ライフサイエンスコーパス: MED

1 MED is a milder disease with radiographic features often

2 MED-assigned patients who underwent CABG had lower 5-yea

3 MED-FASP offers efficient exploration of previously unus

4 y apparent over a narrow dose range around 1 MED.

5 The results show that after exposure to 1 MED of UV, the skin of subjects from all groups suffered

6 respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV.

7 erate sunburn (two minimal erythema doses [2 MED]) was sufficient to suppress CHS in all volunteers b

8 Overall, 2 MED caused 17%-20% suppression of elicitation responses

9 posed buttock skin was exposed to 1, 2 and 3 MED of each spectrum.

10 the applied stimuli after exposure to 2 or 3 MED.

11 suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively

12 CCAAT box, a CF1, a HIP1 binding motif and a MED-1 element; (d) modulated weakly by a positive-acting

13 provides significant genetic evidence for a MED locus on the short arm of chromosome 2 (2p24-p23), a

14 pathway, while reduction of Med15 levels, a MED subunit in the tail domain, suppressed the Nodal sig

15 We find that a transcriptional activator, MED-1, associates in vivo with the end-1 and end-3 targe

16 randomly assigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) s

17 We found that although MED accurately rebuilds gene expression levels from deco

18 tual and academic achievement deficits among MED survivors.

19 vity in U87MG mouse xenografts, achieving an MED of 1.5 mg/kg, following weekly intravenous dosing.

20 two expansion mut-ations in this repeat: an MED patient carrying a (GAC)6allele and a PSACH patient

21 (27+/-17 and 27%, respectively; P<0.03) and MED (58+/-42 and 33%; P<0.05) versus CTRL (88+/-52 and 7

22 of endoderm differentiation by the SKN-1 and MED-1/2 transcription factors.

23 nt GATA-type transcription factors MED-1 and MED-2 are encoded by an unlinked, redundant pair of intr

24 actor gene tbx-35, a target of the MED-1 and MED-2 divergent GATA factors, was previously found to re

25 nefit from the inclusion of colorimetric and MED measurements along with traditional risk factors to

26 In contrast, GBM and MED contained progressively fewer infiltrating leukocyte

27 ence of phenotypic overlap between PSACH and MED.

28 sequences in combination with nearby Sp1 and MED-1 sites together account for virtually all promoter

29 vator for nuclear receptors, and an SRB- and MED-containing cofactor complex (SMCC) that mediates act

30 MYC oncogene, we predict interaction between MED and FBP1 might also have implications for cancer ini

31 mesendodermal progenitors are controlled by MED-1 and -2, members of the GATA factor family.

32 ly shown that the binding site recognized by MED-1 is a noncanonical RAGTATAC site that is not expect

33 Impairment of viral replication by MED subunits was at a post-integration step.

34 e MED sites, we have identified 19 candidate MED targets.

35 e compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equa

36 c low-fat or Mediterranean/low-carbohydrate (MED/LC) diet+28 g walnuts/day with/without added moderat

37 o Rituxan-induced apoptosis than Myc(ON)CD20(MED).

38 In the E cell, MED-1,2 activate transcription of the endoderm-promoting

39 mers and wet winters (Mediterranean climate; MED) are especially vulnerable to climate change.

40 This 3-cluster solution was replicated in CO-MED and was similar for the HAM-D scale.

41 dications to Enhance Depression Outcomes (CO-MED) trial (n = 640).

42 The human Mediator complex (MED) is composed of 28 elements and represents a fundame

43 s a hypomorphic allele of Med10, a conserved MED middle domain subunit.

44 ciaries with a prescription yielding a daily MED of more than 120 mg did not decline after adoption o

45 ibers; 5% had prescriptions yielding a daily MED of more than 120 mg in any calendar quarter; and 0.3

46 Motif expression decomposition (MED) was recently introduced to describe the expression

47 i) metal-enhanced electrochemical detection (MED) and (ii) label-free surface plasmon resonance (SPR)

48 a metal-enhanced electrochemical detection (MED) sensor, which relied on the redox properties of a s

49 nts the concept of metal-enhanced detection (MED) for the determination of DNA-DNA reactions and pres

50 ems (NEMS) and molecular electronic devices (MEDs).

