ライフサイエンスコーパス: MDR1 gene

1 recombinant retrovirus expressing the human MDR1 gene.

2 on of the endogenous, chromosomally embedded MDR1 gene.

3 ymphoma cell line transfected with the human MDR1 gene.

4 ant to doxorubicin via overexpression of the mdr1 gene.

5 R1 promoter and expression of the endogenous MDR1 gene.

6 so regulate transcription of the chromosomal MDR1 gene.

7 in is a multidrug transporter encoded by the MDR1 gene.

8 of murine NIH3T3 cells expressing the human MDR1 gene.

9 l blood showed no evidence of the transduced MDR1 gene.

10 increase in the level of dimer repair in the MDR1 gene.

11 only a minor increase in dimer repair in the MDR1 gene.

12 nscription, and expression of the transfered MDR1 gene.

13 ein (P-gp) 170 that is encoded by the ABCB1 (MDR1) gene.

14 Using primers for the human MDR1 gene, a single product was detected by reverse-tran

15 We investigated the mechanisms of MDR1 gene activation by CCAAT/enhancer binding protein b

16 c pathways that control the origin of ABCB1 (MDR1) gene activation with acquired multidrug resistance

17 on in the TDN p53 cells was not secondary to mdr1 gene amplification and Pgp was functional as demons

18 age at fragile site 1q31 was associated with mdr1 gene amplification through the BFB mechanism.

19 de C/EBPbeta binding of the chromatin of the MDR1 gene and interactions of C/EBPbeta with the Y box a

20 carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the m

21 criptional activation of both the endogenous MDR1 gene and MDR1 reporter constructs by the histone de

22 ctivity together with mutant p53 and induces MDR1 gene and P-glycoprotein (P-gp, ABCB1), resulting in

23 d c-Jun bound to the promoter regions of the MDR1 gene and promoted the expression of MDR1.

24 or chloroquine resistance-associated crt and mdr1 genes and at the end of the survey period for dhfr

25 Both the MGC4175 and MDR1 genes are located at chromosome position 7q21.

26 induced cyclobutane pyrimidine dimers in the MDR1 gene at different levels of MDR1 mRNA expression.

27 rug resistance is enhanced expression of the mdr1 gene, but the precise factors and physiological con

28 Sp1 in the transcriptional activation of the MDR1 gene by genotoxic stress, and indicate that YB-1, i

29 eport that ANA-modified siRNAs targeting the MDR1 gene can exhibit improved efficacy as compared to u

30 petal auxin transport due to mutation of the MDR1 gene caused 21% of nascent lateral roots to arrest

31 P-glycoprotein (Pgp), the product of the MDR1 gene, confers multidrug resistance on cancer cells

32 dentity of germ-line variations in the ABCB1/MDR1 gene contributing to IBD susceptibility.

33 plex analysis and sequencing reveal a mutant mdr1 gene (deletion of a phenylalanine at amino acid res

34 Allelic variations of the MDR1 gene determine disease extent as well as susceptibi

35 an exogenous human multi-drug resistance 1 (MDR1) gene enables dramatic ex vivo stem cell expansion

36 tic fibrosis (Cftr and multidrug resistance (Mdr1) genes encode structurally similar proteins which a

37 The MDR1 gene encodes P-glycoprotein 170, an efflux transpor

38 Multidrug resistance 1 (MDR1) gene encodes for P-glycoprotein (P-gp), a Mr 170,0

39 The MDR1 gene encoding the multidrug pump P-glycoprotein is

40 Analysis of mdr1 gene expression by reverse transcription PCR demons

41 es alpha and theta occur in conjunction with MDR1 gene expression in cells and tissues that have acqu

42 model that allows noninvasive bioimaging of mdr1 gene expression in vivo and in real time.

43 A reverse correlation between WTH3 and MDR1 gene expression was also observed in MCF7/AdrR, and

44 , we tested the ability of siRNAs to inhibit MDR1 gene expression.

45 g MDR, we adopted RNA interference to target MDR1 gene expression.

46 family of transcription factors and inducing mdr1 gene expression.

47 ncogenes, or changes in temperature increase MDR1 gene expression.

48 The P-glycoprotein product (Pgp) of the MDR1 gene has been implicated in the multiple drug resis

49 Examination of the MDR1 gene identified a binding site for hypoxia inducibl

50 nce to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and pr

51 These results show that expression of the MDR1 gene in human hematopoietic progenitor cells can co

52 ort that 2-AAF could also activate the human MDR1 gene in human hepatoma and embryonic fibroblast 293

53 aled that Candida biofilms expressed CDR and MDR1 genes in all the developmental phases, while plankt

54 ubsequent studies confirmed hypoxia-elicited MDR1 gene induction and increased P-glycoprotein express

55 Transfection of the mutant mdr1 gene into drug-sensitive MES-SA sarcoma cells confe

56 These data show functional transfer of the MDR1 gene into nonmyeloablated murine hosts.

57 DR1 P-glycoprotein (Pgp), the product of the MDR1 gene involved in multidrug resistance in cancer cel

58 Taken together, these data indicate that the MDR1 gene is hypoxia responsive, and such results may id

59 protein encoded by the multidrug resistance (MDR1) gene is associated with the emergence of the MDR p

60 P-glycoprotein (P-gp), encoded by the MDR1 gene, is a plasma membrane transporter which efflux

61 coprotein drug transporter, a product of the MDR1 gene, is a significant problem in cancer therapeuti

62 or P-glycoprotein (P-gp), the product of the MDR1 gene, is implicated as the primary cause of multidr

63 lycoprotein (P-gp), the product of the human MDR1 gene, localized to chromosome 7q21.

