ライフサイエンスコーパス: MC1R

1 MC1R agonist- but not MC1R antagonist-conjugated nanopar

2 MC1R and MC3R mRNA and protein were both expressed in th

3 MC1R and TYR are associated with pigmentation, freckling

4 MC1R antagonists human beta-defensin 3 and agouti signal

5 MC1R encodes a 317-amino acid G-coupled receptor that co

6 MC1R encodes a cyclic AMP-stimulating G-protein-coupled

7 MC1R genotype was predictive of hair melanin expressed a

8 MC1R is a candidate gene involved in alternative male mo

9 MC1R nucleotide diversity, pi, was much higher (10.1 x 1

10 MC1R overexpression, treatment with the MC1R ligand, or

11 MC1R palmitoylation, primarily mediated by the protein-a

12 MC1R SNP R163Q was also significantly (P<0.001) associat

13 MC1R variants are more frequent in subjects with melanom

14 MC1R variants may influence orofacial pain perception an

15 MC1R variants may predispose to melanoma as a result of

16 MC1R was positively associated with BRAF V600E cases but

17 MC1R's associations with BRAF V600E cases limited to ind

18 MC1R, number of moles, skin reaction to first summer sun

19 MC1R-cAMP signaling promotes PKA-mediated phosphorylatio

20 ic loci: IRF4 (rs12203592, P=1.8 x 10(-27)), MC1R (compound heterozygosity score, P=2.3 x 10(-24)), a

21 mes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genome-wide significance with

22 curve (AUC) for a model by Han et al. with 7 MC1R variants was 0.72 (95% confidence interval (CI): 0.

23 d to rate their itching, and genotyped for 8 MC1R SNPs.

24 ude OCA2-HERC2 (combined P = 3.80 x 10(-8)), MC1R (P = 1.82 x 10(-13)), a region near TYR (P = 1.57 x

25 riants for therapeutic benefit by activating MC1R protein palmitoylation.

26 sferase ZDHHC13, is essential for activating MC1R signalling, which triggers increased pigmentation,

27 sulfide bond) is essential for high-affinity MC1R binding and inverse agonism.

28 exhibited excellent MC4R selectivity against MC1R whereas those with an amino acid had moderate MC4R/

29 ating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by p

30 less MC1R model containing Mc1r(-/-) albino, MC1R(+)Mc1r(-/-) albino, Mc1r(-/-) pigmented, and MC1R(+

31 dy design with complete determination of all MC1R coding region variants.

32 a-melanocyte stimulating hormone (alphaMSH), MC1R function can be antagonized by a secreted factor, a

33 didate genes for melanism (ASIP [agouti] and MC1R) and identified three independent deletions associa

34 ecific interaction between MC1R antigens and MC1R-Abs when the target melanoma cells are present in t

35 ficant negative association between BRAF and MC1R mutations for head/neck melanomas.

36 All host characteristics and MC1R were more strongly associated with multiple BCC cas

37 n, inferring a steroidogenic-independent and MC1R-dispensable anti-proteinuric effect of melanocortin

38 stics (freckles, nevi, phenotypic index) and MC1R status with incident amelanotic melanomas were eval

39 r probe for small-animal PET of melanoma and MC1R expression in melanoma xenografted mouse models.

40 gmentation genes: MATP, IRF4, TYR, OCA2, and MC1R.

41 +)Mc1r(-/-) albino, Mc1r(-/-) pigmented, and MC1R(+)Mc1r(-/-) pigmented mice was generated.

42 ssociations between self-identified race and MC1R single-nucleotide polymorphisms (SNPs) with severit

43 door tanning, burns from indoor tanning, and MC1R (AUC = 0.77, 95% CI: 0.74, 0.81).

44 anocortin 1 receptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

45 eptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

46 The above analogs are MC1R agonists, as their effects were abrogated by an ana

47 We identified 5 additional genes (ASIP, MC1R, POMC, and SILV) and one additional region (GSTT2-2

48 with wild-type (WT), but not RHC-associated MC1R variants, which protects PTEN from WWP2-mediated de

49 We also found no association between MC1R status and any somatic mutations in this community

50 est study to date on the association between MC1R variants and BRAF mutant melanoma.

51 lar basis underlying the association between MC1R variants and melanomagenesis.

