ライフサイエンスコーパス: MAIT cell

1 nds to mucosal-associated invariant T cells (MAIT cells).

2 tivate polyclonal and quasi-monoclonal mouse MAIT cells.

3 ityllumazine [RL] Ags) capable of activating MAIT cells.

4 mor tissue reduced IFN-gamma production from MAIT cells.

5 cytokine expression (IFNgamma, TNF) by human MAIT cells.

6 convert to lumazines, as potent antigens to MAIT cells.

7 ssed in both circulating and intrasinusoidal MAIT cells.

8 RL-6-CH(2)OH), specifically detect all human MAIT cells.

9 ompounds, that either inhibited or activated MAIT cells.

10 eactivity in a discrete subset of TRAV1-2(+) MAIT cells.

11 exacerbations and is a plausible target for MAIT cells.

12 ts that control the generation of functional MAIT cells.

13 on of MR1 Ags as well as into the biology of MAIT cells.

14 geneous and largely distinct from TRAV1-2(+) MAIT cells.

15 tes known as mucosal associated invariant T (MAIT) cells.

16 NKT cells or mucosal-associated invariant T (MAIT) cells.

17 , were named mucosal-associated invariant T (MAIT) cells.

18 In the rabbit, which has very few NKT and no MAIT cells, a previously unrecognized iTRA was identifie

19 This study reveals profound MAIT cell abnormalities in patients harboring metabolic

20 These antigens also induce MAIT cell accumulation in mouse lungs after administrati

21 Thus, MAIT cells acquire innate-like antimicrobial responsiven

22 apy rapidly decreased liver inflammation and MAIT cell activation and cytotoxicity, and increased the

23 IL-18 levels and MAIT cell activation correlate with disease severity in

24 ted 1 surface expression and enhances mature MAIT cell activation in the in vitro cocultures.

25 ment with interferon-alpha leads to specific MAIT cell activation in vivo in parallel with an enhance

26 Antigen solution structures, MAIT cell activation potencies (EC50 3-500 pM), and chem

27 l stereochemical and energetic influences on MAIT cell activation, enabling design of a water stable

28 IT cells, providing the capacity to modulate MAIT cell activation.

29 d MR1 cell surface expression, and inhibited MAIT cell activation.

30 ide new insights into antigen properties and MAIT cell activation.

31 gen-binding cleft of MR1, were essential for MAIT cell activation.

32 he cell surface, resulting in enhanced mouse MAIT cell activation.

33 otein 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can

34 MAIT cells activation was observed during infection with

35 Here we show that MAIT-cell activation requires key genes encoding enzymes

36 ween and within individuals, suggesting that MAIT cell adaptation was a direct consequence of exposur

37 MAIT cells also expressed high levels of IL-7R, and we s

38 Colonic MAIT cells also produced TNF-alpha, IL-2, and granzyme B

39 The frequency of MAIT cells among T cells was significantly lower in bloo

40 n that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cel

41 ely activate mucosal-associated invariant T (MAIT) cells, an abundant population of innate-like T cel

42 sms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells

43 is associated with a striking deficiency of MAIT cells and high mast cell mediator levels.

44 lecule CD1d, suggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).

45 enotypic characterization of human and mouse MAIT cells and revealed unanticipated TCR heterogeneity

46 l feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host de

47 pathways to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells.

48 Th2, Th17, mucosally associated invariant T (MAIT) cells, and type 2 innate lymphoid cells.

49 resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (alphabeta T cell receptors

50 antitative and functional data indicate that MAIT cells are a specialized cell population highly adap

51 MAIT cells are activated by a wide variety of bacterial

52 cent studies have shown that mouse and human MAIT cells are activated by antigen-presenting cells (AP

53 and velpatasvir, we found that intrahepatic MAIT cells are activated by monocyte-derived cytokines a