51 information in molecular electronic devices (MEDs).

52 FASP and the related multienzyme digestion (MED) FASP method.

53 using multiple enzymes for sample digestion (MED), primarily an increase of sequence coverage, have b

54 s were maintained on multi-electrode dishes (MED) with an 8x8 array of electrodes and examined for ph

55 At present, the role of distinct MED subunits in general transcription versus transcripti

56 s specified by the activity of the divergent MED-1,2 GATA factors.

57 We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild p

58 ide screen of family with autosomal-dominant MED not linked to the EDM1-3 genes provides significant

59 utcome was daily morphine-equivalent dosage (MED) of opioids dispensed from 60 days before to up to 7

60 he ratio between the minimum effective dose (MED) for significant impairment in rotarod performance a

61 digm (X-maze) with a minimum effective dose (MED) of 0.1 microgram/kg.

62 s yielding a daily morphine-equivalent dose (MED) of more than 120 mg, and treatment for nonfatal pre

63 ols were exposed to 1 minimum erythema dose (MED) of UVR delivered from Waldmann UV-6 bulbs to the up

64 The minimal erythema dose (MED) was established for each subject exposed to UVA/UVB

65 start with 70% of the minimal erythema dose (MED) with 20% increments at each treatment thereafter.

66 ed by colorimetry and minimal erythema dose (MED), respectively.

67 Individual minimal erythema doses (MED) for each source were determined and previously unex

68 xposed to 0.75 and 2 minimum erythema doses (MED) of SSR on the upper inner arm.

69 ither 0, 0.6, 1 or 2 minimal erythema doses (MED).

70 GSK931145 had lower minimum effective doses (MEDs) in the MEST test than other GlyT1 inhibitors.

71 nd determination of minimum eliciting doses (MEDs).

72 scription initiation window and a downstream MED-1 element (GCTCCC/G).

73 an Inr-like sequence as well as a downstream MED-1 element.

74 ent, multiple start site element downstream (MED-1), decreased transcription in drug-resistant cells

75 the treatment of male erectile dysfunction (MED) with a lower incidence of PDE-associated adverse ef

76 potential use in male erectile dysfunction (MED).

77 sponsible for multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH).

78 a (PSACH) and multiple epiphyseal dysplasia (MED) are autosomal dominant osteochondrodysplasias that

79 a (PSACH) and multiple epiphyseal dysplasia (MED) are relatively common skeletal dysplasias belonging

80 a (PSACH) and multiple epiphyseal dysplasia (MED) are two human autosomal dominant skeletal dysplasia

81 Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some

82 Multiple epiphyseal dysplasia (MED) is a relatively mild and clinically variable osteoc

83 can result in multiple epiphyseal dysplasia (MED), a disease characterized by delayed and irregular b

84 uch disorder, multiple epiphyseal dysplasia (MED), is characterized by mild dwarfism and early-onset

85 a (PSACH) and multiple epiphyseal dysplasia (MED/EDM1).

86 21st century replacement of the equatorward MED margins by the arid climate type.

87 drier in both the old and newly established MED zones.

88 As an example, MED results are used to demonstrate that motifs generall

89 he divergent GATA-type transcription factors MED-1 and MED-2 are encoded by an unlinked, redundant pa

90 were selected as development candidates for MED and other indications.

91 ve recently been shown to be responsible for MED and PSACH.

