ライフサイエンスコーパス: MALT

1 MALT has a prominent T-cell signature and a marginal zon

2 MALT lymphomas are characterized genetically by the t(11

3 MALT lymphomas have a more indolent course than non-MALT

4 evels that resulted in reduced CARMA1/Bcl-10/MALT-1 complex formation and NF-kappaB-dependent cell su

5 , they have similarly analyzed low-grade (12 MALT, 16 CLL/SLL) and high-grade (19 DLCL) lymphomas.

6 anaplastic large cell (Ki-1+) lymphoma, 0/2 MALT lymphoma) showed hypermethylation of the promoter.

7 . pylori-positive chronic gastritis (n = 7), MALT (n = 12), or MALT lymphoma (n = 12) were undertaken

8 ese genes in the MALT, we have established a MALT-specific gene transfer model using replication-defe

9 g the translocation t(1;18)(q21;q21) forms a MALT lymphoma, the growth of which is independent of H.

10 d infiltration and the formation of acquired MALT.

11 cobacter pylori infection, and this acquired MALT may eventually develop into low-grade B-cell MALT l

12 e management of patients with ocular adnexal MALT lymphoma, especially monoclonal antibody therapy an

13 een adequately tested only in ocular adnexal MALT lymphomas where upfront doxycycline may be a reason

14 a state-of-the-art summary of ocular adnexal MALT lymphomas.

15 . pylori-associated follicular gastritis and MALT lymphomas high endothelial venules coexpressed muco

16 that observed in B cells of normal MALT and MALT acquired as a consequence of Helicobacter pylori-as

17 AI was 3.4- and 1.4-fold higher in MALT and MALT lymphoma tissue, respectively, in the same comparis

18 he AI and Cdc2/Cdk1 or cyclin B1 in MALT and MALT lymphoma tissues.

19 cosal venules are similar in normal MALT and MALT lymphomas, and factors controlling normal mucosal B

20 on of the clinical features of nodal MZL and MALT-type MZL showed that more patients with nodal MZL p

21 ere dramatically increased in the spleen and MALTs.

22 Another MALT lymphoma translocation, t(11;18)(q21;q21), fuses th

23 he LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18).

24 ll these low-grade lesions are classified as MALT lymphomas.

25 for apoptotic cells in H. pylori-associated MALT may help in identifying a population of patients wi

26 ar lymphoma (3 cases) and mucosa-associated (MALT) lymphoma (3 cases) strong (2+) pRB staining was li

27 on through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains.

28 s have been based on the distinction between MALT and non-MALT lymphomas.

29 niques have aided in the distinction between MALT lymphoma and other lymphoproliferative disorders an

30 is work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models t

31 Members of this "Bis-MALT-C(18-28)" series were poor solubilizers of DAGK in

32 on yielded an identical sized band from both MALT and follicular lymphoma.

33 d from colonization of lymphoid follicles by MALT lymphoma cells, following which the tumor cells wer

34 and protein fold in comparison to caspases, MALT-1 proteins (mucosa-associated lymphoidtissue lympho

35 may eventually develop into low-grade B-cell MALT lymphoma.

36 gastritis and other low-grade gastric B-cell MALT lymphomas.

37 In conclusion, MALT subgroups with distinct pathologic features defined

38 alternative to radiotherapy for conjunctival MALT lymphomas.

39 atients with an increased risk of developing MALT lymphoma.

40 detected CagA expression in 20 of 42 DLBCL (MALT) cases (47.6%) and in 13 of 21 "pure" DLBCL cases (

41 nce interval, 2.8%-7.5%; P = .024) for DLBCL(MALT).

42 o) DLBCL patients and 56.3% (18/32) of DLBCL(MALT) patients achieved complete pathologic remission (p

43 LBCL patients and 94.1% (32/34) of the DLBCL(MALT) patients.

44 ransformed gastric MALT lymphomas, the DLBCL(MALT).

