ライフサイエンスコーパス: MAPKKK

1 MAPKKK dual leucine zipper-bearing kinases (DLKs) are re

2 the existence of 20 MAPKs, 10 MAPKKs and 60 MAPKKKs, implying a high level of complexity in MAPK sig

3 ptosis signal-regulating kinase 1 (ASK-1), a MAPKKK that responds to oxidative stress by triggering c

4 The JNK pathway includes a MAPKKK (Wallenda/DLK), a MAPKK (Hemipterous/MKK7), and t

5 Tpl2 is a MAPKKK in the MAPK (i.e. ERK) pathway, and the Tpl2-MEK-

6 Tak1 is a MAPKKK that can be activated by growth factors and cytok

7 TGFbeta activated kinase 1 (TAK1) is a MAPKKK that in cell culture systems has been shown to ac

8 MEKK1 is a MAPKKK that regulates both the extracellular signal regu

9 stimulation of the MAPK pathway by c-Mos, a MAPKKK.

10 ur knowledge, this is the first example of a MAPKKK that regulates metastasis through control of tumo

11 complex through synergistic interaction of a MAPKKK, a MAPKK, and a MAPK molecule like MEKK2-JNKK2-JN

12 lar and pheromone signals, despite sharing a MAPKKK, Ste11, and having homologous MAPKs (Fus3 and Hog

13 uence signaling by the yeast kinase Ste11, a MAPKKK molecule that participates in three distinct MAP

14 K5-MPK3/MPK6 module is downstream of YODA, a MAPKKK.

15 0 immunoprecipitates functioned as an active MAPKKK indicating that it is not grossly misfolded.

16 ctivates Kss1 by generating a pool of active MAPKKK (Ste11), whereas additional scaffolding is needed

17 in N. benthamiana compromised both Pto- and MAPKKK alpha -mediated PCD, and coexpression of TFT7 wit

18 0 genes encoding distinct MAPKs, MAPKKs, and MAPKKKs, respectively, were silenced using virus-induced

19 ants silenced for various MAPKs, MAPKKs, and MAPKKKs, those in which GmMAPK4 homologs (GmMPK4s) were

20 carrying knockout alleles of the Arabidopsis MAPKKK genes ANP1, ANP2, and ANP3.

21 Mixed lineage kinases (MLKs) are MAPKKK members that activate JNK and reportedly lead to

22 I, TIR-1/SARM adaptor protein and NSY-1/ASK1 MAPKKK, is localized to postsynaptic sites in the AWC ax

23 apoptosis signal-regulating kinase 1 (ASK1; MAPKKK) inhibitor and by a p38 inhibitor, indicating the

24 composed of the dual leucine zipper-bearing MAPKKK DLK-1, the MAPKK MKK-4, and the p38 MAP kinase PM

25 GCK and RIP, in turn, signal by binding MAPKKKs upstream of the SAPKs and p38s.

26 nserved when compared with its S. cerevisiae MAPKKK counterpart.

27 on between loss of function in the conserved MAPKKK dlk-1 and an alpha-tubulin mutation, specifically

28 ctive Ras and active Cdc2, utilize different MAPKKKs to activate MEK1 and p42 MAPK.

29 zipper-bearing MAP kinase kinase kinase (DLK MAPKKK) to regulate the signal transduction cascade.

30 e Wallenda dileucine zipper kinase (Wnd/DLK) MAPKKK.

31 domain associates in vivo with an endogenous MAPKKK that can activate the p38 pathway in vitro.

32 on of TFT7 with tomato MAPKKK alpha enhanced MAPKKK alpha -mediated PCD.

33 alpha protein is regulated, we screened for MAPKKK alpha -interacting proteins in tomato and identif

34 at a phorbol-responsive PKC is upstream from MAPKKK and Raf.

35 has evolved to interact with a specific host MAPKKK to perturb plant immunity-related signaling.

36 A human MAPKKK, MTK1 (= MEKK4), mediates activation of both p38

37 In Ras immunoprecipitates, MAPKKK activity was stimulated approximately threefold b

38 An S535A substitution in MAPKKK alpha reduced interaction with TFT7 and both PCD-

39 The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptoge

40 ogen-activated protein kinase kinase kinase (MAPKKK alpha ) as a positive regulator in tomato (Solanu

41 kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).

42 MAP kinase kinase kinase (MAPKKK) activity was assayed in c-Raf-1 and H-Ras immuno

43 molog of the human MAP kinase kinase kinase (MAPKKK) ASK1, an activator of JNK and p38 kinases.

44 tivated protein kinase (MAPK) kinase kinase (MAPKKK) cascade that operates downstream of this growth

45 ogen-activated protein kinase kinase kinase (MAPKKK) essential to sexual differentiation.