92 We identified a role for MED in KC proliferation and differentiation in cultured

93 Patients treated for MED had significantly less NWM (p < 0.01) and significan

94 the hypotheses that (1) patients treated for MED in childhood have reduced volumes of normal white ma

95 en pediatric patients previously treated for MED were matched on the basis of age at the time of eval

96 Full-Scale IQ among the patients treated for MED.

97 Common reasons for crossover from MED to CABG were progressive symptoms or acute decompens

98 yeloid and lymphoid cells compared with GBM, MED, or NT.

99 ell-characterized endoderm-promoting SKN-1-->MED regulatory cascade.

100 specification in the absence of the SKN-1-->MED transcriptional input, accounting for the impenetran

101 nts with high skin types tended to have high MEDs (P<0.001).

102 Knockdown of 9 out of 28 human MED proteins significantly impaired viral replication wi

103 tory pain (CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg, p.o.).

104 rature standard 1 (CP154526-1) was inactive (MED > 30 mg/kg (po)).

105 Strikingly, the lipid ligand MED (myristoylated alanine-rich C kinase substrate effec

106 ing two central players, TFIID and Mediator (MED), in potentiating activated transcription.

107 ranscriptional coactivator complex Mediator (MED) facilitates transcription of nuclear hormone recept

108 The MEDIATOR (MED) complex plays diverse functions in plant developmen

109 etween Psi and the transcriptional mediator (MED) complex, a known sensor of signaling inputs.

110 The transcriptional Mediator (MED) is a multiprotein complex that transmits informatio

111 s guideline-based antidepressant medication (MED) and were randomly assigned to add-on therapy with c

112 region for 2 hours 3 times a day), medicine (MED; carvedilol therapy at 12.5 mg PO BID), or control (

113 stent transmission of CCYV by Mediterranean (MED) cryptic species of B. tabaci complex.

114 N), 5 glioblastoma (GBM), 6 medulloblastoma (MED), and 5 nontumor brain (NT) control samples obtained

115 ter treatment for childhood medulloblastoma (MED), the pathophysiology underlying this process is poo

116 100 mg MED), low (<50 mg MED), or none (0 mg MED).

117 rge (>/=100 mg MED), moderate (50 to <100 mg MED), low (<50 mg MED), or none (0 mg MED).

118 We categorized dosages as large (>/=100 mg MED), moderate (50 to <100 mg MED), low (<50 mg MED), or

119 ), moderate (50 to <100 mg MED), low (<50 mg MED), or none (0 mg MED).

120 tivity in the rat situational anxiety model (MED = 3 mg/kg (po)), whereas a literature standard 1 (CP

121 To date, no MED-like zinc fingers have been described outside of C.

122 Nonetheless, MED provides accurate estimates of relative binding stre

123 (STR), hippocampus (HC), medulla oblongata (MED) and anterior cingulate (ACNG) and five peripheral t

124 nce interval: 1.07, 1.43) per 10 mJ/cm(2) of MED.

125 mputer simulation to examine the accuracy of MED.

126 erns, these define three distinct classes of MED-regulated genes: MS-specific, E-specific, and E plus

127 s how and why the geographic distribution of MED will change based on the latest-available climate pr

128 northward and eastward future expansions of MED over both the Euro-Mediterranean and western North A

129 A recessive form of MED (EDM4) has also been reported; it is caused by a mut

130 ith mild PSACH and the second with a form of MED, we identified different substitutions for a residue

131 These dominant forms of MED (EDM1-3) are caused by mutations in the genes encodi

132 PSACH and some forms of MED result from mutations in cartilage oligomeric matrix

133 PSACH and some forms of MED result from mutations in the gene for cartilage olig

134 ously been shown to cause different forms of MED.

135 Moreover, genetic manipulation of MED activity modified Psi-dependent growth, which sugges

136 was previously observed in a murine model of MED caused by a Matn3 V194D mutation, some mutant protei

137 hanisms that underpin the pathophysiology of MED we generated a murine model of epiphyseal dysplasia

138 The novel phenotype of MED and mild myopathy is likely caused by a dominant-neg

139 erythema was approximately 60% regardless of MED.

