ライフサイエンスコーパス: MMTV

1 MMTV Gag localizes to discrete cytoplasmic foci in mouse

2 MMTV isolated from infected mice lacking these LBPs cann

3 MMTV-bound bacterial lipopolysaccharide triggered Toll-l

4 MMTV-Cre- or adenoviral-Cre-mediated SmoM2 expression in

5 MMTV-Cre;NRP2(loxP/loxP) mice exhibited significant defe

6 MMTV-D stability could help direct activation-associated

7 MMTV-Espl1 mice in a C57BL/6 genetic background develop

8 MMTV-LTR promoter-driven HA-14-3-3zeta transgenic mice (

9 MMTV-neu transgenic mice developed anemia after tumor on

10 MMTV-neu;Nedd9(-/-) mammospheres had striking defects in

11 MMTV-SP uses endoplasmic reticulum-associated degradatio

12 ent ITAM-containing proteins, one encoding a MMTV provirus and the other a B cell receptor fusion pro

13 oteins from an immortalized cell line from a MMTV-neu mouse model and from MCF7 human breast cancers

14 ession during breast cancer progression in a MMTV-PyMT transgenic mouse model.

15 An MMTV-Cre driver was used to target knockout to the epith

16 MMTV Gag and YB-1 was RNA dependent, and an MMTV RNA reporter construct colocalized with Gag and YB-

17 Using both human breast tumor cells and an MMTV-Wnt mouse breast tumor model, we show that RKIP ind

18 of our MT prostate model with those from an MMTV-MT breast model (23) shows both tissue-specific and

19 acity for transactivation (as measured in an MMTV luciferase reporter assay).

20 se, Hunk, from a mammary tumor arising in an MMTV-neu transgenic mouse.

21 to-mesenchymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progr

22 Constitutive overexpression of an MMTV/Mgat3 transgene inhibits early mammary tumor develo

23 g a floxed Ccn6 mouse which was bred with an MMTV-Cre mouse.

24 A floxed NRP2 mouse was bred with an MMTV-Cre strain to generate a mammary gland-specific kno

25 of the immunosuppressive cytokine IL-10 and MMTV evasion of host immunity.

26 creased apoptosis were seen in MMTV-HER2 and MMTV-Neu mammary glands lacking ErbB3, thus inhibiting p

27 of cancer (RIP1-Tag2 model of insulinoma and MMTV-PyMT model of breast cancer).

28 We tested the Env proteins of JSRV and MMTV, as well as human endogenous retrovirus K (HERV-K)1

29 ce is replicated faithfully in MMTV-PyMT and MMTV-Her2 transgenic mouse models of breast cancer.

30 ioned media (CM) obtained from MMTV-PyMT and MMTV-Her2/Neu tumor cells cultured in vitro were suffici

31 mouse mammary tumor virus (MMTV)- PyMT- and MMTV- Wnt1-driven mammary tumorigenesis and metastasis.

32 rom GFPRem dramatically reduced both Rem and MMTV-SP levels and function.

33 determines cleavage, retrotranslocation, and MMTV-SP function.

34 egulation of cap-independent translation and MMTV-induced tumorigenesis contrasts with the well estab

35 ogression of mammary tumors in MMTV-Wnt1 and MMTV-PyMT transgenic mice and by the tumor sphere cultur

36 /-) mice, arguing that mA3 is the major anti-MMTV restriction factor that is induced upon DC maturati

37 deamination was important for APOBEC3's anti-MMTV activity.

38 tumor virus-polyoma virus middle T antigen (MMTV-PyMT)-induced breast cancer to conduct such an eval

39 AQP1(+/+) MMTV-PyVT mice developed large breast tumors with total

40 +/-1/mouse) was much lower than in AQP1(+/+) MMTV-PyVT mice (31+/-8/mouse, P<0.005).

41 , 12 mice) were greatly reduced in AQP1(-/-) MMTV-PyVT mice (P<0.005).

42 ression was increased in tumors in AQP1(-/-) MMTV-PyVT mice.

43 microvascular anatomy in tumors of AQP1(-/-) MMTV-PyVT mice, with reduced vessel density.

