ライフサイエンスコーパス: MCC

1 MCC binding to the second molecule of Cdc20 is mediated

2 MCC binds APC/C-bound CDC20 to inhibit substrate access.

3 MCC formation inhibits the anaphase-promoting complex/cy

4 MCC inhibits the anaphase-promoting complex/cyclosome (A

5 MCC inhibits the ubiquitin ligase anaphase promoting com

6 MCC is a critical checkpoint inhibitor of the anaphase-p

7 MCC is composed of the checkpoint proteins BubR1, Bub3,

8 MCC is composed of the checkpoint proteins Mad2, BubR1,

9 MCC levels in IEC increase in colitis and colitis-associ

10 MCC velocity was most dramatically accelerated by the sy

11 MCC, which contains a second molecule of CDC20, blocks A

12 MCC-K3 also exhibited excellent cyclic stability, facile

13 MCCs frequently contain Merkel cell polyomavirus (MCPyV)

14 A total of 53 of 282 (19%) MCC tumors in this cohort were virus-negative using this

15 utagenic harman was observed (CMC: 1.2-13.2; MCC: 5.2-11.4ng/g) for increasing levels of fibers and a

16 MCV-positive (n = 13) and -negative (n = 21) MCC tumors and cell lines.

17 d for MCC activated with a KOH/C ratio of 3 (MCC-K3).

18 Low-fat patties with 0.5-3% MCC/CMC were prepared using 90% of beef and 10% of an aq

19 g models were approximately as accurate as a MCC model in describing the experimental results.

20 well as a validation cohort of 14 additional MCC cases (n = 16).

21 ent computational studies showed that CC and MCC behavioral patterns could be explained by reinforcem

22 ration and disease, mucus concentrations and MCC were compared with FEV1, and both were significantly

23 erences in the active site region of GCC and MCC explain their distinct substrate preferences.

24 Specific subtype rates for SCC, MM, and MCC were 812, 75, and 2 per 100000 person-years, respect

25 ant skin cancer overall and for SCC, MM, and MCC were calculated per 100000 person-years.

26 icrocrystalline cellulose particles (NCC and MCC, respectively) were prepared, followed by freeze-dry

27 nt roles to play in checkpoint signaling and MCC generation.

28 ession was observed in MCC tumor tissues and MCC cell lines.

29 e more likely to have chronic conditions and MCCs compared with adults without a history of cancer.

30 ributed to individual chronic conditions and MCCs.

31 tal enhancers, they largely bind together at MCC gene promoters.

32 show that Mps1 promotes APC/C inhibition by MCC components through phosphorylating Bub1 and Mad1.

33 3 and p31(comet) prevent APC/C inhibition by MCC components, but cannot reactivate APC/C already boun

34 with this co-regulation, cilia extension by MCCs is more severely compromised in foxn4 and foxj1 dou

35 tructure of a human APC/C-MCC complex (APC/C(MCC)).

36 atomic resolution structure of a human APC/C-MCC complex (APC/C(MCC)).

37 d eisosomes or membrane compartment of Can1 (MCC), which correspond to approximately 200-nm-long furr

38 rboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC).

39 racterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors.

40 ), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ tr

41 Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer w

42 Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor frequently

43 Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine n

44 Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic sk

45 Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendo

46 Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma

47 Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tum

48 o the primary site in Merkel cell carcinoma (MCC) is not uncommon.

49 Merkel cell carcinoma (MCC) tumor cells express several markers detected in nor

50 s (MCPyV) can lead to Merkel cell carcinoma (MCC), a lethal form of skin cancer.

51 s of such pathways in Merkel cell carcinoma (MCC), a rare but lethal cutaneous neuroendocrine (NE) ma

52 majority of cases of Merkel cell carcinoma (MCC), an aggressive skin cancer with a high metastatic p

53 an important role in Merkel cell carcinoma (MCC).

54 initive treatment for Merkel cell carcinoma (MCC).

55 ng the proportion of Merkel cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV)

56 development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms.

57 BCB5) confers resistance to standard-of-care MCC chemotherapeutic agents and provide proof-of-princip

58 mation of the mandibular condylar cartilage (MCC) and its subchondral bone is an important but unders

59 ineage of the mandibular condylar cartilage (MCC) are not well understood.

