ライフサイエンスコーパス: MAPK cascade

1 documented that IQGAP1 is a scaffold in the MAPK cascade.

2 on of B-Raf and subsequent activation of the MAPK cascade.

3 cycle mechanism for activating the B-Raf/MEK/MAPK cascade.

4 n/CDK) inhibits signaling through the mating MAPK cascade.

5 al-regulated kinase (ERK) kinase and the ERK MAPK cascade.

6 amental cellular functions via the Pbs2-Hog1 MAPK cascade.

7 and others, many of which are regulated via MAPK cascade.

8 G protein for Ste20 to activate the tethered MAPK cascade.

9 s is particularly evident in the case of the MAPK cascade.

10 timuli that are known to activate the stress MAPK cascade.

11 ity through downstream activation of the JNK MAPK cascade.

12 nsure localized activation of the associated MAPK cascade.

13 ion of ERK, the effector molecule of the Ras/MAPK cascade.

14 goes increased phosphorylation by the mating MAPK cascade.

15 ein complexes, which function upstream of an MAPK cascade.

16 o facilitate signal transmission through the MAPK cascade.

17 equired for the functional integrity of this MAPK cascade.

18 diverse pathogens converge into a conserved MAPK cascade.

19 unction as negative regulators of the p42/44 MAPK cascade.

20 ransduce the signals from ouabain to the Ras/MAPK cascade.

21 1/Wld(s) protein inhibits activation of this MAPK cascade.

22 only minor contributions associated with the MAPK cascade.

23 ompartment is required for completion of the MAPK cascade.

24 in signalling to downstream activation of an MAPK cascade.

25 s-1 mutants is partly dependent on the DLK-1 MAPK cascade.

26 -RAF and blocked the ability to activate the MAPK cascade.

27 scaffold protein bind to the kinases in the MAPK cascade.

28 ylation and activation besides the canonical MAPK cascade.

29 ase (RSK) is a key downstream element of the MAPK cascade.

30 llular signaling cascades, including the ERK/MAPK cascade.

31 duction and maintenance of LTP including the MAPK cascade.

32 the transport defect is mediated through the MAPK cascade.

33 r Grb2 binding and opposes activation of the MAPK cascade.

34 complex assembly and activation of MEKK1 and MAPK cascades.

35 uding Ste20 kinase, which activates multiple MAPK cascades.

36 ion of the phosphatidylinositol 3-kinase and MAPK cascades.

37 gands at the cell surface and scaffolding of MAPK cascades.

38 a stress response mediated in part by fungal MAPK cascades.

39 ignaling, including the recruitment of plant MAPK cascades.

40 semble multiple components and regulators of MAPK cascades.

41 responsive mitogen-activated protein kinase (MAPK) cascade.

42 ppropriate mitogen-activated protein kinase (MAPK) cascade.

43 nase (JNK) mitogen-activated protein kinase (MAPK) cascade.

44 nase (ERK)/mitogen-activated protein kinase (MAPK) cascade.

45 ion of the mitogen activated protein kinase (MAPK) cascade.

46 otein) and mitogen-activated protein kinase (MAPK) cascade.

47 in for the mitogen-activated protein kinase (MAPK) cascade.

48 biting the mitogen-activated protein kinase (MAPK) cascade.

49 eceptor and activates the p42/44 MAP kinase (MAPK) cascade.

50 lling predominantly through the RAF/MEK/ERK (MAPK) cascade.

51 by the Ras mitogen-activated protein kinase (MAPK) cascade.

52 nase (ERK)-mitogen-activated protein kinase (MAPK) cascades.

53 ulation of mitogen activated protein kinase (MAPK) cascades.

54 and/or p38 mitogen-activated protein kinase (MAPK) cascades.

55 hree major mitogen-activated protein kinase (MAPK) cascades.

56 ERK and/or possibly the JNK (but not the p38-MAPK) cascades.

57 f two branches of MAMP-activated MAP kinase (MAPK) cascades.

58 ivation of mitogen-activated protein kinase (MAPK) cascades.

59 s scaffold mitogen-activated protein kinase (MAPK) cascades.

60 control of mitogen-activated protein kinase (MAPK) cascades.