52 sing due to the specific interaction between MC1R antigens and MC1R-Abs when the target melanoma cell

53 There was also a relation between MC1R status and hair color, most prominently for the b*

54 , fear of pain mediated the relation between MC1R variant status and dental fear (B = 1.60, 95% confi

55 BCC risk conferred by MC1R tended to be stronger among those with darker pigme

56 Individuals carrying MC1R variants, especially those associated with red hair

57 s melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apo

58 n expression from MC1R in favour of chimeric MC1R-TUBB3 isoforms in cultured melanocytes.

59 VR susceptibility as a result of compromised MC1R function are unclear, but hypotheses include reduce

60 signaling, possibly due to high constitutive MC1R activity.

61 By contrast, MC1R responds primarily to those chimeras with a sequenc

62 In contrast, MC1R antagonists agouti signaling protein (ASIP) or huma

63 seful biomarker for the DNA repair-deficient MC1R phenotype.

64 We observed 85 different MC1R variants, 10 of which occurred at a frequency >1%.

65 ese loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q

66 However, the endogenous MC1R agonists lack selectivity for the MC1R and thus can

67 57BL/6J-Mc1r(e/e)J mice, in which endogenous MC1R is prematurely terminated, expressing Mc1r RHC vari

68 melanin ratio, with a dosage effect evident: MC1R homozygote mean, 1.46; heterozygote, 4.44; and wild

69 entally tested signal processing in the FGFR/MC1R/B-Raf/C-Raf/MAPK1,2 network in human melanoma cells

70 CTH are endogenous nonselective agonists for MC1R, MC3R, MC4R, and MC5R.

71 defensin 3 (HBD3) acted as an antagonist for MC1R, inhibiting the alpha-melanocortin (alpha-melanocyt

72 compound heterozygosity and homozygosity for MC1R variants.

73 timulating hormone (alphaMSH, the ligand for MC1R), therefore MC1R variants could alter the autocrine

74 On the basis of our theoretical model for MC1R, using mutagenesis, we have examined 19 transmembra

75 ignificantly elevated when this was null for MC1R.

76 ader effects on growth, revealing a role for MC1R in normal fetal development.

77 affected families, and considered a role for MC1R in this condition.

78 Hence, a role for MC1R in youthful looks independent of its known melanin

79 The results highlight a central role for MC1R palmitoylation in pigmentation and protection again

80 on equally in primary podocytes derived from MC1R-null and wild-type mice.

81 anning, result in a shift in expression from MC1R in favour of chimeric MC1R-TUBB3 isoforms in cultur

82 ctivation of MAPK1,2, whereas signaling from MC1R results in transient activation of MAPK1,2.

83 strategy in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by act

84 t in melanocytes expressing loss-of-function MC1R.

85 te pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice.

86 Furthermore, in the absence of functional MC1R, fewer p53 clones were observed in pigmented than i

87 available despite the absence of functional MC1R.

88 onstructed from four pre-selected functional MC1R SNPs (p = 2.69 x 10(-12)), which was replicated in

89 Consistent with this hypothesis, the gene MC1R exhibits reduced diversity in African populations f

90 The melanocortin 1 receptor gene (MC1R) is responsible for normal pigment variation in hum

91 phenotypes and melanocortin 1 receptor gene (MC1R) variants in relation to early-onset BCC.

92 lymorphisms in melanocortin-1 receptor gene (MC1R).

93 Certain variants in a low-penetrance gene, MC1R, the melanocortin 1 receptor gene, increase melanom

94 anning and the melanocortin 1 receptor gene, MC1R.

95 The effect of germline MC1R genotype on development and severity of CMN led us

96 ined the role of Phe(7) in ACTH on human (h) MC1R, MC3R, and MC4R binding and signaling.

97 how MC1R photoprotects, an in vivo hairless MC1R model containing Mc1r(-/-) albino, MC1R(+)Mc1r(-/-)

98 uptake in the B16F10 murine model, with high MC1R expression, but much lower uptake in the A375M huma

99 lly achieved in preclinical models with high MC1R expression.

