ライフサイエンスコーパス: MRF

1 MRF can also be used to identify the presence of a speci

2 MRF is a nuclear protein containing an evolutionarily co

3 MRF thus provides an alternative way to quantitatively d

4 cific transcription factors, including HLH-1/MRF and UNC-120/SRF, which together orchestrate specific

5 In total, 171 MRF neurons that projected to the C5-C6 ventral horn wer

6 A total of 94 MRF neurons responsive to bilateral electrical stimulati

7 s, they require E protein partners to form a MRF-E protein heterodimer, which represents the function

8 Semi-automatic segmentation incorporating a MRF model was performed in all patients below the C4 ver

9 n appropriate pattern-recognition algorithm, MRF inherently suppresses measurement errors and can thu

10 Although MRFs are essential for myogenic commitment and different

11 e structural motifs that are conserved among MRFs: an alanine-threonine (Ala-Thr) dipeptide of the ba

12 pharyngeal muscle fate both by promoting an MRF-associated myogenic program in myoblasts and by main

13 val tail muscle development and thus that an MRF-dependent myogenic regulatory network probably exist

14 In contrast, myf 5 and MRF 4 mRNAs are detected at significant levels in embryo

15 Myf 5 and MRF 4 transcripts are detected in stage 15 forelimbs, wh

16 A survey of MyoD, myf 5, and MRF 4 transcripts in other embryonic tissues reveals tha

17 roduct required for normal development), and MRF-2 (which represses expression from the cytomegalovir

18 lix family (bHLH) (myoD, myf-5, myogenin and MRF-4) to induce myogenic differentiation.

19 with a high percentage in RRN, PoO, PoC, and MRF.

20 ed by Hes/Hey downstream of Notch as well as MRF activities are integrated at the level of the p57(ki

21 troponin I reporter gene activity as well as MRF-directed transcription from a multimerized skeletal

22 ion using a Uni-ZAPTM XR vector and XL1-Blue MRF' host.

23 In addition to the anonymization afforded by MRF, this format also facilitates the decoupling of the

24 The methods used by MRF-MGL efficiently characterised IMD isolates and infor

25 y element of p57(kip2) directly activated by MRFs in myoblasts but repressed by the Notch targets Hes

26 opagate and amplify the signals initiated by MRFs.

27 Ci-MRF is the sole myogenic regulatory factor (MRF) of the

28 Conversely, inhibiting Ci-MRF activity with antisense morpholinos down-regulated t

29 invertebrate chordate Ciona intestinalis (Ci-MRF).

30 mple in vivo assay based on misexpressing Ci-MRF in the notochord of Ciona embryos.

31 Ala-Thr dipeptide is necessary for normal Ci-MRF function, and that while eliminating the C/H domain

32 ity and revealed the myogenic activity of Ci-MRF by inducing the expression of four muscle marker gen

33 Injection of Ci-MRF mRNA into eggs resulted in increased embryonic muscl

34 ndividually has no demonstrable effect on Ci-MRF, simultaneous loss of both motifs significantly redu

35 We conclude that Ci-MRF is required for larval tail muscle development and t

36 Within the CNS, MRF is specifically expressed by postmitotic oligodendro

37 Consequently, MRF-MRF comparison for remote homology detection shall b

38 e the function of each of the four conserved MRF genes in zebrafish, an organism that has retained a

39 model very short-range residue correlation, MRFs can model long-range residue interaction pattern an

40 st - Magnetic Resonance Fingerprinting (DC - MRF) methodology is described that can detect and indepe

41 Different MRF neuronal groups were found to respond to locomotion,

42 of muscle determination and differentiation (MRFs) together with two candidate markers of satellite c

43 genes on the networks using a local discrete MRF model.

44 n to a skeletal muscle lineage by disrupting MRF function via a mechanism that is independent of the

45 strate differential requirements of distinct MRFs for the induction of microRNA gene expression durin

46 ty that the regulative behavior of distinct, MRF-expressing populations explains the functional compe

47 gest that the differential use of duplicated MRF paralogues in this novel two-component myogenic syst

48 Hh is known to enhance MRF expression.

49 oes not alter the ability of CKII to enhance MRF transcriptional activity, suggesting that the effect

50 These findings establish MRF as a critical transcriptional regulator essential fo

51 ting muscle cells, muscle regulatory factor (MRF) 4 is normally the last of the four MRFs to be expre

52 The activity of myogenic regulatory factor (MRF) genes is essential for vertebrate muscle developmen

53 the first of the myogenic regulatory factor (MRF) genes to be activated in preexisting somites in a r

54 Myogenic regulatory factor (MRF) genes, MYOD1, MYOG, MYF6 and MYF5, are critical for

55 iption factor myelin gene regulatory factor (MRF) is required to maintain the integrity of myelin in

56 The myogenic regulatory factor (MRF) MYF5 is the earliest to be expressed during myogene

57 -MRF is the sole myogenic regulatory factor (MRF) of the ascidian Ciona intestinalis, an invertebrate

58 we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS my

59 grams that require muscle regulatory factor (MRF)-family genes.