64 Polymorphisms in the MDR1 gene may affect the pharmacokinetics of many common

65 y canine kidney cells transfected with human MDR1 gene (MDCK/MDR1), followed by pharmacokinetics stud

66 uggest that the rate of transcription in the MDR1 gene must be substantially increased before there i

67 C/EBPbeta activates the endogenous MDR1 gene of MCF-7 cells, and this activation was associ

68 s of CNVs revealed that a single copy of the mdr1 gene on chromosome 5 and a novel amplification of t

69 ith retroviral vectors expressing either the MDR1 gene or a variant of human dihydrofolate reductase

70 e product of the multidrug resistant type 1 (MDR1) gene, P-glycoprotein (Pgp), resulting in improved

71 ynonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to alt

72 using only PBPCs incubated ex vivo, that the MDR1 gene product may play a role in engraftment, and th

73 er frequently involves overexpression of the MDR1 gene product P-glycoprotein (P-gp), a drug transpor

74 previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless res

75 horylation of the human multidrug resistance MDR1 gene product P-glycoprotein for its drug transport

76 The expression of the MDR1 gene product was stable over a 6-month period in vi

77 hrome P450 reductase and P-glycoprotein (the MDR1 gene product) but has no detectable effect on expre

78 Overexpression of P-glycoprotein (P-gp), the MDR1 gene product, confers multidrug resistance (MDR) to

79 The human MDR1 gene product, P-glycoprotein (Pgp), a tandemly dupl

80 l mechanisms including overexpression of the MDR1 gene product, P-glycoprotein and glutathione-relate

81 An antibody (C219) to the MDR1 gene product, P-glycoprotein, caused a functional b

82 these drugs are transport substrates for the MDR1 gene product, P-glycoprotein, JNK was assayed in tw

83 biquitination regulates the stability of the MDR1 gene product, P-glycoprotein, thereby affecting the

84 Human P-glycoprotein, the MDR1 gene product, requires both Mg(2+)-ATP binding and

85 n reducing expression of P-glycoprotein, the MDR1 gene product.

86 drugs can be mediated by P-glycoprotein, the MDR1 gene product.

87 The multidrug resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is frequently i

88 also includes human multidrug resistance 1 (MDR1) gene product P-glycoprotein (Pgp).

89 e demonstrate that the multidrug resistance (MDR1) gene product P-glycoprotein, a Mr approximately 17

90 The multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), and the multi

91 The human multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), is well known

92 ient transfection with either 1073 bp of the MDR1 gene promoter or deletion fragments thereof to -8 b

93 late expression of the multidrug resistance (MDR1) gene promoter.

94 tion of C/EBPbeta plays an important role in MDR1 gene regulation.

95 MDR1 mRNA expression, we find a low level of MDR1 gene-specific repair and inefficient repair of the

96 graftment rate of donor cells containing the MDR1 gene, suggest that the majority of stem cells that

97 ucleotide to the human multidrug resistance (MDR1) gene, taken up by the cells in a dose-dependent ma

98 rain barrier, chemotherapeutic regimens, and MDR1 gene therapy protocols in vivo.

99 This study differed from previous MDR1 gene therapy studies in that patients received only

100 We hypothesize that inactivation of the MDR1 gene through CpG methylation contributes to the pat

101 document that although AEG-1 does not affect MDR1 gene transcription, it facilitates association of M

102 PKC suggest that activation of PKC engenders MDR1 gene transcription.

103 otential roles of PKC-alpha and PKC-theta in MDR1 gene transcriptional regulation were explored.

104 and that chemotherapy may selectively expand MDR1 gene-transduced hematopoietic cells relative to Neo

105 ious observations of in vivo selection using MDR1 gene transfer followed by taxol administration may

106 , a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that ente

107 transcription of the P-glycoprotein-encoding MDR1 gene via direct DNA binding through a novel p53 DNA

108 expression of P-glycoprotein, the product of MDR1 gene, was strongly and selectively inhibited by the

109 that wild-type p53 regulates the endogenous mdr1 gene we stably introduced a trans-dominant negative

110 nting the haplotypic variations of the ABCB1/MDR1 gene were identified initially following the charac

111 marrow RNA showed that transcripts from the MDR1 gene were present in a fraction of the engrafted do

112 K562 cells infected with the MDR1 gene, which were never selected on chemotherapeutic