ライフサイエンスコーパス: MRP2

1 r multidrug resistance-associated protein 2 (MRP2).

2 isoform of the multidrug resistance protein (Mrp2).

3 in human biopsies revealed up-regulation of MRP2.

4 tes, with some minor contribution from mouse Mrp2.

5 ]pyridine) is transported by BCRP, MDR1, and MRP2.

6 nd the multispecific organic anion exporter, mrp2.

7 at its canalicular transport did not require mrp2.

8 on was noted in TR- mutant rats deficient in mrp2.

9 ssociated proteins (MRP), including MRP1 and MRP2.

10 sphate (cAMP) increases plasma membrane (PM)-MRP2.

11 crease MARCKS phosphorylation or decrease PM-MRP2.

12 thout affecting cAMP-induced increases in PM-MRP2.

13 ug metabolism and drug transporters mdr1 and mrp2.

14 ition by the multidrug resistant transporter Mrp2.

15 ction that required the PDZ-binding motif of Mrp2.

16 se elements in the promoter regions of mouse Mrp2 [-185 base pairs (bp)], Mrp3 (-9919 bp), and Mrp4 (

17 The MRP2 5'-untranslated region (5'UTR) contains seven upstr

18 tion of an MRP2 polymorphism, -24C>T, in the MRP2 5'UTR, demonstrated no effect on mRNA expression or

19 We conclude that among the uORFs in the Mrp2 5'UTR, the uORF starting at nucleotide -109 probabl

20 We investigated MRP2 5'UTRs [-247 (-247 to -1), -204 (-204 to -1), or -9

21 In HepG2 cells transfected with SV40-MRP2-5'UTR-Luciferase cassettes, luciferase activities o

22 e multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.

23 Multidrug resistance protein 2 (MRP2), a marker selectively transported to the apical (i

24 characterized using Tr(-) rats (deficient in mrp2, a canalicular transporter for organic anions), the

25 BSEP, MDR1, MDR2, and MRP2 ABC transporters are targeted to the apical (canali

26 o1a/1b(-/-)/(-/-)) or the efflux transporter Mrp2 (Abcc2(-/-)) were intravenously injected with (99m)

27 MRP2 (ABCC2), a member of the ATP binding cassette super

28 esistant-associated protein 1 (MRP1; ABCC1), MRP2 (ABCC2), and MRP4 (ABCC4).

29 gnificant reduction in hepatic expression of Mrp2 (Abcc2), the principal canalicular multispecific or

30 ts, deficient in the canalicular transporter Mrp2 (Abcc2).

31 drug-resistance associated transport protein Mrp2 (ABCC2).

32 ; multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp

33 Multidrug resistance-associated protein 2 (Mrp2, Abcc2) is an ATP-binding cassette transporter loca

34 Multidrug resistance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in th

35 e multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated

36 the immunoprecipitation-enriched samples of MRP2/ABCC2 following proteolysis with trypsin.

37 the absolute amount of MRP2/ABCC2 protein in MRP2/ABCC2 gene-transfected MDCK cells as well as the ba

38 ot able to detect the basal levels of canine Mrp2/Abcc2 in MDCK cells.

39 cells as well as the basal levels of canine Mrp2/Abcc2 protein in MDCK cells.

40 ccessfully determined the absolute amount of MRP2/ABCC2 protein in MRP2/ABCC2 gene-transfected MDCK c

41 le to many current research needs related to MRP2/ABCC2 protein.

42 thod was developed to quantitatively measure MRP2/ABCC2 using LC-MS/MS for detection of a selective t

43 e multidrug resistance-associated protein 2 (MRP2/ABCC2) plays an important role in hepatobiliary eff

44 Multidrug resistance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the

45 1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

46 Mrp2 activity is regulated by insertion into the plasma

47 Thus, MRP1/MRP2 acts as an RNA matchmaker by stabilizing the RNA mo

48 Substrates of Mrp2 affect the ability of the protein to interact with

49 Finally, human MRP2 also transported As(GS)(3).

50 e sought to determine whether the absence of Mrp2 alters the accumulation and toxicity of platinum in

51 ned structures of Trypanosoma brucei apoMRP1/MRP2 and an MRP1/MRP2-gRNA complex.