61 by serves as a key negative regulator of the MAPK cascade, a major signaling pathway involved in neur

62 In the classical MAPK cascade, a signal is transmitted via sequential pho

63 osed that the ER mediating activation of the MAPK cascade, a signaling pathway important for cell div

64 on, we find that the protein kinase C (Pkc1)/MAPK cascade, a well-established regulator of actin, act

65 nts of the mitogen activated protein kinase (MAPK) cascade, a widely occurring signaling motif, in re

66 Unexpectedly, CDPKs and MAPK cascades act differentially in four MAMP-mediated r

67 siae, components of the pheromone-responsive MAPK cascade activate Fus3 and Kss1 MAPKs to induce mati

68 includes a mitogen activated protein kinase (MAPK) cascade activated by a G-protein coupled receptor

69 itutions, we show that alternatively but not MAPK cascade-activated p38 up-regulates the transcriptio

70 Although the MAPK cascade activates a number of downstream cell death

71 In yeast, it is not known how the same MAPK cascade activates Kss1 MAPK to promote invasive gro

72 However, insulin-mediated IRS-1/MAPK cascade activation contributes to growth in the adu

73 ice display increased cell death and blunted MAPK cascade activation in response to oxidative stress,

74 SHP2 is required for RAS-ERK MAP kinase (MAPK) cascade activation, and Noonan syndrome mutants en

75 o enhanced mitogen-activated protein kinase (MAPK) cascade activation; 2) reactive oxygen species-ind

76 ion and early embryogenesis; the Mos/MEK/p42 MAPK cascade also exhibits bistable responses, and the C

77 ons in the mitogen-activated protein kinase (MAPK) cascade, also known as the RAS-MEK-extracellular s

78 mulating cellular responses, such as evoking MAPK cascades, altering cell cycle progression, and caus

79 ceptor signaling pathway, which bypasses the MAPK cascade and activates p38alpha and p38beta by phosp

80 promotes the activation of the canonical ERK MAPK cascade and cyclin D1 expression by stimulating the

81 nd defects in growth factor-mediated Ras/Raf/MAPK cascade and ER signaling are also found in AR-/- MC

82 These observations directly connect the ERK MAPK cascade and HLH proteins in a linear pathway.

83 uely to interact rapidly with kinases of the MAPK cascade and other signaling pathways, providing a n

84 c cells to UCN-01 leads to activation of the MAPK cascade and that interruption of this process by ME

85 ion and stimulates cell responses by evoking MAPK cascades and activating AP-1 transcription complex

86 that the novel PKCs differentially regulate MAPK cascades and apoptosis in an isoenzyme-specific and

87 ated cardiomyocytes, there was activation of MAPK cascades and downstream targets, implicated previou

88 ng to radiation include the ATM/P53 pathway, MAPK cascades and NF-kappaB activation, as well as signa

89 mbers of a mitogen-activated protein kinase (MAPK) cascade and salt tolerance-mediating TFs.

90 prototypic mitogen-activated protein kinase (MAPK) cascade and triggers a dose-dependent differentiat

91 involving mitogen-activated protein kinase (MAPK) cascades and global transcriptional changes to boo

92 B irradiation, blocked activation of the p38 MAPK cascade, and abolished MAPKAPK-2 kinase activity an

93 he actin cytoskeleton, activation of the ERK MAPK cascade, and augmentation of anti-CD3-induced proli

94 ein Sarm1 is required for activation of this MAPK cascade, and this Sarm1-MAPK pathway disrupts axona

95 vating the mitogen-activated protein kinase (MAPK) cascade, and blocks apoptosis by inducing the phos

96 MAPK cascades are involved in signaling multiple defense

97 MAPK cascades are often embedded in positive feedback lo

98 MAPK cascades are organized by scaffold proteins, which

99 signal of mitogen activated protein kinase (MAPK) cascade are time delay between stimulus and respon

100 Mitogen-activated protein kinase (MAPK) cascades are central components of the intracellul

101 Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signaling pa

102 Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules do

103 Mitogen-activated protein kinase (MAPK) cascades are important signaling modules in eukary

104 Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue d

105 ating that mitogen-activated protein kinase (MAPK) cascades are involved in plant defense responses.

106 Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in th

107 Mitogen-activated protein kinase (MAPK) cascades are rapidly activated upon plant recognit

108 where the mitogen-activated protein kinase (MAPK) cascades are repeatedly employed in mediating dist

109 Mitogen-activated protein kinase (MAPK) cascades are the central components of the intrace

110 n addition, losartan treatment inhibited the MAPK cascade as shown by decreased expression of P-p38 M

111 c-Met display activation of AKT/mTOR and Ras/MAPK cascades as well as increased lipogenesis and glyco

112 fy the p38 mitogen-activated protein kinase (MAPK) cascade as a signaling pathway downstream of TRIF

113 ng through mitogen-activated protein kinase (MAPK) cascades as the treatment of VICs with the MAPK/ex

114 from p53-mediated activation of the Ras/Raf/MAPK cascade, as demonstrated by suppression of Cox-2 in

115 wn to exhibit cross-talk and to regulate the MAPK cascade, as inhibition of PI-3K prevented activatio

116 idual domains with the components of the two MAPK cascades, ASK1-MKK4-JNK3 and c-Raf-1-MEK1-ERK2.

