ライフサイエンスコーパス: MCMV

1 MCMV activated the PERK-ATF4 pathway but only induced a

2 MCMV commandeers patrolling monocytes to mediate systemi

3 MCMV D+/R- and D-/R- allogeneic transplants were perform

4 MCMV infection exacerbates late renal allograft damage a

5 MCMV infection increased phosphorylated STAT3 (p-STAT3)

6 MCMV infection increased the expression of chemokines th

7 MCMV infection initially reduced the numbers of LCMV-spe

8 MCMV mutants lacking M45 or expressing C-terminally trun

9 MCMV-infected grafts contained greater frequencies of NK

10 MCMV-infected Mut3 mice exhibited a shorter survival tim

11 MCMV-memory NK cells did not display enhanced activation

12 At day 42, MCMV-infected transplants had higher damage scores (15.6

13 A MCMV mutant lacking the PVR inhibitor was attenuated in

14 increased IFN-gamma was evident during acute MCMV infection in vivo.

15 We found that acute MCMV infection increased rapid T cell recruitment to the

16 operly through TLR3, TLR7 and TLR9, to acute MCMV infection to determine whether liver antiviral defe

17 After MCMV infection, Ly49D augmented IFN-gamma production by

18 oid and nonlymphoid tissues for months after MCMV infection, IL-12 receptor-deficient NK cells failed

19 and were unable to mediate protection after MCMV challenge.

20 oduce high levels of IFN-gamma rapidly after MCMV infection.

21 mechanisms mediate T cell recruitment after MCMV infection.

22 both lymphoid and nonlymphoid tissues after MCMV infection.

23 ed for NK cell-mediated host defense against MCMV infection.

24 and are beneficial for host defense against MCMV infection.

25 K cells in C57L mice fail to protect against MCMV infection.

26 itopes to vaccinate mice and protect against MCMV.

27 K cells showed diminished protection against MCMV infection and exhibited more apoptosis compared wit

28 ubset also confers better protection against MCMV infection compared with the NKR-P1B(+)Ly49H(+) subs

29 us, EBI3 dampens the immune response against MCMV infection, resulting in prolonged viral persistence

30 ly M45 gene provided no protection, although MCMV vectors expressing the high-avidity epitope SSIEFAR

31 t as effectively as WT memory NK cells in an MCMV challenge model.

32 The identification of an MCMV gene involved in cell rounding provides the basis f

33 on complete loss of genome replication of an MCMV mutant carrying a deletion of the ie3-specific exon

34 This prompted the construction of an MCMV mutant lacking ie611 but retaining the coding capac

35 transcripts prompted the construction of an MCMV mutant lacking ie611 but retaining the coding capac

36 DCs infected with an MCMV strain encoding the gB498 epitope from HSV-1 were u

37 We found that human CMV- and MCMV-specific T cells displayed shared genetic programs,

38 of MCMV infection, the infectious dose, and MCMV gene expression but was independent of IFNAR1, IL-1

39 ablish CD8(+) T cell memory to influenza and MCMV infection.

40 nfection allows presentation of SIINFEKL and MCMV-derived Ags by different cells within the same anim

41 MV UL128 homologue) and r131 (HCMV UL130 and MCMV m129/130 homologues).

42 subsets on anti-murine cytomegalovirus (anti-MCMV) responses after syngeneic hematopoietic stem cell

43 early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and

44 more complex with a persistent virus such as MCMV.

45 ivity to the technique, interactions between MCMV, a glycoprotein-specific primary antibody to MCMV,

46 NK cells, which can be directly activated by MCMV protein m157, preferentially proliferated during MC

47 ese viral receptors, the M33 GPCR carried by MCMV is an activator of CREB, NF-kappaB, and phospholipa

48 data indicate that activation of NK cells by MCMV provides early nonspecific protection against M. tu

49 n induction of STAT3 Y705 phosphorylation by MCMV.

50 Here, we identify a transcript produced by MCMV that binds to miR-27 and mediates its degradation.

51 ion, Ly49D augmented IFN-gamma production by MCMV-specific Ly49H(+) NK cells and preferentially promo

52 strate that MHC-I mimicry strategies used by MCMV to avoid NK cell control are biologically relevant

53 Here, we demonstrate that mouse CMV (MCMV) also down-regulates the surface PVR.

54 CD4 T cell responses specific for mouse CMV (MCMV) epitopes and use a major histocompatibility comple

55 ia monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-in

56 The CC chemokine MCK-2 encoded by mouse CMV (MCMV) has an atypical structure consisting of a classic

57 a robust primary response during mouse CMV (MCMV) infection but do not require this signal for memor

58 However, mouse CMV (MCMV) infection recently was shown to bypass the require

59 of direct versus cross priming in mouse CMV (MCMV) infection using recombinant viruses.