60 tified host factors [Mu replication factors (MRF alpha 2)], which displace the transpososome in an AT

61 The myogenic regulatory factors (MRFs) are a subclass of a much larger group of basic hel

62 lated family of myogenic regulatory factors (MRFs) are expressed during somitogenesis although cells

63 Myogenic regulatory factors (MRFs) are required for mammalian skeletal myogenesis.

64 Myogenic regulatory factors (MRFs) are vital transcription factors that act at multip

65 e expression of myogenic regulatory factors (MRFs) myf5 and myod in specific muscle precursor cell po

66 g the activity of muscle regulatory factors (MRFs) of the Myod family above a threshold.

67 tch pathway and myogenic regulatory factors (MRFs) orchestrate the proliferation, specification and d

68 Myogenic regulatory factors (MRFs), including Myf5, MyoD (Myod1) and Myog, are muscle

69 Myogenic regulatory factors (MRFs), muscle-specific transcription factors, are implic

70 rganized by the myogenic regulatory factors (MRFs), Myf5, MyoD, Myf6, and myogenin, where myogenin pl

71 helix-loop-helix muscle regulatory factors (MRFs), such as MyoD, to convert nonmuscle cells to a myo

72 in are dominant myogenic regulatory factors (MRFs), which are involved in control of muscle-specific

73 gets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2

74 s a regulation by muscle regulatory factors (MRFs).

75 he MyoD family of muscle regulatory factors (MRFs).

76 etween CTCF and myogenic regulatory factors (MRFs).

77 rs known as the myogenic regulatory factors (MRFs): Myf5, Mrf4, myogenin and MyoD.

78 n, and the four myogenic regulatory factors (MRFs.) Most mutant satellite cells entered the cell cycl

79 B proteins, the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the hem

80 op-helix (bHLH) myogenic regulatory factors (MRFs; MyoD, Myf5, myogenin and MRF4) and Pax3, a paired-

81 f myogenic regulatory transcription factors (MRFs) are well known to govern lineage commitment and di

82 rs of the myogenic regulatory factor family (MRFs) and on extrinsic cellular cues, including Wnt sign

83 genic regulatory factors of the Myod family (MRFs) are transcription factors essential for mammalian

84 genic regulatory factors of the myod family (MRFs) are transcription factors essential for mammalian

85 s embryo, we show that CeMyoD is a bona fide MRF that can convert almost all cells to a muscle-like f

86 ted MRI (WBDWI) using a Markov random field (MRF) model to derive tumor total diffusion volume (tDV)

87 nt algorithm based on a Markov random field (MRF) model, called MRFSeq, that uses additional gene coe

88 datasets by defining a Markov random field (MRF) over super-voxels in the foreground and applying mo

89 We use a Markov random field (MRF) prior to map the network connections among genes.

90 s article, we develop a Markov random field (MRF)-based method for identifying genes and subnetworks

91 d visual field test (Melbourne Rapid Field, (MRF)) conducted at the bedside aided swift and appropria

92 e key components: 1) a Markov Random Fields (MRF) representation of a protein family; 2) a scoring fu

93 n be fully captured by Markov random fields (MRFs).

94 we term 'magnetic resonance fingerprinting' (MRF)--that permits the simultaneous non-invasive quantif

95 During mouse development Myf5 is the first MRF to be expressed and it acts by integrating multiple

96 f MRF, indicating an ongoing requirement for MRF in the expression of these genes.

97 s, we have developed the Mapped Read Format (MRF), a compact data summary format for both short and l

98 ivered to the medullary reticular formation (MRF) by diffusion from a cannula inserted through a guid

99 The mesencephalic reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuc

100 ile inputs to medullary reticular formation (MRF) neurons after acute and chronic dorsal column (DC)

101 s onto single medullary reticular formation (MRF) neurons.

