown with s

45 rt evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLCbeta3.

46 e resonance energy transfer studies with the M3 muscarinic receptor (M3R), a prototypic class A GPCR,

47 beta-Cell M3 muscarinic receptors (M3Rs) are known to play an esse

48 We propose that the M3 muscarinic receptor maximizes the efficiency of PLCbe

49 determine the cellular mechanisms underlying M3 muscarinic receptor-mediated proliferation of H508 hu

50 third intracellular (i3) loop of the M2- and M3-muscarinic receptors (MR) and the importance of this

51 Consistent with this was the fact that two M3-muscarinic receptor mutants deficient in agonist-indu

52 Similar to the wild type m2 and m3 muscarinic receptors, none of the investigated hybrid

53 ction of airway smooth muscle is mediated by M3 muscarinic receptors on the airway smooth muscle.

54 Thus, activation of Gq-coupled M3 muscarinic receptors or application of a phorbol este

55 athrin-mediated endocytosis of the activated m3 muscarinic receptors or Galpha(q) involvement in this

56 Similar results were obtained when native m3 muscarinic receptors present in rat brain membranes w

57 of disulfide bonds in Cys-substituted mutant M3 muscarinic receptors present in their native membrane

58 indicating that interaction of SET with the M3 muscarinic receptor reduces its signaling capacity.

59 inking data, we initially generated a mutant m3 muscarinic receptor (referred to as m3'(3C)-Xa) in wh

60 eriments using a modified version of the rat m3 muscarinic receptor (referred to as m3') as a model s

61 r cells, cholinergic ligand interaction with M3 muscarinic receptors results in transactivation of EG

62 he stimulus-dependent phosphorylation of the m3-muscarinic receptor, rhodopsin, and possibly other G-

63 y active m2 receptors with the corresponding m3 muscarinic receptor sequence (AALS) or deletion of Al

64 cribe a complex pattern of the regulation of M3 muscarinic receptor signaling.

65 ipase C, indicating a specific regulation of M3 muscarinic receptor signaling.

66 but beta-arrestin-independent endocytosis of m3 muscarinic receptors since tubulin interaction with d

67 udy, we report that the stimulation of human m3 muscarinic receptors stably transfected into HEK293 c

68 med using antibodies against the m1, m2, and m3 muscarinic receptor subtypes and VIP receptors 1 and

69 nalyzed the ability of a series of hybrid m2/m3 muscarinic receptors to interact with a mutant alphas

70 g structure-based docking against the M2 and M3 muscarinic receptors, we screened 3.1 million molecul

71 At days 17 and 60, M2- and M3-muscarinic receptors were found in goblet cells, wher

72 hamster ovary cells transfected with the rat M3 muscarinic receptor, which lack EGFR, acetylcholine-i

73 chemotaxis; the beta2-adrenoreceptor and the M3-muscarinic receptor, which couple respectively to Gs

74 retreatment of cells expressing either m1 or m3 muscarinic receptors with methyl-beta-cyclodextrin pr

75 tail, that were generated by "splitting" the m3 muscarinic receptor within the third intracellular lo