45 Similar to DLBCL(MALT), a substantial portion of early-stage HP-positive

46 ith mucosa-associated lymphoid tissue (DLBCL[MALT]) and without ("pure" DLBCL) the features of MALT l

47 r it is clinically different from extranodal MALT-type lymphoma, we compared the clinical features of

48 SF15; soluble TNFSF15 then led to TRADD/FADD/MALT-1- and caspase-8-mediated autocrine IL-1 secretion.

49 For MALT lymphomas, local control, disease-free survival, an

50 The majority of data were available for MALT lymphoma of the ocular adnexa (OAML) including a to

51 Studies on the use of doxycycline for MALT lymphomas (137 patients) reported complete response

52 LT lymphoma was 2.5-fold lower than that for MALT tissues.

53 Frequent use of V1-69 appears to differ from MALT lymphomas that develop at other sites.

54 Gastric MALT lymphoma is a model malignancy for examination of h

55 bacter pylori-positive gastritis and gastric MALT lymphoma.

56 depth of infiltration of the wall by gastric MALT lymphoma as measured by endoscopic ultrasound has b

57 with antibiotics can be followed by gastric MALT lymphoma regression in most cases.

58 Apart from gastric MALT lymphoma, antibiotic therapies have been adequately

59 Early-stage, low-grade gastric MALT lymphoma that was associated with Helicobacter pylo

60 Among low-grade gastric MALT lymphoma, mutations were found in 3 of 11 tumors th

61 ecutive patients with stage I to IIE gastric MALT lymphoma who obtained a pathologic remission after

62 In gastric MALT lymphoma Helicobacter pylori is the most common sti

63 The pathogenesis of gastric MALT lymphoma has been elucidated to a large degree in r

64 study pathogenesis and treatment of gastric MALT lymphoma in humans.

65 a higher than expected incidence of gastric MALT lymphoma in immunosuppressed transplant recipients

66 have furthered the understanding of gastric MALT lymphoma pathogenesis, clinical behavior, and treat

67 phoepithelial lesions, a hallmark of gastric MALT lymphoma.

68 is associated with HP dependence of gastric MALT lymphoma.

69 ic marginal zone in a single case of gastric MALT lymphoma.

70 t(11;18)(q21,q21) is found in 30% of gastric MALT lymphomas and is associated with a failure to respo

71 A subset of H. pylori-positive gastric MALT lymphomas, including infiltrative tumors, may respo

72 t endoscopy demonstrated early-stage gastric MALT lymphoma with associated Helicobacter pylori gastri

73 s efficacy on high-grade transformed gastric MALT lymphomas, the DLBCL(MALT).

74 nvolvement of the marginal zone when gastric MALT lymphomas disseminate to the spleen, which is in ke

75 s for the treatment of patients with gastric MALT lymphoma requiring further treatment beyond H pylor

76 medical records of six patients with gastric MALT lymphoma were retrospectively reviewed.

77 our liver transplant recipients with gastric MALT lymphoma were reviewed.

78 clinical management of patients with gastric MALT lymphoma.

79 ntibacterial therapy in patients with non-GI MALT lymphomas was performed.

80 the time being in patients with other non-GI MALT lymphomas.

81 otic therapy in nongastrointestinal (non-GI) MALT lymphomas.

82 tion signature to that of the salivary gland MALT lymphoma.

83 be involved in the growth of salivary gland MALT lymphomas is further suggested by the noted restric

84 ier work in establishing that salivary gland MALT lymphomas represent a highly selected B-cell popula

85 (VH and VL) expressed by five salivary gland MALT lymphomas were cloned and sequenced.

86 High-grade MALT lymphoma tended to show a slightly higher mutation

87 latter patient was found to have high-grade MALT lymphoma with low-grade MALT lymphoma abutting the

88 gh-grade lesions with or without a low-grade MALT component.

89 have high-grade MALT lymphoma with low-grade MALT lymphoma abutting the tumor.

90 When low-grade MALT lymphoma is suspected on the basis of barium study

91 varying size in four patients with low-grade MALT lymphoma.

92 For low-grade MALT lymphomas confined to the gastric wall and without

93 As many as 50% of low-grade MALT lymphomas contain an (11;18)(q21; q21) chromosomal

94 come in the management of gastric, low-grade MALT lymphomas.

95 nt role in the clonal expansion of low-grade MALT lymphomas.

96 ation frequency (2 of 25, 8%) than low-grade MALT tumor (6 of 95, 6.3%).

97 igh-grade lesions may arise from a low grade-MALT component or arise de novo and can spread to lymph

98 356 pSS patients, of whom 75 had MALT and 19 non-MALT NHL and 600 healthy controls were g

99 Seventy-three were classified as having MALT-type MZL because of involvement of a mucosal site a

100 , accessible, and effective tool to identify MALT lymphoma patients at risk of poor outcomes.