54 Together these data demonstrate MAIT cells are activated following viral infections, and

55 MAIT cells are activated in an MR1-restricted manner by

56 Here, we demonstrate that MAIT cells are also activated during human viral infecti

57 Finally, we show that IL-17(+) MAIT cells are also increased in childhood obesity, and

58 provides in vivo evidence demonstrating that MAIT cells are an important T-cell subset with activitie

59 MAIT cells are CD161(+), express a V7.2 TCR, are primari

60 Therefore, murine MAIT cells are considerably more heterogeneous than prev

61 MAIT cells are deficient in blood and bronchial tissue i

62 MAIT cells are dependent upon MR1 expression and exposur

63 In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion i

64 T cell receptors (TCRs), we demonstrate that MAIT cells are detectable in a broad range of tissues in

65 These data indicate that MAIT cells are enriched in human AT and display an IL-17

66 ontrast, mature IL-18Ralpha(+) CD8alphaalpha MAIT cells are enriched in the fetal small intestine, li

67 MAIT cells are enriched in the human liver, which is con

68 colleagues (2014) demonstrate that, although MAIT cells are found in psoriatic skin, they are not inc

69 for the first time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by stap

70 ll responses, as well as that MR1-restricted MAIT cells are important for tuberculosis protective imm

71 We provide evidence that CD161++ /MAIT cells are not preferentially infected but may be de

72 MAIT cells are of interest because of their reactivity a

73 MAIT cells are present in intestinal tissues and liver,

74 argely contributed by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develo

75 MAIT cells are rare and immature in the fetal thymus, sp

76 avin metabolite antigens have suggested that MAIT cells are relatively homogeneous and uniform in res

77 in this study reveal for the first time that MAIT cells are systemically depleted in an AIDS virus in

78 Mucosa-associated invariant T (MAIT) cells are "innate" T cells that express an invaria

79 Mucosa-associated invariant T (MAIT) cells are a large innate-like T-cell subset in hum

80 Mucosal associated invariant T (MAIT) cells are a prevalent and unique T-cell population

81 Mucosal-associated invariant T (MAIT) cells are a recently described abundant, proinflam

82 Mucosal-associated invariant T (MAIT) cells are a recently discovered, innate-like subse

83 Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by the

84 Mucosa-associated invariant T (MAIT) cells are a unique innate T cell subset that is ne

85 Mucosa-associated invariant T (MAIT) cells are a unique population of alphabeta T cells

86 Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacteri

87 Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by

88 Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved alphabeta T-

89 Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved antimicrobia

90 Mucosal-associated invariant T (MAIT) cells are enriched in the liver as compared with t

91 Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regul

92 Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermedia

93 Mucosa-associated invariant T (MAIT) cells are innate-like T cells with a conserved TCR

94 Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens pre

95 Mucosal-associated invariant T cells (MAIT cells) are innate-like T-cells that recognize deriv

96 cells, called mucosa-associated invariant T (MAIT) cells, as the most powerful source of pro-inflamma

97 omes were changes in frequencies of Th17 and MAIT cells between health and asthma using Mann-Whitney

98 Understanding MAIT cell biology has been restrained by the lack of rea

99 of MAIT TCR and MR1-ligand heterogeneity on MAIT cell biology is unclear.

100 Despite the advances in understanding MAIT cell biology, the molecular and structural basis be

101 escribe new MR1 ligands that do not activate MAIT cells but compete with bacterial and synthetic comp

102 AT MAIT cells, but not circulating MAIT cells, were capable

103 -OE-RU from bacterial cultures that activate MAIT cells, but not from non-activating bacteria, indica

104 molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)

105 These results suggest that MAIT cells can discriminate between pathogen-derived lig

106 eral recent advances in our understanding of MAIT cell characteristics and functions secure their upc

107 cells in plaques of psoriasis are devoid of MAIT cell characteristics.

108 humans and differential reactivity of human MAIT cell clones according to the bacteria.