52 MRP2 and BSEP were expressed with baculoviruses in insec

53 ment of PC12 cells with interfering RNAs for MRP2 and glycogen synthase kinase 3beta (GSK3beta) resul

54 itical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-de

55 ment: 1) PBOH-glucuronide is a substrate for Mrp2 and may compete with other organic anions for bilia

56 ch exhibit functional and properly localized Mrp2 and Mrp3 over time in culture.

57 uced, whereas the apical export transporters Mrp2 and Mrp4 are increased, resulting in a significant

58 uded that the efflux system for MTX includes MRP2 and MRP4, in addition to MRP1 and MRP3, and that MR

59 Here we examine the interaction of Mrp2 and NHERF-1 and its physiological significance in H

60 iated with increased expression GST-Pi, Mrp1/Mrp2 and P-glycoprotein, which function together to redu

61 Mrp2 and RAR alpha:RXR alpha protein abundance and activ

62 eta treatment of primary hepatocytes reduced Mrp2 and RXR alpha expression.

63 e were reduced 4- to 6-fold in Bcrp1;Mdr1a/b;Mrp2(-/) (-) and Bcrp1;Mrp2;Mrp3(-/-) mice compared with

64 r multidrug resistance-associated protein 2 (Mrp2) and basolateral Mrp3 mediate the excretion of orga

65 f multidrug resistance-associated protein 2 (MRP2) and of bile salt export pump (BSEP) variants and m

66 r multidrug resistance-associated protein 2 (Mrp2) and the effect of pretreatment with dibutyryl-cycl

67 which encode for the efflux transporter Mrp1/Mrp2) and the multidrug resistance gene (MDR1, which enc

68 , multidrug resistance-associated protein 2 (Mrp2), and breast cancer resistance protein (BCRP) expre

69 r multidrug resistance-associated protein 2 (Mrp2), and the backflux transporter Mrp4, as determined

70 xpression (Western blots) of P-glycoprotein, Mrp2, and BCRP.

71 etermine expression of MRP3/Mrp3, CPF/Lrh-1, Mrp2, and Bsep.

72 We conclude that Bcrp1, Mdr1a/b, Mrp2, and Mrp3 significantly affect tissue disposition a

73 Three (MRP1, MRP2, and MRP3) of the four members that have this struc

74 dings strongly suggest that NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expre

75 profoundly up-regulates apical expression of MRP2, and that interfering with hepoxilin A(3) synthesis

76 with 80 mg/kg PB increased P-glycoprotein-, Mrp2-, and BCRP-mediated transport and protein expressio

77 MRP2 appeared to have no role.

78 Specific knockdown of Mrp2 (approximately 50% decrease in expression) resulted

79 tispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding cassette (ABC) transporters that co

80 specific organic anion transporter (cMOAT or MRP2) are ATP-binding cassette transporters that confer

81 ndocytic retrieval and decreased function of Mrp2 at 20 minutes and significantly accelerated the exo

82 he upregulation of P-glycoprotein, Bcrp, and Mrp2 at blood-CNS barriers.

83 3, -132, and -98 nucleotides relative to the Mrp2 ATG) and contains potential upstream open reading f

84 Here we show that Arabidopsis MRP2 (AtMRP2) localizes to the vacuolar membrane fractio

85 The role of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion

86 , and sulfinpyrazone, inhibitors of MRP1 and MRP2, but was minimally affected by membrane potential o

87 ol increases the transport rates of BSEP and MRP2, but with the latter, may also modify the binding s

88 vation, implicating HNF1 in the induction of MRP2 by HCV.

89 In contrast, induction of MRP2 by phenobarbital, an activator of CAR, was comparab

90 d multidrug resistance-associated protein 2 (MRP2) by conventional PKCalpha (cPKCalpha), novel PKCdel

91 Prior in vitro studies suggest that Mrp2 can bind to Na(+)/H(+) exchanger regulatory factor

92 ransport of arsenic into bile depends on the MRP2/cMOAT transporter and that glutathione is obligator

93 Mrp2 co-precipitated with NHERF-1 in co-transfected HEK2

94 olites and in ABCC2 encoding the transporter MRP2 contributing to the biliary excretion of the reacti

95 Nonetheless, P-gp, Mrp2, Cyp3a, and Ces2a clearly restricted vinorelbine av

96 ls of PhIP metabolites were reduced in Bcrp1;Mrp2-deficient mice.

97 of 4MUG was also approximately 35% lower in Mrp2-deficient mouse livers.