60 The outcome of mouse CMV (MCMV) infection varies among different inbred mouse stra

61 ed for immune-mediated control of mouse CMV (MCMV) infection.

62 pitope KCSRNRQYL, and show that a mouse CMV (MCMV) vector provides complete immune control of recombi

63 We have previously characterized mouse CMV (MCMV)-encoded immune-evasive IFN signaling inhibition an

64 We assessed the ability of mouse CMV (MCMV)-induced memory Ly49H(+) NK cells to respond to cha

65 ulators of innate defense against mouse CMV (MCMV).

66 its the early innate response to murine CMV (MCMV) but is essential for the optimal generation of vir

67 ed an m1-m16-deleted recombinant murine CMV (MCMV) expressing Mycobacterium tuberculosis Ag 85A to sh

68 erized the role of the conserved murine CMV (MCMV) gene M79.

69 ry inflation, first described in murine CMV (MCMV) infection, is characterized by the accumulation of

70 months in mice with established murine CMV (MCMV) infection.

71 immune defense against human and murine CMV (MCMV) infection.

72 inct phases of activation during murine CMV (MCMV) infection: a nonselective phase mediated by proinf

73 served, as a similar sequence in murine CMV (MCMV) intron A was found to interact with CTCF and simil

74 Here, we used the murine CMV (MCMV) model of infection to determine that IFITM3 limits

75 V infections is reflected in the murine CMV (MCMV) model.

76 toma, we assessed the effects of murine CMV (MCMV) perinatal infection in a GFAP-cre; Nf1(loxP/+); Tr

77 Using murine CMV (MCMV) recombinants expressing a single CD8 T cell epitop

78 In a murine CMV (MCMV) renal transplantation model, ganciclovir prophylax

79 essing NK cells are essential to murine CMV (MCMV) resistance in MA/My mice.

80 imilar DNA sequence was found in murine CMV (MCMV) that is required for CTCF to bind to MCMV MIE gene

81 e that were infected or not with murine CMV (MCMV), a herpesvirus that infects the salivary gland and

82 demonstrate that infections with murine CMV (MCMV), but not with lymphocytic choriomeningitis virus,

83 ity against the mouse homologue, murine CMV (MCMV), in lethally irradiated mice given allogeneic puri

84 e this, we designed recombinant murine CMVs (MCMVs) encoding a SIINFEKL-enhanced GFP fusion protein u

85 LCMV-specific memory T cells, but continued MCMV persistence did not further erode memory T cells sp

86 d G2(+) NK cells might recognize and control MCMV infection.

87 beyond their recognized role in controlling MCMV replication, NK cells preserve organ integrity and

88 by the mouse innate immune system to counter MCMV.

89 f deletion mutants of mouse cytomegalovirus (MCMV) a mutant was identified that did not elicit cell r

90 -stranded DNA viruses mouse cytomegalovirus (MCMV) and human adenovirus.

91 ne cells critical for mouse cytomegalovirus (MCMV) clearance.

92 The mouse cytomegalovirus (MCMV) immediate early 3 protein (611 amino acids; pIE611

93 Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the m

94 e NK cell response to mouse cytomegalovirus (MCMV) infection by comparing the activation and differen

95 vated NK cells during mouse cytomegalovirus (MCMV) infection in response to signals from the proinfla

96 During mouse cytomegalovirus (MCMV) infection, the first wave of type I interferon (IF

97 mouse NK cells during mouse cytomegalovirus (MCMV) infection.

98 cell formation after mouse cytomegalovirus (MCMV) infection.

99 ed memory cells after mouse cytomegalovirus (MCMV) infection; therefore, we examined the role of Bim

100 -) mice infected with mouse cytomegalovirus (MCMV) or recombinant viruses expressing the viral m157 g

101 AIM2 inflammasome by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require

102 epitopes derived from mouse cytomegalovirus (MCMV) that are recognized by CD4 T cells in BALB/c mice,

103 red for resistance to mouse cytomegalovirus (MCMV), as identified through unbiased genetic screening.