109 We confirmed that MAIT cell clones were unable to respond to MR1(-/-) clon

110 In line with this interpretation, MAIT cell clones with distinct TCRs responded differenti

111 receptor alpha (TCRalpha) repertoire in the MAIT cell compartment without redistribution to other an

112 ngs are consistent with a model in which the MAIT-cell compartment, possibly as a result of persisten

113 T cells and mucosal-associated invariant T (MAIT cells), conserved TCRs define other subsets of huma

114 To investigate how MAIT cells contribute to mucosal immunity in vivo, we us

115 Mucosa-associated invariant T (MAIT) cells contribute to host immune protection against

116 he mechanisms behind conventional T-cell and MAIT cell cytotoxic responses to NTHi.

117 We show that MAIT cell cytotoxic responses were upregulated by a comb

118 Adoptive transfer of Mo-DCs to MAIT cell-deficient mice (MR1(-/-) mice) rescued their d

119 We also report that MAIT cell-deficient mice had higher bacterial loads at e

120 We further demonstrate that MAIT cell-dependent GM-CSF production stimulated monocyt

121 anding of HIV/SIV pathogenesis and implicate MAIT cell depletion in the disease process.

122 Furthermore, we show that MAIT cell-derived signals synergize with microbial stimu

123 MAIT cells detect bacterially derived metabolites presen

124 Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives pres

125 cells were identified as potential APCs for MAIT cell development and activation.

126 Furthermore, MAIT cell development is dependent upon the expression o

127 lthough 5-A-RU does not bind MR1 or activate MAIT cells directly, it does form potent MAIT-activating

128 Tetramer-sorted MAIT cells displayed a T(H)1 cytokine phenotype upon ant

129 Colonic MAIT cells displayed an activated memory phenotype and e

130 oreover, in both patient groups, circulating MAIT cells displayed an activated phenotype that was ass

131 pathogenic, rather than protective, role for MAIT cells during infection.

132 MPhi was found to play only a minor role in MAIT cell effector function.

133 MAIT cell effector responses against E. coli and C. albi

134 Some of these ligands inhibited MAIT cells ex vivo and in vivo, while others, including

135 Similarly, MAIT cells exhibit a proapoptotic propensity with elevat

136 MAIT cells exit the thymus as naive cells and acquire an

137 In the early acute phase of infection, MAIT cells expanded robustly in the lungs, where they pr

138 Independently of localization, MAIT cells express CD127 and Ki67 in vivo and readily pr

139 Consistent with high IL-17A production, most MAIT cells express high levels of retinoic acid-related

140 Most MAIT cells express the promyelocytic leukemia zinc finge

141 Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TC

142 Mucosal-associated invariant T (MAIT) cells express a semiinvariant alphabeta T cell rec

143 Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) a

144 NKT and mucosal-associated invariant T (MAIT) cells express semi-invariant TCR and restriction b

145 Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TC

146 Both human and mouse MAIT cells expressed a broad TCR-beta repertoire, and al

147 ified from peripheral blood, intrasinusoidal MAIT cells expressed markers of T cell activation; howev

148 pertoire, and although the majority of human MAIT cells expressed TRAV1-2-TRAJ33, some expressed TRAJ

149 In addition, tetramer(+) MAIT cells expressing CD4, CD8, or neither developing in

150 ogeneous subsets of tetramer(+) Valpha19i-Tg MAIT cells expressing CXCR3 and alpha4beta1 were recruit

151 an macaques, several studies have shown that MAIT cell frequencies actually decrease in peripheral bl

152 increased in childhood obesity, and altered MAIT cell frequencies in obese children are positively a

153 MAIT cell frequencies were strikingly reduced in both bl

154 MAIT-cell frequencies were reduced in peripheral blood o

155 MAIT-cell frequencies were strikingly reduced in asthma

156 tivation and cytotoxicity, and increased the MAIT cell frequency among intra-hepatic but not blood T

157 ic parameters but also increased circulating MAIT cell frequency at 3 months after surgery.