60 ther the data indicate that the beta-catenin MCC is needed for mucosal repair and carcinogenesis.

61 he Cdc20 subunit intrinsic to the MCC (Cdc20(MCC)) is ubiquitinated, a process that results in APC/C

62 that conformational dynamics of APC/C(CDC20)-MCC modulate E2 activation and determine distinctive ubi

63 als conformational variation of APC/C(CDC20)-MCC underlying this multifaceted regulation.

64 However, rotation about the CDC20-MCC assembly and conformational variability of APC/C mod

65 Multiciliated cell (MCC) differentiation involves extensive organelle biogen

66 Motile multiciliated cells (MCCs) have critical roles in respiratory health and dise

67 Micro- and nano-crystalline cellulose (MCC and NCC, respectively) particles isolated from cellu

68 Microcrystalline cellulose (MCC) or carboxymethyl cellulose (CMC) can be used as fat

69 o high-aspect-ratio, micro-coating channels (MCCs) followed by topical application of powder drug-coa

70 arity to MCC tumor samples, we characterized MCC cell lines via gene expression microarrays.

71 howed impaired airway mucociliary clearance (MCC) and higher pulmonary inflammation at baseline, wher

72 Mucociliary clearance (MCC) in subjects with CB was negatively correlated with

73 Mucociliary clearance (MCC) is a critical host innate defense mechanism in airw

74 Mucociliary clearance (MCC) is a major airway host defence system that is impai

75 d in both established MCC lines and clinical MCC specimens at levels significantly higher than those

76 hich poses a significant barrier to clinical MCC treatment.

77 The HAAs in patties containing CMC(MCC) were found in the following concentrations; MeIQx (

78 ta gave a Matthews' correlation coefficient (MCC) of 0.53 (accuracy, 75%).

79 (ACC) and Matthews Correlation Coefficient (MCC) of Rice_Phospho 1.0 to be 82.0% and 0.64, significa

80 oved by replacing the multicapillary column (MCC) with a capillary column (CC).

81 Microporous carbon compartments (MCCs) were developed via controlled carbonization of whe

82 roduction of the mitotic checkpoint complex (MCC) consisting of BubR1, Bub3, Mad2, and Cdc20.

83 assembly of the mitotic checkpoint complex (MCC) consisting of BubR1-Bub3, Mad2, and Cdc20, which in

84 The mitotic checkpoint complex (MCC) coordinates proper chromosome biorientation on the

85 The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and

86 Bub3 to form the mitotic checkpoint complex (MCC), a potent inhibitor of the anaphase-promoting compl

87 int is active, a mitotic checkpoint complex (MCC), composed of the checkpoint proteins Mad2, BubR1, B

88 inhibited by the Mitotic Checkpoint Complex (MCC), which assembles when the checkpoint is activated.

89 roduction of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 to inactivate the Anaphase Pr

90 porated into the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cycl

91 AC generates the mitotic checkpoint complex (MCC), which inhibits the APC/C and delays chromosome seg

92 the form of the mitotic checkpoint complex (MCC), with the APC/C. apc14Delta mutants display increas

93 /C(Cdc20) is the mitotic checkpoint complex (MCC).

94 mplex called the mitotic checkpoint complex (MCC).

95 formation of the mitotic checkpoint complex (MCC: Cdc20-Mad3-Mad2 [13-15]).

96 eate a novel multiprotein cytosolic complex (MCC) involved in beta-catenin signaling in the intestine

97 g produces the "mitotic checkpoint complex" (MCC), which prevents anaphase by targeting Cdc20, the ac

98 reduced on a dataset of transient complexes (MCC=0.303).

99 a new class of metal-coordination complexes (MCCs) as anolytes for NRFBs.

100 and asthma) and multiple chronic conditions (MCCs) and the incremental annual health care use, medica

101 ns are managing multiple chronic conditions (MCCs), and trends are particularly alarming in youth.

102 In contrast, MCC blending augmented the specific surface area and por

103 ariant called moody conditional cooperation (MCC), with which they basically tend to cooperate when m

104 ng to Mad2 and Mad3/BubR1 (forming the "core MCC") and the other one (Cdc20(A)) through additional bi

105 tion: (1) sequestration of Cdc20 in the core MCC, sufficient at low Cdc20 concentrations; (2) inhibit

106 the bilateral ACC, median cingulate cortex (MCC) and right SFG.