104 In infections with mouse cytomegalovirus (MCMV), MCMV-specific NK cells undergo clonal expansion,

105 e recent studies: (i) mouse cytomegalovirus (MCMV)-induced memory; (ii) cytokine-induced memory; and

106 is indispensible for mouse cytomegalovirus (MCMV)-specific NK cell expansion and generation of memor

107 rine betaherpesvirus, mouse cytomegalovirus (MCMV).

108 s were infected with murine cytomegalovirus (MCMV) after birth at 2 days (P2) or 4 weeks of age and t

109 persistent viruses, murine cytomegalovirus (MCMV) and lymphocytic choriomeningitis virus (LCMV; Cl13

110 host immune system, murine cytomegalovirus (MCMV) encodes three proteins that modulate cell surface

111 mic infection with a murine cytomegalovirus (MCMV) engineered to express HEL induced extensive prolif

112 f cytomegaloviruses, murine cytomegalovirus (MCMV) has been used as a model for in vivo studies of HC

113 of mouse cells with murine cytomegalovirus (MCMV) induces the rapid down-regulation of an antiviral

114 necrosis induced by murine cytomegalovirus (MCMV) infection or death receptor activation and suppres

115 Murine cytomegalovirus (MCMV) infection severely impaired saliva secretion indep

116 ed susceptibility to murine cytomegalovirus (MCMV) infection.

117 microglia following murine cytomegalovirus (MCMV) infection.

118 tently infected with murine cytomegalovirus (MCMV) into NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /Szj mice re

119 e hepatotropic virus murine cytomegalovirus (MCMV) involves complex cytokine and cellular interaction

120 ollision of a single murine cytomegalovirus (MCMV) on a platinum ultramicroelectrode (UME, radius of

121 hastic collisions of murine cytomegalovirus (MCMV) on ultramicroelectrodes (UMEs), extending the obse

122 espond to a specific murine cytomegalovirus (MCMV) protein and that in the absence of T and B cells,

123 tudy, we report that murine cytomegalovirus (MCMV) protein pM92 regulates viral late gene expression

124 Murine cytomegalovirus (MCMV) rapidly induces activation of nuclear factor kappa

125 odel of experimental murine cytomegalovirus (MCMV) retinitis in mice with retrovirus-induced immunosu

126 g primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replicati

127 In this study, murine cytomegalovirus (MCMV) was used as a persistent infection model to study

128 he protease (mPR) of murine cytomegalovirus (MCMV), which is essential for viral replication.

129 edly enhanced by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2, which promotes recruit

130 Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necro

131 This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector f

132 tis virus (LCMV) and murine cytomegalovirus (MCMV).

133 K cells in a mouse model of cytomegalovirus (MCMV) infection.

134 Using Deltaie611 MCMV, we demonstrated the dispensability of the canonica

135 Using Deltaie611 MCMV, we demonstrated the dispensability of the canonica

136 of infection with m157-deletant (Deltam157) MCMV was improved in mice carrying H-2 molecules unrecog

137 T cell epitope from HSV-1 fused to different MCMV genes, we show that magnitude and kinetics of T cel

138 During MCMV infection, NK cells required MyD88, but not IL-1R,

139 During MCMV infection, the NKR-P1B(-)Ly49H(+) NK cell subset pr

140 gamma compared with Sca-1(-) NK cells during MCMV infection.

141 In contrast, during MCMV infection, NK cell responses to cytokines remained

142 omoting early liver antiviral defense during MCMV infection.

143 (as well as KLRG1) on NK cells early during MCMV infection, differential expression of Sca-1, as wel

144 in Eri1 failed to expand efficiently during MCMV infection, and virus-specific responses were also d

145 The numbers of NK cells elicited during MCMV infection are reduced by IL-2 neutralization.

146 e of pIE611 for viral gene expression during MCMV infection in an unbiased global approach, we used l

147 MV-specific TM retain memory function during MCMV infection and can re-establish CMV immunity when ne

148 ell recruitment to the salivary gland during MCMV infection.

149 n Ly49H(+) and Ly49H(-) NK cells late during MCMV infection.

150 icient (Ebi3(-/-) ) C57BL/6 (B6) mice during MCMV infection.

151 ein m157, preferentially proliferated during MCMV infection but did not show enhanced IFN-gamma produ

152 wild-type mice, and depletion of Treg during MCMV infection in Foxp3-diphtheria toxin receptor mice o

153 d T cells specific for nonrecombinant (i.e., MCMV-derived) Ags.