140 Here, we investigated the in vivo role of MED by generating a conditional null mice model in which

141 With these understandings, judicious use of MED will likely provide useful information about eukaryo

142 rmation of food allergy and determination of MEDs in adults and children with body weight >28.8 kg (a

143 In the quest for the next generation of MEDs, it is likely that monolayers of bistable MIMs will

144 spectroscopic and other means in support of MEDs that store information through switching collection

145 INTERPRETATION: Results from SPYRAL HTN-OFF MED provide biological proof of principle for the blood-

146 SPYRAL HTN-OFF MED was a multicentre, international, single-blind, rand

147 the impenetrance of mutants lacking SKN-1 or MED-1,2 activity.

148 amenable to CABG were randomized to CABG or MED in the STICH trial (Surgical Treatment for Ischemic

149 s in an additional 14 families with PSACH or MED phenotypes.

150 Differences in skin type or MED are not associated with clinically important differe

151 pes I-IV patients regardless of skin type or MED.

152 of 65 medically managed transplant patients (MED), 30 patients supported with an LVAD, and 5 nonfaili

153 his domain a missense mutation that produced MED Fairbank.

154 into their molecular electronic properties, MEDs incorporating hundreds to thousands of molecules tr

155 PSACH-MED patients often have a mild myopathy characterized by

156 We hypothesize that the myopathy in PSACH-MED originates from an underlying tendon and ligament pa

157 on of the musculoskeletal phenotype of PSACH-MED and is directly relevant to the clinical management

158 however, the myopathy associated with PSACH-MED has not previously been studied.

159 Our data suggest the key target of the Psi/MED network in controlling developmentally regulated tis

160 cursor cells (GNP) and a MB cell line, PZp53(MED).

161 ing igf2 signaling inhibited growth of PZp53(MED) cells, implicating igf2 as a potential clinical tar

162 duced by complete Freund's adjuvant in rats (MED = 1 mg/kg, p.o).

163 10 patients (9.0%) assigned to CABG received MED only.

164 wer 5-year mortality than those who received MED only (25% vs 42%; hazard ratio, 0.50; 95% confidence

165 Knockdown of the selected MED factors compromised HIV transcription induced by Tat

166 asured erythemal UV sensitivity of the skin (MED) is a more useful predictor of DNA photodamage than

167 Some MED targets encode transcription factors related to thos

168 Biochemical analysis of the SRB-MED complex from the sin4 suppressor strain revealed a s

169 aled a structurally distinct form of the SRB-MED complex that lacks a subset of mediator subunits.

170 e, whose product is also a member of the SRB-MED complex, failed to suppress ydr1(cs) and bur6(cs) mu

171 4 gene, which encodes a component of the SRB-MED complex.

172 ion is not due to general defects in the SRB-MED complex.

173 nd RSC in addition to SAGA, SWI/SNF, and SRB/MED.

174 equires SAGA, SWI/SNF, and SRB mediator (SRB/MED) and identify key nonessential subunits of these com

175 eriments show that Mbf1p, SAGA, SWI/SNF, SRB/MED, RSC, CCR4-NOT, and the Paf1 complex all are recruit

176 identified polypeptides, but none of the SRB/MED proteins or other factors found associated with the

177 Mammalian counterparts of the yeast SRB/MED transcriptional 'mediator' complex have recently bee

178 (2) deficits in NWM among patients surviving MED can at least partially explain deficits in their int

179 stent transmission mode of CCYV by B. tabaci MED.

180 ession data from only 30 conditions and that MED results are robust to the existence of unknown occur

181 Intriguingly, we find that MED and TFIID interact functionally to modulate transcri

182 We report that MED-1 binds invariant noncanonical sites in the end gene

183 We show that MED FASP in combination with the total protein approach

184 The MED concept has been tested for voltammetric detection o

185 The MED concept relies on the idea that metallic films depos

186 The MED/LC diet mobilizes specific ectopic fat depots, and e

187 The MED/LC diet was superior to the low-fat diet in decreasi

188 nt impairment in rotarod performance and the MED for significant neuroprotection.