44 that mA3 expression in target cells blocked MMTV infection at a postentry step and acted together wi

45 To allow detection and localization of both MMTV-SP and the C-terminal cleavage product, we prepared

46 LTR of the mouse mammary tumor virus (147 bp MMTV-A).

47 fap2c, in mouse mammary epithelium driven by MMTV-Cre promoted aberrant growth of the mammary tree le

48 t mechanistic breast cancer models driven by MMTV-Wnt1 and a human head and neck squamous cell carcin

49 trains for their abilities to be infected by MMTV and showed that susceptibility to infection correla

50 Conditional knockout of Runx1 in MECs by MMTV-Cre led to a decrease in luminal MECs, largely due

51 elopment in the mouse model of breast cancer MMTV-neu, a model characterized by amplification of the

52 induced mammary tumor formation in Chk1(+/-);MMTV-Cre animals with a median time to tumor latency of

53 in MMTV-miR-22 TG mice, as well as compound MMTV-neu or -PyVT-miR-22 TG mice.

54 Rnf5-deficient MMTV-PyMT mammary tumors were less differentiated and sh

55 nm) that partially activates an AR-dependent MMTV promoter (55% of maximal response) while antagonizi

56 on is diminished significantly in developing MMTV-Cre;NRP2(loxP/loxP) mammary glands compared with co

57 from Dmp1(+/+);MMTV-cyclin D1 and Dmp1(+/+);MMTV-D1T286A mice but significantly down-regulated in th

58 pre-malignant mammary glands from Dmp1(+/+);MMTV-cyclin D1 and Dmp1(+/+);MMTV-D1T286A mice but signi

59 Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibited a sup

60 r data support the hypothesis that efficient MMTV particle assembly is dependent upon the interaction

61 Additionally, they examine MMTV-PyMT control or POSTN null mice to test the effect

62 In female MMTV-HER2/neu transgenic mice, we found that ERalpha and

63 mammary hyperplasia and carcinoma in female MMTV-neu mice without causing weight loss or affecting n

64 Ccn6(fl/fl);MMTV-Cre mice developed invasive high grade mammary carc

65 Ccn6(fl/fl);MMTV-Cre mice displayed severe defects in ductal branchi

66 signal peptidase in the ER is necessary for MMTV-SP function in a reporter assay, but many requireme

67 As predicted, TGFbeta2 was high in four MMTV-Hoxb7/Her2 transgenic mouse tumor cell lines and tw

68 F-1alpha levels and tumor cells created from MMTV-Neu mice harboring deletion of Hif1alpha alleles re

69 cer cell lines and tumor cells cultured from MMTV-PyMT mice.

70 rated using Akt1 knockout cells derived from MMTV-ErbB2 transgenic mice.

71 s established from tumor tissue derived from MMTV-Neu/Tcfap2c(L/L) control animals and parallel cell

72 atic Mvt-1 mammary cancer cells derived from MMTV-PyVmT/FVB-N transgenic mice and c-Myc/vegf tumor ex

73 al delay in tumor growth, cells derived from MMTV-PyVT;Nedd9(-/-) tumors are characteristically hyper

74 two separate lineages that are distinct from MMTV.

75 Indeed, tumors isolated from MMTV-Neu mice contain elevated HIF-1alpha levels and tum

76 Conditioned media (CM) obtained from MMTV-PyMT and MMTV-Her2/Neu tumor cells cultured in vitr

77 compared mammary progenitor cell pools from MMTV-neu;Nedd9(-/-) versus MMTV-neu;Nedd9(+/+) mice.

78 h high levels of MELK in mammary tumors from MMTV-Wnt1/MELK-GFP bitransgenic mice resulted in a signi

79 Furthermore, MMTV incorporation of a weak agonist LPS from Bacteroide

80 tritransgenic mice (TetO-MYC;TetO-Kras(G12D);MMTV-rtTA) in which MYC and mutant Kras can be regulated

81 endence upon Ras mutations we have generated MMTV regulated Myc and Myc T58A transgenic mice.

82 We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly

83 Histopathologically, MMTV-Espl1 tumors are highly heterogeneous showing featu

84 alysis of the Akt2/miR-21 pathway in hypoxic MMTV-PyMT-induced mouse mammary adenocarcinomas and huma

85 e distinct mouse lines carrying an identical MMTV-Cre transgene (lines A, D, and F).