98 (24 micromol) did not induce cholestasis in Mrp2-deficient TR(-) rats whereas 2 micromol of inverted

99 lated perfused livers (IPLs) from Wistar and Mrp2-deficient TR- rats.

100 Mrp2 down-regulation and IL-1 beta up-regulation were ob

101 mbranes suggested partial internalization of Mrp2 during the acute phase of cholestasis at 20 minutes

102 insertion of green fluorescent protein (GFP)-Mrp2 expressed in HepG2 cells was monitored by total int

103 Western blot studies indicated an absence of MRP2 expression in both blood-brain barrier preparations

104 ceptibility, we characterized Pgp, MRP1, and MRP2 expression in CD33+ cell lines and CD33+ AML sample

105 clear translocation of Nrf2, which activates MRP2 expression in macrophages upon infection by the par

106 Organ-specific regulation of Mrp2 expression in obstructive cholestasis is associated

107 Renal Mrp2 expression is preserved under these conditions.

108 In addition, we have shown that MRP2 expression is regulated by the pregnane X receptor

109 A significant decrease in MRP2 expression levels was observed following GSK3beta i

110 SK3beta overexpression was found to increase MRP2 expression levels.

111 Down-regulation of Mrp2 expression may explain impaired biliary excretion o

112 Preservation of renal Mrp2 expression may permit urinary excretion of toxic or

113 mice, suggesting that the down-regulation of Mrp2 expression was caused by post-transcriptional event

114 16alpha-carbonitrile-dependent induction of MRP2 expression was not evident in hepatocytes derived f

115 Renal RAR alpha:RXR alpha and Mrp2 expression were preserved under these conditions.

116 transport-deficient rats (TR(-)), which lack Mrp2 expression, showed none of these substrate effects.

117 ld be associated with suppression of hepatic Mrp2 expression.

118 ve polymerase chain reaction showed Mrp1 and Mrp2 expression.

119 MRP1, but not MRP2, expression correlated with MRP activity.

120 Finally, ATP increased GFP-Mrp2 fluorescence in the plasma membrane of HepG2 cells,

121 r of the Kelch-related protein family termed MRP2 (for Mayven-related protein 2) that is specifically

122 mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kineto

123 dies and demonstrated endocytic retrieval of Mrp2 from the canalicular membrane into pericanalicular

124 ay mediate cholestatic effects by retrieving MRP2 from the plasma membrane.

125 d multidrug resistance-associated protein 2 (Mrp2) from the canalicular membrane leading to cholestas

126 Mrp2 function is impaired in various experimental models

127 epoxilin A(3) synthesis and/or inhibition of MRP2 function results in a marked reduction in inflammat

128 n filaments, inhibits Nrf2 translocation and Mrp2 gene activation by pB(25)R infection.

129 ssays demonstrated that transcription of the Mrp2 gene at the various initiation sites was tissue-spe

130 d whether transgenic expression of the human MRP2 gene could protect against cisplatin injury in vivo

131 Transgenic expression of the human MRP2 gene in Mrp2-null mice reduced the accumulation and

132 Trypanosoma brucei apoMRP1/MRP2 and an MRP1/MRP2-gRNA complex.

133 While MRP2 has been shown to be expressed specifically in brai

134 We identified MRP2 in a screen designed to isolate genes that are regu

135 TLC increased PM-PKC and decreased PM-MRP2 in both HuH-NTCP cells and hepatocytes.

136 The measured half-lives of 14C-labeled Mrp2 in control, pregnant, and PCN-treated rats were 27,

137 plain the post-transcriptional regulation of Mrp2 in control, pregnant, and PCN-treated rats.

138 indings represent an alternative function of Mrp2 in hepatocytes.

139 first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-de

140 p3 may compensate for the down-regulation of Mrp2 in obstructive cholestasis.

141 cAMP did not affect PM-PKC and increased PM-MRP2 in these cells.

142 overlapping functions of Bcrp1, Mdr1a/b, and Mrp2 in vivo, we generated Bcrp1;Mdr1a/b;Mrp2(-/-) mice,

143 e multidrug resistance-associated protein-2 (Mrp2) in mediating cholestasis induced by estradiol-17be

144 d multidrug resistance associated protein-2 (Mrp2) in pregnancy and throughout lactation in rats.

