ライフサイエンスコーパス: MBT

1 MBT demarcates transition from synchronous short cell cy

2 MBT depletion kinetics in the hydroponic medium with pla

3 MBT depletion rate was related to the initial exposure c

4 MBT repeats are important for the transcriptional repres

5 MBT repeats, domains of approximately 100 amino acids, h

6 MBT values in streams and lake surface water were signif

7 MBT, although more expensive, offers an effective, safe,

8 MBT-1 structurally resembles the H-L(3)MBT protein, whos

9 MBT-1(-/-) myeloid progenitor cells exhibit a maturation

10 nnamic acid), and 2-mercaptobenzothiazole (2-MBT).

11 H-L(3)MBT acts as a histone deacetylase-independent transcript

12 H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL interacting domains.

13 We found that H-L(3)MBT binds in vivo to TEL, and we have mapped the region

14 ulate that the interaction of TEL with H-L(3)MBT can direct a PcG complex to genes repressed by TEL,

15 H-L(3)MBT contains three repeats of 100 residues called MBT re

16 We report that H-L(3)MBT is a transcriptional repressor and that its activity

17 TL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on

18 MBT-1 structurally resembles the H-L(3)MBT protein, whose deletion is predicted to be responsib

19 human homolog of the Drosophila polycomb L(3)MBT tumor suppressor protein and thus a candidate tumor

20 omoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL in

21 ethal (3) malignant brain tumor protein, L(3)MBT, and the histone deacetylase, Rpd3, associated with

22 H-L(3)MBT, the human homolog of the Drosophila lethal(3)malign

23 rst detected at neurula, some 10 hours after MBT, indicating that transcription is significantly dela

24 s are correlated with activation at or after MBT.

25 upon synthesis of zygotic Ago proteins after MBT.

26 ed prior to MBT, but activation of Tcf after MBT cannot rescue ventralized embryos, suggesting that b

27 mL(-1) and 1.37 microg mL(-1) for CN(-) and MBT, respectively.

28 endent growth inhibition of murine (MB49 and MBT-2) and human (HT-1376, UM-UC-3, RT-4, J82, and TCCSU

29 ing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models.

30 argeted by other E2Fs or by L3MBTL1, another MBT domain-containing protein that interacts with RB1.

31 transcription, while Smad1/5/8 activation at MBT appears to involve transcription-independent regulat

32 ranscripts localize to dorsal blastomeres at MBT.

33 le control in zebrafish embryos commences at MBT and that the reduction of cyclin D1 expression compr

34 A second feature at MBT is a massive increase in zygotic transcription and a

35 scriptional activation of the MARCKS gene at MBT.

36 zygotic activation of the Xenopus genome at MBT.

37 the onset of Xenopus MARCKS transcription at MBT.

38 ion of immediately early genes in Xenopus at MBT.

39 the overall transcriptional silencing before MBT.

40 ontains three repeats of 100 residues called MBT repeats, whose function is unknown, and a C-terminal

41 lies (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor).

42 ts include glucose and amino acid conjugated MBT metabolites.

43 Arabidopsis seedlings to multiple conjugated-MBT metabolites of differential polarity that accumulate

44 w rational debate on achievable vs desirable MBT-derived SRF quality, informing the development of re

45 accompanied by malignant brain tumor domain (MBT) and sterile alpha motif (SAM) domains.

46 The Drosophila MBT is marked by blastoderm cellularization and follows

47 erable sequence homology with the Drosophila MBT protein (for "mushroom body tiny"), however, which i

48 n (SERS) enhancement factor ratio EF(BDT)/EF(MBT) of approximately 130 was observed uniformly across

49 Our observations support a model for MBT regulation by DNA-based titration and suggest that d

50 The proposed scheme for MBT biosynthesis involves assembly of the MBT backbone b

51 SFMBT1 (Scm [Sex comb on midleg] with four MBT [malignant brain tumor] domains 1) is a poorly chara

52 We have identified human MBT domain-containing protein L3MBTL2 as an integral com

53 The human MBT-1 gene is located on chromosome 6q23, a region frequ

54 To identify MBT regulators, we developed an assay using Xenopus egg

55 -to-cytoplasmic ratio has been implicated in MBT timing, our data show that nuclear size also contrib

56 suggested a role for the N/C volume ratio in MBT timing, none directly tested the effects of altering

57 of these activities plays a broader role in MBT-associated changes than was previously suspected.

58 ings comparable with efficient incineration, MBT, and bioreactor landfilling technologies.