100 Individuals carrying the homozygote MC1R risk haplotype looked on average up to 2 years olde

101 r (FGFR) and melanocyte stimulating hormone (MC1R) receptors stimulates B-Raf and C-Raf isoforms that

102 To determine how MC1R photoprotects, an in vivo hairless MC1R model conta

103 However, how MC1R activity is modulated by ultraviolet irradiation, w

104 However, MC1R diversity in non-African populations that have evol

105 Human MC1R variants with reduced or absent function are associ

106 More than 65 human MC1R alleles with nonsynonymous changes have been identi

107 (Arg151Cys, Arg160Trp, and Asp294His) human MC1R.

108 oat pigmentation is mediated solely by human MC1R.

109 gnalling protein, blocks activation of human MC1R, its action is unlike that on the mouse receptor in

110 o detectable chimeric mRNA could be found in MC1R expressing mouse melanocytes.

111 y in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by activating

112 cological rescue to reduce UV mutagenesis in MC1R-defective, melanoma-susceptible individuals.

113 on may be present in European populations in MC1R.

114 ed podocytopathy was completely preserved in MC1R-null mice, marked by reduced albuminuria and dimini

115 Brief treatment with alpha-MSH resulted in MC1R desensitization, whereas continuous treatment up to

116 in IRF4 (Phet = 3.94 x 10(-4)), rs1805007 in MC1R (Phet = 7.71 x 10(-3)), and two SNPs in DEF8 (rs426

117 ere indicate little regional substructure in MC1R.

118 we investigated whether genetic variants in MC1R modulate the risk of PD by sequencing the entire ge

119 Germline variants in MC1R, the gene encoding the melanocortin-1 receptor, and

120 served in a mouse colony bearing an inactive MC1R.

121 nset BCC risk prediction model incorporating MC1R and indoor tanning extends the work of other skin c

122 llow pheomelanin pigment, whereas increasing MC1R activity stimulates the production of black/brown e

123 irm that ASIP diminishes agonist-independent MC1R basal signaling whereas HBD3 is a neutral MC1R anta

124 We conclude that genetic variations in IRF4, MC1R, RALY/ASIP, and BNC2 contribute to the acquired amo

125 lternative splicing of the classically known MC1R (MC1R317).

126 ism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface.

127 We have linked MC1R genotype with chemical measures of melanin quantity

128 Along with two known pigmentation loci, MC1R and OCA2, the IRF4 rs12203592 T allele was associat

129 viously confirmed pigmentation-related loci: MC1R, ASIP, TYR, SLC45A2, OCA2, IRF4 and BNC2.

130 melanoma xenografted in mice, indicating low MC1R expression.

131 s those with an amino acid had moderate MC4R/MC1R selectivity.

132 s in the exons of six genes, comprising MHC, MC1R and four others.

133 Individuals with two or more MC1R non-synonymous variants were 3.59 times (95% CI=2.3

134 as assayed for agonist activity at the mouse MC1R, MC3R, MC4R, and MC5R.

135 n which to determine the precise role of MSH-MC1R.

136 The activation of p53-POMC/MSH-MC1R signaling is required for the UV-induced melanogeni

137 ling pathway interacts with the p53-POMC/MSH-MC1R signaling pathway, and both are crucial in melanoge

138 -Bip-NH(2) tetrapeptides possessed nanomolar MC1R and MC5R potency but micromolar MC3R and MC4R agoni

139 well as melanoma risk, including in or near MC1R, MX2, and TERT/CLPTM1L (P < 1 x 10(-10)).

140 by gene sequencing to bear dominant-negative MC1R mutations.

141 1R basal signaling whereas HBD3 is a neutral MC1R antagonist that blocks activation by melanocortins.

142 yellow (e/e) mouse, bearing a nonfunctional MC1R, thereby incrementing our knowledge on this topic.

143 MC1R agonist- but not MC1R antagonist-conjugated nanoparticles exhibit signifi

144 coefficient 1.32; 95% CI: 0.23-2.40) but not MC1R SNP genotype was associated with increased itch sco

145 s study identifies and characterizes a novel MC1R isoform (MC1R350) generated by alternative splicing

146 Activation of MC1R in melanocytes by alpha-melanocyte-stimulating horm

147 e photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene.

148 Diminished function alleles of MC1R are associated with decreased tanning and increased

149 ree of penetrance for red hair of alleles of MC1R.

