ライフサイエンスコーパス: MS

1 MS analysis revealed that Pif1 was modified in several d

2 MS quantification of multiple drug targets and tissue pr

3 MS-based metabolomics methods are powerful techniques to

4 ing the two-dimensional tandem mass scan (2D MS/MS scan) in which all precursor ions and their subseq

5 d as a reference for investigators seeking a MS-based tool to address structural questions in protein

6 tivated at their secular frequencies and all MS/MS experiments can be performed, including the two-di

7 Furthermore, pIC(50)s, as measured by AMI-MS, showed a good correlation with values generated by R

8 An MS-compatible RNA digestion buffer was developed to mini

9 e spectra, kinetics, biochemical assays, and MS analyses, we show that the conserved nucleophilic res

10 tionation, an improved sequence database and MS we determined the composition, evolutionary relations

11 ites can be more easily identified by MS and MS/MS.

12 d locations were determined from MS scan and MS/MS of PB products assisted by Python programs.

13 not previously detected by two-hybrid or AP-MS techniques.

14 At baseline, MS was 10.4 +/- 5.2 dB (n = 361), and the eMS was 9.3 +/

15 ed to evaluate the signal difference between MS lesions and normal-appearing white matter in patients

16 re tested in immunoprecipitation followed by MS for their ability to capture the endogenous protein f

17 eling sites can be more easily identified by MS and MS/MS.

18 Data obtained by MS are often zero-inflated.

19 ed to collision-activated dissociation (CAD; MS(2) experiments).

20 sults of a Metabo-ring trial involving 16 CE-MS platforms among 13 different laboratories spanning tw

21 in metabolomics where liquid chromatography-MS-based analyses cannot be applied.

22 that synaptic loss is significant in chronic MS, likely contributing to disability accrual.

23 In principle, CIT-MS can be easily adapted to track the flux of other labe

24 However, most commercial MS platforms typically involve a separation or cleanup p

25 y developed a series of sulfoxide-containing MS-cleavable cross-linkers to facilitate the detection a

26 further development of sulfoxide-containing MS-cleavable cross-linkers with new functionalities.

27 This requires custom MS/MS methods to equally sample all isomeric oxidation p

28 ignificantly improve the performance of DBDI-MS and potentially other ion sources involving high volt

29 FD(6mm)) and sMS in the central 10 degrees (MS(10)) and the overall pattern (MS(18)).

30 on desorption electrospray ionization (DESI) MS for the label-free study of enzymatic reactions direc

31 roteomic method enabled by a newly developed MS-compatible photocleavable surfactant, 4-hexylphenylaz

32 ron are similar or different among different MS immunopatterns is currently unknown.

33 ompared to the operation of conventional ESI-MS.

34 s that are unresolved using conventional ESI-MS/MS.

35 mproved up to 19-fold compared to direct ESI-MS of single-phase droplets (aqueous plugs segmented by

36 tation in a fully automated platform for ESI-MS-based high-throughput screening.

37 Direct-infusion ESI-MS showed that the tested volatile eluent salts seem to

38 However, most ESI-MS based analyses require no more than 25 mug of protein

39 lar complexes were characterized by NMR, ESI-MS, UV-vis, ITC, and cyclic voltammetric studies.

40 result combinations: BC positive and PCR/ESI-MS negative, 4.3%; BC positive and PCR/ESI-MS positive,

41 positive, 15.3%; and BC negative and PCR/ESI-MS negative, 70.1%.

42 sepsis (sepsis-2 definition), BC and PCR/ESI-MS on whole blood were positive in 14.6% and 25.6% of ca

43 I-MS negative, 4.3%; BC positive and PCR/ESI-MS positive, 10.3%; BC negative and PCR/ESI-MS positive,

44 -MS positive, 10.3%; BC negative and PCR/ESI-MS positive, 15.3%; and BC negative and PCR/ESI-MS negat

45 ectrospray ionization mass spectrometry (ESI-MS)-based sample injection at a sampling rate faster tha

46 spray ionization mass spectrometry (UPLC/ESI-MS).

47 ium exchange mass spectrometry (H/D exchange MS), to characterize the global and peptide-level confor

48 We used hydrogen-deuterium exchange MS to map the binding interface of the evasin P672 that

49 ysis, 1D (1)H NMR and mass spectroscopy (FIA-MS/MS and LC-MS/MS) techniques.

50 lyzed using GC and quadrupole time-of-flight MS with APCI and SQDIA acquisition.

51 raphy-fluorescence-mass spectrometry (LC-FLR-MS) workflows have been limited with only a small amount

52 ver peptide backbones, a desired feature for MS(n) analysis.

53 show that greater genetic predisposition for MS is associated with higher global brain WM FA at an ea

54 Whether genetic risk for MS is associated with brain structure during early neuro

55 the development of efficacious therapies for MS.

56 This review is intended as a tutorial for MS-based protein HOS elucidation and as a reference for

57 C=C bond locations were determined from MS scan and MS/MS of PB products assisted by Python prog

58 uencing data and peptide identification from MS/MS data.

59 y of Fourier transform mass spectrometry (FT-MS) has made it an increasingly popular technique for di

60 Example analysis using FT-MS data from a soil microbiology study demonstrates the

61 cyclotron resonance mass spectrometry (FTICR MS) provides a unique opportunity for molecular analysis

62 al approach, including NMR, MS, HPLC-PDA, GC-MS and spectrophotometric analyses, was proposed to anal

63 ing gas chromatography-mass spectrometry (GC-MS).

64 chromatography-tandem mass spectrometry (GC-MS/MS) with sum of concentrations (gas + particle phase)

65 e profiles identified by means of HS-SPME-GC-MS analysis, significantly differed in terms of terpenes

66 chromatography-mass spectrometry (HS-SPME-GC-MS) method for the quantification of 3-monochloropropane

67 With the same SBSE-GC x GC-MS methodology, a quantitative targeted analysis was per

68 (1)H NMR, FTIR, and GC/MS characterization of the fluids indicated that they ar

69 HDX-MS of fibrillating hCT (pH 7.4; 25 degrees C) suggested

70 se enzymes, Nepenthesin II (NepII), in a HDX-MS workflow.

71 nstrate that the information provided by HDX-MS experiments and by the model of exchange are sufficie

72 igh-throughput screening applications by HDX-MS.

73 Hydrogen-deuterium exchange (HDX-MS) mapped onto a full structural model of the ligase re

74 gen-deuterium exchange kinetics with MS (HDX-MS) to interrogate the high-order structure of proteins

75 xchange combined with mass spectrometry (HDX-MS) is a widely applied biophysical technique that probe

76 en/deuterium exchange mass spectrometry (HDX-MS) of complexes I and II on membranes elucidated struct

77 en-deuterium exchange-mass spectrometry (HDX-MS) to investigate how FIXa responds to assembly with FV

78 en-deuterium exchange mass spectrometry (HDX-MS).

79 romatography-tandem mass spectrometry (HILIC-MS/MS).

80 eed ethanol extracts were determined by HPLC-MS analysis to be essentially free of toxic gossypol.

81 aphy-tandem mass spectrometry coupling (HPLC-MS/MS) is classically used to characterize post-transcri

82 biopsy tissue, using mass spectrometry (HPLC-MS/MS) (n = 27) and immunohistochemistry (IHC) (n = 64),

83 ph triple quadrupole mass spectrometry (HPLC-MS/MS) were used to characterize raw and fermented coffe

84 lariciresinol) in green coffee by using HPLC-MS/MS.

85 gh-resolution tandem mass spectrometry (HRMS/MS) analysis.

86 The extracts are analyzed by IC-DRC-ICP-MS for Cr(VI).

87 EM of each sample, and overall 97.7% for ICP-MS.

88 Our ICP-MS-based method comprises the analysis of 20 elements (M

89 pectrometry (ICP-MS) and single-particle ICP-MS.

90 pH 2.0 and pH 7.5 and analysed using SEC-ICP-MS.

91 tively coupled plasma mass spectrometry (ICP-MS) and single-particle ICP-MS.

92 tively coupled plasma mass spectrometry (ICP-MS) operated in single particle (SP) mode.

93 tively coupled plasma mass spectrometry (ICP-MS) showed titanium presence in all groups proportional

94 s using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained resi

95 on and cation exchange columns) and an ICPMS/MS system were used to study the seasonal variations of

96 yclotron resonance mass spectrometry (FT-ICR MS) enables extensive compositional characterization of

97 during IMS experiments on a hybrid QhFT-ICR MS.

98 he online nano solid phase extraction-FT-ICR-MS method provides novel insight into the processes affe

99 ESI-IM-MS reveals the presence of multiple conformers for the d

100 Ion mobility-mass spectrometry (IM-MS) has become a powerful tool for glycan structural cha

101 CSs) from ion mobility mass spectrometry (IM-MS) measurements are routinely compared to computational

102 Imaging mass spectrometry (imaging MS) is a prominent technique for capturing distributions

103 tions coupled to mass spectrometry (SLIM IMS-MS) for the rapid and simultaneous characterization of t

104 mobility spectrometry mass spectrometry (IMS-MS) could be performed.