59 9.8% of the initial MBT mass spike was present in the plants after 3 h and d

60 sistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono

61 mains 1) is a poorly characterized mammalian MBT domain-containing protein homologous to Drosophila S

62 Unlike other mammalian MBT domain proteins characterized to date that selective

63 ide ion (CN(-)) and 2-mercaptobenzothiazole (MBT) in water samples with satisfactory results.

64 2-Mercaptobenzothiazole (MBT) is a tire rubber vulcanizer found in potential sour

65 cridine (9-AA), and 2-mercaptobenzothiazole (MBT) were investigated for lipid detection efficiency in

66 nzenedithiol (BDT) and 4-methylbenzenethiol (MBT), to form -S/Au and -CH(3)/Au interfaces with essent

67 of PHF20L1 or incubation of a small molecule MBT domain binding inhibitor in cultured cells accelerat

68 yltin (TBT), dibutyltin (DBT), monobutyltin (MBT), and total butyltins (SigmaBT) was analyzed in the

69 The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this

70 es two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelate intracellu

71 Multiple novel MBT-derived plant metabolites were detected via LC-QTOF-

72 We have engineered the naturally occurring MBT domain repeats of L3MBTL1 to serve as a universal af

73 e DNA-to-cytoplasmic ratio in the control of MBT timing.

74 It is the founding member of a family of MBT domain-containing proteins that has three members in

75 Since the most prominent form of MBT produced by M. tuberculosis lacks this beta-methyl g

76 uantified the plant assimilation kinetics of MBT using Arabidopsis under hydroponic conditions.

77 ble interest in deciphering the mechanism of MBT assembly, with the goal of targeting select biosynth

78 d DNA amount contribute to the regulation of MBT timing with neither parameter being dominant.

79 r size also contributes to the regulation of MBT timing, demonstrating the functional significance of

80 development contribute to the regulation of MBT timing.

81 ing the cell cycle at and around the time of MBT.

82 A rapid transition of MBT vs. temperature/pH relationships occurring at the bo

83 ing TEX86 as a surface temperature proxy, or MBT and/or CBT for reconstructing pH, in anoxic or euxin

84 ency with improved selectivity against other MBT-containing proteins.

85 de a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control

86 C. elegans contains one other MBT-repeat-containing protein, MBTR-1.

87 The Au130(p-MBT)50 can be viewed as an elongated version of the Au10

88 Comparison of the Au130(p-MBT)50 structure with the recently discovered icosahedra

89 large gold nanocluster formulated as Au130(p-MBT)50, where p-MBT is 4-methylbenzenethiolate.

90 luster formulated as Au130(p-MBT)50, where p-MBT is 4-methylbenzenethiolate.

91 Our findings highlight a PcG/MBT collaboration that attains repressive chromatin with

92 l alpha-helical structure, the SPM (SCM, PH, MBT domain, which is structurally similar to the SAM (st

93 Overexpression of cyclin A2/cdk2 in post-MBT embryos results in increased proliferation specifica

94 Decreasing nuclear size in post-MBT haploid embryos caused a further delay in cell cycle

95 tion of apoptosis in embryos irradiated post-MBT, distinct roles for these complexes during apoptosis

96 ng, and the addition of H3/H4 shortened post-MBT cell cycles.

97 at the twelfth cleavage; and a shorter post-MBT wave of transcription that becomes apparent as devel

98 The post-MBT survival mechanism arrests cells in G(1) phase by in

99 ion of Cdc2/Cdk2 on tyr15 occurs in each pre-MBT cell cycle, and dephosphorylation of Cdc2/Cdk2 by Cd

100 by knockdown of mitotic cyclins extended pre-MBT S phase.

101 n given to transcriptional regulation in pre-MBT development.

102 that increasing the N/C volume ratio in pre-MBT embryos leads to premature activation of zygotic gen

103 induced checkpoint response is absent in pre-MBT embryos, introduction of a threshold amount of undam

104 cell cycle and the timing of cleavage in pre-MBT embryos.

105 rsists throughout development, including pre-MBT cell cycles that lack checkpoints.

106 ptosis are evident in embryos irradiated pre-MBT.

107 Persistence of pre-MBT levels of Twine was sufficient to prevent cell-cycle

108 k1 contribute to the speed of the rapid, pre-MBT S phases and that down-regulation of these activitie

109 In the pre-MBT cycles, all genomic regions replicate simultaneously

110 egins early and is maintained throughout pre-MBT stages.

111 -Ser suggests that the megasynthase produces MBT derivatives with beta-methyl oxazoline rings.

112 N/C volume ratio also contributes to proper MBT timing.

113 conserved aspartic acid (D355) in the second MBT repeat.

114 which is relieved at the midblastula stage (MBT).

