ライフサイエンスコーパス: MAP kinase kinase kinase

1 P) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase.

2 etween ubc2 and ubc4, a pheromone-responsive MAP kinase kinase kinase.

3 ng the JNK pathway via an, as yet, undefined MAP kinase kinase kinase.

4 evisiae gene product, STE11, which encodes a MAP kinase kinase kinase.

5 hough LRRK2 does not function as a canonical MAP-kinase-kinase-kinase.

6 ptosis-signal regulating kinase 1 (ASK1) and MAP kinase kinase kinase 1 (MEKK1), stimulate c-Jun kina

7 ng the important cellular signaling molecule MAP kinase kinase kinase 2 (MAP3K2), at exactly the same

8 Here, we show that MAP kinase kinase kinase 4 (MEKK4) is strongly expressed

9 MEKK1 encodes a MAP kinase kinase kinase and is a member of a tandemly d

10 e 4 (MKK4), a signaling intermediate between MAP kinase kinase kinase and JNK/p38.

11 n requires a chitin receptor and one or more MAP kinase kinase kinases and MAP kinase kinases.

12 Two related MAP kinase kinase kinases, apoptosis-signal regulating k

13 o domains in other proteins that mediate Ras-MAP kinase kinase kinase associations; however, this RBL

14 tion and the Ras-dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition

15 t studies suggest that Rap1 can activate the MAP kinase kinase kinase B-Raf that is either endogenous

16 Ras binding to members of the Raf family of MAP kinase kinase kinases, C-Raf and B-Raf.

17 Furthermore, the MAP kinase kinase kinase CARD domain-containing protein

18 ligases for the dual-leucine-zipper-bearing MAP kinase kinase kinase (DLK MAPKKK) to regulate the si

19 /thr kinases are most closely related to the MAP kinase kinase kinase family.

20 We identified a MAP kinase kinase kinase gene (MAPKKKalpha) that is requ

21 s a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated

22 , a homologue of Mst11, which corresponds to MAP kinase kinase kinase in Magnaporthe oryzae, and urat

23 was phosphorylated and activated by MEKK1, a MAP kinase kinase kinase in the JNK signaling cascade.

24 we show that TPL-2 , which is homologous to MAP-kinase-kinase kinases in its catalytic domain, forms

25 Mos, a mitogen-activated protein (MAP) kinase kinase kinase, indirectly activates MAP kina

26 c-MOS, a MAP kinase kinase kinase, is a regulator of oocyte matur

27 optosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase, is required for TNF-mediated J

28 kinase family that has been shown to act as MAP kinase kinase kinase kinase (MAP4K).

29 Msn probably functions as a MAP kinase kinase kinase kinase in Drosophila, activatin

30 osomal protein S6 kinase p70(S6K1), plus the MAP kinase kinase kinase kinase MINK, which had not prev

31 in neuronal signaling by a conserved axonal MAP kinase kinase kinase, known as Wallenda (Wnd) in Dro

32 s recent studies characterizing the specific MAP kinase kinase kinases (MAP 3-kinases) that link MAP

33 ase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks).

34 Cot (also known as Tpl2) is a member of the MAP kinase kinase kinase (MAP3K) family that is known to

35 to target Ste11, an evolutionarily conserved MAP kinase kinase kinase (MAP3K) in yeast.

36 na there are approximately 80 genes encoding MAP kinase kinase kinases (MAP3K), 10 genes encoding MAP

37 ddition, a direct PKA site that inhibits the MAP kinase kinase kinase Map3k5 (ASK1) is upstream of JN

38 amino acid (TAO) kinases are Ste20p-related MAP kinase kinase kinases (MAP3Ks) that activate p38 MAP

39 MAP kinase kinase kinase (MAPKKK) activity was assayed i

40 nsy-1 encodes a homolog of the human MAP kinase kinase kinase (MAPKKK) ASK1, an activator of

41 h phenotype yielded mutations in wallenda, a MAP kinase kinase kinase (MAPKKK) homologous to vertebra

42 (VIGS) to study the role of candidate plant MAP kinase kinase kinase (MAPKKK) homologs of human MEKK

43 as a novel protein that interacts with Win1 MAP kinase kinase kinase (MAPKKK) of the stress-activate

44 Recently, we set out to identify the MAP kinase kinase kinase (MAPKKK) responsible for this m

45 tosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase (MAPKKK) that is required for c

46 c-Mos is a germ cell-specific MAP kinase kinase kinase (MAPKKK) that plays an essentia

47 screen in yeast, we have identified a human MAP kinase kinase kinase (MAPKKK) that shares homology w

48 y to other fungal mitogen-activated protein (MAP) kinase kinase kinase (MAPKKK) genes.

49 tein kinases: (i) the SSK2, SSK22, and STE11 MAP kinase kinase kinases (MAPKKKs), (ii) the PBS2 MAPKK

50 ase cascade composed of the Ssk2p and Ssk22p MAP kinase kinase kinases (MAPKKKs), the Pbs2p MAPKK, an

51 cs4 response regulator and stress-responsive MAP kinase kinase kinases (MAPKKKs).

52 ys including Raf, mitogen-activated protein (MAP) kinase kinase kinase (MEK), and MAP kinases.

53 We found that MAP kinase kinase kinase (MEKK) 1, a JNK1 activator, ind

54 ation, as well as mitogen-activated protein (MAP) kinase kinase kinase (MEKK) 1, MAP kinase kinase (M

55 protein kinase cascade: MEKK1, -2, or -4 for MAP kinase kinase kinase; MKK4 and/or MEK1 for MAP kinas

56 athway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase M

57 studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), wh

58 slational activation of mRNA encoding Mos, a MAP kinase kinase kinase necessary for the activation of

59 , depending on the expression pattern of the MAP kinase kinase kinases of the Raf family: Raf-1 and B

60 identified it as the Mos protooncoprotein, a MAP kinase kinase kinase present at low levels in mitoti

61 ed effector of polarity signaling, encodes a MAP kinase kinase kinase-related protein that stimulates

62 roteasomal degradation of TAK1, the upstream MAP kinase kinase kinase required for JNK activation.

63 l cloning and was found to encode a putative MAP kinase kinase kinase similar to CTR1, a negative reg

64 y shown that the conserved actin-interacting MAP kinase kinase kinase Ssk2p/MEKK4, a member of the hi

65 One of these proteins, Sho1, utilizes the MAP kinase kinase kinase Ste11 to activate Pbs2.

66 e it binds the osmosensor Sho1, the upstream MAP kinase kinase kinase Ste11, and the downstream MAP k

67 us with the yeast MAP kinase kinase STE7 and MAP kinase kinase kinase STE11.

68 to members of the mitogen-activated protein (MAP) kinase kinase kinase subfamily, this protein kinase

69 The MAP kinase kinase kinase TGFbeta-activated kinase 1 (TAK

70 MEKK4 is a MAP kinase kinase kinase that interacts with GADD45 in v

71 ctivates dual leucine-zipper kinase (DLK), a MAP-kinase kinase kinase that then activates MKK7 and ER

72 ation of MEKK2, a mitogen-activated protein (MAP) kinase kinase kinase upstream of ERK5 that is requi

73 s synaptic terminal growth by regulating the MAP kinase kinase kinase Wallenda.

74 Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kina