145 f multidrug resistance-associated protein 2 (Mrp2) in the biliary excretion of PB and metabolites was

146 MRP2 interacted with GSK3beta through its NH2 terminus c

147 cantly accelerated the exocytic insertion of Mrp2 into the canalicular membrane and the recovery of b

148 The structures show that MRP1/MRP2 is a heterotetramer and, despite little sequence ho

149 MRP2 is an actin-binding protein of the kelch-related pr

150 als in canalicular insertion and function of Mrp2 is not known.

151 These studies demonstrate that MRP2 is regulated by three distinct nuclear receptor sig

152 Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organ

153 p multidrug resistance-associated protein 2 (Mrp2) is diminished in experimentally induced models of

154 n the process extension of rat OLGs, whereas MRP2/KLHL1 antisense reduced the process length of prima

155 MRP2/KLHL1 expression was abundant during the specific s

156 MRP2/KLHL1 is expressed in oligodendrocyte precursors an

157 Overexpression of MRP2/KLHL1 resulted in a significant increase in the pro

158 Furthermore, murine OLGs isolated from MRP2/KLHL1 transgenic mice showed a significant increase

159 MRP2/KLHL1 was localized in the cytoplasm and along the

160 Moreover, a direct endogenous association of MRP2/KLHL1 with actin was observed, which was significan

161 se studies provide insights into the role of MRP2/KLHL1, through its interaction with actin, in the p

162 g-resistance associated protein (MRP) 2, and Mrp2 knockout mice displayed increased vinorelbine plasm

163 e after oral administration, suggesting that Mrp2 limits the intestinal uptake of vinorelbine.

164 These data suggest that deficiency in Mrp2 lowers platinum excretion and increases susceptibil

165 g hepoxilin A(3) synthesis and/or inhibiting MRP2 may lead to the development of new therapeutic stra

166 closporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other important drug transporters.

167 These data indicate that the process of Mrp2-mediated transport of high concentrations of E(2)17

168 Mrp2 message was increased (2.3-fold) by PB pretreatment

169 and Mrp2 in vivo, we generated Bcrp1;Mdr1a/b;Mrp2(-/-) mice, which are viable and fertile.

170 cretion was reduced 41-fold in Bcrp1;Mdr1a/b;Mrp2(-/-) mice.

171 tes were excreted into bile predominantly by Mrp2, mouse Bcrp mediated the biliary excretion of sulfa

172 MRP2 mRNA and protein levels were up-regulated in PC12 c

173 no significant differences were observed in Mrp2 mRNA expression among these groups.

174 Transcription of rat hepatic Mrp2 mRNA is initiated at multiple sites (-213, -163, -1

175 Mrp2 mRNA levels diminished profoundly after endotoxin (

176 MRP2 mRNA levels were induced following treatment of hum

177 AR agonists results in a robust induction of MRP2 mRNA levels.

178 ndicate for the first time that the 5'UTR of MRP2 mRNA transcripts and the uORF at -105 markedly infl

179 Polysomal distribution analysis of Mrp2 mRNA was consistent with increased Mrp2 protein syn

180 Mrp2 mRNA was stable in pregnancy and postpartum, wherea

181 In NHERF-1(-/-) mouse liver, Mrp2 mRNA was unchanged but Mrp2 protein was reduced in

182 ult2a1, Ugt1a1), and Phase III transporters (Mrp2, Mrp3).

183 NAD(P)H:quinone oxidoreductase 1, as well as Mrp2, Mrp3, and Mrp4 expression.

184 xyanisole demonstrated that the induction of Mrp2, Mrp3, and Mrp4 is Nrf2-dependent.

185 decreased liver IL-10, FXR, CAR, VDR, BSEP, MRP2, MRP3, MRP4 was also observed in ANIT-induced chole

186 ubin metabolism and excretion (CYP2B, CYP3A, MRP2, MRP3, UGT1A, and glutathione S-transferase alpha),

187 fold in Bcrp1;Mdr1a/b;Mrp2(-/) (-) and Bcrp1;Mrp2;Mrp3(-/-) mice compared with wild-type mice.

188 These mice, together with Bcrp1;Mrp2;Mrp3(-/-) mice, were used to study the effects of t

189 In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice, the

190 d, to a much lesser extent, by MRP1, but not MRP2-MRP6 or BCRP/MXR.

