ライフサイエンスコーパス: MAPK phosphatase

1 SP14; also known as MKP6) is classified as a MAPK phosphatase.

2 anscription are specifically eliminated by a MAPK phosphatase.

3 sion studies, we established that DUPD1 is a MAPK phosphatase.

4 ding c-Cbl and RasGAP, and more than that of MAPK phosphatase.

5 ogy to the mitogen-activated protein kinase (MAPK) phosphatases.

6 chieve the following: inducing expression of MAPK phosphatase 1 (MKP-1) and p21(Cip1) and decreasing

7 However, the physiological contribution of MAPK phosphatase 1 (MKP-1) as a nuclear antagonist of bo

8 MAPK phosphatase 1 (Mkp-1) deactivates p38 and JNK, abro

9 otein thiol modification and inactivation of MAPK phosphatase 1 (MKP-1), a nuclear phosphatase.

10 eased activation of ERK1/2, stabilization of MAPK phosphatase 1 (MKP-1), and induction of TNF-alpha w

11 d3 inhibited the dephosphorylation of p38 by MAPK phosphatase 1 (MKP-1).

12 action of P(4)/PR, we considered the role of MAPK phosphatase 1 (MKP-1/DUSP1), which catalyzes dephos

13 as syringae pv tomato DC3000 and report that mapk phosphatase 1 (mkp1), an Arabidopsis mutant that is

14 erize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1).

15 es expression of the GR-dependent model gene MAPK phosphatase 1 in the lung, confirming the dissociat

16 These changes result in MAPK phosphatase 1 stabilization, which shortens and blu

17 Finally, the basal expression of MAPK phosphatase 1, a MAPK-regulated gene involved in re

18 ead C2, hypoxia-inducible factor-1alpha, and MAPK phosphatase 1.

19 The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an immediate-early gene c

20 including mitogen-activated protein kinase (MAPK) phosphatase 1 (mkp1), which dephosphorylates membe

21 MAPK phosphatase-1 (DUSP1/MKP-1) is a mitogen and stress

22 MAPK phosphatase-1 (MKP-1) and activated ERK1/2 were mea

23 iuretic peptide increased phosphorylation of MAPK phosphatase-1 (MKP-1) concomitant with inhibited ph

24 MAPK phosphatase-1 (MKP-1) expression was increased upon

25 LVS infection also rapidly induced MAPK phosphatase-1 (MKP-1) expression; PI3K and TLR2 sig

26 The dual specificity protein phosphatase MAPK phosphatase-1 (MKP-1) has been shown to dephosphory

27 MAPK phosphatase-1 (MKP-1) has been shown to dephosphory

28 Overexpression of MAPK phosphatase-1 (MKP-1) in ectoderm inhibited MAPK ac

29 Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity an

30 MAPK phosphatase-1 (MKP-1) inhibits the MAPK pathway and

31 MAPK phosphatase-1 (MKP-1) is encoded by mkp-1, a stress

32 ivation leads to both the rapid induction of MAPK phosphatase-1 (MKP-1) mRNA and its sustained expres

33 We also found that MAPK phosphatase-1 (MKP-1) negatively regulates S. pneum

34 expression via specific up-regulation of the MAPK phosphatase-1 (MKP-1) that, in turn, leads to depho

35 ual specificity protein-tyrosine phosphatase MAPK phosphatase-1 (MKP-1) was highly represented in thi

36 Upon vitamin D treatment, the expression of MAPK phosphatase-1 (MKP-1) was significantly upregulated

37 38-inactivating dual specificity phosphatase MAPK phosphatase-1 (MKP-1) were also partially protected

38 d that mapracorat enhanced the expression of MAPK phosphatase-1 (MKP-1), a critical negative regulato

39 in HEK293 cells transient overexpression of MAPK phosphatase-1 (MKP-1), a dual-specificity phosphata

40 possibly through prolonged downregulation of MAPK phosphatase-1 (MKP-1).

41 pression of the dual specificity phosphatase MAPK phosphatase-1 (MKP-1).