154 owed preferential proliferation during early MCMV infection.

155 RQYL is expressed within the immediate-early MCMV gene ie2 The same epitope expressed within the earl

156 viral loads following a challenge in elderly MCMV-infected animals and also reduced the differentiati

157 tion and a subunit vaccine approach elicited MCMV-specific and protective immunity.

158 the number of cells specific for endogenous MCMV Ags.

159 in a depressed early response to endogenous MCMV Ag.

160 depression of immune responses to endogenous MCMV Ags.

161 n intensifies MCMV immunopathology, enhances MCMV burden in multiple organs, and suppresses MCMV-spec

162 erfusion with tcMCMV or adenovirus expressed MCMV proteins induced a 2- to 6-fold increase in systemi

163 When MCMV infection was given first (MCMV+LCMV), the magnitude of the acute T cell response t

164 Mice were evaluated for MCMV-specific antibodies, T-cell responses, germinal cen

165 protein allowed differentiation of MCMV from MCMV bound by antibody from the collision frequency decr

166 ccelerated virus clearance and recovery from MCMV infection.

167 Fs m131 and m129 MCK-2 is essential for full MCMV infectivity in macrophages and for persistent infec

168 ficient hosts provided significantly greater MCMV resistance compared with transfer of total NK popul

169 leomorphic rhabdomyosarcomas (RMS) harboring MCMV DNA, RNA, and protein.

170 estigating the role of the cytokine IL-22 in MCMV infection, we discovered an unanticipated function

171 Rapid NF-kappaB activation was absent in MCMV-infected NEMO-deficient fibroblasts, indicating tha

172 As in MCMV, only the inflating epitope showed immunoproteasome

173 NK cell depletion in MCMV-infected transplants also improves histology.

174 contributed minimally to retinal disease in MCMV-infected eyes of MAIDS-10 mice.

175 M2 phenotype in the absence of FcgammaRs in MCMV-infected Fcer1g and FcgR2b knockout mice.

176 mPR expression and viral growth was found in MCMV-infected cells treated with Salmonella carrying the

177 vivo, there was increased p-STAT3 in NSCs in MCMV-infected compared with control mice.

178 ication in spleen and liver were observed in MCMV-infected Ebi3(-/-) and wild-type (WT) B6 mice.

179 A similar phenotype in MCMV-infected Clr-b-deficient mice, which lack the ligan

180 type, and functions similar to those seen in MCMV and are reproduced using alternative routes of admi

181 n-deficient adenovirus expressing individual MCMV genes (gB, gH, IE1; controls: saline and replicatio

182 Early on after infection, MCMV antigen was predominantly localized in CD45+ lympho

183 ch harbored equivalent amounts of infectious MCMV.

184 at the history of LCMV infection intensifies MCMV immunopathology, enhances MCMV burden in multiple o

185 n on the vascular endothelium and interrupts MCMV dissemination to the salivary glands independent of

186 ppression (MAIDS), we initially investigated MCMV-infected eyes for evidence of apoptosis-associated

187 In addition, latent MCMV infection suppressed the proportion of naive CD8(+)

188 ne to LCMV and then infected with MCMV (LCMV+MCMV), they had more severe immunopathology, enhanced vi

189 r formation, and protection against a lethal MCMV challenge.

190 ector NK cells to generate a pool of mature, MCMV-specific memory cells.

191 nfections with mouse cytomegalovirus (MCMV), MCMV-specific NK cells undergo clonal expansion, and dis

192 evidence of apoptosis-associated molecules, MCMV-infected eyes of MAIDS-10 mice showed significant a

193 Moreover, MCMV induced ER chaperone Bip but actively blocked IRE1-

194 - to 6-fold increase in systemic and mucosal MCMV-specific antibodies, a 3- to 6-fold increase in GC

195 th naive cells when challenged with a mutant MCMV lacking m157, highlighting their antigen-specific r

196 rtantly, as with RIP3(-/-) mice, vIRA mutant MCMV pathogenesis is restored in DAI(-/-) mice, consiste

197 ashion in the steady-state in the absence of MCMV or any infection.

198 K cells and subsequently impaired control of MCMV replication.

199 ized and antigen-specific for the control of MCMV upon rechallenge.