158 We determined that circulating MAIT cell frequency was dramatically decreased in both p

159 Measurements included MAIT cell frequency, phenotype, and cytokine-producing c

160 r levels of activation and cytotoxicity than MAIT cells from blood (P < .0001).

161 Accordingly, MAIT cells from normal mice more closely resemble human

162 nic and/or commensal bacteria, distinguishes MAIT cells from peptide- or lipid-recognizing alphabeta

163 MAIT cells from the liver had higher levels of activatio

164 rvations contrast with previous reports that MAIT cells from Valpha19 TCR transgenic mice are PLZF(-)

165 te the origin and differentiation pathway of MAIT-cells from a naive type-17 precommitted CD161(++)CD

166 t drugs and drug-like molecules can modulate MAIT cell function in mammals.

167 To probe MAIT cell function, we show here that purified polyclona

168 indings establish a novel mechanism by which MAIT cells function to promote both innate and adaptive

169 Thus, the conserved and innate-like MAIT cells harbor multiple layers of functional heteroge

170 Mouse MAIT cells have a CD44(hi)CD62L(lo) memory phenotype and

171 that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could e

172 We suggest that MAIT cells have the capacity to promote local immune res

173 Mucosal-associated invariant T (MAIT) cells have a semi-invariant TCR Valpha-chain, and

174 Until recently, little was known about MAIT cells; however, several recent advances in our unde

175 bsiella pneumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signal

176 in the tumor microenvironment act to reduce MAIT cell IFN-gamma production.

177 T cell receptors (TCRs)), and the subsequent MAIT cell immune responses are thought to protect the ho

178 NTHi constitutes a target for pulmonary MAIT-cell immune responses, which are significantly impa

179 Finally, although the MAIT cell immunoproteome was overall relatively homogeno

180 imidine adducts are microbial signatures for MAIT-cell immunosurveillance.

181 es of a T cell antigen receptor (TCR) from a MAIT cell in complex with MR1 bound to the non-stimulato

182 studies have implicated MR1 presentation to MAIT cells in bacteria recognition, although the mechani

183 performed flow cytometry on CD3+Va7.2+CD161+ MAIT cells in blood of 55 cHBV patients.

184 ls, but they had higher percentages of CD38+ MAIT cells in blood, which declined on entecavir treatme

185 uency, phenotype, and functional capacity of MAIT cells in colon adenocarcinomas and unaffected colon

186 MAIT TCR, and our emerging understanding of MAIT cells in disease.

187 f human MR1, forms MR1 tetramers that detect MAIT cells in human PBMCs, and stimulates cytokine expre

188 ervations may aid in deciphering the role of MAIT cells in immune responses to HBV.

189 Little is known about the role of MAIT cells in livers of patients with chronic hepatitis

190 lyzed the frequency and function of CD161++ /MAIT cells in peripheral blood and tissue from patients

191 effective antiretroviral therapy, levels of MAIT cells in peripheral blood were not restored.

192 Interestingly, MAIT cells in rectal mucosa were relatively preserved, a

193 We describe a novel deficiency of MAIT cells in severe asthma.

194 Here, we analyzed MAIT cells in the blood and adipose tissues of patients

195 inverse correlation between the frequency of MAIT cells in the liver and histologically determined le

196 ata provide evidence for a cytotoxic role of MAIT cells in the lung and highlight important differenc

197 Together our data highlight the role of MAIT cells in the maintenance of gut integrity and the c

198 ation of the gut microbiota, we investigated MAIT cells in this pathology.

199 analyses showed significant accumulation of MAIT cells in tumor tissue, irrespective of tumor stage

200 Most MAIT cells in unaffected colon tissues produced IFN-gamm

201 ers detected CD4(+), CD4(-)CD8(-) and CD8(+) MAIT cells in Valpha19 transgenic mice.

202 ion and the synthetic ligand activate murine MAIT cells in vitro and in vivo.