86 ngle-cell transplantation assays to identify MMTV-Her2/Neu mouse mammary TICs as CD24(+):JAG1(-) at a

87 In MMTV-cNeu(Tg/Tg) mice, which model HER2/Neu-amplified br

88 In MMTV-ErbB2 transgenic mice, loss of Pak1 prolonged survi

89 reast cancer, and constitutive activation in MMTV-SmoM2 transgenic mice caused alterations in mammary

90 glands and accelerated activation of Akt in MMTV-Neu mice.

91 n tumor cell allografts in nude mice, and in MMTV-Neu transgenic mice.

92 pothesis, we used DMH1, a BMP antagonist, in MMTV.PyVmT expressing mice.

93 n vivo analysis, indicated tumors arising in MMTV-neu;Nedd9(-/-) mice had undergone mutational select

94 of BITC for prevention of mammary cancer in MMTV-neu mice.

95 the casr gene in mammary epithelial cells in MMTV-PymT mice reduced tumor PTHrP expression and inhibi

96 of the already transformed mammary cells, in MMTV-Wnt1 mice.

97 f YB-1 resulted in a significant decrease in MMTV particle production, indicating that YB-1 plays a r

98 Furthermore, Lgr4 deletion in MMTV- Wnt1 tumor cells or knockdown in human breast canc

99 Here we show that Ube2o deletion in MMTV-PyVT or TRAMP mice profoundly impairs tumor initiat

100 blation impeded mammary tumor development in MMTV-Wnt1 mice, further underscoring a requirement of TG

101 22 promotes aggressive metastatic disease in MMTV-miR-22 TG mice, as well as compound MMTV-neu or -Py

102 addition, GFP(+) basal cells are expanded in MMTV-Wnt1 breast tumors but not in ErbB2 tumors.

103 this difference is replicated faithfully in MMTV-PyMT and MMTV-Her2 transgenic mouse models of breas

104 Kiss1r heterozygosity in MMTV-PyMT mice was sufficient to attenuate breast cancer

105 origenesis with increased lung metastasis in MMTV-Neu mouse model of spontaneous breast cancer.

106 that only a limited effect on metastasis in MMTV-neu;Nedd9(-/-) mice compared with MMTV-neu;Nedd9(+/

107 in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, incre

108 e PyMT model, as no changes were observed in MMTV-c-Neu mice carrying the Apc(Min/+) mutation.

109 ed mammary tumour formation were observed in MMTV-RANK transgenic mice after multiparity or treatment

110 core, reminiscent of structures observed in MMTV-Wnt1 tumours.

111 significantly delays mammary tumor onset in MMTV-Wnt1 females, whereas acute deletion of Pygo2 in MM

112 opment of breast cancer of luminal origin in MMTV-ErbB2 mice.

113 In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the ma

114 that epithelia-specific ablation of Pygo2 in MMTV-Wnt1 transgenic mice results in delayed mammary duc

115 females, whereas acute deletion of Pygo2 in MMTV-Wnt1 tumor cells leads to a significant decrease in

116 uction, indicating that YB-1 plays a role in MMTV capsid formation.

117 eration and increased apoptosis were seen in MMTV-HER2 and MMTV-Neu mammary glands lacking ErbB3, thu

118 TFAP2C, we examined mammary tumorigenesis in MMTV-Neu transgenic female mice with or without conditio

119 ased during progression of mammary tumors in MMTV-Wnt1 and MMTV-PyMT transgenic mice and by the tumor

120 C59 blocked progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/beta-

121 matrix metalloproteinases are upregulated in MMTV-LRP6 mice that could contribute to the hyperplasia

122 nts indicated that overexpression of Zpo2 in MMTV-PyMT mammary tumor cell lines enhances lung metasta

123 in four preclinical model systems, including MMTV-huHER2 and huCD3 transgenic mice.

124 Indeed, MMTV-PyVT;Nedd9(-/-) cells have increased cell cycle, ce

125 O(2), NH(2), and OH analogues also inhibited MMTV-Wnt1 murine mammary stem cell viability.

126 Although wingless integrated MMTV (Wnt)/beta-catenin signaling plays an essential rol

127 mor development and metastasis, we interbred MMTV-PyMT mice with E2F1, E2F2, or E2F3 knockout mice.

128 Interestingly, MMTV-Cre, Grp78(f/f) mammary glands displayed only sligh

129 d-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic breast cancer) de

130 al outgrowth compared with either littermate MMTV-Cre;NRP2(+/loxP) or MMTV-Cre mice.

131 lore this possibility, the highly metastatic MMTV-PyMT mice were crossed with 25 AKXD (AKR/J x DBA/2J

132 omoter-driven HA-14-3-3zeta transgenic mice (MMTV-HA-14-3-3zeta) developed mammary tumors, whereas co

133 The breast cancer mouse model, MMTV-PyMT (PyMT), developed breast tumors with lung meta

134 d mice with an inducible form of mS100a7a15 (MMTV-mS100a7a15 mice).

135 ed dynamics compared to a nearby nucleosome (MMTV-B) that is the initial target of transcription acti

136 mary Tumor Virus promoter-region nucleosome (MMTV-D) has greater inherent stability than and reduced

137 ary tumor virus (MMTV)-neu and 50 nuliparous MMTV-wnt1 transgenic mice were treated with RARalpha ago

138 restored both protein levels and activity of MMTV-SP.

139 ne deamination by virion-packaged APOBEC3 of MMTV early reverse transcription DNA occurred only at lo

140 The association of MMTV Gag and YB-1 in cytoplasmic granules was not disrup

141 However, the association of MMTV Gag and YB-1 was RNA dependent, and an MMTV RNA rep

142 his may reflect the long-term coexistence of MMTV and APOBEC3 in mice.

143 n (KD) miR-155 in the myeloid compartment of MMTV-PyMT mice, a mouse model of spontaneous breast carc

144 ile APOBEC3-mediated cytidine deamination of MMTV may occur, it is not the major means by which APOBE

145 nding the cancer-prone mammary epithelium of MMTV-Neu mice influences tumor development.

146 LRP6 antibodies specifically block growth of MMTV-Wnt1 or MMTV-Wnt3 xenografts in vivo.

147 agonist, Mesd, markedly suppressed growth of MMTV-Wnt1 tumors without causing undesirable side effect

148 The morphogenetic pathway of MMTV assembly is similar to that of Saccharomyces cerevi

149 Pygo2 in modulating the lineage potential of MMTV-Wnt1 tumor initiating cells.

150 is essential for the efficient production of MMTV particles, a process directed by the viral Gag prot

151 reversal suggests the specific selection of MMTV-PyVT;Nedd9(-/-) cells for growth in an in vivo micr

152 s to predict pathway activity in subtypes of MMTV-Myc mammary tumors.

153 cells (DCs) are the first in vivo targets of MMTV infection.

154 cid signal peptide (SP) at the N terminus of MMTV Rem or envelope proteins.

155 , we used virions from the mammary tissue of MMTV-infected inbred wild-type mice with different allel

156 rity of the late-appearing mammary tumors of MMTV-polyoma virus middle T;Nedd9(-/-) mice are characte

157 ect of these polymorphic APOBEC3 proteins on MMTV infection.

158 irus-driven polyoma virus middle T oncogene (MMTV-PyVT)].

159 h either littermate MMTV-Cre;NRP2(+/loxP) or MMTV-Cre mice.

160 TV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Neu transgenic mice.

161 es specifically block growth of MMTV-Wnt1 or MMTV-Wnt3 xenografts in vivo.

162 gly, in spite of their aggressive phenotype, MMTV-PyVT;Nedd9(-/-) cells persistently have low levels

163 Deletion of the Bcl3 gene in ErbB2-positive (MMTV-Neu) mice resulted in a 75% reduction in metastatic

164 ase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and

165 cancer [murine mammary tumor virus promoter (MMTV-NIC)].

166 lexes is facilitated by YB-1, which promotes MMTV virus assembly.

167 Here, the normal microenvironment redirects MMTV-neu-transformed tumorigenic cells to participate in

168 that the timed secretion of Wingless-related MMTV (mouse mammary tumor virus) integration site 3 (WNT

169 which secrete the morphogen Wingless-related MMTV (mouse mammary tumor virus) integration site 3 (WNT

170 Wingless-related MMTV integration site 1 (WNT1)/beta-catenin signaling pl

171 A receptor (2.9-fold), and wingless-related MMTV integration site 7B (2.8-fold).

172 secreted modulator of WNT (Wingless-related MMTV integration site)/beta-catenin signaling, is both n

173 ammary epithelium of our previously reported MMTV-tva transgenic mice, we detected high-grade, poorly

174 t the major means by which APOBEC3 restricts MMTV infection in vivo.

175 (MEC) populations, and oncogenic signaling, MMTV-ErbB2 transgenic mice were administered AZD4547 (2-

176 mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT) model of luminal breast cancer, induction of

177 mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT), which mimics RANK and RANKL expression patte

178 to the less stable and more dynamic target, MMTV-B.

179 (DCIS) in a transgenic mouse model [FVB/N-Tg(MMTV-PyMT)634Mul].

180 ivated in the MMTV-expressing cells and that MMTV-induced apoptosis resistance was completely restore

181 We found that MMTV, when ingested by newborn mice, stimulates a state

182 Our data revealed that MMTV Gag colocalized with YB-1, a translational regulato

183 Our studies revealed that MMTV-Cre, Grp94(f/f) mammary glands, despite GRP94 defic

184 awn from the free energy profiles, show that MMTV folds by a hierarchical mechanism with parallel pat

185 Our results show that MMTV suppresses apoptosis through ITAM-mediated Src tyro

186 Here, we show that MMTV-Her2/Neu mammary tumor cells cultured as nonadheren

187 Here we show that MMTV-infected cells or cells transfected with rem or env

188 We previously showed that MMTV Env expression transformed normal mammary epithelia

189 this LPS to stimulate TLR4, suggesting that MMTV intensifies these immunostimulatory properties.

190 The MMTV-neu;Nedd9(-/-) genotype selectively reduced both th

191 Overexpression of L9 in cells expressing the MMTV(C3H) provirus resulted in specific, robust accumula

192 model of mammary tumorigenesis harboring the MMTV-HER2 oncogene and mutation of MED1 to evaluate its

193 ing antisense oligonucleotides (ASOs) in the MMTV (mouse mammary tumor virus)-PyMT mouse mammary carc

194 xycycline-induced expression of FIP1C in the MMTV-ErbB2 mouse model resulted in delayed mammary tumor

195 o found that Src kinase was activated in the MMTV-expressing cells and that MMTV-induced apoptosis re

196 equences of genetic ablation of Nedd9 in the MMTV-HER2/ERBB2/neu mouse mammary tumor model.

197 However, in the MMTV-Her2/neu transgenic mouse model, the identity of TI

198 eless, our analysis of tumors arising in the MMTV-Myc model of mammary carcinogenesis reveals substan

199 In the MMTV-neu mouse model of breast cancer and the U251 xenog

200 celerated the onset of mammary tumors in the MMTV-Neu mouse model of breast cancer.

201 MTV-RANK and wild-type mice, but also in the MMTV-neu transgenic spontaneous tumour model.

202 antly limits mammary tumor initiation in the MMTV-polyoma virus middle T genetic model.

203 Thus, in the MMTV-PyMT mouse mammary model, increased ELF5 levels dri

204 mutant delays onset of mammary tumors in the MMTV-PyMT mouse model of breast cancer.

205 In the MMTV-PymT mouse model of mammary carcinoma, we found tum

206 gene-driven breast cancer progression in the MMTV-PyMT mouse model.

207 In the MMTV-PyMT oncomouse model of breast cancer, in which we

208 In the MMTV-PyMT transgenic mouse model of breast cancer and in

209 gh studies of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in

210 n Src inhibitor, SKI-606 (bosutinib), in the MMTV-PyVmT transgenic mouse model of breast cancer.

211 The absence of Dek in the MMTV-Ron mouse model led to a significant delay in tumor

212 The treatment was more effective in the MMTV-wnt1 model in which Am580 also induced differentiat

213 In the MMTV-Wnt1 mouse model, regression of mammary tumors by F

214 ve antagonist of Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model.

215 genesis with kinetics similar to that of the MMTV-c-src(Act) mice.

216 ective Dmp1 deletion was found in 21% of the MMTV-D1 and D1T286A mammary carcinomas, and the Dmp1 het

217 expressing human FLAG-PAD2 downstream of the MMTV-LTR promoter develop spontaneous neoplastic skin le

218 expression in the mammary epithelium of the MMTV-Neu mouse.

219 In the context of the MMTV-PyMT mammary tumor model, the lack of peripheral le

220 In this study, we used the MMTV-Neu-Tg mouse mammary tumor model to identify potent

221 Using the MMTV-Polyoma Middle T antigen (PyMT) mouse model of huma

222 Thus, MMTV has evolved to rely on the interaction with the mic

223 The mammary tumors arising in Tip30(-/-)/MMTV-Neu mice were exclusively ER+/PR-.

224 in (GFP) from the NS promoter and bred it to MMTV-Wnt1 mice, so that NS-expressing cells can be prosp

225 genetics of susceptibility and resistance to MMTV infection.

226 n in animals, we have generated a transgenic MMTV-Espl1 mouse model that overexpresses Separase prote

227 mammary tumor tissues from double-transgenic MMTV-Hoxb7/Her2 mice than tumors from single-transgenic

228 anted mammary tumors derived from transgenic MMTV-PyMT mice were scanned with (18)F-FDG PET/CT.

229 Here, we exploit the transgenic MMTV-ErbB2 (v-erb-b2 avian erythroblastic leukemia viral

230 ide additional evidence in triple transgenic MMTV/QR/Arom mice, wherein the QR expression is induced

231 induces a normalized growth of transplanted MMTV-PyMT breast tumours cells.

232 not only in hormone- and carcinogen-treated MMTV-RANK and wild-type mice, but also in the MMTV-neu t

233 nduced lung fibrosis model we used wild-type MMTV mice and a triple transgenic mouse SPC-rtTA(+/-)Tet

234 Fibroblast growth factor (Fgf)-Wingless type MMTV integration site family (Wnt) genetic module in the

235 the sonic hedgehog pathway and Wingless type MMTV integration site family were validated by immunohis

236 eas the roles of the canonical wingless-type MMTV (mouse mammary tumor virus) integration site family

237 d 3 main clusters of HCCs: the wingless-type MMTV integration site (32 of 89; 36%), interferon-relate

238 cued by local treatment with a Wingless-type MMTV integration site (Wnt) antagonist, Dickkopf-1 (Dkk1

239 The vital role of Wingless-type MMTV integration site (Wnt)/beta-catenin signaling in th

240 converging to dysregulate the Wingless-type MMTV integration site (Wnt)/beta-catenin signaling, a ke

241 errant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathogno

242 The wingless-type MMTV integration site family (WNT)/beta-catenin/adenomat

243 Wingless-type MMTV integration site family (WNT)16 is a key regulator

244 ntified causative mutations in wingless-type MMTV integration site family 1 (WNT1).

245 bone morphogenetic protein and wingless-type MMTV integration site family member (Wnt) superfamilies,

246 s in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric i

247 includes the Wnt family member wingless-type MMTV integration site family member 16B (WNT16B).

248 ted protein, which retains the Wingless-type MMTV integration site family member-ligand-binding domai

249 a repressor of canonical WNT (wingless-type MMTV integration site) signaling.

250 haracteristics of the primary tumors, unlike MMTV-Wnt1 mice.

251 Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null back

252 lly deleted from tissues of adult mice using MMTV-Cre.

253 re characteristically hyperaggressive versus MMTV-PyVT;Nedd9(+/+) cells in anchorage-independent grow

254 r cell pools from MMTV-neu;Nedd9(-/-) versus MMTV-neu;Nedd9(+/+) mice.

