ライフサイエンスコーパス: MEK kinase

1 activation of PI3K/Akt and p38 MAPK, but not MEK kinase.

2 hat is independent of both Mcs4 and the Wak1 MEK kinase.

3 Raf is a candidate MEK kinase.

4 ctors and, in turn, activates its substrate, MEK kinase.

5 ulates Ras GTP-loading and activates Raf and MEK kinases.

6 m components of the MAPK pathway, B-Raf, and MEK kinases.

7 TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/

8 e we show that nuclear c-Abl associates with MEK kinase 1 (MEKK-1), an upstream effector of the SEK1-

9 MEK kinase 1 (MEKK1) activates the c-Jun NH2-terminal ki

10 Aggregation of FcepsilonRI stimulated MEK kinase 1 (MEKK1) activity, which activates JNK kinas

11 d to inhibition of ANF expression induced by MEK kinase 1 (MEKK1) and the hypertrophic agonists.

12 o activate this pathway; a dominant-negative MEK kinase 1 (MEKK1) blocks activation of SAPK by NIK.

13 The coding sequence of rat MEK kinase 1 (MEKK1) has been determined from multiple,

14 We examined the function of the MAP3K MEK kinase 1 (MEKK1) in proinflammatory signaling.

15 MEK kinase 1 (MEKK1) induces apoptosis through the activ

16 Recombinant forms of MAP3K MEK kinase 1 (MEKK1) interact in vivo and in vitro with

17 MEK kinase 1 (MEKK1) is a 196-kDa enzyme that is involve

18 MEK kinase 1 (MEKK1) is a 196-kDa protein that, in respo

19 MEK kinase 1 (MEKK1) is highly expressed in the growing

20 MEK kinase 1 (MEKK1) which activates the JNK activator,

21 Targeted disruption of the gene encoding MEK kinase 1 (MEKK1), a mitogen-activated protein kinase

22 We show that both JNK isoforms transmit MEK kinase 1 (MEKK1)-mediated morphogenetic signals duri

23 -GTPase activating protein, RAB35), kinases (MEK kinase 1 and 4, PKC, MLCK, cyclin G-associated kinas

24 activation by expression of kinase-inactive MEK kinase 1(MEKK1) or dominant-negative IkappaB (DeltaI

25 aspase 3 are inhibited in cells deficient in MEK kinase 1, an upstream activator of JNK in reovirus-i

26 The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals require

27 production is required for activation of the MEK kinase-1 (MEKK-1)--> SAPK pathway.

28 to an extent comparable to that achieved by MEK kinase-1.

29 MEK kinase 2 (MEKK2) is a 70-kDa protein serine/threonin

30 fluorescence imaging demonstrate that T cell MEK kinase 2 (MEKK2) is translocated to the T cell/antig

31 We show that MEK kinase 2 (MEKK2), a MAPK kinase kinase (MAP3K) that

32 domain-containing adaptor protein that binds MEK kinase 2 (MEKK2), a mitogen-activated protein kinase

33 Targeted disruption of the MEK kinase 2 gene had no effect on activation of the JNK

34 s activation is inhibited by MAP/ERK kinase (MEK) kinase 2 (MEKK2) gene disruption.

35 rgeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 pr

36 These results strongly argue that MEK kinase activity of Raf-1 is not essential for normal

37 Here we purified and characterized the MEK kinase activity present in Xenopus M phase-arrested

38 e hyperphosphorylation of Raf-1 inhibits its MEK kinase activity.

39 and Akt kinases, while partially inhibiting MEK kinase activity.

40 itogen-activated protein kinase kinase (MAPK/MEK) kinase and phosphatidylinositol-3 (PI3) kinase, res

41 Spa2p interacts with Ste11p (MAPK kinase [MEK] kinase) and Ste7p (MEK) of the mating signaling pat

42 A dominant-negative form of the MEK kinase B-Raf also blocks circadian and cAMP modulati

43 only partially impaired in cells lacking the MEK kinase Bck1.

44 ernative pathways, e.g. Janus kinase/STAT or MEK kinase/c-Jun NH2-terminal protein kinase.

45 otentiated by signalling through the Ras-Raf-MEK kinase cascade and inhibited by a direct interaction

46 Raf-mitogen-activated protein kinase kinase (MEK) kinase cascade.

47 on of Ras activation, negative regulation of MEK kinase (e.g. Raf) activities, and up-regulation of d

48 interactions in addition to its established MEK kinase function.

49 Inhibitors of B-Raf and MEK kinases hold promise for the management of cutaneous

50 Pharmacological inhibition of MEK kinase in iPSC-derived JMML cells reduced their GM-C

51 activated alleles of Ras or calcineurin, or MEK kinase, in the case of AP-1.

