ライフサイエンスコーパス: MCH receptor

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1 based model of the recently identified human MCH receptor.

2 tors (melanocortin receptors) and one or two MCH receptors.

3 nd functional assays on cells expressing the MCH receptors.

4 ue to lack of identification of hypothalamic MCH receptors.

5 tic manipulation studies in mice at both the MCH receptor 1 (MCHR1) as well as the MCH peptide levels

6 is a hypothalamic neuropeptide that acts via MCH receptor 1 (MCHR1) in the mouse.

7 ic neuropeptide that acts in rodents via the MCH receptor 1 (MCHR1) to regulate a wide variety of phy

8 Furthermore, administration of the MCH receptor-1 antagonist GSK-856464 [4-(4-ethyl-5-methy

9 In this study, we used MCH receptor-1 knock-out (MCHR1 KO) and wild-type (WT) m

10 We conclude that both Asp(123)(3.32) in the MCH receptor and Arg(11) in the MCH peptide are required

11 have analysed the tissue localization of the MCH receptor and find that it is expressed in several br

12 es sleep, drug abuse behavior, and mood, and MCH receptor antagonists are currently being developed a

13 Antagonists of the MCH receptor are expected to affect food intake and weig

14 s in non-neuronal cells transfected with the MCH receptor gene.

15 sing non-neuronal cells transfected with the MCH receptor gene; these cells exhibited an increase in

16 trating hormone (MCH) are obese and a second MCH receptor has been identified.

17 as been hampered because the identity of the MCH receptor has been unknown until now.

18 ude that MCH1R is a physiologically relevant MCH receptor in mice that plays a role in energy homeost

19 fied the full complement of melanocortin and MCH receptors in both zebrafish and the pufferfish, Fugu

20 However, the wide distribution of MCH receptors in peripheral tissues suggests additional

21 n receptor, SLC-1, has been identified as an MCH receptor (MCH-R1).

22 The rodent MCH receptor (MCH1R) is highly expressed in the nucleus

23 coupled receptor SLC-1 was identified as the MCH receptor (MCHR).

24 an phenotype, as does ablation of the rodent MCH receptor, MCHR-1.

25 MCH receptor (MCHR1) activation in the AcbSh increases f

26 In addition, the MCH receptor (MCHR1) was coexpressed on about 50-55% of

27 ting hormone (MCH) as ligands for both human MCH receptors (MCHR1 and MCHR2).

28 Genetic activation of MCH receptors or infusion of MCH specifically in the lat

29 nds to and activates equally well both human MCH receptors present in the brain.

30 We showed that the activation of MCH receptors promotes nonalcoholic fatty liver disease

31 eurons send numerous projections to multiple MCH receptor-rich targets with presumed roles in sensory

32 sms, indicating that therapies targeting the MCH receptor should act on the neuronal regulation of fo

33 In addition, we demonstrate that the MCH receptor SLC-1 is expressed in adipocytes, suggestin

34 ation of a G protein-coupled receptor as the MCH receptor subtype 2 (MCHR2).

35 ies for further evaluation that express both MCH receptor subtypes.

36 report the identification of a second human MCH receptor termed MCH-2R, which shares about 38% amino

37 colonic epithelial cells express functional MCH receptors, the activation of which induces IL-8 expr

38 se monocytic cells, which express endogenous MCH receptor, we found that treatment with MCH enhanced

39 bility to bind to and activate the wild-type MCH receptor, whereas [Ala(11)]-MCH displayed a 3000-fol

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