107 Malformations of the cerebral cortex (MCCs) are devastating developmental disorders.

108 The cell line designated CTC-MCC-41 has been cultured for more than one year, and the

109 This thorough analysis showed that CTC-MCC-41 cells resemble characteristics of the original tu

110 , the development of an additional cutaneous MCC tumor is clinically consistent with a second primary

111 nd 'bulk' drug powder inside relatively deep MCCs are crucial to induce the sustained drug release.

112 to initiate development of epidermis-derived MCC-like tumors in mice.

113 is a specific feature of well-differentiated MCC cell lines that express NE markers.

114 , may promote viral infection and thus drive MCC.

115 4 complements Foxj1 transcriptionally during MCC differentiation, thereby shaping the levels of gene

116 Mutating these motifs eliminates MCC binding to the APC/C, thereby abolishing the SAC and

117 n4 activity is inhibited in Xenopus embryos, MCCs show transient ciliogenesis defects similar to thos

118 expression was detected in both established MCC lines and clinical MCC specimens at levels significa

119 e Drosophila cell polarity gene lgl, exhibit MCCs resembling severe periventricular heterotopia (PH).

120 ABCB5-expressing MCC cells in heterogeneous cancers preferentially surviv

121 thods with improvement between 0.02-0.07 for MCC, 4.18-21.47% for ST and 0.013-0.131 for AUC.

122 for binding of the MCC to the APC/C and for MCC disassembly.

123 reas UISO xenograft tumors were atypical for MCC.

124 am checkpoint signals and is dispensable for MCC assembly.

125 atients undergoing (18)F-FDG PET imaging for MCC between January 1997 and October 2010 at the Peter M

126 ght decrease of the content of norharman for MCC (0.5-1.6ng/g).

127 mol kg(-1) at 25 degrees C were obtained for MCC activated with a KOH/C ratio of 3 (MCC-K3).

128 APC/C and whether Mad2 is required only for MCC assembly and not for its action on the APC/C.

129 downstream target of Multicilin required for MCC differentiation in Xenopus skin.

130 -p31(comet) intercepts and disassembles free MCC not bound to APC/C through mediating the local unfol

131 TP-dependent factor that releases Cdc20 from MCC and identified it as chaperonin containing TCP1 or T

132 fidence interval = 1.20-2.62) and death from MCC (hazard ratio = 1.85, 95% confidence interval = 1.19

133 MCPyV isolated from MCC typically contains wild-type ST but truncated forms

134 We also found that the release of Mad2 from MCC caused a marked (although not complete) decrease in

135 vious work showed that Mad2 is released from MCC by the joint action of the TRIP13 AAA-ATPase and the

136 scents with asthma in the US who suffer from MCCs have increased asthma symptoms, missed school days,

137 es (UISO, MCC13, and MCC26) and fresh frozen MCC tumors.

138 le; and (3) occupancy of the APC/C with full MCC, where Mad3 and Apc15 are involved.

139 may be a major proximate mechanism governing MCC behavior.

140 revisiae - KF551990 and Pichia gummiguttae - MCC 1273) and influence of jamun seeds on the physico-ch

141 verse asthma outcomes associated with having MCCs.

142 riae 2 + 3 (FIMs), diphtheria, tetanus, Hib, MCC and PCV13 serotypes were compared to responses in a

143 boplatin and etoposide in vitro and in human MCC xenograft-bearing mice in vivo.

144 nciple that ABCB5 blockade can inhibit human MCC tumor growth through sensitization to drug-induced c

145 reconstitution studies have shown that human MCC-APC/C can contain two molecules of Cdc20 [5-7].

146 d structural studies revealed that the human MCC binds two Cdc20 molecules, one (Cdc20(M)) through we

147 tients 18 years or older with stage I to III MCC of the extremities and/or trunk treated with definit

148 for extremities and/or trunk stage I to III MCC, with OS equivalent to that found at higher-dose reg

149 To illustrate MCC-Seq, we use whole-genome bisulfite sequencing on adi

150 a novel therapeutic regimen to help improve MCC in smoking-related chronic bronchitis.

151 tility of this molecular target for improved MCC therapy.