42 Adenovirus-mediated adiponectin and MAPK phosphatase-1 (MKP1) overexpression were used to ve

43 Induction of MAPK-dependent genes c-fos and MAPK phosphatase-1 by BHTOOH was also blocked by Ras-N-1

44 e activation of a kinase upstream of JNK) or MAPK phosphatase-1 gene (which dephosphorylates and inac

45 by IFN-gamma was enhanced by overexpressing MAPK phosphatase-1 that inactivates MAPK.

46 which then prevented the ERK activation and MAPK phosphatase-1 up-regulation normally induced by TGF

47 r, the induction and nuclear localization of MAPK phosphatase-1, a factor known to mediate glucocorti

48 ta activated ERK, which in turn up-regulated MAPK phosphatase-1, thereby inactivating p38 MAPK.

49 on of MAPK-dependent genes c-jun, c-fos, and MAPK phosphatase-1.

50 phosphorylation of JNK and the expression of MAPK phosphatase-1.

51 ation of downstream of tyrosine kinase-1 and MAPK phosphatase-1.

52 expression was attenuated in the absence of MAPK phosphatase-1.

53 ion of the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) have increased fatty acid ox

54 uscle, the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a critical negative regul

55 Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a member of the MAPK phos

56 Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is the MAPK phosphatase fami

57 ression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereaf

58 ERK (pERK), protein phosphatase 1 (PP1), and MAPK phosphatase-2 (MKP-2) during adulthood in control a

59 cts as a transcriptional regulator of MKP-2 (MAPK phosphatase-2), a dual specificity protein phosphat

60 sequent TCR stimulation via the induction of MAPK phosphatase 3 (MKP-3).

61 Also, MAPK phosphatase 3, a negative regulator of FGF signalin

62 o identify mitogen-activated protein kinase (MAPK) phosphatase 3 (MKP3) whose expression was correlat

63 Recent studies show that MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene t

64 m normoxia-exposed cells depleted of PP2A or MAPK phosphatase-3 were also less able to dephosphorylat

65 ted phosphatases (protein phosphatase 2A and MAPK phosphatase-3) demonstrated decreased activity in h

66 PK inhibitors exhibited only partial effect, MAPK-phosphatase-3 expression significantly blocked the

67 as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice.

68 lial nitric oxide synthase (eNOS), JNK3, and MAPK phosphatase 7 (MKP7).

69 nregulates mitogen-activated protein kinase (MAPK) phosphatase-7 and enhances phosphorylation of both

70 olled by the balance between MAPK kinase and MAPK phosphatase activities.

71 pecificity phosphatases (also referred to as MAPK phosphatases) and thereby inhibits the dephosphoryl

72 Overexpression of MAPK phosphatase CL 100 prevented TGF-beta1 promoter act

73 ole of the mitogen-activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1

74 ht into the regulation of a dual-specificity MAPK phosphatase during meiotic maturation and the adapt

75 n, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost.

76 ase in the mitogen-activated protein kinase (MAPK) phosphatase DUSP1 following treatment with Ang-(1-

77 nding sites and downstream signaling via the MAPK-phosphatase DUSP1 triggers tau phosphorylation and

78 though the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, mediates dexamethasone-induced

79 ed a number of candidate loci, including the MAPK phosphatase DUSP14 in particular, that are promisin

80 cytokine production of myeloid cells by the MAPK phosphatase Dusp16.

81 AS (KRAS(WT)) or decreased expression of the MAPK phosphatase DUSP6 promoted resistance to ALK inhibi

82 We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared

83 In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis a

84 n kinase (MAPK) phosphatase-1 (MKP-1) is the MAPK phosphatase family member that negatively regulates

85 PK) phosphatase-1 (MKP-1) is a member of the MAPK phosphatase family that functions as a negative reg

86 lights the critical role of dual-specificity MAPK phosphatases in the regulation of developmental out

87 ound that down-regulation of nuclear Pmk1 by MAPK phosphatases induced by the stress activated protei

88 Similarly, a knockdown of WIP1 (a p38 MAPK phosphatase) induced premature senescence that also

89 heart were used here to investigate how this MAPK-phosphatase might regulate intracellular signaling

90 ry, in this study we have identified nuclear MAPK phosphatase MKP-1 as a novel molecular target of RO

91 ed kinase [ERK]1/2) and the dual-specificity MAPK phosphatase MKP-1/DUSP1.