150 mber of red hair/low pigmentation alleles of MC1R; we found that together these MC1R alleles explaine

151 he sensor performance, such as the amount of MC1R-Abs loaded, incubation time with the target melanom

152 Association of MC1R variants and melanoma risk independent from sun exp

153 Associations of MC1R with BRAF mutations in melanoma have been inconsist

154 Carriage of MC1R variants was associated with amelanotic melanoma bu

155 ther phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are as

156 ompared with wild-type carriers, carriers of MC1R variants were at higher melanoma risk after statist

157 Carriers of MC1R variants were at increased melanoma risk independen

158 We investigated the effect of MC1R variants on melanoma using a large, international p

159 ts into the pleiotropic molecular effects of MC1R signaling that may function during development and

160 We studied the expression of MC1R under UVR and alpha-MSH stimulation in skin of diff

161 he biological consequences of the failure of MC1R variants to suppress PI3K/AKT signaling are highly

162 contact with the first extracellular loop of MC1R through a series of key hydrophobic interactions.

163 75M melanoma with a relatively low number of MC1R receptors.

164 lopment of an (18)F-labeled probe for PET of MC1R-positive malignant melanoma.

165 -1 is a promising molecular probe for PET of MC1R-positive tumors.

166 Presence of MC1R variant alleles predicted higher levels of dental f

167 addition to the MC1R genotype, regulation of MC1R expression and activity is expected to affect human

168 teristics may not modify the relationship of MC1R variants and melanoma risk, and suggest that associ

169 his model could be accounted for in terms of MC1R genotype.

170 /F10 melanoma tumors with high expression of MC1Rs and Fox Chase Scid mice bearing human A375M melano

171 rt a model of strong selective constraint on MC1R in Northern Island Melanesia This absence of strong

172 typed for single-nucleotide polymorphisms on MC1R and completed self-report measures of fear of pain

173 rastrand cisplatin-adducts in melanocytes or MC1R-transfected HEK293 cells.

174 were 2387 patients with data for phenotypes, MC1R genotype, and primary melanomas scored for histopat

175 agouti signaling protein, the physiological MC1R antagonist, and were absent in melanocytes expressi

176 ty, and lower protection by "non-pigmentary" MC1R effects.

177 Here we demonstrate a potential MC1R-targeted intervention strategy in mice to rescue lo

178 use of noncanonical amino acids in previous MC1R ligand development raises safety concerns.

179 iant and one r variant (defined as any non-R MC1R variant; OR, 1.6; 95% CI, 1.3-2.2) and among those

180 H) that function as melanocortin 1 receptor (MC1R) agonists.

181 etween cell surface melanocortin 1 receptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

182 s an agonist at the melanocortin-1 receptor (MC1R) but an antagonist at the MC4R.

183 oding region of the melanocortin-1 receptor (MC1R) gene is associated with constitutive pigmentation

184 ce variation in the melanocortin-1 receptor (MC1R) gene is associated with red hair in the normal pop

185 hat variants of the melanocortin 1 receptor (MC1R) gene may predict greater levels of dental fear.

186 lanoma and germline melanocortin-1 receptor (MC1R) gene status.

187 Melanocortin 1 receptor (MC1R) gene variants alter pigment synthesis in vivo, and

188 show that the human melanocortin 1 receptor (MC1R) gene, a critical component of the facultative skin

189 1 that includes the Melanocortin-1 receptor (MC1R) gene, which regulates colour polymorphisms in nume

190 olymorphisms in the melanocortin 1 receptor (MC1R) gene.

191 th variation in the melanocortin-1 receptor (MC1R) gene.

192 (R alleles) in the melanocortin 1 receptor (MC1R) gene.

193 ve, but the role of melanocortin 1 receptor (MC1R) has been implicated and was examined here.

194 The melanocortin-1 receptor (MC1R) is a key regulator of pigmentation in mammals and

195 Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populatio

196 tion alleles of the melanocortin 1 receptor (MC1R) lead to red hair, freckling, and sun sensitivity.