102 of the medial medullary reticular formation (MRF) participate in generating vestibulo-respiratory res

103 in the medial medullary reticular formation (MRF) provide inputs to phrenic and abdominal motoneurons

104 e lateral mesencephalic reticular formation (MRF) that in turn project to the nucleus reticularis pon

105 ts of the mesencephalic reticular formation (MRF), namely the pedunculopontine and cuneiform nuclei.

106 silateral mesencephalic reticular formation (MRF), periaqueductal gray, Kolliker-Fuse nucleus, and po

107 r part of the medullary reticular formation (MRF).

108 and many cells ultimately expressed all four MRFs simultaneously.

109 whereas Id3 interacted weakly with all four MRFs.

110 tor (MRF) 4 is normally the last of the four MRFs to be expressed.

111 ptide of the basic domain of an invertebrate MRF behaves as a myogenic code.

112 the hit kinases could be connected to known MRFs, directly or through one interaction node.

113 In mice lacking MRF within the oligodendrocyte lineage, premyelinating o

114 sed into the dorsal/lateral PAG, the lateral MRF, or the superficial layers of the SC did not affect

115 rch Foundation Meningococcus Genome Library (MRF-MGL) exploits whole-genome sequencing (WGS) for this

116 elegans embryos lacking activity of the lone MRF ortholog HLH-1, indicating that additional myogenic

117 We conclude that CTCF modulates MRF functional interactions in the orchestration of myog

118 Genetic ablation of MRF in mature oligodendrocytes within the adult CNS resu

119 were rapidly downregulated after ablation of MRF, indicating an ongoing requirement for MRF in the ex

120 eks and peaking at 8 weeks after ablation of MRF.

121 the modulator reduce the binding activity of MRF, as well as the repressing activity on the enhancer.

122 e-specific gene and that multiple classes of MRF-regulated genes exist in Ciona.

123 consistent with substantial conservation of MRF-directed myogenesis in chordates and demonstrate for

124 The expression of MRF is differentiation specific; the DNA binding activit

125 sults demonstrate that ongoing expression of MRF within the adult CNS is critical to maintain mature

126 udy tested the hypothesis that the firing of MRF neurons whose axons could be antidromically activate

127 muscle development is largely independent of MRF function.

128 g pathway(s) that mediates the inhibition of MRF-induced myogenesis by oncogenic Ras, we tested two t

129 Knockdown of MRF in oligodendrocytes by RNA interference prevents exp

130 Loss of MRF function leads to loss of myogenesis by specific pop

131 myelin genes; conversely, overexpression of MRF within cultured oligodendrocyte progenitors or the c

132 s two possibilities: that two populations of MRF neurons provide independent inputs to inspiratory an

133 multigene neighborhoods in the regulation of MRF genes.

134 The role of MRF has also been advocated in modulation of state of ar

135 FGFs, which interferes with the activity of MRFs, suppressed the expression of miR-1, miR-206 and mi

136 gh up-regulation of distinct combinations of MRFs.

137 We found that directed expression of MRFs in the neural tube of chicken embryos induced ectop

138 in the quiescent state before expression of MRFs or desmin and distinguish them from fibroblasts.

139 ere, we define Ascl2 as a novel inhibitor of MRFs.

140 sequester their transcriptional activity on MRF genes.

141 1, encoding HLH-1 (CeMyoD) which is the only MRF-related factor in the nematode.

142 ic regulatory networks were MRF-dependent or MRF-independent.

143 nstream of myelin regulatory factor (MYRF or MRF), a transcriptional regulator that specifically acti

144 Unlike previous MRF-based methods, SMURFLite is computationally feasible

145 Conclusions: The proposed MRF-based model efficiently utilizes the known pathway s

146 We detected a novel nuclear protein, MRF, that binds to multiple sites on the modulator which

147 ns with MyoD, indicating that CTCF regulates MRF-mediated muscle differentiation.