101 between the AI and Cdc2/Cdk1 or cyclin B1 in MALT and MALT lymphoma tissues.

102 rminal caspase recruitment domain (CARD), in MALT lymphomas due to the recurrent t(1;14)(p22;q32).

103 c signaling and implicate its dysfunction in MALT lymphomas.

104 Homing receptor expression in MALT lymphoma B cells was heterogeneous, however, in lin

105 (q21;q21) translocation occurs frequently in MALT lymphomas and creates a chimeric NF-kappaB-activati

106 while the AI was 3.4- and 1.4-fold higher in MALT and MALT lymphoma tissue, respectively, in the same

107 cosal B-cell traffic are also operational in MALT lymphomas.

108 anscripts were specifically overexpressed in MALT, and 2 of these, MMP7 and SIGLEC6, were validated a

109 orambucil Plus Rituximab Versus Rituximab in MALT Lymphoma) was launched to compare chlorambucil alon

110 mitantly, the BCL10 protein is stabilized in MALT lymphomas harboring this fusion.

111 also revealed distinct molecular subsets in MALT.

112 , both proteins are translocation targets in MALT lymphoma.

113 H pylori-independent MALT develops either in the absence of the bacteria or p

114 ALT-lymphoma International Prognostic Index (MALT-IPI) also significantly discriminated between patie

115 The prognostic index (MALT-IPI) constructed using these 3 parameters identifie

116 The new index, MALT-IPI, is a simple, accessible, and effective tool to

117 the mechanisms underlying API2-MALT1-induced MALT lymphomagenesis are not fully understood.

118 show that concurrent gastric and intestinal MALT lymphomas are derived from the same clone and sugge

119 x cases of concurrent gastric and intestinal MALT lymphomas by polymerase chain reaction (PCR) amplif

120 clones of concurrent gastric and intestinal MALT lymphomas.

121 mucosa-associated lymphoid tissue lymphoma (MALT).

122 ibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, t

123 lymphoma (FL), marginal zone lymphoma (MZL), MALT lymphoma or B-small lymphocytic lymphoma (B-SLL) ce

124 ll clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (n

125 pSS patients, of whom 75 had MALT and 19 non-MALT NHL and 600 healthy controls were genotyped for the

126 ased on the distinction between MALT and non-MALT lymphomas.

127 The results of treatment of non-MALT lymphomas using radiotherapy also were good, but th

128 tiple histologic subtypes of lymphoma or non-MALT lymphomas (988 patients) reported local control rat

129 of the c. 1298A > C C allele in the pSS non-MALT group compared to controls and patients without NHL

130 MTHFR variants may be involved in SS non-MALT NHL development, through contribution to defective

131 mphomas have a more indolent course than non-MALT lymphomas, and in the conjunctiva a more conservati

132 In normal stomach and normal MALT, alpha 4 beta 7 and CD62L expression reflected the

133 ins by mucosal venules are similar in normal MALT and MALT lymphomas, and factors controlling normal

134 In normal MALT, H. pylori-associated follicular gastritis and MALT

135 ings with that observed in B cells of normal MALT and MALT acquired as a consequence of Helicobacter

136 y shows for the first time the presence of O-MALT in the mucosa of the African lungfish, an extant re

137 gs collectively suggest that the origin of O-MALT predates the emergence of tetrapods and that TNF fa

138 cosa of anuran amphibians, suggesting that O-MALT evolved from amphibian LAs approximately 250 millio

139 anized secondary mucosal lymphoid tissues (O-MALT) such as Peyer's patches, tonsils, and adenoids.

140 obtained by merging 3 independent cohorts of MALT lymphoma patients.

141 zone B cells are the normal counterparts of MALT lymphoma cells.

142 have been associated with the development of MALT lymphoma including t(11;18) and alterations in Bcl-

143 pathogenetic pathways in the development of MALT lymphomas.

144 ithin chromosome 18 DNA in three examples of MALT lymphoma bearing this translocation.

145 iological, and molecular genetic features of MALT lymphoma.

146 ) and without ("pure" DLBCL) the features of MALT lymphomas, can achieve long-term complete remission

147 on to the IGH locus can promote formation of MALT lymphomas.

148 his truly represented preferential homing of MALT lymphoma to the splenic marginal zone, we have now

149 On the other hand, the AI index of MALT lymphoma was 2.5-fold lower than that for MALT tiss

150 have been implicated in the pathogenesis of MALT lymphoma.