197 S) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to fibrogenesis in experime

198 The melanocortin 1 receptor (MC1R) mediates the tanning response through induction of

199 design of specific melanocortin-1 receptor (MC1R) targeted imaging probes, we report on the effect o

200 ndividuals carrying melanocortin-1 receptor (MC1R) variants, especially those associated with red hai

201 The melanocortin 1 receptor (MC1R), a G(s) protein-coupled receptor, has an important

202 The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role

203 Loss-of-function in melanocortin 1 receptor (MC1R), a GS protein-coupled receptor that regulates sign

204 The melanocortin 1 receptor (MC1R), a GS-coupled receptor that signals through cAMP a

205 Melanocortin type 1 receptor (MC1R), also known as alpha-melanocyte-stimulating hormon

206 is regulated by the melanocortin 1 receptor (MC1R), is an effective protection against melanoma.

207 gene in humans, the melanocortin 1 receptor (MC1R), is known to account for substantial variation in

208 lls expressing melanocortin type-1 receptor (MC1R), that the nature of targeting ligands, i.e., wheth

209 tor, but not to the melanocortin 1 receptor (MC1R), whereas ASIP binds with high affinity to all thre

210 ific ligand for the melanocortin 1 receptor (MC1R), which has been evaluated as a cell-surface marker

211 The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic tran

212 l disruption of the melanocortin 1 receptor (MC1R).

213 l population is the melanocortin-1 receptor (MC1R).

214 g downstream of the melanocortin-1 receptor (MC1R).

215 ne, melanocyte stimulating hormone receptor (MC1R), is strongly associated with distinct differences

216 MSH) receptor (melanocortin type 1 receptor [MC1R]) is overexpressed in most murine and human melanom

217 The melanocortin receptor, MC1R, is a key regulator of pigmentation in mammals, and

218 cterized at the mouse melanocortin receptors MC1R and MC3R-MC5R and human melanocytes known to expres

219 activity at the mouse melanocortin receptors MC1R, MC3R, MC4R, and MC5R.

220 activity at the mouse melanocortin receptors MC1R, MC3R, MC4R, and MC5R.

221 fects on the melanocortin 1 and 4 receptors (MC1R and MC4R) in the skin and the brain, respectively,

222 d, whereas exposure to UV radiation reduced, MC1R gene and membrane protein expression.

223 es have used a Mendelian framework to relate MC1R genotype to phenotype, by measuring pigmentary stat

224 We report MC1R-mediated or pharmacologically-induced cAMP signalin

225 these two ligands is potent in the frog skin MC1R assay (EC(50) = 10(-7) M for 9 and EC(50) = 10(-5)

226 d is as potent as alpha-MSH in the frog skin MC1R assay.

227 wide range of bioactivities at the frog skin MC1R; e.g. H-d-Phe-c[Hcy-His-d-Phe-Arg-Trp-Cys]-Thr-NH(2

228 Some MC1R variants have been associated with skin cancer risk

229 g peptide conjugates displaying subnanomolar MC1R binding affinity.

230 that these Gd-Tx micelles are able to target MC1R-expressing xenograft tumors in vitro and in vivo mo

231 times more selective over this receptor than MC1R or MC5R, respectively, and had no detectable bindin

232 We conclude that MC1R genotype may influence post-burn scarring.

233 Our results confirm that MC1R is a low-penetrance susceptibility locus for melano

234 is study aimed to replicate the finding that MC1R variant status predicts dental fear and to determin

235 We have found that MC1R or cAMP signaling also directly decreases prolifera

236 In order to test the hypothesis that MC1R variation has been constrained in Melanesians the c

237 viduals with darker phenotypes indicate that MC1R genotypes specifically provide information about BR

238 The results indicate that MC1R protects by a combination of pigmentary and non-pig

239 These results show that MC1R and cAMP signaling can directly inhibit melanoma gr

240 ependent Caucasian populations, we show that MC1R variants are strongly associated with BRAF mutation

241 Our results suggest that MC1R genetic variants modulate the risk of PD disease in

242 tion and demonstrate for the first time that MC1R isoform-specific expression is closely related to s

243 The MC1R gene also may be etiologically important for fear o

244 The MC1R-Abs were immobilized in amino-functionalized silica

245 Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, we hypot

246 e Trp(9) in the tetrapeptide template at the MC1R resulted in only up to a 220-fold potency change, w

247 nd receptor selectivity were observed at the MC1R.

248 These studies establish the MC1R-PTEN axis as a central regulator for melanocytes' r

249 R and human melanocytes known to express the MC1R.

250 rast agent payloads to tumors expressing the MC1R.