117 dosage-dependent requirement for the Erk1/2 MAPK cascade at the level of Mek1/2 MAPKKs.

118 ular signal-regulated kinase 1 and 2 (p42/44(MAPK)) cascade, because the MEK-1/2 inhibitor, PD98059 d

119 tudies document IQGAP1 as a scaffold for the MAPK cascade, binding directly to B-Raf, MEK, and ERK an

120 that link the growth factor receptors to the MAPK cascade by activating c-Raf and B-Raf, respectively

121 mic mechanism is that peak activation of the MAPK cascade by adrenal corticosteroids is delayed but p

122 Furthermore, the regulation of the MAPK cascade by both Ras and PKC is intimately linked, c

123 ends of Ste5, stimulating activation of the MAPK cascade by optimizing orientation of the bound kina

124 ined by cell type-specific activation of the MAPK cascade by transcriptional up-regulation of the IGF

125 rylation mechanism such as that found in the MAPK cascade can theoretically exhibit bistability.

126 Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing

127 o mating pheromone and assembles a G protein-MAPK cascade complex at the plasma membrane.

128 uitment of mitogen-activated protein kinase (MAPK) cascade components Ste11 (MAPK kinase kinase), Ste

129 ion of the mitogen-activated protein kinase (MAPK) cascade comprised of the Raf, MEK and extracellula

130 Activation of this MAPK cascade confers resistance to both bacterial and fu

131 MAPK cascades consist of a core of three protein kinases

132 a specific mitogen-activated protein kinase (MAPK) cascade consisting of three tobacco MAPKs, SIPK, N

133 Multiple kinases of the mating MAPK cascade contribute to pheromone-induced phosphoryla

134 Aberrant regulation of MAPK cascades contribute to cancer and other human disea

135 The MAPK cascade contributed to the cardioprotective profile

136 complex, together with the stress-signaling MAPK cascade, contributes to cell-polarity maintenance u

137 These results demonstrate that a plant MAPK cascade controls multiple defense responses against

138 During Xenopus oocyte maturation, the MAPK cascade converts an increasing progesterone stimulu

139 revious work hints that the mating Fus3/Kss1 MAPK cascade cross-regulates the Ras/cAMP pathway during

140 A mitogen-activated protein kinase (MAPK) cascade determines terminal stomatal fate by promo

141 rmal growth factor receptor (EGFR) activated MAPK cascade developed by Schoeberl and co-workers (1) t

142 es exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor respons

143 echanisms that control activation of the MEK/MAPK cascade during mitosis are poorly understood.

144 ntified B-Raf as a critical activator of the MAPK cascade during mitosis in Xenopus egg extracts and

145 Activation of the MAPK cascade during mitosis is critical for spindle asse

146 ila contains a mos ortholog that activates a MAPK cascade during oogenesis and is nonessential for me

147 utants highlight the pivotal role of the ERK-MAPK cascade during the evolution of the dentition in ro

148 ggest an essential role for selected PKC and MAPK cascade enzymes in mediating a range of end respons

149 Surprisingly, spores activated the MAPK cascade (ERK, p38) within 30 min and stimulated exp

150 However, all three MAPK cascades (ERK, JNK and p38 MAPK) are required for T

151 The metabolic profile associated with the MAPK cascade (ERK1/2, p38, and JNK) in macrophages was s

152 onstrate that PBP phosphorylation by Raf/MEK/MAPK cascade exerts a positive effect on PBP coactivator

153 olds have emerged as important regulators of MAPK cascades, facilitating kinase activation and provid

154 thways, TGF-beta and Kit Receptor Signaling, MAPK Cascade, Growth Factors and Inflammatory Pathways,

155 sustained high levels of Mos kinase and the MAPK cascade have no effect on SOCE activation.

