ライフサイエンスコーパス: MHC class I gene

1 ng 5], is a key transcription coactivator of MHC class I genes.

2 orthologs of the six fixed, functional human MHC class I genes.

3 ewly identified transcriptional regulator of MHC class I genes.

4 ly, NLRC5, as a transcriptional regulator of MHC class I genes.

5 sociates with and activates the promoters of MHC class I genes.

6 of species-specific expansion of paralogous Mhc class I genes.

7 ional block or may express only nonclassical MHC class I genes.

8 nserved in the promoters of human and murine MHC class I genes.

9 he HLA-E gene is distinct from that of other MHC class I genes.

10 o cellular major histocompatibility complex (MHC) class I genes.

11 s transcription of major histocompatibility (MHC) class I genes.

12 the X1 box, to be involved in NLRC5-mediated MHC class I gene activation.

13 Strikingly, nearby tap2 and MHC class I genes also retain ancient sequence lineages,

14 and transactivates the proximal promoters of MHC class I genes, although the molecular mechanism of t

15 Recent work has shown that MHC class I genes and CD3zeta, an obligate component of

16 is pathogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial.

17 vide the first direct evidence incriminating MHC class I genes and CD8(+) T cells in the pathogenesis

18 The major histocompatibility complex (MHC) class I genes are induced synergistically by interf

19 These findings identify MHC class I genes as direct targets of Foxp3 whose expre

20 o be unique to MHCII genes, because previous MHC class I gene-based therapies failed to produce Tregs

21 elated to the expressed cotton-top tamarin's MHC class I genes, but does show some similarity to So-N

22 isolates of ASFV increased the expression of MHC class I genes, but there was no parallel increase in

23 tic ducks predominantly use UAA, one of five MHC class I genes, but whether biased expression is also

24 sttranscriptional mechanism of regulation of MHC class I genes by IFN-gamma.

25 IFNs regulate most MHC class I genes by stimulating transcription initiatio

26 The major histocompatibility complex (MHC) class I gene cAMP response element (CRE)-like site,

27 Patr-AL is an expressed, non-polymorphic MHC class I gene carried by approximately 50% of chimpan

28 s to biased expression of a single classical MHC class I gene coevolving with TAP transporters, where

29 The promoters of MHC class I genes contain a well-conserved core module,

30 In contrast, a nonclassical MHC class I gene discovered in the chimpanzee is not pre

31 These findings demonstrate that the self MHC class I gene dosage may regulate the extent of CD8(+

32 nventional major histocompatibility complex (MHC) class I genes encode molecules that present intrace

33 ws combinatorial fine-tuning of the level of MHC class I gene expression in response to intrinsic and

34 CIITA also up-regulates MHC class I gene expression in vitro.

35 Tight regulation of MHC class I gene expression is critical for CD8 T cell a

36 In this report, we demonstrate that MHC class I gene expression is enhanced by the T cell en

37 Locus-specific down-regulation of MHC class I gene expression is frequently observed in hu

38 Therefore, characterization of MHC class I gene expression of Papio subspecies is a pre

39 onses, shuttles to the nucleus and activates MHC class I gene expression.

40 TF1 family transcription factors, to promote MHC class I gene expression.

41 e describe two highly divergent nonclassical MHC class I genes found in the chicken (Gallus gallus) t

42 ted CTL epitopes, we sequenced and expressed MHC class I genes from three ELA-A1 horses.

43 e bone marrow transduced with the allogeneic MHC class I gene H-2K(b) led to long-term expression of

44 of recombinant murine genes composed of the MHC class I gene H-2L(d) and the Fc portion of immunoglo

45 vaccination is performed with an allogeneic MHC class I gene (H-2 Kd)-modified tumor, the T cells ob

46 transduced major histocompatibility complex (MHC) class I gene (H-2K(b)) in bone marrow (BM)-derived

47 the human major histocompatibility complex (MHC) class I genes has been shown previously to increase

48 These findings suggest that KIR and MHC class I genes have coevolved as an interacting syste

49 hanism of IFN-gamma stimulation of the human MHC class I gene HLA-A2, several human tumor cell lines

