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1 MAR indices ranged from 0.2 to 1.
2 MAR lines had fewer nonexpressing cells than control lin
3 MAR measurement is a promising approach for directly ass
4 MAR measurement predicted drug response using samples as
5 MAR revealed heterogeneity in drug sensitivity not only
6 MAR sequences were also found within the Ig V loci at a
7 MAR was positively correlated and MER was negatively cor
8 MARs comprise one of the few classes of eukaryotic nonco
9 MARs facilitate long-range chromatin remodeling required
10 MARs play varied but poorly understood roles in eukaryot
13 such that constructs bearing both 5' and 3' MARs are passed to their offspring with greater frequenc
14 In callus, two of the MAR elements (Adh1 5' MAR and ARS1) reduced transgene silencing but had no eff
15 Three MAR elements, two from maize (Adh1 5' MAR and Mha1 5' MAR) and one from yeast (ARS1), had very
18 nts, two from maize (Adh1 5' MAR and Mha1 5' MAR) and one from yeast (ARS1), had very different effec
19 recognition sites for topoisomerase II and a MAR region were observed in the transgene integration ta
20 sis of nuclear scaffolds failed to confirm a MAR at this site, and extensive mapping demonstrated tha
22 The demonstration of a DMR and an active MAR in the 5' flank of opossum IGF2 mirrors the regulato
27 tern analysis of proteins bound to pUC18 and MAR plasmids indicates that XRCC4, DNA ligase IV and sca
33 point out discordance between sequence-based MAR predictions and in vivo MAR function and predict a n
34 ations within the mbr is to disrupt the BCL2 MAR and replace it with the IGH MARs located just downst
36 as confirmed to be specific to TRPM1 because MAR serum did not stain these cells in a Trpm1(-/-) mous
38 Lys chromatin domain, even when bracketed by MARs, is not resistant to XCI; (iii) transcription facto
41 s (MARs): an exceptionally intense computed 'MAR potential' and profound duplex destabilization and f
42 show that HPV18 promoter contains consensus MAR element in the LCR and E6 sequences where SMAR1 bind
44 transgene expression, a question arises: Do MARs increase transgene expression by increasing the per
46 nsport models for the fate of arsenic during MAR, and develop strategies to minimize arsenic release.
48 R1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone acetylation at
55 Given our continued clinical suspicion for MAR, the patient's serum was sent for evaluation for TRP
56 nd assumed that the degree of departure from MAR varied according to an individual's self-reported HI
57 st assumed that the degree of departure from MAR was the same for all individuals with missing HIV se
58 sed to assess sensitivity to departures from MAR, both when estimating the prevalence of a partially
60 we show that the majority of PARPs generate MAR, not PAR, and demonstrate that the H-Y-E motif is no
63 ve deviants" were defined as having a higher MAR and a lower MER than the respective median values.
64 ated with higher nutritional quality (higher MAR, lower ED), regardless of whether costs were calcula
69 ify SARs and 2 m NaCl extraction to identify MARs revealed that approximately one-half of the sites w
70 upt the BCL2 MAR and replace it with the IGH MARs located just downstream of each breakpoint, we conc
71 mice, suggesting that the visual deficits in MAR are caused by the uptake of TRPM1 autoantibodies int
73 hould be developed alongside improvements in MAR and evaluated in "real-life" salinity-affected setti
74 primary target of autoantibodies produced in MAR patients with reduced b-wave is the TRPM1 cation cha
77 on with that of FBP and linear interpolation MAR, noise with IFS was similar close to and far from th
80 Anabolic load-induced periosteal lamellar MAR (0.58 +/- 0.14; Pkd1(Dmp1-cKO) vs. 1.68 +/- 0.34 mum
82 ed to the time before CXL for UCVA (0.01 log MAR; 95% confidence interval -0.14 to 0.15, P = .944), B
84 val -0.14 to 0.15, P = .944), BCVA (0.05 log MAR; 95% confidence interval -0.05 to 0.15, P = .310), a
87 tion at the base hospital which included log MAR visual acuity, refraction, applanation tonometry and
91 we evaluated the expression from the E micro MAR element in mice 2 to 24 weeks posttransplant with tr
92 ceiving vectors with the E micro and E micro MAR elements upstream of the PGK promoter, there was a 2
95 ively in B cells transduced with the E micro MAR-containing vector and not other cells types or vecto
96 of the five human MARs and the single mouse MAR recruit heterogeneous nuclear ribonucleoprotein A1 (
98 nt region (MAR) sequence compared with a non-MAR sequence and were similar in size to DNA loops extra
100 and in vivo MAR function and predict a novel MAR-independent mechanism for long-distance activation o
101 over the melt season, totaled just 37-75% of MAR, suggesting nontrivial subglacial water storage even