151 of-function mechanism in the pathogenesis of MALT lymphoma.

152 The local control rate of MALT lymphomas with treatments involving radiotherapy av

153 not as favorable as the treatment results of MALT lymphomas.

154 ease entity rather than an advanced stage of MALT-type MZL because the clinical presentations and sur

155 truly a disease or just an advanced stage of MALT-type MZL.

156 he LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12.

157 ed tumor onset and induced transformation of MALT lymphoma to activated B-cell diffuse large-cell lym

158 compared to the mantle and marginal zones of MALT tissues.

159 can occur, and in studies reporting only on MALT lymphomas (884 patients), the 5-year and 10-year di

160 chronic gastritis (n = 7), MALT (n = 12), or MALT lymphoma (n = 12) were undertaken.

161 ctivity of glycogen synthase kinase 3beta or MALT-1, both of which have been previously shown to medi

162 chronic gastritis tissue, those with MALT or MALT lymphoma had an increase in PCNA labeling index of

163 Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3

164 ) and DLCLs (12 of 19) showed a loss of p27; MALT and CLL/SLL, however, were p27 positive.

165 The paracaspase MALT 1 is a major player in lymphocyte activation and pr

166 BCL10 cDNAs from t(1;14)-positive MALT tumours contained a variety of mutations, most resu

167 API2-MALT1-positive MALT lymphomas manifest antibiotic resistance and aggres

168 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%).

169 Importantly, primary MALT lymphomas harbouring the API2-MALT1 fusion uniquely

170 s in early MESA-associated lesions represent MALT lymphomas or more benign types of expansions has be

171 Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by

172 nd 8 hub genes for distinguishing primary SS/MALT lymphoma from primary SS.

173 ts with primary SS and those with primary SS/MALT lymphoma revealed pathways and molecular targets as

174 modules related to primary SS and primary SS/MALT lymphoma were significantly enriched with genes kno

175 ts with primary SS, patients with primary SS/MALT lymphoma, and subjects without primary SS (non-prim

176 rin-mediated cell adhesion, while primary SS/MALT lymphoma-associated modules were enriched with gene

177 ular mechanisms of primary SS and primary SS/MALT lymphoma.

178 The MALT-lymphoma International Prognostic Index (MALT-IPI)

179 oma occurred 6 months after excision and the MALT lymphoma remained indolent during the course of her

180 howed the same sized dominant product in the MALT lymphoma and the follicular lymphoma.

181 To study the roles of these genes in the MALT, we have established a MALT-specific gene transfer

182 cell development, these findings suggest the MALT lymphoma cell of origin may be a germinal center B

183 his review we provide an introduction to the MALT, highlight barriers to vaccine delivery at differen

184 rising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilectio

185 as of the mucosa-associated lymphoid tissue (MALT) arise from lymphoid populations that are induced b

186 inal zone mucosa-associated lymphoid tissue (MALT) B-cell lymphoma is the most common extranodal non-

187 as of the mucosa-associated lymphoid tissue (MALT) have recently been shown to be associated with Hel

188 defects, mucosa-associated lymphoid tissue (MALT) hyperplasia, and dysplasia.

189 mphoma of mucosa-associated lymphoid tissue (MALT) is related to Helicobacter pylori infection and ma

190 igin) and mucosa-associated lymphoid tissue (MALT) lymphoma (19 of 45 = 42%) (postgerminal center), b

191 f gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML).

192 pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma (n = 33) and compared the results to GEP

193 r adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (POAML) is the most common orbital tumor,

194 ximab for mucosa-associated lymphoid tissue (MALT) lymphoma and steroids for prolonged cough.

195 r gastric mucosa-associated lymphoid tissue (MALT) lymphoma cells preferentially to localize around r

196 iption of mucosa-associated lymphoid tissue (MALT) lymphoma in 1983 rapid advances have been made in

197 low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in the parotid gland.

198 1;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB

199 f gastric mucosa-associated lymphoid tissue (MALT) lymphoma is dependent on Helicobacter pylori infec

200 Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is indolent and often associated with Hel

201 Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid ce

202 Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid ne

203 g gastric mucosa-associated lymphoid tissue (MALT) lymphoma linked with Helicobacter pylori infection

204 Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach (MLS) has recently been de

205 ry showed mucosa-associated lymphoid tissue (MALT) lymphoma with immunoglobulin kappa monotype.