203 Activation of human MAIT cells in whole blood leads to MR1- and cytokine-dep

204 of Th17 and mucosal associated invariant T (MAIT) cells in airway inflammation; to characterise asso

205 ogy of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of spec

206 tic (NOD) strain, we detected alterations in MAIT cells, including increased production of granzyme B

207 In conclusion, MAIT cells infiltrate colon tumors but their ability to

208 rate that the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved.

209 velopment of mucosal-associated invariant T (MAIT) cells is dependent upon the class Ib molecule MHC-

210 cteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2(+) T cell recep

211 s and human immunodeficiency virus patients, MAIT cells isolated from HBV patients are not deleted bu

212 Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vi

213 mation, regulated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1

214 ents, we show that the most active synthetic MAIT cell ligand displays the same functional avidity fo

215 d human MR1 tetramers loaded with the potent MAIT cell ligand, reduced 6-hydroxymethyl-8-D-ribityllum

216 r, these results show that most, if not all, MAIT cell ligands found in Escherichia coli are related

217 a show systemically decreased frequencies of MAIT cells likely attributable to enhanced turnover in S

218 developmental stages and checkpoints for the MAIT cell lineage in humans and mice.

219 AIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an

220 Thus, tumor-associated MAIT cells may affect antitumor immune responses by thei

221 The alterations in MAIT cells may be contributing to obesity-related steril

222 MAIT cells may therefore provide an attractive therapeut

223 cells and CD8 cells, but most potently from MAIT cells (median IFN-gamma-positive frequencies, 2.9,

224 he optimal development of the classic murine MAIT cell memory/effector subset.

225 ricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and gammadel

226 Monitoring of MAIT cells might represent a new biomarker of T1D, while

227 Mucosal-associated invariant T (MAIT) cells might play a role in control of viral replic

228 Circulating MAIT cells more frequently produced IL-17 upon stimulati

229 Peripheral MAIT cells of patients in the HBeAg-negative phase were

230 , however, the cognate recognition of MR1 by MAIT cells on the infected MPhi was found to play only a

231 not CD1d-dependent NKT cells, MR1-dependent MAIT cells, or gammadelta T cells.

232 ory T cells, mucosal-associated invariant T (MAIT) cells, other T-cell subsets, and granulocyte media

233 d to wild-type (WT) mice, demonstrating that MAIT cells play a unique role among innate lymphocytes i

234 However, whether MAIT cells play an important, and perhaps unique, role i

235 We show that the CD161++ /MAIT cell population is significantly decreased in early

236 se of surrogate markers may misrepresent the MAIT cell population.

237 y, distribution, and clonotypic structure of MAIT cell populations in the peripheral blood, liver, me

238 Furthermore, stage 3 MAIT cell populations were expanded in mice deficient in

239 a and granzyme B in lung CD4(+), CD8(+), and MAIT cell populations.

240 ction, we show here that purified polyclonal MAIT cells potently inhibit intracellular bacterial grow

241 or gammat (RORgammat), whereas RORgammat(lo) MAIT cells predominantly express T-bet and produce IFN-g

242 Stage 1 and stage 2 MAIT cells predominated in thymus, while stage 3 cells p

243 However, the knowledge of MAIT cell presence and function in tumors is virtually a

244 Throughout the course of infection, MAIT cells produced the critical cytokines IFN-gamma, TN

245 e iValpha19 transgenic and Vbeta6 transgenic MAIT cell progenitors requires MHC-related 1-expressing

246 We provide evidence to show that MAIT cells promote early differentiation of CCR2-depende

247 Overall, our data demonstrate that MAIT cells promote early pulmonary GM-CSF production, wh

248 bacterial and synthetic compounds activating MAIT cells, providing the capacity to modulate MAIT cell

249 In comparison with MAIT cells purified from peripheral blood, intrasinusoid

250 n an Ag-dependent manner, thereby modulating MAIT cell recognition.