191 as ATP-dependent but was neither mediated by MRP2 nor stimulated by cholesterol.

192 m were detected in the kidneys and livers of Mrp2-null mice compared with wild types.

193 nsive proximal tubule injury was observed in Mrp2-null mice compared with wild-type mice.

194 Kidneys from naive Mrp2-null mice had elevated glutathione S-transferase mR

195 nsgenic expression of the human MRP2 gene in Mrp2-null mice reduced the accumulation and nephrotoxici

196 vehicle- and cisplatin-treated wild-type and Mrp2-null mice were collected for quantification of plat

197 Enhanced platinum concentrations in Mrp2-null mice were observed in DNA and cytosolic fracti

198 r multidrug resistance associated protein 2 (Mrp2) on chloride channel activation and cell volume reg

199 ed in the membrane vesicles expressing human MRP2 or breast cancer resistance protein.

200 ey injury, which can be rescued by the human MRP2 ortholog.

201 ssociated with the expression of Oatp1a1 and Mrp2 (P < .001, r = 0.74 and P < .001, r = 0.70, respect

202 In conclusion, Mrp2 plays a role in regulation of chloride channel func

203 Characterization of an MRP2 polymorphism, -24C>T, in the MRP2 5'UTR, demonstrat

204 the putative HNF1 binding site of the human MRP2 promoter abrogated HCV-induced activation, implicat

205 otein and mRNA expression were increased and MRP2 promoter activity was increased 7-fold.

206 ha nuclear protein levels and binding to the Mrp2 promoter cis element.

207 Both the ntcp FpB element and the mrp2 promoter contain potential retinoid-response elemen

208 We have recently reported that the rat Mrp2 promoter is activated by RAR alpha:RXR alpha, and t

209 r gene constructs containing 1 kb of the rat MRP2 promoter were prepared and transiently transfected

210 leukin-1beta down-regulation of the ntcp and mrp2 promoters were mapped to RXRalpha:RARalpha-response

211 atic models resulted in a marked decrease in Mrp2 protein (P < 0.01) and its tissue localization at t

212 MRP2 protein and mRNA expression were increased and MRP2

213 Differences in the degradation of Mrp2 protein cannot explain the post-transcriptional reg

214 organic anions for biliary excretion and 2) Mrp2 protein expression and functional capacity is decre

215 stable in pregnancy and postpartum, whereas Mrp2 protein expression decreased significantly in pregn

216 plays an important role in the regulation of Mrp2 protein expression.

217 sis or degradation consistent with different Mrp2 protein expression.

218 s of Mrp2 mRNA was consistent with increased Mrp2 protein synthesis after PCN treatment.

219 We hypothesized that Mrp2 protein undergoes altered rates of protein synthesi

220 Mrp2 protein was increased slightly in PB-treated livers

221 /-) mouse liver, Mrp2 mRNA was unchanged but Mrp2 protein was reduced in whole cell lysates and membr

222 Mrp2 protein was significantly increased in rats treated

223 iol, and common bile duct ligation (CBDL) on Mrp2 protein, messenger RNA (mRNA) expression, and Mrp2

224 role for the translational regulation of rat Mrp2 protein.

225 s in contrast to the progressive decrease in Mrp2 protein.

226 In contrast to Mrp2, protein expression of ecto-ATPase and P-gp remaine

227 Mrp2 remained localized at the apical/canalicular membra

228 the expression and functional regulation of Mrp2 remains largely unknown.

229 that ABC transporters (ABCB1/MDR1 and ABCC2/MRP2, respectively) show dramatic overexpression, wherea

230 Ralpha:RARalpha heterodimers to the ntcp and mrp2 retinoid-response elements.

231 ated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cy

232 was to test the hypothesis that TLC-induced MRP2 retrieval involves PKC-mediated MARCKS phosphorylat

233 ults support the hypothesis that TLC-induced MRP2 retrieval involves TLC-mediated activation of PKC f

234 was impaired in parallel with the extent of Mrp2 retrieval.

235 NRP/B, MAYVEN, or MAYVEN-related protein 2 (MRP2), revealed that the NRF2-NRP/B complex is important

236 RAR alpha, RXR alpha, and Mrp2 RNA levels were determined by using ribonuclease pr

237 a critical role in the induction of hepatic MRP2 secondary to HCV subgenomic replication.

238 In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and

239 rane labeling for Mrp3 at a time when apical Mrp2 staining was significantly diminished.