148 investigate the role of myogenic regulators (MRFs), Myf5, MyoD, Myogenin and MRF4 in the regulation o

149 ence (i.e. 62%) in a subset of PN-responsive MRF neurons is significantly greater than for the subset

150 greater than for the subset of PN-responsive MRF neurons that did not respond to urinary bladder dist

151 Free Grammars and Markov Random Fields (SCFG/MRF).

152 The SCFG/MRF models are constructed using atomic-resolution RNA 3

153 A mutation in myog, encoding a second MRF, has little obvious phenotype at early stages, but e

154 Lite, a method that combines both simplified MRFs and simulated evolution to substantially improve re

155 na exhibits a similar reliance on its single MRF-family gene, and diverse mechanisms activate Ci-Mrf

156 ry and expiratory motoneurons or that single MRF neurons have collateralized projections to both grou

157 e role in embryonic myogenesis of the single MRF gene of the invertebrate chordate Ciona intestinalis

158 hibits myogenic differentiation by targeting MRFs and facilitates the generation of postnatal satelli

159 Competitive binding assays demonstrate that MRF requires the presence of multiple A+T stretches for

160 simplest explanation for these data is that MRF neurons that receive input from the vestibular nucle

161 We propose that MRF binds over the entire modulator and exerts repressor

162 These results suggest that MRF may act as a repressor of enhancer function.

163 We discovered that MRFs and MEF2 regulate a remarkably extensive array of t

164 We found that MRFs play an unexpectedly wide-ranging role in directing

165 The MRF alpha 2 transition factors, assembled into a prerepl

166 The MRF-MGL represents an effective, broadly applicable mode

167 Although the MRF alpha 2 components are apparently not encoded by cur

168 help registration in textureless areas, the MRF over super-voxels efficiently propagates motion info

169 In particular, we compare the MRF prior to a situation where independent Bernoulli pri

170 r simulation studies show that employing the MRF prior improves on selection accuracy.

171 ct evidence to demonstrate that cells in the MRF relay vestibular signals monosynaptically to respira

172 ion of the clique potential functions in the MRF so its maximum a posteriori estimation can be reduce

173 lutionarily ancient, but that changes in the MRF targets for particular signals contribute to myogeni

174 nists (if endogenous) acting at sites in the MRF would be effective muscle relaxants during pregnancy

175 le group of brainstem neurons located in the MRF.

176 Lidocaine or muscimol injections into the MRF produced a large increase in diaphragm and abdominal

177 determine whether functional lesions of the MRF affect inspiratory and expiratory muscle responses t

178 ectron microscopy that MyoD, a member of the MRF family, also plays a role in fetal synapse formation

179 respect, MyoD and MRF4, both members of the MRF family, exist in vivo as phosphoproteins and contain

180 e bladder were found for 51% (n = 48) of the MRF neurons tested.

181 xtensive electrophysiological mapping of the MRF using extracellular recordings at rest and during lo

182 tly located in the magnocellular part of the MRF, but were absent from both the dorsal and ventral re

183 after dextrose deposits, further reduced the MRF-evoked EMG responses over the course of 1 h.

184 These data support the hypothesis that the MRF participates in generating vestibulo-respiratory res

185 Thus, the MRF-SRF and YAP-TEAD pathways interact indirectly throug

186 ltiple spinal pathways from the penis to the MRF may correspond to different functions, including tho

187 locomotor neuronal system present within the MRF in behaving NHPs under normal conditions, in accorda

188 es of a locomotor neuronal system within the MRF in behaving NHPs.

189 Although the MRFs are unique in their ability to confer a myogenic ph

190 express either MyoD or myf5 first among the MRFs; most cells then expressed both myf-5 and MyoD simu

191 However, the MRFs can be computationally prohibitive when beta strand

192 ng that the effect of CKII expression on the MRFs is indirect.

193 Given that the MRFs require dimerization with E protein partners to act

194 Most (135/171 or 79%) of these MRF neurons lacked spontaneous firing.

195 of a locomotor neuronal circuit within these MRF in behaving primates.

196 functional compensatory activities of these MRFs.

197 including all sequences deleted in the three MRF knockout alleles, with a basal promoter and a lacZ r

198 ormation from the male external genitalia to MRF, and (2) ascending bilateral projections in the vent

199 in myogenic cells and in the embryo prior to MRF expression but absent in nonmyogenic fibroblasts.

200 gans (bladder, descending colon, urethra) to MRF.

201 ethod of Multipliers) algorithm aligning two MRFs.

202 scoring function measuring similarity of two MRFs; and 3) an efficient ADMM (Alternating Direction Me

203 e earliest myogenic regulatory networks were MRF-dependent or MRF-independent.

204 ues model nested pairs and insertions, while MRF ideas handle crossing interactions and base triples.

205 ar-distal enhancer chromatin associated with MRF genes in Mb and Mt than previously reported from stu

206 ifferentiation state, might collaborate with MRFs.

207 Ascl2 competes with MRFs for binding to E-boxes in the promoters of muscle g