92 s homologs of the mammalian dual-specificity MAPK phosphatases MKP-1/CL100 and found that overexpress

93 n of MKP-1, a stress-inducible member of the MAPK phosphatase (MKP) family of dual specificity protei

94 PKK), a homolog of mammalian MKK7, and VHP-1 MAPK phosphatase (MKP), a homolog of mammalian MKP7, als

95 was performed to analyze the involvement of MAPK phosphatase (MKP)-1 in crosstalk.

96 dence of a critical and nonredundant role of MAPK phosphatase (MKP)-1 in the negative control of MAPK

97 MAPK phosphatase (MKP)-1 is an archetypal member of the

98 -activated protein kinase (MAPKs) regulator, MAPK phosphatase (MKP)-3, in the resolution of postopera

99 one to (DP)JNK prevented its inactivation by MAPK phosphatase (MKP)-5; however, JNK was still able to

100 ed with an induction of the dual specificity MAPK phosphatases (MKP)-1 and -2, and blockade of MKP in

101 dal lung mRNA was analyzed by microarray and MAPK phosphatases (MKP)-1 quantitative polymerase chain

102 MAPK phosphatases (MKP-1 and/or MKP-5), which are known

103 The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large pr

104 Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is the major member of MKPs th

105 GRGDSP or mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 small interfering RNA (siRNA)

106 gulated by mitogen-activated protein kinase (MAPK) phosphatases (MKP), which are generally up-regulat

107 The MAPK phosphatase, MKP-1, is capable of inactivating both

108 The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many h

109 MAPK phosphatases (MKPs) are critical modulators of the

110 MAPK phosphatases (MKPs) are dual specificity protein ph

111 MAPK phosphatases (MKPs) are important negative regulato

112 MAPK phosphatases (MKPs) that negatively regulate MAPK a

113 class of dual-specificity phosphatases, the MAPK phosphatases (MKPs), inhibit MAPK signaling by deph

114 in kinases (MAPKs), which are inactivated by MAPK phosphatases (MKPs), represent a central signaling

115 ganisms, are inactivated by dual specificity MAPK phosphatases (MKPs).

116 ch in turn are controlled by redox-sensitive MAPK phosphatases (MKPs).

117 f dual-specificity phosphatases known as the MAPK phosphatases (MKPs).

118 of a family of 10 dual-specificity (Thr/Tyr) MAPK phosphatases (MKPs).

119 MAPK activity is regulated negatively by MAPK phosphatases (MKPs).

120 t least 11 mitogen-activated protein kinase (MAPK) phosphatases (MKPs) and only 3 major groups of MAP

121 Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are dual specificity protein p

122 Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) constitute a family of 11 dual

123 roach, we found that Slt2 phosphorylates the MAPK phosphatase Msg5 both in the N-terminal regulatory

124 promotion of recovery parallels that of the MAPK phosphatase Msg5.

125 in signaling Sst2 and partially required the MAPK phosphatase Msg5.

126 d the expression/activation of several known MAPK phosphatases not to be affected by PRL, suggesting

127 Elimination of MAPK phosphatases restored more robust outputs for all r

128 ion was attenuated in oocytes expressing the MAPK phosphatase rVH6.

129 s with the mitogen-activated protein kinase (MAPK) phosphatase Sdp1.

130 Here we describe how the stress-inducible MAPK phosphatase, Sdp1, presents an unusual solution to

131 specificity is linked to Kss1 immunity to a MAPK phosphatase that constitutively inhibits basal acti

132 pecific, tyrosine-specific phosphatases, and MAPK phosphatase type 1.

133 on of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates

134 s (PTP1B, CD45, and HePTP), dual specificity MAPK phosphatases (VHR, MKP3, and MKP5), and Ser/Thr pro

135 closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzym