ライフサイエンスコーパス: MHC class Ib-restricted

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1 ge, this is the first evidence for a defined MHC class Ib-restricted antiviral CD8 T cell response th

2 one marrow-chimeric mice, we have shown that MHC class Ib-restricted, but not MHC class Ia-restricted

3 We recently identified a protective MHC class Ib-restricted CD8 T cell response to infection

4 This study motivates efforts to uncover MHC class Ib-restricted CD8 T cell responses in other vi

5 patibility complex (MHC) class Ia molecules, MHC class Ib-restricted CD8 T cells have been implicated

6 MHC class Ib-restricted CD8(+) T cell responses were als

7 ta(2)-microglobulin-deficient mice that lack MHC class Ib-restricted CD8(+) T cells altogether.

8 ate T cells are exclusively selected on HCs, MHC class Ib-restricted CD8(+) T cells appear to be sele

9 ouse model, we demonstrate that not only are MHC class Ib-restricted CD8(+) T cells capable of being

10 hat these two distinct populations may allow MHC class Ib-restricted CD8(+) T cells to occupy differe

11 We show here that the activated phenotype of MHC class Ib-restricted CD8(+) T cells was partially acq

12 pulation of beta(2)-microglobulin-dependent, MHC class Ib-restricted CD8(+) T cells with specificity

13 These data demonstrate that other MHC class Ib-restricted CD8(+) T cells, in addition to H

14 To investigate the immune potential of MHC class Ib-restricted CD8(+) T cells, we have generate

15 ) T cells, major histocompatibility complex (MHC) class Ib-restricted CD8(+) T cells show an activate

16 w that following L. monocytogenes infection, MHC class Ib-restricted CTLs are evident in vivo.

17 eria-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis, since C57BL/6-derived

18 enes-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis.

19 MHC class Ib-restricted cytolytic effector cells specifi

20 nclassical major histocompatibility complex (MHC) class Ib--restricted cytolytic activity is expresse

21 We found that the antilisterial Qa-1b (MHC class Ib)-restricted effector subset is not detected

22 e conclusion that although Listeria-specific MHC class Ib-restricted effector cells are present follo

23 hematopoietically derived cells, similar to MHC class Ib-restricted "innate-type" lymphocytes.

24 Nonclassical MHC class Ib-restricted invariant T (iT) cell subsets ar

25 hepatocytes are susceptible to cytolysis by MHC class Ib restricted Listeria-specific CTL.

26 eveal a dynamic shift in Ag dependence by an MHC class Ib-restricted memory CD8 T cell response durin

27 pand after rechallenge, and it is unknown if MHC class Ib-restricted memory CD8+ T cells generated by

28 ells, however, is not a universal feature of MHC class Ib-restricted memory responses.

29 This first direct characterization of an MHC class Ib-restricted T cell response indicates that C

30 al infection, but the relative importance of MHC class Ib-restricted T cells in antimicrobial immunit

31 The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common develo

32 by the failure of CD8(+) T cells (presumably MHC class Ib-restricted) to respond to the infection.

33 Thus, the distinct functional properties of MHC class Ib-restricted versus MHC class Ia-restricted C

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