189 sus -11.5% for the MED/LC; P<0.001), and the MED/LC group decreased reported carbohydrates intake (-3

190 ted fat intake (-21.0% versus -11.5% for the MED/LC; P<0.001), and the MED/LC group decreased reporte

191 different across the spectrum of age in the MED group (53% versus 49% for quartiles 4 and 1, respect

192 In the MED group, left ventricular ejection fraction was 61+/-4

193 CBT-arm, 40% in the ECT-arm, and 44% in the MED-arm.

194 CBT-arm, 28% in the ECT-arm, and 33% in the MED-arm.

195 ion in waist circumference was higher in the MED/LC group (-6.9 +/- 6.6 cm) than in the LF diet group

196 IPF volume had reduced twice as much in the MED/LC group compared with the LF group [-37 +/- 26.2 mL

197 ence rebound with the greatest effect in the MED/LC(PA+) group (P<0.05).

198 We have previously isolated the MED complex from primary keratinocytes (KCs) as the vita

199 Here, we provide an evaluation of the MED activity on HIV replication.

200 cells to selectively deplete subunits of the MED and TFIID complexes to dissect the contribution of e

201 ice model in which a critical subunit of the MED complex, MED1, is deleted from their KCs.

202 bsequently activated upon recruitment of the MED complex.

203 he T-box factor gene tbx-35, a target of the MED-1 and MED-2 divergent GATA factors, was previously f

204 We report that the MED-1 and -2 GATA factors specify the entire fate of EMS

205 We have previously shown that the MED-1,2 divergent GATA factors act apparently zygoticall

206 We report that the MED-1,2 target gene tbx-35, which encodes a T-box transc

207 ers lack a TATA box, and Pint belongs to the MED-1 class of promoters, which initiate transcription a

208 cantly improved in the SCS compared with the MED and CTRL groups (P<0.001 for both).

209 onal regulatory inputs, including SKN-1, the MEDs, PAL-1, and the Wnt/MAPK-activated form of POP-1, a

210 l sites in the end genes, revealing that the MEDs are atypical members of the GATA factor family that

211 icacy of CABG compared with medical therapy (MED) in patients with heart failure caused by ischemic c

212 ive therapy (ECT-arm), or no add-on therapy (MED-arm).

213 y searching the genome for clusters of these MED sites, we have identified 19 candidate MED targets.

214 STJs) associated with the crossbars of these MEDs, have a profound influence on device operation and

215 CABG added to MED has a consistent beneficial effect on cardiovascular

216 CABG added to MED has a more substantial benefit on all-cause mortalit

217 r compared with younger patients assigned to MED (79% versus 60% for quartiles 4 and 1, respectively;

218 ormed in 65/602 patients (10.8%) assigned to MED, and 55/610 patients (9.0%) assigned to CABG receive

219 ).The main reason for crossover from CABG to MED was patient/family decision.

220 They were deemed crossover to MED.

221 ssigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) surgery in t

222 The CABG-to-MED crossover population had higher 5-year mortality com

223 10, reduction of Med12 and Med13 levels, two MED subunits in the regulatory domain, led to an enhance

224 Thus, Med10 appears to be a unique MED subunit that differentially transduces information f

225 diovascular hospitalization with CABG versus MED in younger compared with older patients (Pinteractio

226 The effect of CABG versus MED on all-cause mortality tended to diminish with incre

227 ssociated with lower mortality compared with MED in per-protocol and several time-dependent analyses

228 Compared with MED patients, diastolic pulmonary pressures trended lowe

229 of matrilin-3 in two unrelated families with MED (EDM5).

230 nt growth, which suggests Psi interacts with MED to integrate developmental growth signals.

231 s no impact on disease severity in mice with MED.

232 Patients with MED and a waddling gait but minimal radiographic hip inv