ライフサイエンスコーパス: MODS

1 MODS carries a high mortality and morbidity rate and adv

2 MODS detected 94.0% of 1,908 positive sputum cultures, w

3 MODS is a novel assay which can detect the organisms res

4 MODS transcripts differentially expressed in the hyperac

5 MODS was defined as a Denver Multiple Organ Failure scor

6 d it afforded therapeutic protection against MODS in a rat model of AP.

7 nger (tempol) on the circulatory failure and MODS (kidney, liver, lung) caused by coadministration of

8 2 to fraction of inspired oxygen (FIO2), and MODS scores.

9 sociated with improvement in lung injury and MODS scores and reduced mortality.

10 evels and similar changes in lung injury and MODS scores.

11 omponents of the lung injury score (LIS) and MODS score.

12 ococcus aureus, synergize to cause shock and MODS in the rat.

13 systemic inflammatory response syndrome and MODS.

14 pathway activation in relation to AP and AP-MODS in humans, by carrying out a prospective observatio

15 he lung, kidney and liver in experimental AP-MODS.

16 Acute mortality from AP-MODS exceeds 20%, and the lifespans of those who survive

17 ies available to protect individuals from AP-MODS.

18 therapeutic strategy in the treatment of AP-MODS, and they open up a new area for drug discovery in

19 bolism, is central to the pathogenesis of AP-MODS.

20 itis multiple organ dysfunction syndrome (AP-MODS); a devastating inflammatory condition with a morta

21 KT cell numbers, to patient outcomes such as MODS warrants further investigation.

22 copic observation drug susceptibility assay (MODS), a novel assay developed in Peru which uses an inv

23 icro g/ml), there was 100% agreement between MODS results read at day 11 and the reference method.

24 e-positive: 91 (94%) by MGIT and 74 (76%) by MODS (p = 0.002).

25 We prospectively compared MODS and Xpert MTB/RIF with standard microscopy and cult

26 M], 262 [19] vs 148 [35]; P<.001); decreased MODS score (mean [SEM], 0.7 [0.2] vs 1.8 [0.3]; P<.001);

27 markers in patients who would later develop MODS, with down-regulation of neutrophil deconvolution m

28 between patients who did or did not develop MODS (9.8 + 4.6 mEq/L vs. 9.4 + 4.4 mEq/L), but had good

29 red with the 16 patients who did not develop MODS (NoMODS), maximal differential expression was seen

30 likely than normothermic patients to develop MODS (21% vs. 9%, P = 0.003).

31 critically injured patients later developed MODS.

32 Patients who developed MODS also had elevated mtDNA DAMP levels compared with t

33 discriminated between patients who developed MODS and those who did not, and many of these difference

34 ers of the hyperacute response and different MODS phenotypes, and requires validation in other critic

35 sive and may lead to multiorgan dysfunction (MODS).

36 protects against multiple organ dysfunction (MODS) in experimental acute pancreatitis (AP).

37 series) and is a significant risk factor for MODS but not mortality.

38 ermia remained a significant risk factor for MODS when systolic blood pressure, volume of fluid, and

39 a subgroup of patients at increased risk for MODS to permit effective therapeutic intervention.

40 The most important MODS-related pathophysiologic conditions known to date h

41 In MODS versus NoMODS, 363 genes were differentially expres

42 The mean change in MODS was an increase of 8.5 and 8.7 points, respectively

43 ith significant differences in the change in MODS.

44 Bacterial loads, MODS, leukopenia, neutrophil infiltration, immune cell a

45 MGIT, MODS and Xpert MTB/RIF on the initial specimen identifie

46 The sensitivity of MGIT, MODS and Xpert MTB/RIF was 88%, 71% and 76%, respectivel

47 worsening organ failure (increased modified MODS).

48 Chronic Health Evaluation II score, modified MODS, and prothrombin time and the lowest platelet count

49 ive value of base deficit for development of MODS is blunted in the presence of hypothermia.

