ライフサイエンスコーパス: MEN2A

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1 MEN2A is a dominantly-inherited cancer predisposition sy

2 s with multiple endocrine neoplasia type 2A (MEN2A) and familial medullary thyroid carcinoma (FMTC) c

3 Multiple endocrine neoplasia type 2A (MEN2A) is predisposed by mutations in the RET proto-onco

4 ndrome multiple endocrine neoplasia type 2A (MEN2A).

5 or for multiple endocrine neoplasia type 2A (MEN2A).

6 that induction of the constitutively active MEN2A-specific RET mutant, RET2A(C634R), correlates with

7 protein previously associated with FMTC and MEN2A, it is very likely that they represent mutations t

8 rranged during Transfection (RET) gene cause MEN2A, MEN2B, and familial medullary thyroid carcinoma (

9 We have developed a Drosophila model for MEN2A and MEN2B diseases by targeting oncogenic forms of

10 d by germline mutations in the RET (formerly MEN2A, MEN2B) proto-oncogene located on chromosomal band

11 to construct mice in which the most frequent MEN2A mutation, Cys-634-Arg, was expressed under the con

12 ivating germline mutations observed in human MEN2A and familial MTC (FMTC).

13 between G691S/S904S and modifier effects in MEN2A families in any of the four European families anal

14 membrane of cysteine residues implicated in MEN2A and MTC syndromes.

15 a cysteine replacement that is prevalent in MEN2A cases - the A639G/A641R mutations significantly re

16 ns of RET lead to other conditions including MEN2A, familial medullary thyroid carcinoma and intestin

17 C) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellu

18 ing the cysteine-rich region of the protein (MEN2A-like mutations) are correlated with different phen

19 Perhaps most significantly, MEN2A adrenal tumors also display these changes in cell

20 ause multiple endocrine neoplasia syndromes (MEN2A and MEN2B).

21 The RET point mutations associated with MEN2A, MEN2B, or FMTC, or the chromosomal breakpoints an

22 Also, children from families with MEN2A, MEN2B, or FMTC, who are found to have inherited a

23 eventive thyroidectomies on 50 patients with MEN2A (group A).

24 In patients with MEN2A treated by preventive total thyroidectomy routine

25 re significantly deregulated in tumours with MEN2A-like and MEN2B-like mutations; however, further in

26 ositive weak effect on tumor spectrum within MEN2A, which requires replication in a larger series.

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