46 TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and can activate JNK and p38.

47 ctivated protein (MAP) kinase kinase kinase (MAPKKK) genes.

48 ons in wallenda, a MAP kinase kinase kinase (MAPKKK) homologous to vertebrate DLK and LZK.

49 of candidate plant MAP kinase kinase kinase (MAPKKK) homologs of human MEKK1 in pathogen-resistance p

50 nteracts with Win1 MAP kinase kinase kinase (MAPKKK) of the stress-activated MAP kinase cascade.

51 endent, cAMP-insensitive MAPK kinase kinase (MAPKKK) pathway in 3T3-L1 cells.

52 ut to identify the MAP kinase kinase kinase (MAPKKK) responsible for this mitotic activation, using c

53 also interacted with the MAPK kinase kinase (MAPKKK) Ste11p.

54 ogen-activated protein kinase kinase kinase (MAPKKK) superfamily that has been shown to be activated

55 ogen-activated protein kinase kinase kinase (MAPKKK) that activates c-jun N-terminal kinase (JNK) and

56 ogen-activated protein kinase kinase kinase (MAPKKK) that activates the pro-apoptotic signaling pathw

57 nase 1 (ASK1) is a MAP kinase kinase kinase (MAPKKK) that is required for c-Jun N-terminal kinase (JN

58 germ cell-specific MAP kinase kinase kinase (MAPKKK) that plays an essential role during meiotic divi

59 identified a human MAP kinase kinase kinase (MAPKKK) that shares homology with members of the mixed l

60 nase kinase 1 (MEKK1), a MAPK kinase kinase (MAPKKK) upstream of the SAPKs, thereby coupling TRAF2 to

61 opment by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA).

62 onse 1 (CTR1, a Raf-like MAPK kinase kinase (MAPKKK)) to activate the positive MKK9-MPK3/6 cascade.

63 ogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important rol

64 ogen-activated protein kinase kinase kinase (MAPKKK; At1g73660).

65 K, a MAPK kinase (MAPKK) and a MAPKK kinase (MAPKKK).

66 PK, MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK).

67 MAPK), MAPK kinase (MAPKK) and MAPKK kinase (MAPKKK).

68 , a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK).

69 , a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK).

70 inase (MAPKK or MEK) and a MAPKK/MEK kinase (MAPKKK/MEKK).

71 se kinase kinase dual leucine zipper kinase (MAPKKK DLK).

72 gen-activated protein kinase kinase kinases (MAPKKK) was cloned by functional complementation of the

73 gen-activated protein kinase kinase kinases (MAPKKKs) play a role in the control of plant cell divisi

74 SSK22, and STE11 MAP kinase kinase kinases (MAPKKKs), (ii) the PBS2 MAPKK, and (iii) the HOG1 MAP ki

75 Ssk2p and Ssk22p MAP kinase kinase kinases (MAPKKKs), the Pbs2p MAPKK, and the Hog1p MAPK.

76 stress-responsive MAP kinase kinase kinases (MAPKKKs).

77 Potential upstream MAPKK kinases (MAPKKKs or MEKKs) in this cascade include the orthologs

78 ow here that Wis4, a protein kinase of a new MAPKKK class, phosphorylates Wis1 in vitro and activates

79 ains carried a mutation in SSK2, a member of MAPKKK signaling pathway.

80 3T3-L1 extracts identified a single peak of MAPKKK activity that was largely insensitive to elevated

81 -535, is present in the C-terminal region of MAPKKK alpha.

82 both PCD-eliciting ability and stability of MAPKKK alpha.

83 multiple MAMP-mediated signaling upstream of MAPKKK at the plasma membrane linked to the receptor.

84 s support a model in which the ANP family of MAPKKKs positively regulates cell division and growth an

85 milar mechanism might be applicable to other MAPKKKs from both yeast and higher eukaryotes.

86 le, providing two key links; that of a plant MAPKKK to its upstream regulators and of brassinosteroid

87 Here we show that a specific plant MAPKKK, NPK1, activates a MAPK cascade that leads to the

88 These results indicate that SIS8, a putative MAPKKK, is a regulator of sugar response in Arabidopsis

89 presented evidence that Mos was the relevant MAPKKK.

90 However, a second MAPKKK distinct from Mos was readily detectable as well.

91 Here, we partially purify this second MAPKKK and identify it as B-Raf.

92 lowing two-step activation mechanism of SSK2 MAPKKK.

93 nent osmosensor activates the SSK2 and SSK22 MAPKKKs by direct interaction of the SSK1 response regul

94 y highly similar to the yeast Ssk2 and Ssk22 MAPKKKs.