152 allele-specific expression (ASE) analysis in MCC gene.

153 three groups, highest frequencies of ASE in MCC were concordantly found in CRC group, whereas lowest

154 differentiation and cancer cell behavior in MCC.

155 mutant lacking these motifs is defective in MCC maintenance in mitotic human cells but is capable of

156 s suggest a potential ontologic dichotomy in MCC, characterized by either viral-dependent or UV-depen

157 n has emerged as the key oncogenic driver in MCC carcinogenesis.

158 ablished that miR-375 is highly expressed in MCC tumors, but its biological role in MCC remains unkno

159 To determine TrkA expression in MCC as a rationale for potential targeted therapy.

160 -infiltrating lymphocytes (TIL) and PD-L1 in MCC tumors.

161 ibitory action, suggesting a role of Mad2 in MCC for APC/C inhibition.

162 lish ABCB5 as a chemoresistance mechanism in MCC and suggest utility of this molecular target for imp

163 duced HLA class-I expression was observed in MCC tumor tissues and MCC cell lines.

164 but the role of these putative oncogenes in MCC development, and this tumor's cell of origin, are un

165 oration of new targeted treatment options in MCC, especially for patients who do not respond to anti-

166 sidue in GCC is replaced by phenylalanine in MCC, which blocks access by the larger geranyl-CoA subst

167 ed in MCC tumors, but its biological role in MCC remains unknown.

168 APC/C. apc14Delta mutants display increased MCC association with the APC/C and are unable to silence

169 n budding yeast, APC:Cdc20 and its inhibitor MCC at the mitotic checkpoint, and PP2A:B55 and its inhi

170 ssion mimicking that of human intraepidermal MCC.

171 yses and complete ciliary rescue of knockout MCCs identify TAp73 as the conserved central transcripti

172 -talk, we have synthesized bivalent ligands (MCC series) that contain mu opioid agonist and CCR5 anta

173 y (RT) dose following resection of localized MCC of the extremities or trunk.

174 s, whereas WaGa and Mkl-1 more closely model MCC.

175 helial fluid secretion and absorption modify MCC velocity (MCCV).

176 Most MCC tumors contain integrated copies of the viral genome

177 Our University of Michigan Multidisciplinary MCC Program database was used to obtain characteristics

178 C were identified from the multidisciplinary MCC Program at the University of Michigan, a tertiary ca

179 the molecular pathogenesis of MCPyV-negative MCC is largely unexplored.

180 ve sequencing on two cases of MCPyV-negative MCC, as well as a validation cohort of 14 additional MCC

181 nto the underlying biology of viral-negative MCC and paves the road for further investigation into ne

182 s with virus-positive tumors, virus-negative MCC patients had significantly increased risk of disease

183 driven by MCPyV and that such virus-negative MCCs, which can be quite reliably identified by immunohi

184 This novel MCC may be an attractive therapeutic target in preventin

185 inds to both Cdc20 and Mad2, thus nucleating MCC formation.

186 We observed MCC behavior in both games, but the MCC that we observed

187 To determine the oncogenic activity of MCC tumor-derived T antigens in vivo, a conditional, tis

188 trumentation types promoting the adoption of MCC-IMS technology in a wide range of diverse applicatio

189 is developed and employed in the analysis of MCC-IMS spectra from 264 breath and ambient air samples.

190 he intermediary processes in the assembly of MCC are not sufficiently understood.

191 The assembly of MCC in active checkpoint is initiated by the conversion

192 ical design principles for future classes of MCC-based anolytes.

193 Diagnosis of MCC was confirmed by staining positive for cytokeratin 2

194 , and motility during the differentiation of MCC progenitors.

195 Conversely, the disassembly of MCC that takes place when the checkpoint is turned off i

196 ATPase promotes the complete disassembly of MCC, necessary for the inactivation of the mitotic check

197 mooligomers, also promote the disassembly of MCC.

198 l enable detailed, mechanistic dissection of MCC generation and checkpoint silencing.

199 ion also alleviated CS-induced impairment of MCC, CS-induced pulmonary inflammation and CS-associated

200 ced pulmonary inflammation and impairment of MCC.

201 polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV small and l

202 s (MCV) has been implicated in a majority of MCC tumors; however, viral-negative tumors have been rep

203 role in ongoing post-treatment management of MCC.