240 120-min cumulative biliary excretion of the Mrp2 substrate 5-(and-6)-carboxy-2', 7'-dichlorofluoresc

241 In TR-hepatocytes the Mrp2 substrate had no effect on volume regulation.

242 ary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), wa

243 The MRP2 substrates CCK8 and vasopressin exhibited Michaelis

244 Two conjugated estrogens that are not Mrp2 substrates did not produce this effect.

245 with their ability to activate channels, the Mrp2 substrates increased the rate of volume regulatory

246 of multidrug-resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the can

247 We analyzed Mrp2 synthesis, expression, and degradation in control f

248 nctional homology between Ycf1p and MRP1 and MRP2, these data support the hypothesis that GSH efflux

249 rotein, messenger RNA (mRNA) expression, and Mrp2 tissue localization were determined in rat livers b

250 ganic anion secretion into bile by targeting Mrp2 to the canalicular membrane.

251 sP(3)R2-mediated Ca(2+) signals in targeting Mrp2 to the canalicular membrane.

252 Immunostaining localized P-glycoprotein and Mrp2 to the luminal surface of the capillary endothelium

253 utamylation similarly affects the ability of MRP2 to transport MTX.

254 nd multidrug resistant associated protein 2 (Mrp2) to the plasma membrane.

255 quence was identified 440 bp upstream of the MRP2 transcription initiation site that contains an ever

256 testine, and HepG2 cells identified multiple MRP2 transcription initiation sites.

257 The relative abundance of these Mrp2 transcripts expressed in tissues varied with age fr

258 ipts and the uORF at -105 markedly influence MRP2 translation.

259 ect of cAMP on PKCs, TC uptake, and Ntcp and Mrp2 translocation was studied in isolated rat hepatocyt

260 P and bistratene A on TC uptake and Ntcp and Mrp2 translocation were not additive.

261 esults suggest that cAMP stimulates Ntcp and Mrp2 translocation, at least in part, by activating nPKC

262 delta translocation, TC uptake, and Ntcp and Mrp2 translocation.

263 ion plays a role in cAMP-stimulated Ntcp and Mrp2 translocation.

264 delta translocation, TC uptake, and Ntcp and Mrp2 translocation.

265 lation method was used to determine Ntcp and Mrp2 translocation.

266 s to SFN increased P-glycoprotein, Bcrp, and Mrp2 transport activity and protein expression; SFN incr

267 We found that cholesterol stimulates MRP2 transport activity for substrates of different mole

268 urs in parallel with decreased bile flow and Mrp2 transport activity.

269 brane cholesterol content modulates BSEP and MRP2 transport kinetics differently.

270 mitant with the overexpression of macrophage MRP2 transporter.

271 e multidrug resistance-associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from c

272 In the liver, Mrp2 transports bilirubin-glucuronide, glutathione (GSH)

273 sion may induce adaptive responses involving MRP2 via HNF1 activation.

274 onal growth factor (NGF)-induced PC12 cells, MRP2 was expressed along the neurite processes and coloc

275 1 was expressed in 8 (50%) of 16 tumors, and MRP2 was expressed in 5 (31%) of 16 tumors.

276 The rate of incorporation of 35S into Mrp2 was highest in PCN-treated rats.

277 tp1a/1b) and multidrug resistance protein 2 (Mrp2) was investigated by small-animal SPECT.

278 ly synthesized mitochondrial matrix protein, MRP2, was also inhibited due to depletion of TbTim17, Tb

279 To assess whether changes were specific for Mrp2, we also examined the expression of canalicular ect

280 4, and for the apical bilirubin transporter, Mrp2, were all increased.

281 A coding for multidrug resistance protein 2 (MRP2), which transports GSH into bile, are half wild-typ

282 ug resistance-associated protein genes (MRP1/MRP2, which encode for the efflux transporter Mrp1/Mrp2)

283 E(2)17G induces endocytic internalization of Mrp2, which occurs in parallel with decreased bile flow

284 eased associations of MRP2 with GSK3beta and MRP2 with actin were observed in the NGF-treated PC12 ce

285 Additionally, increased associations of MRP2 with GSK3beta and MRP2 with actin were observed in

286 DN) PKC reversed TLC-induced decreases in PM-MRP2 without affecting cAMP-induced increases in PM-MRP2