156 MAPK cascades have also emerged as battlegrounds of plan

157 nase (MEK)/mitogen-activated protein kinase (MAPK) cascade have been examined in human myeloid leukem

158 kinase/mitogen-activated protein kinase (MEK/MAPK) cascade have been examined in relation to paclitax

159 UO126, both selective inhibitors of the ERK MAPK cascade, have no effect on TNFalpha or IL-1beta-ind

160 bsequent activation of the ERK, JNK, and p38(MAPK) cascades; however, it is not known if either or bo

161 further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner.

162 eta burden and chronic activation of the ERK MAPK cascade in an alpha7 nAChR-dependent manner that ev

163 the Wis1 MAPKK of the stress-activated Spc1 MAPK cascade in fission yeast also has a MAPK-docking si

164 tyltransferase activities along with the ERK/MAPK cascade in insular cortex.

165 r activation and/or dysregulation of the PKC/MAPK cascade in modulation of leukemic cell apoptosis fo

166 protein 1, a downstream component of the p38-MAPK cascade in neutrophils, by mass spectrometry, Weste

167 t in part, by blocking activation of the p38-MAPK cascade in neutrophils, which is known to promote c

168 dicating that PCSTE11 is associated with the MAPK cascade in P. carinii.

169 st that survivin is regulated by the Bcr-Abl/MAPK cascade in Ph+ CML.

170 These data demonstrate an involvement of the MAPK cascade in regulating DAT transport capacity in str

171 ein is required for activation of the mating MAPK cascade in response to mating pheromone and assembl

172 rther underscoring the role of the Pbs2-Hog1 MAPK cascade in the pathogenesis of cryptococcosis.

173 tions to the efficiency of signaling by this MAPK cascade in vivo.

174 However, new insights suggest that MAPK cascades in both organisms do not operate independe

175 marize current knowledge of the functions of MAPK cascades in phytopathogenic fungi and highlight the

176 biochemical evidence for the involvement of MAPK cascades in Pto-mediated resistance.

177 e, TAK1, is known to act upstream of IKK and MAPK cascades in several cell types, and is typically ac

178 Our results uncover important roles of MAPK cascades in the regulation of plant cold response.

179 We constructed insulated mammalian MAPK cascades in yeast to explore how intrinsic and extr

180 ion of the mitogen-activated protein kinase (MAPK) cascade in mammalian cell lines positively regulat

181 icated the mitogen-activated protein kinase (MAPK) cascade in regulating plant HR cell death as well

182 nase (ERK) mitogen-activated protein kinase (MAPK) cascades in the activation and transactivation of

183 he p42/p44 mitogen-activated protein kinase (MAPK) cascade includes Ras, Raf, Mek, and Erk MAPK.

184 and Galpha13 can initiate the activation of MAPK cascades, including JNK, p38, and ERK5, which in tu

185 ted by the mitogen-activated protein kinase (MAPK) cascade, induces cell mitosis.

186 n therefore offers an orthogonal approach to MAPK cascade inhibition.

187 Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation o

188 the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1.

189 Here, a MAPK cascade involving MKK9-MPK6 is shown to play an imp

190 The Ras-Raf-MAPK cascade is a key growth-signaling pathway and its u

191 Previous work has suggested that the Kss1 MAPK cascade is activated independently of the mating G

192 The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with act

193 Phorbol ester stimulation of the MAPK cascade is believed to be mediated through the prot

194 p38 is indeed mediated by AMPK, and the p38 MAPK cascade is downstream of AMPK in the signaling path

195 In addition, the Ras-p42/44 MAPK cascade is hyper-activated.

196 The ERK-MAPK cascade is known to play a central role in dental d

197 pexophagy on their own, suggesting that this MAPK cascade is necessary but not sufficient to trigger

198 nsulin-like growth factor I (IGF-I)-mediated MAPK cascade is often activated in hepatocellular carcin

199 Our data demonstrate that ERK1/2-MAPK cascade is regulated by the opening of CALHM1 Ca(2+

200 ther show that E2-mediated activation of the MAPK cascade is required for the long-lasting enhancemen

201 oper balance between the Ras/MEK/ERK and JNK MAPK cascades is necessary for TGF-beta induction of CTG

202 e in the understanding of how GPCRs activate MAPK cascades is the discovery that beta-arrestin, a pro

203 Mitogen-activated protein kinase (MAPK) cascade is a ubiquitous signaling module that tran

204 served Ras/mitogen-activated protein kinase (MAPK) cascade is an integral part of the processes of ce

205 rthe grisea, the MST11-MST7-PMK1 MAP kinase (MAPK) cascade is essential for appressorium formation an

206 Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular

207 ivation of mitogen-activated protein kinase (MAPK) cascades is implicated in cocaine-induced neuroada

208 (scaffold protein for the pheromone response MAPK cascade) is mislocalized to the cytosol, even in th

209 scaffold protein of the pheromone-initiated MAPK cascade) is recruited.