50 criptomic signature for later development of MODS was present in this hyperacute window; it showed a

51 ll numbers and the subsequent development of MODS.

52 A comprehensive prospective evaluation of MODS is under way in Peru, and independent validation in

53 The most prevalent mediating factors of MODS were examined for their potential to induce apoptos

54 or settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

55 Contemporary management of MODS is entirely supportive, and no specific therapeutic

56 increases in the serum levels of markers of MODS normally observed in this model.

57 The pathogenesis of MODS remains unclear, and several models are proposed, s

58 o a new understanding of the pathogenesis of MODS.

59 a unifying theory for the pathophysiology of MODS.

60 Significant predictors of MODS using multivariate analysis included minimum StO2 (

61 ; p =.02] and in patients with > or =3-organ MODS (9.2% [5.1,16.7] vs. 15.5% [8.3, 28.6]; p =.01).

62 with survival in patients with > or =3-organ MODS (p =.01).

63 with less %FO in patients with > or =3-organ MODS.

64 rstand the effect of hypothermia on outcome (MODS and mortality).

65 P-MODS correlated strongly with pediatric intensive care u

66 P-MODS was calculated by summing the worst score for all v

67 ediatric Multiple Organ Dysfunction Score (P-MODS); c) correlation of the score with outcome at pedia

68 ion across many centers, it is likely that P-MODS could function as a quantitative, clinically releva

69 A low StO2 value predicts MODS and mortality in trauma patients and is a durable m

70 change in Multiple Organ Dysfunction Score (MODS; range, 0 to 24, with higher scores indicating more

71 Four patients died secondary to severe MODS.

72 Ps is associated with the evolution of SIRS, MODS, and mortality in severely injured human subjects.

73 microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis

74 microscopic observation drug susceptibility (MODS) assay, was compared to that of the reference 7H10

75 Microscopic Observation Drug Susceptibility (MODS) culture or the Xpert MTB/RIF assay might be used t

76 ystemic multiple organ dysfunction syndrome (MODS) and death.

77 cluding multiple organ dysfunction syndrome (MODS) and death.

78 ment in multiple organ dysfunction syndrome (MODS) and development of nosocomial infections.

79 to the multiple organ dysfunction syndrome (MODS) caused by endotoxin.

80 nent of multiple organ dysfunction syndrome (MODS) following pulmonary infection.

81 odified Multiple Organ Dysfunction Syndrome (MODS) score (which did not score for thrombocytopenia).

82 score), multiple organ dysfunction syndrome (MODS) score, admission status, days without nutrition, U

83 ates in multiple organ dysfunction syndrome (MODS) that is normally triggered by gut ischemia-reperfu

84 Multiple organ dysfunction syndrome (MODS) was present in 103 patients; 59 survived (57%).

85 ressive multiple organ dysfunction syndrome (MODS), and an unfavorable outcome.

86 sepsis, multiple organ dysfunction syndrome (MODS), and death.

87 e syndrome, multiorgan dysfunction syndrome (MODS), and death.

88 (SIRS), multiple organ dysfunction syndrome (MODS), and mortality.

89 sequent multiple organ dysfunction syndrome (MODS), associated with trauma in a rat model of hemorrha

90 in the multiple organ dysfunction syndrome (MODS), with or without accompanying sepsis.

91 cluding Multiple Organ Dysfunction Syndrome (MODS).

92 ment of multiple organ dysfunction syndrome (MODS).

93 of the multiple organ dysfunction syndrome (MODS).

94 id and rifampin drug susceptibility testing, MODS is as accurate as and more rapid than the reference

95 Human HDLs attenuate the MODS associated with ischemia and reperfusion injury aft

96 om the primary injury site may contribute to MODS.

97 2 had a greater incidence of progression to MODS as defined by the Marshall MOD score, a longer dura

98 ained by direct susceptibility testing using MODS demonstrated excellent concordance for isoniazid an

99 as not affected the outcome of patients with MODS.