ライフサイエンスコーパス: MHC class II gene

1 ion on T1D that is distinct from that of any MHC class II gene.

2 dhesion complex genes, and were depleted for MHC class II genes.

3 transcriptional coactivator CIITA regulates MHC class II genes.

4 titutive and IFN-gamma-induced expression of MHC class II genes.

5 ition to the established associations of the MHC class II genes.

6 A) is the master integrator of expression of MHC class II genes.

7 iption factor required for the expression of MHC class II genes.

8 rved X1 box sequence located upstream of all MHC class II genes.

9 the nuclear translocation and expression of MHC class II genes.

10 vator (CIITA) is the 'master coactivator' of MHC class II genes.

11 HLA-DR2(+) transgenic mice lacking all mouse MHC class II genes.

12 y of CIITA to transactivate transcription of MHC class II genes.

13 BRG-1, CIITA was unable to activate cellular MHC class II genes.

14 NF complex are required for transcription of MHC class II genes.

15 required for IFN-gamma-induced expression of MHC class II genes.

16 r (CIITA) activates the transcription of all MHC class II genes.

17 ulatory factors controlling transcription of MHC class II genes.

18 oth constitutive and inducible expression of MHC class II genes.

19 red for CIITA to function as an activator of MHC class II genes.

20 lin-dependent diabetes mellitus is linked to MHC class II genes.

21 ns required for the functional regulation of MHC class II genes.

22 e immune response to insulin is regulated by MHC class II genes.

23 E elements and is required for expression of MHC class II genes.

24 -binding proteins that functionally regulate MHC class II genes.

25 ression of major histocompatibility complex (MHC) class II genes.

26 ion of the major histocompatibility complex (MHC) class II genes.

27 with human major histocompatibility complex (MHC) class II genes.

28 minimum amount of IFN-gamma is required for MHC class II gene activation despite the fact that the l

29 cular map of chicken MHC genes (containing a MHC class II gene and two rRNA genes) to Rfp-Y validated

30 essential for transcriptional activation of MHC class II genes and mediates enhanced MHC class I tra

31 ecruitment to proximal promoter sequences in MHC class II genes and more distally involving the canon

32 activator (CIITA) is a critical regulator of MHC class II genes and other genes involved in the Ag pr

33 ependently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent in

34 the RFX complex to DNA, transcription of all MHC class II genes and the appearance of these determina

35 s involved in the immune response, including MHC class II genes and the interleukin-4 gene.

36 ar mechanism for the uncoupled regulation of MHC class II genes and the processing enzyme GILT in hum

37 ulation of Major Histocompatibility Complex (MHC)class II genes and an effective immune response.

38 ter of the HLA-DRA gene, the canonical human MHC class II gene; and with increased Rb binding to the

39 The human MHC class II genes are associated with genetic susceptib

40 The MHC class II genes are coordinately regulated by conserv

41 syngeneic major histocompatibility complex (MHC) class II genes are cell-based vaccines for the trea

42 Major histocompatibility complex (MHC) class II genes are regulated at the transcriptional

43 ls genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based

44 s found to be required for expression of all MHC class II genes associated with antigen presentation.

45 spatial proximity between PML bodies and the MHC class II gene cluster in different human cell types.

46 The proximal promoters of all MHC class II genes contain a sequence element, the 19-bp

47 sed vaccines is preserved in both CD4-/- and MHC class II-/- gene-deficient animals.

48 cleotides corresponding to the X2 box of the MHC class II genes DPA and DQB were used to screen B cel

49 he cells of these patients do not transcribe MHC class II genes due to a defect in the trans-acting f

50 uced expression of IFN-gamma-inducible genes-MHC class II gene E beta; MHC class II transactivator; I

51 luding the major histocompatibility complex (MHC) class II genes (eg, HLA-DRA) which correlated with

52 The major histocompatibility complex (MHC) class II genes encode a series of heterodimeric cel

53 ct control of CIITA is necessary to regulate MHC class II gene expression and induction of an immune

54 CIITA, a master regulator of MHC class II gene expression and truncated in B-cell lym

55 ivator (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells

56 vity and may function to selectively enhance MHC class II gene expression in dendritic cells.

57 Precise regulation of MHC class II gene expression is crucial for development

58 ransactivator (CIITA), is a key regulator of MHC class II gene expression that associates and coopera

59 t this domain contributes to MHC class I and MHC class II gene expression with a bias for activation

60 le cells induces CIITA expression as well as MHC class II gene expression.

61 ing the macromolecular assemblies that drive MHC class II gene expression.

62 echanism involved in regulation of CIITA and MHC class II gene expression.

63 to loss of major histocompatibility complex (MHC) class II gene expression, is caused by inherited mu

64 ibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1, but these gene

65 s independently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1.

66 Additionally, unlike the classical MHC class II genes, HLA-DOB expression was present in th

67 e of consistent and strong associations with MHC class II genes in Caucasian patients with inflammato

68 bryonic trophoblast cells from up-regulating MHC class II genes in response to IFN-gamma.

69 Furthermore, IFN-gamma induction of the MHC class II genes in solid human tumor lines requires r

70 l activator (CIITA) is a master regulator of MHC class II genes, including DR, DP, and DQ, and MHC cl

71 are investigating the transfer of allogeneic MHC class II genes into recipient bone marrow cells (BMC

72 In an attempt to define the MHC class II genes involved in disease, we previously st

73 The transcription of nonconventional MHC class II genes is, however not affected by CIITA def

74 In the present study, we characterize an MHC class II gene-linked butyrophilin family member, but

75 iations in major histocompatibility complex (MHC) class II genes may be of pathogenetic importance in

76 CB with type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MI

77 regulatory sequences are conserved among all MHC class II genes, multiple base pair changes are found

78 Coordinate regulation of MHC class II genes occurs in a tissue-specific and cytok

79 ) mice to eliminate any effect of endogenous MHC class II genes on the development of autoimmune dise

80 nhance CIITA-induced gene expression from an MHC class II gene promoter.

81 egulatory factors required for expression of MHC class II genes, rather than the genes themselves, ar

82 Expression of MHC class II genes requires CIITA.

83 fp-Y, encompassing two MHC class I and three MHC class II genes, separated from the B system by a reg

84 association of type 1 diabetes with specific MHC class II genes, such as I-A(g7) in nonobese diabetic

85 scriptionally a more potent activator of the MHC class II gene than the form expressed in B cells.

86 In addition to the MHC class II genes, there are at least two MHC-linked di

87 Transfer of MHC class II genes, through allogeneic bone marrow (BM)

88 Previous studies have shown cattle MHC class II genes to be subdivided into two distinct su

89 s II transactivator, the master regulator of MHC class II gene transcription.

90 gulator of major histocompatibility complex (MHC) class II gene transcription.

91 These results demonstrate the potential of MHC class II gene transfer to permit tolerance to solid

92 Other MHC class II genes were found to predict survival simila

93 pattern of dyscoordinate regulation of their MHC class II genes, which is reflected in a new phenotyp

94 as a CIITA-inducible gene, and DO beta as a MHC class II gene whose expression is independent of CII

95 ransport in live APCs, we replaced the mouse MHC class II gene with a version that codes for a class