115 miconazole 50 mg mucoadhesive buccal tablet (MBT) is a novel delivery system with potent in vitro act

116 or suppressor l(3)mbt, contains three tandem MBT repeats (3xMBT) that are critical for transcriptiona

117 d procedure with a modified Blalock-Taussig (MBT) shunt, the first palliative stage for single-ventri

118 instructions on the modified Bass technique (MBT) after their toothbrushing performance was monitored

119 ve identified a putative PcG protein, termed MBT-1, that is associated with Rnf2, an in vivo interact

120 The protein's C-terminal MBT repeats bind mono and dimethylated histones in vitro

121 MEGX concentration, methionine breath test (MBT), galactose elimination capacity (GEC), dual cholate

122 Together, we conclude that MBT-1 specifically regulates the maturational advancemen

123 del in the frog, Xenopus laevis, posits that MBT timing is controlled by a maternally loaded inhibito

124 -source LC-MS/MS fragmentation revealed that MBT was converted by Arabidopsis seedlings to multiple c

125 We also show that MBT-1 appears to influence myelopoiesis by transiently e

126 The MBT domain is structurally related to protein domains th

127 The MBT domains bind at least two nucleosomes simultaneously

128 The MBT is triggered by a critical nucleocytoplasmic (N/C) r

129 eas the biochemical changes accompanying the MBT in the vertebrate embryo have been extensively docum

130 % of the DTSG (COG, 40%) totally adopted the MBT (P <0.05).

131 of the cyclin E1 protein detected after the MBT does not occur indirectly as a result of degradation

132 of a mitotic spindle also operates after the MBT in blastomeres that are treated with aphidicolin, if

133 In contrast, deleting S phase after the MBT in cycle 15 did not dramatically affect mitotic timi

134 The disappearance of Cdc25A after the MBT may underlie in part the lengthening of the cell cyc

135 is becomes sensitive to nocodazole after the MBT, but not before.

136 mental" activation of Chk1 shortly after the MBT.

137 signal only in embryos irradiated after the MBT.

138 tiple mechanisms prevent apoptosis after the MBT.

139 tive effect against apoptosis only after the MBT.

140 e, DNA damage activates XChk1 only after the MBT.

141 aded with a much shorter half-life after the MBT.

142 turbed cell cycle before, but not after, the MBT.

143 ding protein (TBP) increases robustly at the MBT and that the mechanism underlying this increase is t

144 hat Xenopus Claspin is phosphorylated at the MBT at both DNA replication checkpoint-dependent and -in

145 collaborate to control the cell cycle at the MBT by directly mediating the normal repression of mater

146 At the MBT in embryos, Chk1 is transiently activated to lengthe

147 ein from the cytoplasm to the nucleus at the MBT is critical for the execution of a genetic program c

148 he nuclear translocation of CBTF(122) at the MBT is likely to be coupled to the degradation of matern

149 Not all phosphorylation that occurs at the MBT is reproduced in egg extracts.

150 ivation of the checkpoint kinase Chk1 at the MBT results in the SCF(beta-TRCP)-dependent degradation

151 chronous nuclear divisions must pause at the MBT to allow the formation of a cellular blastoderm thro

152 les nor the disappearance of cyclin E at the MBT were dependent on protein synthesis.

153 roper levels of zygotic transcription at the MBT, and that genes activated in the second wave of expr

154 At the MBT, down-regulation of Cdc25 phosphatase and the result

155 At the MBT, embryonic transcription is upregulated and cell cyc

156 e activation of zygotic transcription at the MBT, including expression of the gene tribbles, whose ac

157 contributes to the cell-cycle change at the MBT, including the addition of a G2 phase and onset of l

158 The cell cycle changes at the MBT, including the addition of gap phases and checkpoint

159 At the MBT, S phase is dramatically lengthened by the onset of

160 This site becomes hyperphosphorylated at the MBT, thus allowing the docking of proteins required for

161 Smicl might regulate gene expression at the MBT, we have discovered that it interacts with the tail

162 Although XChk1 mRNA is degraded at the MBT, XChk1 protein persists throughout development, incl

163 robust activation of Nodal signaling at the MBT.

164 otic transcription of N/C ratio genes at the MBT.

165 iate high-level zygotic transcription at the MBT.

166 induces a novel Chk2-dependent block at the MBT.

167 (bp) repeat sequence, recruited HP1a at the MBT.

168 nal to zygotic control of development at the MBT.

169 has an additional essential function at the MBT.

170 n B bypass the requirement for mei-41 at the MBT.

171 uired to terminate the cleavage stage at the MBT.

172 y new zygotic transcription beginning at the MBT.