251 of MR1-Ag tetramers that specifically stain MAIT cells, recognition by the MAIT TCR, and our emergin

252 MAIT cells recognize microbial riboflavin metabolites of

253 Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by t

254 Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens pr

255 ogeneity were apparent across the functional MAIT cell repertoire as a whole, especially for TCRbeta

256 R1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-cell subse

257 1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of alphabeta T cel

258 T cells and mucosal-associated invariant T (MAIT) cells represent peculiar T-lymphocyte subpopulatio

259 Mechanistic studies showed that MAIT cells required both MR1 and IL-12 40 kDa subunit (I

260 We analyzed MAIT cells resident in the vascular bed of livers and sh

261 ylococcal enterotoxin B (SEB); ii) the human MAIT cell response to SEB is rapid and far greater in ma

262 The MAIT cell response to T-cell receptor-mediated stimulati

263 Here, we found that MAIT cell responses against Escherichia coli and Candida

264 n, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occur in a T cell recepto

265 nstrate considerable functional diversity of MAIT cell responses, as well as that MR1-restricted MAIT

266 Here, we evaluated the TCR repertoire of MAIT cells responsive to three classes of microbes.

267 were deficient in MR1, and therefore lacked MAIT cells, revealed a loss of gut integrity and increas

268 of MR1-deficient (MR1(-/-)) mice, which lack MAIT cells, revealed defects in early mucosal cytokine p

269 this inhibitory activity was dependent upon MAIT cell selection by MR1, secretion of gamma interfero

270 the hematopoietic cell type responsible for MAIT cell selection remains unresolved.

271 Frequencies of Valpha7.2(+)CD161(+) MAIT cells, surface expression of the major histocompati

272 s been suggested through the analysis of the MAIT cell TCR repertoire in humans and differential reac

273 exist in cord blood, from which a prominent MAIT cell (TCR Valpha7.2(+)) population emerges post-nat

274 from normal mice more closely resemble human MAIT cells than previously appreciated, and this provide

275 In contrast to invariant NKT cells and MAIT cells, this population has a highly diverse TCRalph

276 In contrast to TRAV1-2(+) MAIT cells, this TRAV12-2-expressing clone displays a di

277 antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway.

278 In this study, we found levels of MAIT cells to be severely reduced in circulation in pati

279 ial-independent, cross-species reactivity of MAIT cells to define the molecular basis of MAIT-TCR/MR1

280 cells were generated in vitro by exposure of MAIT cells to Escherichia coli.

281 The ability of MAIT cells to exhibit microbe-specific functional specia

282 (-)CD8(-), although a small subset of CD4(+) MAIT cells was also detected.

283 Notably, whereas the function of residual MAIT cells was at least partly restored by effective ant

284 checkpoint that generated mature functional MAIT cells was controlled by multiple factors, including

285 Production of interferon gamma by MAIT cells was dependent on monocyte-derived interleukin

286 Similarly, cytokine production by blood MAIT cells was strongly decreased after surgery.

287 Cytokine-producing MAIT cells were as frequent, but granzyme B-producing MA

288 Notably, most human CD8(+) MAIT cells were CD8alpha(+)CD8beta(-/lo), implying predo

289 In AT from obese subjects, MAIT cells were depleted, were less likely to produce IL

290 MAIT cells were enriched in adipose tissue (AT) compared

291 Residual MAIT cells were highly activated and functionally exhaus

292 In obese patients, MAIT cells were more abundant in adipose tissue than in

293 s were as frequent, but granzyme B-producing MAIT cells were more frequent upon stimulation with Esch

294 The MAIT cells were not deleted in blood or liver of cHBV pa

295 Low frequencies of MAIT cells were observed in the peripheral blood, MLNs,

296 MAIT cells were reduced in bronchial biopsies from subje

297 tly lower frequencies of IFN-gamma-producing MAIT cells were seen, whereas there were no differences

298 AT MAIT cells, but not circulating MAIT cells, were capable of producing IL-10.

299 results underscore an important property of MAIT cells, which can be of translational relevance to r

300 Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recogniz