50 Rats transgenic for the human MHC class I gene HLA-B27 are susceptible to a spontaneou

51 on-to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; P(c

52 All expressed human MHC class I genes (HLA-A, -B, -C, -E, -F, and -G) have f

53 including major histocompatibility complex (MHC) class I genes (HLA-A, HLA-B and B2M with p = 0.0001

54 The human MHC class I gene, HLA-B27, is a strong risk factor for s

55 IFN-gamma-induced transcription of the human MHC class I gene, HLA-E.

56 ression of a retrovirally encoded allogeneic MHC class I gene in bone marrow-derived cells can be use

57 sion of a retrovirally transduced allogeneic MHC class I gene in bone marrow-derived cells from recom

58 ents-CCAAT, TATAA-like, Sp1BS, and Inr-of an MHC class I gene in primary B-cells during both basal an

59 o the three codominantly expressed classical MHC class I genes in humans and mice.

60 One of the hallmarks of MHC class I genes in outbred populations is their extrao

61 rast to all other classical and nonclassical MHC class I genes in primates, the rate of synonymous nu

62 ss I genes in humans to as many as 22 active MHC class I genes in rhesus and levels of sequence diver

63 The limited variability of MHC class I genes in the Callitrichinae is likely the re

64 ed MHC class I, UAA, although they have five MHC class I genes in the complex, arranged TAP1-TAP2-UAA

65 of bovine major histocompatibility complex (MHC) class I genes in transfected mouse Ltk- cells.

66 genera exhibit limited variability of their MHC class I genes, in contrast to the high variability d

67 The rhesus monkey's complement of MHC class I genes includes the products of at least one

68 Cytokine induction of the MHC class I genes increases the nascent molecules availa

69 In this article, we show that NLRC5-mediated MHC class I gene induction requires the W/S and X1, X2 c

70 ivity that is necessary for transcription of MHC class I genes: inhibition of the AT activity repress

71 We show that expression of the MHC class I genes is downregulated in HPV-positive kerat

72 The expression of several MHC class I genes is up-regulated at the transcriptional

73 ription of major histocompatibility complex (MHC) class I genes is regulated by both tissue-specific

74 expressed major histocompatibility complex (MHC) class I genes isolated from a range of equid specie

75 MHC class I gene knockout mice were the most susceptible

76 MHC class I gene loss and dramatic reduction in function

77 Biased expression of one MHC class I gene may make viral escape within an individ

78 Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promo

79 In addition to MHC class I genes, NLRC5 also induced the expression of

80 , we have cloned and characterized classical MHC class I genes of pig-tailed macaques and have identi

81 The MHC class I genes of the New World primate, the cotton-t

82 These findings reveal a novel influence of MHC class I genes on CD4(+) T-cell responses to viral in

83 The MHC class I gene, PD1, has neither functional TATAA nor

84 e reported to express distinct but undefined MHC class I gene products.

85 ur predominantly at the level of the TCR and MHC class I gene products.

86 nclude the major histocompatibility complex (MHC) class I gene products, interferon-induced genes, an

87 Although CIITA also transactivates MHC class I gene promoters, loss of CIITA in humans and

88 cal roles of NLRC5/class I transactivator in MHC class I gene regulation and host defense by CD8(+) T

89 unction of the products of this nonclassical MHC class I gene remains unknown.

90 An in-depth analysis of the MHC class I gene repertoire in the two orangutan species

91 In gene trees of primate MHC class I genes, sequences from the Callitrichinae clu

92 e genus, therefore, expresses its own set of MHC class I genes, suggesting that an unusually high rat

93 CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more gl

94 us, basal and activated transcriptions of an MHC class I gene target distinct core promoter domains,

95 PS1 may represent a remnant of a once active MHC class I gene that is no longer functional in the cot

96 The ability of MHC class I genes to facilitate CD4(+) Th1 development c

97 rst example of a locus-specific repressor of MHC class I gene transcription in human tumor cells.

98 Three duck MHC class I genes (UBA, UCA, and UEA) are predicted to b

99 ion of the major histocompatibility complex (MHC) class I gene, we determined nucleosome occupancy an

100 and three putative nonclassical full-length MHC class I genes were found.

101 topes were presented by different molecules, MHC class I genes were identified in cDNA clones from Ar