102 retinogram (ERG) phenotype characteristic of MAR resemble the congenital visual disease caused by mut
107 try could greatly simplify the evaluation of MARs or other sequence elements that affect transgene ex
109 ere analyzed extensively for the presence of MARs by in vitro matrix-binding assay, and for interacti
110 t genetic evidence that at least a subset of MARs performs an important biological function, possibly
116 ing intravitreal injection of TRPM1-positive MAR IgG into wild-type mouse eyes, and the appearance of
117 of live retinal neurons with TRPM1-positive MAR serum resulted in the selective accumulation of IgG
118 omology searches revealed that the predicted MAR reflected the recent insertion of a LINE 3'-UTR segm
120 , we analyzed the co-occurrence of predicted MARs with highly conserved noncoding DNA regions in huma
122 Conversely, more than half of the predicted MARs co-occur with one or more independently identified
125 that the single-cell mass accumulation rate (MAR), profiled over many hours with a suspended microcha
127 gene dose, as were mineral apposition rate (MAR) and expression of Runx2-II, Osteocalcin, Dmp1, and
128 ion rate (BFR), and mineral apposition rate (MAR), improved the trabecular microarchitecture, and dec
129 The highest soot mass accumulation rates (MARs) occurred at the beginning of the Holocene as fuel
130 concentrations and mass accumulation rates (MARs) of soot have mainly occurred since ~1950, the esta
131 below the median, 2) a mean adequacy ratio (MAR) above the median, and 3) a mean excess ratio (MER,
133 average, cell lines transformed with the Rb7 MAR-containing vector expressed GFP at levels 2.0- to 3.
134 s to alternatives [managed aquifer recharge (MAR) and rainwater harvesting] that aimed to reduce sodi
136 ontaminants during managed aquifer recharge (MAR) poses a challenge to maintaining local groundwater
138 s VSD leads to multiple Andreev reflections (MAR), which in the limit of weak tunneling probability s
139 were enriched in a matrix attachment region (MAR) sequence compared with a non-MAR sequence and were
140 ng various nuclear matrix attachment region (MAR) sequences suggest that DNA ends preferentially asso
141 nuclear matrix via matrix attachment region (MAR) sequences, and interaction with MAR-binding protein
146 ions from the Modele Atmospherique Regional (MAR) regional climate model (0.056-0.112 km(3)d(-1) vs.
148 termining phenotype matrix attached regions (MARs) on human chromosomes 14-18 were identified as a fu
149 we mapped nuclear matrix attachment regions (MARs) and DNase I hypersensitive (HS) sites over a 100-k
151 s have shown that matrix attachment regions (MARs) can increase expression of transgenes in whole org
154 flanking nuclear matrix attachment regions (MARs) encompassing the protamine domain were created.
155 nd to the nuclear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhance
157 includes flanking matrix attachment regions (MARs), an origin of bidirectional replication (OBR), and
159 nce attributes of matrix attachment regions (MARs), domains that organize DNA loops on the nuclear ma
160 ions of predicted matrix attachment regions (MARs), possibly related to replication origins, were not
161 tified as nuclear matrix attachment regions (MARs), while integrations in nonneoplastic cells show no
166 istics of nuclear matrix attachment regions (MARs): an exceptionally intense computed 'MAR potential'
169 h refracted log minimum angle of resolution (MAR) distance acuity and Pelli-Robson contrast sensitivi
170 actor in the multiple adaptational response (MAR) family, regulates expression of the Yersinia type I
171 LcrF, a multiple adaptational response (MAR) transcription factor, regulates virulence in Yersin
174 ibose-protein hydrolase for mono-ADP-ribose (MAR) and poly(ADP-ribose) (PAR) chain removal (de-MARyla
175 either attached singly as mono(ADP-ribose) (MAR) or in polymeric chains as poly(ADP-ribose) (PAR).
176 r a segment of the North Mid-Atlantic Ridge (MAR) using sonar, corers, trawls, traps, and a remotely
177 The mean maximum acceptable annual risk (MAR) for each of the SAEs was calculated for various lev
179 oth NP and uncompacted plasmid VMD2-hRPE65-S/MAR can mediate persistent, long-term improvement in an
180 t both plasmid and NP forms of VMD2-hRPE65-S/MAR improved the disease phenotypes in an rpe65(-/-) mod
181 and observe that NP or plasmid VMD2-hRPE65-S/MAR led to structural and functional improvements in the
184 Expression studies demonstrated that iBAC-S/MAR-LDLR completely restored LDLR function in CHO ldlr(-
185 lr(-/-) a7 clonal cell lines carrying iBAC-S/MAR-LDLR demonstrated low copy episomal stability of the
186 with a scaffold matrix attachment region (S/MAR) and vitelliform macular dystrophy 2 (VMD2) promoter
193 nucleosome formation, and the majority of S/MARs contain at least one nucleosome-depleted region.