206 disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma.

207 disease, mucosa-associated lymphoid tissue (MALT) lymphoma, as well as hyperplastic polyps, hyperpla

208 h gastric mucosa-associated lymphoid tissue (MALT) lymphoma, much less is known about the value of an

209 gastric mucosae-associated lymphoid tissue (MALT) lymphoma.

210 cation of mucosa-associated lymphoid tissue (MALT) lymphoma.

211 2;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma.

212 cation in mucosa-associated lymphoid tissue (MALT) lymphoma.

213 cation in mucosa-associated lymphoid tissue (MALT) lymphoma.

214 lmarks of mucosa-associated lymphoid tissue (MALT) lymphoma.

215 ents with mucosa-associated lymphoid tissue (MALT) lymphomas (HR = 0.26, 95%CI: 0.11-0.59, p = 0.001)

216 enesis of mucosa-associated lymphoid tissue (MALT) lymphomas is associated with independent chromosom

217 Mucosa-associated lymphoid tissue (MALT) lymphomas most frequently involve the gastrointest

218 20 (6.7%) mucosa-associated lymphoid tissue (MALT) lymphomas, 4 of 42 (9.5%) follicular lymphomas, an

219 gy of the mucosa-associated lymphoid tissue (MALT) lymphomas, has been implicated in inflammatory pro

220 s in some mucosa-associated lymphoid tissue (MALT) lymphomas.

221 ations in mucosa-associated lymphoid tissue (MALT) lymphomas.

222 Mucosa-associated lymphoid tissue (MALT) may accumulate within gastric mucosa as a result o

223 phomas of mucosa-associated lymphoid tissue (MALT) origin, ranging from further evidence of the role

224 rise from mucosa-associated lymphoid tissue (MALT) secondary to chronic Helicobacter pylori (H. pylor

225 with the mucosa-associated lymphoid tissue (MALT) to induce both mucosal and systemic immunity.

226 (MZL) of mucosa-associated lymphoid tissue (MALT) type is listed as a distinctive entity.

227 ary gland mucosa associated lymphoid tissue (MALT) type lymphomas are B-cell neoplasms that develop o

228 ary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neopl

229 mphoma of mucosa-associated lymphoid tissue (MALT) type.

230 mphoma of mucosa-associated lymphoid tissue (MALT) with a secondary intestinal spread.

231 phomas of mucosa-associated lymphoid tissue (MALT), the clonal relationship between the two tumors an

232 atures of mucosa-associated lymphoid tissue (MALT), the pure (de novo) DLBCLs, in comparison with its

233 n orbital mucosa-associated lymphoid tissue (MALT)-type B cell lymphoma.

234 shed that mucosa-associated lymphoid tissue (MALT)-type lymphomas may develop from MESA, the issue of

235 mphoma of mucosa-associated lymphoid tissue (MALT).

236 mphoma of mucosa-associated lymphoid tissue (MALT).

237 ithin the mucosa-associated lymphoid tissue (MALT).

238 ) in the mucosal-associated lymphoid tissue (MALT).

239 in the mucosal-associated lymphoid tissues (MALTs).

240 apoptosis may confer a survival advantage to MALT B-cells, and constitutive NF-kappaB activation may

241 the transformation of H. pylori gastritis to MALT lymphoma, the extent of cell proliferation, cell vi

242 olution of H. pylori-associated gastritis to MALT lymphoma.

243 ge cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using

244 y expressed at high levels in all four trout MALT.

245 ly in aggressive and antibiotic unresponsive MALT lymphomas, and may further implicate the biologic i

246 patients initially diagnosed elsewhere with MALT lymphoma.

247 on to systemic disease seems high, even with MALT lymphomas, and treatment with radiation is still re

248 lize and optimize treatment of patients with MALT lymphoma.

249 al MZL was lower than that for patients with MALT-type MZL (56% v 81%; P =.09), with a similar result

250 ared to chronic gastritis tissue, those with MALT or MALT lymphoma had an increase in PCNA labeling i

251 d a large mass (> or = 5 cm) than those with MALT-type MZL (31% v 68%; P =.03).

252 l (30% v 75%; P =.007) rates than those with MALT-type MZL.

253 nopathy (56% v 14%; P <.001) than those with MALT-type MZL.