105 In MS patients, Ndst1 is also found overexpressed in oligod

106 The role of B cells in MS was selected as the topic of the 27th Annual Meeting

107 However, methodological limitations (e.g. in MS of phosphopeptides, or antibodies against phosphoepit

108 earch will enable the broader use of gHDX in MS-based workflows for molecular identification and isom

109 Although CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS resea

110 anding where and how remyelination occurs in MS.

111 on of the oligodendrocyte progenitor pool in MS adults.

112 croglia, which may play an important role in MS-associated inflammation and the formation of demyelin

113 ount to optimize neuroprotective strategy in MS.

114 pathway as a potential therapeutic target in MS.

115 onale behind B-cell-directed therapeutics in MS, and proposes strategies to optimize the use of exist

116 be utilized to program the most informative MS(3) on the glycan moiety itself.

117 d of conventional liquid chromatography (LC)-MS, the use of a guard column (i.e., fast chromatography

118 LC-MS/MS method for confirmation of nitrofuran metabolites

119 romatography-tandem mass spectrometry (2D-LC-MS/MS) method which combines commercially available prot

120 oals in this study were to (i) validate a LC-MS method that assesses HBP flux as UDP-GlcNAc ((13)C)-m

121 gase (rat serum and chicken pancreas) (AE-LC-MS/MS) was used in the LC-MS/MS methods, each in a singl

122 potential to replace traditional LBA and LC-MS/MS methods.

123 NMR and mass spectroscopy (FIA-MS/MS and LC-MS/MS) techniques.

124 oaffinity capture, chemical cleavage, and LC-MS/MS.

125 pabilities comparable to the state-of-art LC-MS but suggest a selectivity for the detection of a diff

126 liposome-leakage and cytotoxicity assays, LC-MS/MS-based proteomics, and CCF-4 FRET analysis, we obta

127 rmediate during C(alpha)-thioether bridge LC-MS/MS fragmentation.

128 -tracers) in any metabolite detectable by LC-MS/MS and in various biological models (such as mice).

129 nd the peptidomic profile was assessed by LC-MS/MS.

130 and Laboratory Standards Institute (CLSI) LC-MS C62-A document and the U.S. Food and Drug Administrat

131 Polyphenol composition (LC-MS) and antioxidant capacity (PCL, FRAP) were measured.

132 However, a major challenge for LC-MS-based methods is that there can be a more than 5 orde

133 kup in multiple 96-well filter plates for LC-MS/MS analysis.

134 The hybridization LC-MS/MS was considered an improved alternative for quantit

135 W applied to two large-scale metabolomics LC-MS datasets identifies many misaligned features and succ

136 For the optimized LC-MS/MS method described herein, we applied the guidelines

137 haliana) for deconjugation of folates (PE-LC-MS/MS), or animal-origin deconjugase (rat serum and chic

138 nd alpha-1 acid glycoprotein (AGP) by PGC-LC-MS.

139 mple preparation, an ultra-fast 84-second LC-MS method, and barcoded nanopore sequencing to rapidly i

140 oxidation products quantified in a single LC-MS/MS run.

141 liquid chromatography-mass spectrometry (LC-MS) analysis.

142 liquid chromatography-mass spectrometry (LC-MS) at PND 22 or at 7 weeks of age.

143 liquid chromatography-mass spectrometry (LC-MS) data.

144 liquid chromatography-mass spectrometry (LC-MS/MS).

145 assay was compared to the gold standard (LC-MS/MS), showing a good correlation between both methods,

146 The LC-MS analysis indicated that the beta-Lactoglobulin was th

147 es and conjugated acylcarnitines from the LC-MS/MS analysis of six NIST urine reference materials.

148 n pancreas) (AE-LC-MS/MS) was used in the LC-MS/MS methods, each in a single enzymatic step.

149 Through LC-MS/MS analysis, we discover that majority of miR-21-5p i

150 apoA-I or HDL3 in vitro and in vivo Using LC-MS/MS analysis, we analyzed the pattern of apoprotein cr

151 The interest of using LC-MS/MS as a method for detection of allergens in food is

152 and other hormones were quantified using LC-MS/MS.