210 g that sPLA2-X is involved in activating the MAPK cascade leading to the formation of CysLT via cPLA2

211 s of cell function, CCK also activates three MAPK cascades leading to activation of ERKs, JNKs, and p

212 ent of different MAP3Ks in activation of the MAPK cascades leading to different cellular responses.

213 vating the mitogen-activated protein kinase (MAPK) cascade leading to inflammation and apoptosis.

214 eltaRaf-DD:ER chimera, activation of the p42 MAPK cascade led to phosphorylation of XCL100 and a pron

215 for generating a bistable switch at a single MAPK cascade level.

216 A effector phosphatidylinositol 3-kinase and MAPK cascades, markedly attenuated RhoA-dependent activa

217 The activation of the MAPK cascade may involve conformational changes through

218 he versatility of scaffolds and how a single MAPK cascade mediates different outputs.

219 to environmental stress rapidly activate the MAPK cascade (MKKK/MKK/MAPK).

220 MAPK cascades modulate a diverse set of activities inclu

221 The results suggest that the MAPK cascade module is inherently ultrasensitive but is

222 The protease-G-protein-RACK1-MAPK cascade modules identified in these studies are dis

223 on of the ERK1 and ERK2 (ERK1/2) MAP kinase (MAPK) cascade occurs in >30% of cancers, often through m

224 integrity mitogen-activated protein kinase (MAPK) cascade of Saccharomyces cerevisiae drives changes

225 However, the MAPK cascade often exhibits nonlinear dose-response prop

226 In contrast to this MAPK cascade, other signal transduction pathways operati

227 reveal that OdDHL has little or no effect on MAPK cascades, partially inhibits the Akt/PKB pathway an

228 ng through mitogen-activated protein kinase (MAPK) cascade pathways can show various input-output beh

229 ivators of mitogen-activated protein kinase (MAPK) cascades, phosphatidylinositol-3-kinase, and guani

230 onstrate that a downstream member of the ERK/MAPK cascade phosphorylates a GPCR as well as mediates c

231 Plant MAPK cascades play pivotal roles in signaling plant defe

232 MAPK cascades play the critical role in regulating Ras o

233 cated that mitogen activated protein kinase (MAPK) cascades play a key role downstream of the Pto kin

234 Mitogen-activated protein kinase (MAPK) cascades play an important role in mediating stres

235 Mitogen-activated protein kinase (MAPK) cascades play central roles in innate immune signa

236 The mitogen-activated protein kinase (MAPK) cascades play diverse roles in intracellular and e

237 Mitogen-activated protein kinase (MAPK) cascades play important roles in disease resistanc

238 luding the mitogen-activated protein kinase (MAPK) cascade, promote cell viability by impeding mitoch

239 ans, a p38 mitogen-activated protein kinase (MAPK) cascade promotes innate immune responses to woundi

240 phosphorylation through integration with the MAPK cascade (RAF-1, MEK1/2, and ERK1/2).

241 However, its precise relationship to the MAPK cascade (Ras/Raf/MEK/ERK), another pathway often im

242 tion that the kinase components in mammalian MAPK cascades regulate each other's interactions with a

243 Mitogen-activated protein kinase (MAPK) cascades regulate a wide variety of cellular proce

244 posed that mitogen-activated protein kinase (MAPK) cascades regulate HR cell death based on pharmacol

245 ggests a possible mechanism by which the p38 MAPK cascade regulates remodeling of the actin cytoskele

246 responses and may play a role in one or more MAPK cascades, regulating multiple cellular processes.

247 man cancers with activating mutations in the MAPK cascade, rendered resistant to targeted therapies,

248 ted and activated by a canonical MAP kinase (MAPK) cascade, represent a point of signaling convergenc

249 ated skin cancer, signaled through the Raf-1/MAPK cascade, requires KSR1.

250 The flexibility of MAPK cascade responses enables regulation of a vast arra

251 activation by auxin treatment suggests that MAPK cascade(s) might mediate cellular responses to auxi

252 t the target of this inhibition is Ste5, the MAPK cascade scaffold protein.

253 e specific mitogen-activated protein kinase (MAPK) cascades selectively.