52 Transfection with PKA, MEK, and MEK kinase induced NF-kappaB-dependent transcription by

53 , demonstrating that beta2AR stimulation and Mek kinase inhibition are required for ARA-211 antitumor

54 Notably, Ets-1 is induced by BRAF or MEK kinase inhibition, resulting in increased NRAS expre

55 On the other hand, the MEK kinase inhibitor PD098059 had no effects, further de

56 CK2alpha-mediated RAF-MEK kinase inhibitor resistance was tightly linked to it

57 on this pathway was determined using a known MEK kinase inhibitor, SL327.

58 ated protein kinase (MAP kinase)/ERK kinase (MEK) kinase inhibitor SL327, but not with the nonblood-b

59 n (MAP)/extracellular signal-regulated (ERK; MEK) kinase inhibitors, respectively.

60 The TPL-2 MEK kinase is essential for activation of the Erk MAP ki

61 ude a MAPK kinase (MAPKK or MEK) and a MAPKK/MEK kinase (MAPKKK/MEKK).

62 In this study, we cloned a full-length human MEK kinase (MEKK) 2 cDNA from Jurkat T-cells and demonst

63 le dominant negative forms of Ras, RacI, and MEK kinase (MEKK) inhibited EGF induction.

64 mammalian p65PAK protein kinases), Ste11 [an MEK kinase (MEKK) or MAPK kinase (MEK) kinase], Ste7 (ME

65 The first kinase in the cascade, a MEK kinase (MEKK), is characterized by its ability to ac

66 ted protein kinase (ERK) kinase (MEK), and a MEK kinase (MEKK).

67 MAP/ERK kinase (MEK), in turn activated by a MEK kinase (MEKK).

68 ich is itself activated by Wik1/Wak1/Wis4, a MEK kinase (MEKK).

69 K occurs through a pathway requiring Ras and MEK kinase (MEKK).

70 activation of MAP kinase/ERK kinase (MEK) by MEK kinase (MEKK).

71 this study, we investigated the role of the MEK kinase (MEKK)1/ERK/p90 ribosomal S6 kinase (RSK)1-de

72 ivated/extracellular response kinase kinase (MEK) kinase (MEKK) is a serine-threonine kinase that reg

73 with a dominant-negative MAP kinase kinase (MEK kinase, MEKK-1), confirming that HBx stimulates the

74 Nck-interacting kinase, acts upstream of the MEK kinase MEKK1 to activate the c-Jun N-terminal kinase

75 cascade, activates NHE1 through a Cdc42- and MEK kinase (MEKK1)-dependent mechanism that is independe

76 Endothelial cells that lack the MEK kinase MEKK3 cannot form vessels.

77 wo cDNAs encoding splice variants of a novel MEK kinase, MEKK4.

78 tified a developmentally regulated, putative MEK kinase (MEKKalpha) that contains an F-box and WD40 r

79 MEK kinases (MEKKs) 1, 2, 3 and 4 are members of sequent

80 MEK kinases (MEKKs) are serine-threonine kinases that re

81 t PTP3, suppressed growth defects due to the MEK kinase mutation, BCK1-20, and the MEK mutation, MKK1

82 Although it is known that the MEK kinase of the pathway, Ste11, associates with Ste5,

83 Here, we show that one of three MEK kinases of the HOG pathway, Ssk2p, is specialized to

84 s fully compensated by other Raf proteins or MEK kinases or that its role in MEK/ERK activation is hi

85 af-MEK-MAPK pathway with PD98059, or the Ras-MEK kinase-p38 pathway with SB203580 had no effect on ra

86 tivity also was observed between the LPS and MEK kinase pathways, indicating that mutual antagonism c

87 Inhibitors of MEK kinase, PD98059, or overexpression of dominant negat

88 turn are phosphorylated and activated by MKK/MEK kinases (Raf and MKKK/MEKKs).

89 mains (in order): leucine-rich repeats, Ras, MEK kinase, Ras guanine nucleotide exchange factor N-ter

90 an unidentified protein kinase A-insensitive MEK kinase, rather than Raf-1, to regulate ERK activity.

91 Our results show that B-Raf was the critical MEK kinase required for M phase activation of the MAPK p

92 In addition, U0126 (a selective inhibitor of MEK kinase responsible for ERK phosphorylation) blocked

93 Ste11 [an MEK kinase (MEKK) or MAPK kinase (MEK) kinase], Ste7 (MEK or MAPK kinase), and the transcr

94 aused by deletion of BCK1, a gene encoding a MEK kinase that functions in a mitogen-activated protein

95 that the mixed lineage kinases (MLK1-4) are MEK kinases that reactivate the MEK/ERK pathway in the p

96 eam of Wak1, a homolog of the SSK2 and SSK22 MEK kinases, which transmits the stress signal to the Wi