204 d in human cells by independent mediators of MCC-APC/C binding.

205 Different moieties of MCC are disassembled by different ATP-requiring processe

206 he virus and the highly metastatic nature of MCC.

207 pression and the highly metastatic nature of MCC.

208 , provide insight into the cell of origin of MCC, and suggest that miR-375 silencing may promote aggr

209 Due to their large data size, processing of MCC-IMS spectra is still the main bottleneck of data ana

210 ng multiple primary MCCs from progression of MCC clinically resembling multiple primaries, allowing a

211 sition TAp73 as a novel central regulator of MCC differentiation.

212 d MCC26 cell lines are not representative of MCC tumors, whereas WaGa and Mkl-1 more closely model MC

213 ata analysis strategies in which the size of MCC-IMS data is reduced to enable further analysis.

214 A previously unknown species of MCC, which consists of Mad2, BubR1, and two molecules of

215 ot clear whether or not some subcomplexes of MCC inhibit the APC/C and whether Mad2 is required only

216 rther binds and disassembles subcomplexes of MCC that lack Mad2.

217 sely represented the global transcriptome of MCC tumors.

218 C modulate UBE2C-catalyzed ubiquitination of MCC's CDC20 molecule.

219 We confirm that approximately 20% of MCCs are not driven by MCPyV and that such virus-negativ

220 KOH activation of MCCs was conducted at 700 degrees C with varying mass ra

221 When the checkpoint signal is turned off, MCC is disassembled, a process required for exit from ch

222 le the impact of MCV and viral T-antigens on MCC development has been extensively investigated, littl

223 opomyosin receptor kinase A was expressed on MCC tumor cells in 100% of evaluable specimens.

224 ry, restoration of HLA class-I expression on MCC cells by epigenetic priming is an attractive approac

225 s restored HLA class-I surface expression on MCC cells.

226 olding compounds, the impact of added CMC or MCC was studied concerning the formation of heterocyclic

227 AA-levels with increasing addition of CMC or MCC.

228 1 or 2 meningococcal C vaccine (MCC-CRM- or MCC-TT) doses at 3-4 months had blood samples taken at 2

229 To establish overall survival (OS), MCC-specific survival (MCCSS), and disease-free survival

230 of obligate complexes enhanced performance (MCC=0.381) while performance is somewhat reduced on a da

231 having slightly better overall performance (MCC=0.410, ACC=0.759, SPEC=0.783, SENS=0.676), but consi

232 nts yields essentially the same performance (MCC of 0.43) as a method that was specifically trained f

233 rticularly badly, increased the performance (MCC = 0.61, Acc = 79%).

234 es of clinically designated multiple primary MCC were characterized by tumor sequencing and targeted

235 with clinically designated multiple primary MCC were identified from the multidisciplinary MCC Progr

236 es of clinically designated multiple primary MCC were identified; 4 cases met inclusion criteria for

237 clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has

238 ion for 55 men and 49 women with 105 primary MCCs was obtained; 19 patients developed recurrent disea

239 tcome measures for 104 patients (105 primary MCCs) with tumors less than 2 cm in diameter.

240 is useful in distinguishing multiple primary MCCs from progression of MCC clinically resembling multi

241 h the clinical diagnosis of multiple primary MCCs.

242 For tumor progression MCC has to escape the host's immuno-surveillance, e.g. b

243 ein p31(comet) and the ATPase TRIP13 promote MCC disassembly and checkpoint silencing.

244 approximately 0.71) and TATA-less promoters (MCC approximately 0.80, F1-score approximately 0.89 vers

245 prediction program for both TATA promoters (MCC approximately 0.84 and F1-score approximately 0.91 v

246 by numerous groups have failed to reproduce MCC in mice using oncoproteins from this polyomavirus.

247 Carboplatin- and etoposide-resistant MCC cell lines exhibited increased expression of ABCB5,

248 Importantly, ABCB5 blockade reversed MCC drug resistance and impaired tumor growth in xenotra

249 In selected MCC patients with primary tumors less than 2 cm in diame

250 bined with multicapillary column separation (MCC-IMS) is a well-known technology for detecting volati

251 ective approach, methylC-capture sequencing (MCC-Seq), for sequencing functional methylomes, while si

252 ulation of airway surface hydration may slow MCC in CB and contribute to disease pathogenesis.