200 sponse was sufficient for initial control of MCMV, although at later time points, CD70(-/-) mice beca

201 lacking NKT cells showed reduced control of MCMV, and depleting NK cells further enhanced viral repl

202 However, costimulation of MCMV-memory NK cells with IL-12 and m157 antigen rescues

203 urther apply this method to the detection of MCMV in urine of infected mice.

204 face glycoprotein allowed differentiation of MCMV from MCMV bound by antibody from the collision freq

205 -MHC class I modulate the differentiation of MCMV-specific NK cells and are beneficial for host defen

206 phosphorylation depended on the duration of MCMV infection, the infectious dose, and MCMV gene expre

207 active and document antagonistic effects of MCMV on STAT1/3-dependent target gene expression.

208 e responses to H-2(d)-restricted epitopes of MCMV pp89 and M18 Ags characteristic of infection with o

209 at EBI3 plays a role in the establishment of MCMV latency.

210 ockade of DNAM-1 suppressed the expansion of MCMV-specific Ly49H(+) cells during viral infection and

211 on lymphopenia promoted massive expansion of MCMV-specific T cells when no competing donor T cells we

212 1 played distinct roles in the generation of MCMV-specific effector and memory NK cells.

213 ll depletion improved allograft histology of MCMV-infected grafts.

214 by 7 weeks, there was a generalized loss of MCMV in brain, confirmed by bioluminescent imaging.

215 will be useful in elucidating mechanisms of MCMV reactivation, including the roles of injury and of

216 many of these could promote the migration of MCMV-specific T cells in vitro.

217 s and highlight the complex orchestration of MCMV gene regulation.

218 cytokine response during the early phase of MCMV infection in CD70(-/-) mice was paralleled by a red

219 on on naive blood NK cells was predictive of MCMV resistance.

220 The m20.1 protein of MCMV retains PVR in the endoplasmic reticulum and promot

221 as well as posttranscriptional regulation of MCMV gene products by pIE611.

222 and similarly function in the repression of MCMV MIE gene expression mediated by CTCF.

223 nique domain, resulting from the splicing of MCMV ORFs m131 and m129 MCK-2 is essential for full MCMV

224 urden in multiple organs, and suppression of MCMV-specific T cell memory inflation.

225 CD4 T cells that recognize them to fight off MCMV infection, and show that we can use the epitopes to

226 s age-dependent decline was not dependent on MCMV.

227 by 60% compared to antiviral-treated mice or MCMV-negative animals.

228 ary glands via Wharton's duct with tcMCMV or MCMV proteins focused to the salivary gland via replicat

229 8 Ags characteristic of infection with other MCMVs.

230 The majority of tumors from P2 MCMV-infected mice were pleomorphic rhabdomyosarcomas (R

231 uggesting that this DC subset cross-presents MCMV-encoded Ag in vivo.

232 ve response between a newly defined putative MCMV epitope sequence and a normally subdominant LCMV ep

233 ss-reactive between a newly defined putative MCMV epitope sequence, M57727-734, and the normally subd

234 Infection with a recombinant MCMV inducing a vigorous initial immune response to the

235 vaccination of immunocompetent mice reduced MCMV replication in the same organs where CD4 cytotoxic

236 les of these two IFN-I sources in regulating MCMV defense remain unclear.

237 ticipate simultaneously during MAIDS-related MCMV retinitis, and all may play a role during AIDS-rela

238 for CTCF to bind to MCMV MIE gene to repress MCMV MIE gene expression.

239 though STAT3 phosphorylation did not require MCMV immediate early 1, pM27, and late gene expression,

240 lymphocyte response by 80%, and the residual MCMV tetramer-specific lymphocytes exhibited a less diff

241 Strikingly, MCMV production in the spleens of immunocompetent mice n

242 MV burden in multiple organs, and suppresses MCMV-specific T cell memory inflation.

243 sequence, we show that some of the long-term MCMV-immune mice mount a robust CD8 T cell cross-reactiv

244 We demonstrate that MCMV-specific CD4 T cells can express high levels of gra

245 These observations demonstrate that MCMV-specific memory inflation is maintained by viral re

246 Subsequent studies demonstrated that MCMV-infected eyes of MAIDS-10 mice, but not MAIDS-4 mic

247 r analysis to STAT1 and STAT3, we found that MCMV infection neither destabilizes STAT1 protein nor pr

248 by IL-6 was also abolished, indicating that MCMV antagonizes STAT1 and STAT3 despite the occurrence