196 ern of distribution and genomic context of S/MARs is thought to be important for processes such as ch
202 fs and 6-mer enrichment patterns show that S/MARs are preferentially enriched in poly(dA:dT) tracts,
204 oci-specific studies, we have surveyed the S/MARs in HeLa S3 cells on human chromosomes 14-18 by arra
211 x destabilization (both predictive of strong MARs) correlate with the total number of bizelesin bindi
213 rchy for graft survival with ACR better than MAR better than AMR, which persisted for both early and
214 nstream of each breakpoint, we conclude that MAR exchange is a significant, selectable outcome of the
216 n sites on seven PARPs, and demonstrate that MAR and PAR generating PARPs modify similar amino acids,
217 ite-specific recombination demonstrated that MAR sequences were required for the establishment but no
227 Furthermore, the epitope targeted by the MAR autoantibodies was localized within the amino-termin
228 o test this possibility, we have deleted the MAR from a Chinese hamster ovary variant harboring a sin
229 mine whether the time to at least double the MAR was dependent on age at baseline or starting VA.
231 screened for potential binding sites for the MAR-binding protein, SATB1, and for GATA-3, both of whic
232 ation of segmental reference haplotypes, the MAR algorithm always calculates an exact form of transit
234 15 of 29 (52%, 33-71) participants in the MAR vaccine group had a T-cell response to the Marburg g
235 Nine of 29 (31%, 15-51) participants in the MAR vaccine groups had an antibody response to the Marbu
236 s contains multiple enhancers, including the MAR/intronic (iE(kappa)) and 3' enhancers (3'E(kappa)).
237 level, but betalg transgenes that lacked the MAR were expressed at a lower level than wild-type betal
240 l replicon mapping shows that removal of the MAR has no significant effect either on the frequency or
241 lkaline conditions show that deletion of the MAR interferes with local separation of daughter chromat
242 l flat plain at 3500 m depth in place of the MAR would contain 85.6 kt C, implying an increase of 173
245 contrast, Ku and DNA-PKcs were found on the MAR plasmid only in the presence of DNA ends suggesting
246 Primary production and export flux over the MAR were not enhanced compared with a nearby reference s
247 ancement of biological productivity over the MAR; oceanic bathypelagic species are replaced by benthi
250 fference of VA was determined by whether the MAR between the two eyes differed by less than a factor
251 t factor A preferentially associate with the MAR plasmid in the absence or presence of DNA ends.
252 lar to staining for TRPM1, staining with the MAR sera was strong in dendritic tips and somas and was
253 -binding assay, and for interaction with the MAR-binding proteins cut-like protein x/CCAAT-displaceme
260 om moderate daily symptoms to remission, the MARs ranged from 0.69% to 0.81% and from 0.39% to 0.55%,
262 M1 gene, and Western blots probed with these MAR sera showed the expected band size ( approximately 1
263 ding 5' ends of genes, suggesting that these MARs are primarily involved in transcriptional control.
266 direct lines of evidence suggested that this MAR might be required for origin activation in early S p
269 ability of DNA-PKcs/Ku to direct DNA ends to MAR and pUC18 plasmid DNA is a new activity for DNA-PK a
270 and structural constraints limiting PARPs to MAR synthesis do not limit their ability to modify canon
272 t integrated viral genomes may be subject to MAR-mediated transcriptional effects should facilitate e
273 ntegrated tumor virus genomes are subject to MAR-mediated transcriptional regulation, providing insig
275 become evident: the enzyme used to transform MAR/PAR into phosphoribose must be purified from the rat
277 nd-drinking subjects (SAD), marijuana users (MAR), smoking-and-marijuana users (SAM), marijuana-and-d
278 del to estimate each subject's unblurred VA (MAR(0) in minutes of arc) and equivalent intrinsic blur
280 n sequence-based MAR predictions and in vivo MAR function and predict a novel MAR-independent mechani
283 associated with transcript presence whereas MARs contained within a gene are associated with silence
284 ts expressing mini-white transgenes in which MAR sequences from the human apoB gene were arranged in
285 e potential of a tag-based pipeline in which MAR/PAR is hydrolyzed down to phosphoribose, leaving a 2
287 region (MAR) sequences, and interaction with MAR-binding proteins have been shown to alter chromatin
288 model, the ERG findings in the patients with MAR are more consistent with an attenuation of the DBC c
289 oral response functions of the patients with MAR had normal amplitudes at frequencies of 32 Hz and hi
290 at the vision of at least some patients with MAR is compromised due to autoantibody-mediated inactiva
291 sensitivity loss shown by the patients with MAR is consistent with the dysfunction at the level of t
295 e delayed VEP responses of the patients with MAR to luminance increments may represent a late respons
296 ntrast sensitivity deficits of patients with MAR under photopic conditions are not specific to the MC
299 Staining of mouse and primate retina with MAR sera revealed immunoreactivity in all types of ON bi
300 died the effects of flanking transgenes with MARs on transgene expression levels in maize callus and
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