173 A-to-cytoplasm ratio found in embryos at the MBT.

174 to the elimination of its transcripts at the MBT.

175 y programmed down-regulation of Cdc25 at the MBT.

176 role in early Xenopus development before the MBT as a direct transcription repressor protein.

177 tein coding transcripts activated before the MBT by the maternal T-box factor VegT that are component

178 se organisms that are transcribed before the MBT, but whether precocious expression of specific mRNAs

179 Before the MBT, each cycle is composed of only a short S phase and

180 embryos facilitates transcription before the MBT, without requiring TBP to be prebound to the promote

181 s on the transcriptional capacity before the MBT.

182 o contribute to promoter activity before the MBT.

183 This indicates that the interval between the MBT and the EGT represents a critical developmental peri

184 he seventh cleavage and extending beyond the MBT at the twelfth cleavage; and a shorter post-MBT wave

185 e of mature myeloid blood cells, causing the MBT-1(-/-) mice to die of anemia during a late embryonic

186 mechanism for how the N/C ratio controls the MBT and shows that the regulation of replication initiat

187 nd point to similar mechanisms governing the MBT in diverse species.

188 biochemical purification, we identified the MBT domain-containing protein SFMBT1 as a novel componen

189 chromatin-associated modules, including the MBT-like repeat, Tudor, and PWWP domains.

190 oplasm in embryonic cells that initiates the MBT.

191 the DNA damage response as an element of the MBT and indicate that multiple mechanisms prevent apopto

192 or MBT biosynthesis involves assembly of the MBT backbone by a hybrid nonribosomal peptide synthetase

193 matin involves the coordinated action of the MBT domains, RNA binding, and interaction with PRC1 thro

194 active Nodal signaling, at the onset of the MBT requires preMBT transcription and activity of xnr5 a

195 targeted for degradation at the onset of the MBT through a switch-like mechanism controlled, like Str

196 Several hallmarks of the MBT were delayed for several hours in Delta34Xic1-inject

197 lation of a maternal mRNA at the time of the MBT, as suggested previously.

198 hese factors regulate multiple events of the MBT, including the slowing of the cell cycle, the onset

199 Some aspects of the MBT, such as zygotic transcription, depend on acquisitio

200 logical timers that control the onset of the MBT.

201 s critical for controlling the events of the MBT.

202 zfAPEX1a intron-exon junctions also pass the MBT with similar abnormalities.

203 endogenous protein in the cytoplasm past the MBT, indicating that cytoplasmic retention is a phosphor

204 enous xnf7 protein in the cytoplasm past the MBT.

205 hat the proper number of mitoses precede the MBT.

206 hat depletion of free histones regulates the MBT.

207 two MBT (malignant brain tumor) repeats; the MBT is a protein module structurally similar to domains

208 These results demonstrate that the MBT domain of PHF20L1 reads and controls enzyme levels o

209 These results suggest revisions to the MBT biosynthesis pathway while also identifying new targ

210 wood procedure were randomly assigned to the MBT shunt (275 infants) or the RVPA shunt (274 infants)

211 enopus embryos lack checkpoints prior to the MBT, checkpoints are observed in cell-free egg extracts

212 after stage 7, two cell cycles prior to the MBT.

213 the N/C volume ratio increases prior to the MBT.

214 ts by RNAi did not affect progression to the MBT.

215 spond to an independent timer to trigger the MBT and activation of cell cycle checkpoints.

216 ne protein was abundant and stable until the MBT, when it was destabilized and rapidly eliminated.

217 tact but blocked upstream of XChk1 until the MBT.

218 es the early embryonic cell cycles until the MBT.

219 At T0, 27.27% of DTSG participants used the MBT correctly (COG, 50%), increasing to 54.55% (COG, 60%

220 was higher with the RVPA shunt than with the MBT shunt (74% vs. 64%, P=0.01).

221 was better with the RVPA shunt than with the MBT shunt.

222 he presence of a region containing the three MBT repeats.

223 tributions of nuclear size and DNA amount to MBT timing by simultaneously altering nuclear size and p

224 dependent transcription is required prior to MBT for dorsal-ventral patterning in XENOPUS:

225 ependent transcription is activated prior to MBT, but activation of Tcf after MBT cannot rescue ventr

226 not begin until the mid-blastula transition (MBT) 3 h after fertilization.

227 tic cell cycle, the mid-blastula transition (MBT) and at gastrulation.

228 ressed initially at mid-blastula transition (MBT) and during gastrulation in the entire marginal zone

229 phila embryo at the mid-blastula transition (MBT) concurrently experiences a receding first wave of z

230 emporarily deferred mid-blastula transition (MBT) events.