95 The SSK2/SSK22 MAPKKKs are activated by a 'two-component' osmosensor co

96 Activation of Kss1 by a hyperactive Ste11 MAPKKK also increases cAMP, but mating receptor/scaffold

97 the SHO1 transmembrane protein and the STE11 MAPKKK.

98 y acting as an integral subunit of the STE11 MAPKKK.

99 , which is composed of SSK2, SSK22 and STE11 MAPKKKs, PBS2 MAPKK and HOG1 MAPK.

100 in kinases, namely the SSK2, SSK22 and STE11 MAPKKKs, the PBS2 MAPKK, and the HOG1 MAPK.

101 ignaling because it allows Ste5-bound Ste11 (MAPKKK) to be activated by membrane-bound Ste20 (MAPKKKK

102 ctivated protein kinase kinase kinase-Ste11 (MAPKKK-Ste11), MAPKK-Ste7, and MAPK-Kss1 mediate pheromo

103 s2p and Hog1p, but did so through the Ste11p MAPKKK.

104 inase kinase kinase kinase (MAPKKKK, Ste20), MAPKKK (Ste11), MAPKK (Ste7), and transcription factor (

105 ibited Ang II-stimulated and PDGF-stimulated MAPKKK activity (approximately 80% decrease) and Raf tra

106 ximal signal to sequentially stimulate TAK1 (MAPKKK), MKK4 (MAPKK), and JNK (MAPK).

107 The MAPKKK dual leucine zipper-containing kinase (DLK, Walle

108 The MAPKKK Ste11p functions in three Saccharomyces cerevisia

109 components , including the PAK Ste20 and the MAPKKK Ste11, yet signaling is specific.

110 SMRT-mediated repression is regulated by the MAPKKK cascade and that changes both in the affinity of

111 erminal kinase (JNK) subgroup of MAPK by the MAPKKK MEKK2, we found that strong and specific JNK1 act

112 PKK, Pbs2, which in turn is regulated by the MAPKKK, Ssk2.

113 Furthermore, the MAPKKK YDA and two calcium/calmodulin-regulated receptor

114 her, these data demonstrate that MLK7 is the MAPKKK required for modulation of the stress-activated M

115 ions in a MAP kinase pathway composed of the MAPKKK DLK-1, the MAPKK MKK-4, and the p38 MAPK PMK-3.

116 activated kinase 1 (TAK1) is a member of the MAPKKK family of protein kinases, and is involved in int

117 ZAK is a member of the MAPKKK family with no known role in limb development.

118 a activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from i

119 a-activated kinase 1 (TAK1), a member of the MAPKKK family, is a key mediator of proinflammatory and

120 a-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the i

121 a-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essent

122 the same level or proximally upstream of the MAPKKK level.

123 nt MB displays elevation in the level of the MAPKKK Wallenda/DLK (dual leucine zipper kinase), a prev

124 s inhibited by a kinase-inactive form of the MAPKKK, TGF-beta activated protein kinase (Tak1), which

125 quence homology to the kinase domains of the MAPKKK/MEKK level protein kinases from mouse MEKK2 and -

126 PKK Pbs2p bound to the Sho1p osmosensor, the MAPKKK Ste11p, and the MAPK Hog1p.

127 ASL functions as a scaffold and recruits the MAPKKK YODA and MPK3/6 to spatially concentrate signalin

128 vated Ca(2+) or cAMP on regrowth require the MAPKKK (mitogen-activated protein kinase kinase kinase)

129 This signal is transmitted via the MAPKKK kinase Ste11.

130 by the MAPKK JNKK1, which interacts with the MAPKKK MEKK1 and JNK through its amino-terminal extensio

131 RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-

132 on of the SSK1 response regulator with these MAPKKKs.

133 kinases operating at multiple levels in this MAPKKK pathway, including the MAPKs, MAPK-extracellular

134 ay then recruit Cdc42-bound MAPKKKK Ste20 to MAPKKK Ste11 through direct interactions with Ste20 and

135 trate that silencing expression of a tobacco MAPKKK, Nicotiana Protein Kinase 1 (NPK1), interferes wi

136 ine how PCD-eliciting activity of the tomato MAPKKK alpha protein is regulated, we screened for MAPKK

137 ed PCD, and coexpression of TFT7 with tomato MAPKKK alpha enhanced MAPKKK alpha -mediated PCD.

138 ese data reveal a previously uncharacterized MAPKKK-independent mechanism of Hog1 activation in respo

139 iochemical experiments identify the upstream MAPKKKs Slpr, Tak1, and Wnd as putative substrates.

140 ons in this motif abolished interaction with MAPKKK alpha in vivo and also the PCD-enhancing activity

141 Coexpression of TFT7 with MAPKKK alpha in vivo caused increased accumulation of th