251 enous MC1R agonists lack selectivity for the MC1R and thus can have side effects.

252 hough this suggested a critical role for the MC1R ligand melanocyte stimulating hormone (MSH) in this

253 been successfully developed for imaging the MC1R.

254 Common genetic variants in the MC1R (melanocortin 1 receptor) gene, which determines sk

255 cial age were found for multiple SNPs in the MC1R gene (p < 1 x 10(-7)).

256 A non-synonymous SNP in the MC1R gene (rs1805007 encoding Arg151Cys substitution), a

257 nd two different "in-frame" deletions in the MC1R gene are implicated in melanism in jaguars and jagu

258 2 (OCA2) in all eight, and mutations in the MC1R gene were responsible for the red (rather than yell

259 Genotype-phenotype relations of the MC1R are reviewed, as well as methods to improve the phe

260 ns unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk.

261 s of the MC4R with homologous domains of the MC1R dramatically decreased AGRP 87-132 binding affinity

262 h red hair are homozygous for alleles of the MC1R gene that show varying degrees of diminished functi

263 ined in Melanesians the coding region of the MC1R gene was sequenced in 188 individuals from Northern

264 regulation of expression and activity of the MC1R in primary human melanocyte cultures.

265 f the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 b

266 part by different binding affinities of the MC1R variants for MRAP.

267 18)F-FB-NAPamide specifically recognizes the MC1R in living mice.

268 ease in potency was observed, suggesting the MC1R is more tolerant of the modifications examined here

269 of mouse transgenics to demonstrate that the MC1R signaling pathway influences cancer risk via mechan

270 We found that the MC1R variant p.R160W (rs1805008) is marginally associate

271 ategies in ruffs and other species, thus the MC1R gene is a strong candidate to play a role in altern

272 Therefore, in addition to the MC1R genotype, regulation of MC1R expression and activit

273 Significantly, treatment with the MC1R agonist alpha-MSH or activation of the stress respo

274 MC1R overexpression, treatment with the MC1R ligand, or treatment with small-molecule activators

275 e (alphaMSH, the ligand for MC1R), therefore MC1R variants could alter the autocrine effects of alpha

276 lleles of MC1R; we found that together these MC1R alleles explained 4.1% of variance in skin pattern

277 rize the molecular effects elicited by those MC1R ligands.

278 has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles w

279 dividuals with red hair and fair skin due to MC1R gene variants are at higher risk of cutaneous neopl

280 nces in melanoma cell behaviour secondary to MC1R variants, and suggest an alternative non-pigmentary

281 that trout MRAP interacts with the two trout MC1R variants and MC2R, but failed to detect regulation

282 MC2R function, binds differently to the two MC1R variants.

283 SH significantly reduced growth of wild type MC1R transfected cells, but had no effect on cells trans

284 SH increased intracellular cAMP in wild type MC1R transfected melanoma cells, but the cAMP response w

285 senescence; in the presence of BRAF(V600E), MC1R deficiency-induced elevated PI3K/AKT signaling driv

286 Phylogenetic reconstructions of variant MC1R alleles in geese and skuas show that melanism is a

287 relates with the number of copies of variant MC1R alleles.

288 cAMP response was compromised in the variant MC1R transfected clones.

289 no effect on cells transfected with variant MC1R.

290 e effect in proteinuric glomerulopathies via MC1R-independent mechanisms.

291 non-pigmentary effects in vivo and that when MC1R function is compromised the melanin type in skin is

292 alized upon ligand-receptor binding, whereas MC1R antagonist-conjugated HAuNS remain attached on the

293 alternative non-pigmentary mechanism whereby MC1R variants could modify melanoma susceptibility or pr

294 nvironment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/N

295 nd to determine, for the first time, whether MC1R variant status predicts fear of pain.

296 0.66, 0.78), while that by Smith et al. with MC1R and indoor tanning had an AUC of 0.69 (95% CI: 0.63

297 btype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanom

298 ospheres (HAuNS, diameter=40 nm) coated with MC1R agonist are internalized upon ligand-receptor bindi

299 risk of cutaneous neoplasia, consistent with MC1R having a role in photoprotection.

300 jects underwent pigmentary phenotyping, with MC1R genotyping in 113.