ライフサイエンスコーパス: MCM6

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1 , DNA primase (PRIM1), and minichromosome 6 (MCM6).

2 n autoinhibitory domain in the C terminus of Mcm6.

3 ubs of connectivity: CDC2, CHEK1, CDC45L and MCM6.

4 of lactase in an intron of the adjacent gene MCM6.

5 osome maintenance (MCM) complex of proteins, MCM6.

6 f the pre-replicative complex proteins ORC2, MCM6 and Cdc6 to telomeric DNA.

7 2 for systolic and diastolic blood pressure, MCM6 and DARS for total cholesterol, and TRIB1 for trigl

8 tified DDK phosphorylation sites on Mcm4 and Mcm6 and found that phosphorylation of either subunit su

9 mutational analysis in the Walker A motif of MCM6 and MCM7 of MCM2-7, we show that ATP binding and/or

10 mily, co-isolates through several steps with MCM6 and MCM7, and MCM8 co-immunoprecipitates with MCM4,

11 7, and MCM8 co-immunoprecipitates with MCM4, MCM6 and MCM7, proteins reportedly forming a helicase co

12 with numerous replication factors, including MCM6 and RPA, the latter of which limits the hypoxia-ind

13 g coimmunoprecipitation, we find that Mis5p (MCM6) and Cdc21p (MCM4) are tightly associated with one

14 sequence in an intron of a neighboring gene (MCM6) and modulate lactase transcription in vitro.

15 es associated with FDG uptake (LY6E, RNF149, MCM6, and FAP) were also associated with survival.

16 With the exception of Mcm4, Mcm6, and Psf1, knockdown of individual CMG genes inhibi

17 alysis suggests that CDC2, CHEK1, CDC45L and MCM6 are key players in mediating the biological activit

18 Remarkably, ORC and Mcm6 associated with just the ARS1-A replicator in G(1)

19 We find that MCM6 associates with other MCM subunits during amplifica

20 reover, phosphomimicking mutants in Mcm4 and Mcm6 bind Sld3 without DDK and facilitate DDK-independen

21 the Mcm4(Chaos3) allele, which disrupts MCM4:MCM6 interaction, triggers a Dicer1 and Drosha-dependent

22 evolutionary history in Africa, we sequenced MCM6 introns 9 and 13 and ~2 kb of the LCT promoter regi

23 ted in 8,790 independent EA individuals, and MCM6/LCT and SLC5A10 were also associated among AA.

24 Seven loci in/near EFNA1/SLC50A1, MCM6/LCT, SI, MGAM, MGAM2, SLC5A10, and SLC5A1 showed ge

25 n that MCM2 interacts directly with MCM5 and MCM6; MCM5 with MCM3 and MCM2; and MCM6 with MCM2 and MC

26 We studied the mechanism of the Mcm4-Mcm6-Mcm7 complex, a useful model system because this co

27 The Mcm4/Mcm7 and Mcm4/Mcm6/Mcm7 assemblies can open to load onto circular DNA

28 7 results in the formation of an active Mcm4/Mcm6/Mcm7 helicase assembly.

29 steric exclusion mechanism, similar to Mcm4/Mcm6/Mcm7.

30 into MCM complexes and differs from maternal MCM6 (mMCM6) in having a carboxy-terminal extension and

31 Lethal alleles of MCM6 reveal it is essential for mitotic cycles and endoc

32 The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly ass

33 Although MCM6-rs3754686 is a good milk intake proxy in these popu

34 The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) w

35 ichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy i

36 site for Mcm10 on MCM includes the Mcm2 and Mcm6 subunits and overlaps that for the loading factor C

37 es dephosphorylation, and the Mcm2, Mcm3, or Mcm6 subunits are then actively phosphorylated by kinase

38 The addition of Mcm6 to Mcm4/Mcm7 results in the formation of an active

39 MCM5 and MCM6; MCM5 with MCM3 and MCM2; and MCM6 with MCM2 and MCM4.

40 developmentally regulated mcm gene, zygotic mcm6 (zmcm6), expressed only after gastrulation when the

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