231 equences during the mid-blastula transition (MBT) in Drosophila.

232 ranscription at the mid-blastula transition (MBT) in the suppression of apoptosis in normal embryos.

233 pus development the mid-blastula transition (MBT) marks a dramatic change in response of the embryo t

234 The Xenopus mid-blastula transition (MBT) marks the onset of large-scale zygotic transcriptio

235 ent features at the mid-blastula transition (MBT) observed in most embryos is a pause in cell cycle r

236 referred to as the mid-blastula transition (MBT) remain mysterious.

237 At the mid-blastula transition (MBT), externally developing embryos refocus from increas

238 At the mid-blastula transition (MBT), the cell cycle elongates and several processes bec

239 mbryos prior to the mid-blastula transition (MBT), whereas multivalent genes are correlated with acti

240 ream targets at the mid-blastula transition (MBT).

241 hylation before the mid-blastula transition (MBT).

242 n occurs before the mid-blastula transition (MBT).

243 but not before, the mid-blastula transition (MBT).

244 increased after the mid-blastula transition (MBT).

245 sition known as the mid-blastula transition (MBT).

246 laevis embryos, the midblastula transition (MBT) at the 12th cell division marks initiation of criti

247 sophila embryos, the midblastula transition (MBT) dramatically remodels the cell cycle during the 14(

248 At the midblastula transition (MBT) during Xenopus laevis development, zygotic transcri

249 f development at the midblastula transition (MBT) follows mitosis 13, when the cleavage divisions ter

250 erved feature of the midblastula transition (MBT) is a requirement for a functional DNA replication c

251 The midblastula transition (MBT) is the first morphological event that requires zygo

252 il to undergo timely midblastula transition (MBT) or arrest following ionizing radiation.

253 of expression at the midblastula transition (MBT) requires Smicl and is correlated with the transloca

254 ilization, until the midblastula transition (MBT) when levels of cyclin E1 protein, and associated ki

255 at approximately the midblastula transition (MBT) without apoptosis.

256 The Drosophila midblastula transition (MBT), a major event in embryogenesis, remodels and slows

257 ntinuously until the midblastula transition (MBT), after which it is degraded.

258 nt terminates at the midblastula transition (MBT), at which point the cell cycle slows dramatically,

259 nin starts after the midblastula transition (MBT), but does not rescue dorsal axial structures.

260 At the Xenopus midblastula transition (MBT), cell cycles lengthen, and checkpoints that respond

261 visions pause at the midblastula transition (MBT), coinciding with a dramatic increase in gene transc

262 are followed by the midblastula transition (MBT), during which the cell cycle elongates and zygotic

263 on factors after the midblastula transition (MBT), including a marked decline of the licensing factor

264 quiescent until the midblastula transition (MBT), when large-scale transcription begins.

265 divisions marks the midblastula transition (MBT), when the cell cycle lengthens, acquiring gap phase

266 al transition is the midblastula transition (MBT), when zygotic transcription begins and cell cycles

267 yclin E prior to the midblastula transition (MBT), with or without cdk2, results in a loss of nuclear

268 ing a maximum at the midblastula transition (MBT).

269 divisions until the midblastula transition (MBT).

270 of pre-miRNAs at the midblastula transition (MBT).

271 s cell cycles at the midblastula transition (MBT).

272 , but not after, the midblastula transition (MBT).

273 iption begins at the midblastula transition (MBT).

274 cytoplasm before the midblastula transition (MBT).

275 aintained during the midblastula transition (MBT).

276 aevis embryos at the midblastula transition (MBT).

277 maturation until the midblastula transition (MBT).

278 period known as the midblastula transition (MBT).

279 kpoints comprise the midblastula transition (MBT).

280 pear until after the midblastula transition (MBT; 4000 cells).

281 produced by mechanical-biological treatment (MBT) of municipal waste can replace fossil fuels, being

282 ection of a mechanical-biological treatment (MBT) plant producing solid recovered fuel (SRF) for the

283 cineration, mechanical-biological treatment (MBT), and landfilling).

284 Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 14

285 K382me1 by the triple malignant brain tumor (MBT) repeats of the chromatin compaction factor L3MBTL1.

286 which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysi

287 tein composed of four malignant brain tumor (MBT) repeats.

288 demonstrate that the malignant-brain-tumor (MBT) protein L3MBTL1 is in a complex with core histones,

289 It contains two MBT (malignant brain tumor) repeats; the MBT is a protei

290 e current therapy using in vitro and in vivo MBT-2 murine tumor models.

291 molecular events in precise accordance with MBT morphological progression.

292 t cell cycle remodeling during the zebrafish MBT includes the transcription-independent acquisition o