253 mediated secretion (and possibly synergistic MCC) is lost, ENaC inhibition via exogenous agents may p

254 Our study demonstrates that MCC-Seq provides comparable accuracy to alternative appr

255 We provide a first indication that MCC might confer alterative genetic susceptibility to CR

256 This suggests that MCC risk factors such as UV radiation and aging, which a

257 The MCC contains p85alpha, the class IA subunit of PI3K, alo

258 The MCC-like tumor phenotype was dependent on the FBXW7-bind

259 ffusible 'wait anaphase' signal could be the MCC itself, and explain how reactivating the SAC can rap

260 ants display reduced association between the MCC and APC/C, are defective in poly-ubiquitination of C

261 Both the MCC and NCC particles were rod-shaped and had higher cry

262 observed MCC behavior in both games, but the MCC that we observed was different from that observed in

263 n of individual complex members disrupts the MCC and reduces beta-catenin signaling.

264 ntified ABBA motif class are crucial for the MCC to recognize active APC/C-Cdc20.

265 amino-terminal KEN box required to form the MCC.

266 se that the ABBA-KEN-ABBA cassette holds the MCC onto the APC/C by binding the two Cdc20 molecules in

267 We show how the MCC inhibits active APC/C and that this is essential for

268 eased expression of pSMAD158 and VEGF in the MCC and subchondral bone.

269 /C by binding the two Cdc20 molecules in the MCC-APC/C complex.

270 This case series study investigated the MCC specimens of 55 patients treated at the Department o

271 Degron-like sequences of the MCC subunit BubR1 block degron recognition sites on Cdc2

272 ind additionally required for binding of the MCC to the APC/C and for MCC disassembly.

273 ycan distribution, and mineralization of the MCC.

274 To investigate the role of I-PTH on the MCC and subchondral bone, we carried out our studies usi

275 mens expressed CK20 and synaptophysin on the MCC tumor cells (100% expression).

276 Under this paradigm, the MCC and its underlying bone are thought to result from 2

277 surface hydroxyl groups on the NCC than the MCC particles and complete digestion of hemicellulose on

278 Here, we show that the MCC can inhibit a second CDC20 that has already bound an

279 shows how the Cdc20 subunit intrinsic to the MCC (Cdc20(MCC)) is ubiquitinated, a process that result

280 but cannot reactivate APC/C already bound to MCC.

281 -Cdc20 interaction indirectly contributes to MCC homeostasis.

282 nism that is parallel, but not redundant, to MCC formation.

283 d immunosuppression showed that, relative to MCC patients with virus-positive tumors, virus-negative

284 beta6 holoenzyme of GCC, which is similar to MCC but strikingly different from PCC.

285 To determine their similarity to MCC tumor samples, we characterized MCC cell lines via g

286 lated in highly aggressive, undifferentiated MCC cell lines.

287 4 months and 1 or 2 meningococcal C vaccine (MCC-CRM- or MCC-TT) doses at 3-4 months had blood sample

288 ely 0.80, F1-score approximately 0.89 versus MCC approximately 0.29 and F1-score approximately 0.50).

289 0.84 and F1-score approximately 0.91 versus MCC approximately 0.51 and F1-score approximately 0.71)

290 plexes, our IntPred predictor performs well (MCC=0.370, ACC=0.811, SPEC=0.916, SENS=0.411) and compar

291 yed by human participants to examine whether MCC is observed across different types of game and the p

292 It is unclear whether MCC suffices to inhibit all cellular APC/C.

293 highly metastatic phenotype associated with MCC.

294 immunophenotypical features consistent with MCC, whereas UISO xenograft tumors were atypical for MCC

295 The data obtained with MCC-IMS and CC-IMS were evaluated, studying both the glo

296 Moreover, patients with MCC also exhibited enhanced ABCB5 positivity after carbo

297 Our findings suggest that patients with MCC may develop a second genetically distinct primary tu

298 ) relationships in a cohort of patients with MCC.

299 after definitive treatment in patients with MCC.

300 We first genotyped four polymorphisms within MCC in 312 CRC patients, 270 schizophrenia patients and