254 lifies the reactive oxygen species-activated MAPK cascade signal during the initial phase of salt str

255 shown that mitogen-activated protein kinase (MAPK) cascades signal the induction of inducible nitric-

256 vated external solute stimulates a conserved MAPK cascade that elicits responses that maintain osmoti

257 In S. cerevisiae, Ras regulates the Kss1 MAPK cascade that promotes filamentous growth and cell i

258 otein kinase (MAPK) families and delineate a MAPK cascade that represents the early degenerative resp

259 ed free p38 MAPK to be phosphorylated by the MAPK cascade that was activated by CD40L.

260 d gene silencing, we identified two distinct MAPK cascades that act downstream of MAPKKKalpha.

261 d protein kinase (MAPK) kinase kinase in the MAPK cascades that mediate mating, high osmolarity glyce

262 ber of the mitogen-activated protein kinase (MAPK) cascade that directly activates extracellular sign

263 Unlike the MAP kinase (MAPK) cascade that phosphorylates p38 on the activation

264 rstood for mitogen-activated protein kinase (MAPK) cascades that control different outputs in respons

265 r parallel mitogen-activated protein kinase (MAPK) cascades that control growth and differentiation i

266 s of mitogen-activated protein (MAP) kinase (MAPK) cascades that regulate the c-Jun N-terminal kinase

267 thways, particularly the p42/44 MAPK and p38 MAPK cascades, that lower the threshold for mitochondria

268 Here we show that, unlike the classic MAPK cascade, the alternative pathway results primarily

269 entiation and a downstream target of the ERK MAPK cascade, the cAMP-regulatory element binding (CREB)

270 Our data indicate that, beside the Raf/MAPK cascade, the Ras effector Canoe/AF6 acts downstream

271 ing protein for at least two GPCR stimulated MAPK cascades, the extracellular signal regulated kinase

272 subunit as well as to all three tiers of the MAPK cascade, thereby linking upstream G-protein signall

273 that Cdc24 regulates Ste5 and the associated MAPK cascade through a function that is not dependent on

274 by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf.

275 ivates the mitogen-activated protein kinase (MAPK) cascade through pathways involving Ras and RAF: p5

276 etradecanoylphorbol-13-acetate activated the MAPK cascade to a similar extent, yet only c-Raf-1 activ

277 es, hypoxia-signaling pathways activate this MAPK cascade to drive HIF induction and redirect TSC fat

278 hat PKCdelta activates a MEKK1/MEK3/p38delta MAPK cascade to increase p53 levels and p53 drives p21(C

279 global inhibition dynamics, which allows the MAPK cascade to transmit paracrine EGF signals into spat

280 e from stimulus-dependent recruitment of the MAPK cascade to upstream activators that are unique to o

281 ggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and spec

282 stream receptor-mediated signals through the MAPK cascades to induce physiological responses.

283 stream receptor-mediated signals through the MAPK cascades to induce various physiological responses.

284 iggers the mitogen-activated protein kinase (MAPK) cascade to relay an appropriate signal from the me

285 The YDA MAPK cascade transduces upstream ligand-receptor signali

286 equent downstream activation of the PI3K and MAPK cascades until the postneonatal period.

287 y how dependence upon the canonical PI3K and MAPK cascades varies across HER2+ cancers, and define bi

288 ink between heterotrimeric G proteins and an MAPK cascade via the RACK1 scaffolding proteins.

289 Grb2, in turn, can activate MAPK cascades via an interaction with the Ras guanine nu

290 les to the mitogen-activated protein kinase (MAPK) cascade via alpha7 nicotinic acetylcholine recepto

291 protein to associate with components of the MAPK cascade was also compromised.

292 ut (dynamic range) of the pheromone response MAPK cascade was strongly sensitive to the abundance of

293 of Src and mitogen-activated protein kinase (MAPK) cascades, we determined whether focal adhesion kin

294 lization tool GenMapp, G protein pathway and MAPK cascade were also regulated by budesonide.

295 ins in the mitogen-activated protein kinase (MAPK) cascade were increased compared with MCF-7Ca cells

296 n activate the c-Jun N-terminal kinase (JNK) MAPK cascade when overexpressed, but whose biological fu

297 coupled to mitogen-activated protein kinase (MAPK) cascades, while survival signals are propagated by

298 tify MSK1 as both a downstream target of the MAPK cascade within the SCN and a regulator of clock gen

299 function downstream of or in parallel to an MAPK cascade without the involvement of the RACK1 scaffo

300 PI3K)- and mitogen-activated protein kinase (MAPK)-cascades without cell cycle progression.