255 betaretroviruses, mouse mammary tumor virus (MMTV) and human endogenous retrovirus type K, encode ana

256 icts infection by mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV) and that there are

257 ol infection with mouse mammary tumor virus (MMTV) and murine leukemia virus (MuLV) via an adaptive i

258 Integration of mouse mammary tumor virus (MMTV) at the common integration site Int6 occurs in the

259 Mouse mammary tumor virus (MMTV) encodes a Rev-like protein, Rem, which is involved

260 es, including the mouse mammary tumor virus (MMTV) envelope (Env).

261 The mouse mammary tumor virus (MMTV) Gag protein directs the assembly in the cytoplasm

262 HIV in humans and mouse mammary tumor virus (MMTV) in mice.

263 Mouse mammary tumor virus (MMTV) is a complex murine retrovirus that encodes an HIV

264 Mouse mammary tumor virus (MMTV) is a complex retrovirus that encodes at least thre

265 m2s driven by the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter were morpholog

266 er control of the mouse mammary tumor virus (MMTV) long-terminal repeat (MMT mice).

267 ffect of DEX in a mouse mammary tumor virus (MMTV) luciferase reporter transactivation assay.

268 murine retrovirus mouse mammary tumor virus (MMTV) orchestrates the assembly of immature virus partic

269 ucleosomes in the mouse mammary tumor virus (MMTV) promoter.

270 er control of the mouse mammary tumor virus (MMTV) promoter.

271 mitted retrovirus mouse mammary tumor virus (MMTV) requires the intestinal microbiota for persistence

272 e first time that mouse mammary tumor virus (MMTV), a mammalian retrovirus that assembles intracytopl

273 iruses, including mouse mammary tumor virus (MMTV), are transmitted most efficiently through mucosal

274 ovirus (JSRV) and mouse mammary tumor virus (MMTV), as well as many endogenous retroviruses.

275 eletion inhibited mouse mammary tumor virus (MMTV)- PyMT- and MMTV- Wnt1-driven mammary tumorigenesis

276 Mouse mammary tumor virus (MMTV)-ErbB2 mice lacking PKCdelta (deltaKO) have increas

277 in breast cancer, mouse mammary tumor virus (MMTV)-Her2/neu transgenic mice that develop mammary tumo

278 The mouse mammary tumor virus (MMTV)-MT model of breast cancer has been important for p

279 l of 50 uniparous mouse mammary tumor virus (MMTV)-neu and 50 nuliparous MMTV-wnt1 transgenic mice we

280 tion of tumors in mouse mammary tumor virus (MMTV)-Neu mice.

281 in xenograft and mouse mammary tumor virus (MMTV)-neu mouse models in a manner associated with activ

282 lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model.

283 When mouse mammary tumor virus (MMTV)-neu-induced tumor cells were mixed with normal mam

284 ary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT) genetic model is del

285 crossed with the mouse mammary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Ne

286 on factors in the mouse mammary tumor virus (MMTV)-polyomavirus middle T oncoprotein (PyMT) mouse mod

287 (R175H) mice and mouse mammary tumor virus (MMTV)-Wnt-1 transgenic (mWnt-1) mice to specifically add

288 mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subty

289 d is expressed in mouse mammary tumor virus (MMTV)/PyMT tumors.

290 ain-of-function (mouse mammary tumour virus (MMTV)-RANK transgenic mice) and loss-of function (pharma

291 of the unrelated mouse mammary tumour virus (MMTV).

292 In vivo, MMTV infection delayed involution-induced apoptosis in t

293 ing factors, prompting us to examine whether MMTV utilizes a similar set of host proteins to facilita

294 However, the mechanisms by which MMTV associates with LPS remain unknown.

295 ) have increased tumor latency compared with MMTV-ErbB2 wild-type (deltaWT) mice, and the tumors show

296 y tumorigenesis and metastasis compared with MMTV-neu mice.

297 is in MMTV-neu;Nedd9(-/-) mice compared with MMTV-neu;Nedd9(+/+) mice, but instead a dramatic reducti

298 umber of CD39(+)CD73(+) TDMMCs compared with MMTV-PyMT/TGFbetaRII(WT) control tumors with intact TGF-

299 When crossed with MMTV-neu transgenic mice, 14-3-3zeta.neu transgenic mice

300 or growth, we interbred FABP5-null mice with MMTV-ErbB2/HER2 oncomice, which spontaneously develop ma