249 These findings reveal that MCMV-primed memory NK cells are diminished in their resp

250 Together, our studies show that MCMV epitope-specific CD4 T cells have the potential to

251 Previously, we have shown that MCMV protein pM79 and its human cytomegalovirus (HCMV) h

252 The MCMV genome, like the genomes of other beta- and gammahe

253 The MCMV model is, however, complicated by the virus's low-l

254 The MCMV-specific TM population was stable over time and ret

255 After a transient phase of activation, the MCMV M45 protein blocks all canonical NF-kappaB-activati

256 Although the MCMV genome encodes for MHC class I-homologous decoy lig

257 th receptor activation and suppressed by the MCMV-encoded viral inhibitor of RIP activation (vIRA).

258 the appearance of NK cells that express the MCMV-specific receptor Ly49H.

259 nd oral lavage was strongly decreased in the MCMV-infected Ebi3(-/-) B6 mice, suggesting that EBI3 pl

260 cells and lower serum levels of IL-10 in the MCMV-infected Ebi3(-/-) B6 mice.

261 to delineate pIE611-dependent changes of the MCMV proteome.

262 d delineated pIE611-dependent changes of the MCMV proteome.

263 Treatment reduced the magnitude of the MCMV-specific CD8(+) T-lymphocyte response by 80%, and t

264 e examined the role of Bim in regulating the MCMV-driven memory NK cell pool.

265 ayed shared genetic programs, validating the MCMV model for studies of CMV-specific T cells in vivo.

266 However, some of these MCMV persistently infected mice with acute LCMV infectio

267 Thus, while vulnerable at early times, MCMV became resistant to exogenous ER stress at late tim

268 a glycoprotein-specific primary antibody to MCMV, and polystyrene bead "anchors," which were functio

269 Thus, NK licensing behavior to MCMV corresponds to the donor, and not recipient, MHC ha

270 (MCMV) that is required for CTCF to bind to MCMV MIE gene to repress MCMV MIE gene expression.

271 rapidly responding population of NK cells to MCMV infection, but are highly regulated by Tregs and TG

272 ting the earliest phase of innate defense to MCMV infection, capping replication levels, and blocking

273 n, and both can contribute nonredundantly to MCMV defense, revealing that these two innate lymphocyte

274 CD70(-/-) mice reacted to MCMV infection with a robust type I IFN and proinflammat

275 By examining the NK cell response to MCMV infection in novel BALB substrains congenic for dif

276 defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-

277 composition of the inflationary response to MCMV.

278 cytometry to visualize the host response to MCMV.

279 ed to phosphorylate eIF2alpha in response to MCMV.

280 d late gene expression, it was restricted to MCMV-infected cells and not transmitted to bystander cel

281 howed a modest increase in susceptibility to MCMV infection, demonstrating that translational arrest

282 s, CD70(-/-) mice became more susceptible to MCMV infection.

283 e as immune-privileged vehicles to transport MCMV via the bloodstream to distal organs.

284 actin cytoskeleton observed after wild-type MCMV infection, and isolated expression of the M25 prote

285 In this model, wild-type MCMV, lacking HEL, did not induce overt uveitis, suggest

286 found decreasing STAT3 protein amounts upon MCMV infection, although STAT3 expression normally is po

287 dendritic cells activated only NK cells upon MCMV infection, consistent with their virtual lack of IL

288 the early control of and host survival upon MCMV infection but not the long-term control of LCMV inf

289 Ex vivo, MCMV-memory NK cells displayed reduced phosphorylation o

290 When MCMV infection was given first (MCMV+LCMV), the magnitud

291 When MCMV-infected mice were orally treated with Salmonella c

292 Whereas MCMV-infected eyes of MAIDS-4 mice showed little evidenc

293 his response was more highly correlated with MCMV control than all other immune cell features.

294 iously immune to LCMV and then infected with MCMV (LCMV+MCMV), they had more severe immunopathology,

295 implanted in mice perinatally infected with MCMV versus controls.

296 s abolished in IL-12(-/-) mice infected with MCMV, whereas NK cells were still activated.

297 cted by infecting 22,000 G3 mutant mice with MCMV at an inoculum easily contained by WT animals.

298 Upon infection of mice with MCMV mutants encoding Ag that can either be well or hard

299 and replication deficient adenovirus without MCMV inserts).

300 e and extent of aggregation with and without MCMV.