153 uisition and analysis) for both 3D and 4D-LC/MS setups can be completed within less than 1-2 days, co

154 t, using a label-free proteomic approach (LC/MS/MS) analysis to compare the proteomic profile between

155 liquid chromatography/mass spectrometry (LC/MS) showing that compensated FAF intensities correlate l

156 liquid chromatography/mass spectrometry (LC/MS).

157 sorption/ionization mass spectrometry (MALDI-MS) is an important tool for high-throughput N-glycan pr

158 thylation-sensitive High-Resolution Melting (MS-HRM) approach from dried blood spot (DBS) samples, as

159 Participants with mild MS showed significantly better BCG as reflected by lower

160 of one or more O-glycans under negative-mode MS(2) affords an easy way to discover additional O-glyco

161 mune encephalomyelitis, an established mouse MS model, we report that therapeutic administration of a

162 Accurate mass and tandem multistage MS (MS(n)) were used for structure identification of vaping

163 atible with native MS and improve tandem MS (MS/MS) approaches with respect to when and how energy is

164 lution mass spectrometry (MS) and tandem-MS (MS(n)), the localization of C=C double bonds (DBs) requi

165 , a significant limitation of many multiplex MS methods.

166 Accurate mass and tandem multistage MS (MS(n)) were used for structure identification of vap

167 line protein digests via single-shot nanoLC-MS/MS analysis on a Q Exactive HF system.

168 The charge states produced by native MS of membrane proteins often result in gas-phase protei

169 strates the yet untapped potential of native MS coupled to gas-phase ion chemistry as a means of faci

170 synthesis and highlight the power of native MS in defining protein-associated intermediates and eluc

171 tion methods that are compatible with native MS and improve tandem MS (MS/MS) approaches with respect

172 ulti-methodological approach, including NMR, MS, HPLC-PDA, GC-MS and spectrophotometric analyses, was

173 Unfortunately, the enormous amount of MS data generated often remains incompletely analyzed du

174 CD34+c-Kit+Flt3+ cells from BM of MS-RO+ LCH patients produced Langerhans cell (LC)-like c

175 enabling the assessment of each component of MS and the construction of the MDS prodromal probability

176 pathogenesis and have been the main focus of MS research using the animal model experimental autoimmu

177 ilities associated with progressive forms of MS (P-MS).

178 A hallmark of MS diagnosis is the presence of IgG Abs, which appear as

179 focal lesions - the pathological hallmark of MS.

180 e encephalomyelitis (EAE), a murine model of MS, adoptive transfer of IL-10(+) regulatory B cells (B(

181 Using an animal model of MS, experimental autoimmune encephalomyelitis (EAE), we

182 of demyelinated lesions in rodent models of MS.

183 D4 T cells contribute to the pathogenesis of MS.

184 The primary endpoint was the remission of MS at 12 months.

185 o a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which

186 T(H)17 cells are believed to orchestrate MS pathology, in part, through the production of two pro

187 ense scotoma (eMS) than by using the overall MS.

188 s associated with progressive forms of MS (P-MS).

189 Fingolimod in paediatric MS was associated with consistent control of disease act

190 10 degrees (MS(10)) and the overall pattern (MS(18)).

191 alysis in real time mass spectrometry (pDART-MS).

192 tiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of

193 le sclerosis (RRMS) to secondary progressive MS (SPMS) represents a huge clinical challenge.

194 rs of presentation) of secondary progressive MS at 30 years were presence of baseline infratentorial

195 aper spray ionization mass spectrometry (PSI-MS) on a single instrumental platform.

196 t to SERS signals and compatibility with PSI-MS analysis.

197 nally, we demonstrate the application of QET-MS to the study of heterogeneous chemical kinetics with

198 obtained by colorimetric and UHPLC-ESI-qTOF-MS analysis, respectively.

199 time of flight mass spectrometry (HPLC-QTOF-MS) was used to analyze residues in fish.

200 on-botrytized wines were analysed by LC-QTOF-MS.

201 upole time-of-flight mass spectrometry (QTOF-MS).

202 e characterized using UPLC-tandem quadrupole MS before and after fermentation and baking.

203 Quantitative XL-MS (qXL-MS) provides unique information on protein conformationa

204 rrelation with values generated by RapidFire-MS.

205 el archaeon Haloferax volcanii, we reanalyze MS datasets from various strains and culture conditions.

206 ion that is complementary to high resolution MS/MS.

207 g an untargeted approach via high-resolution MS.

208 an 8000 protein measurements within the same MS time.

209 nown MOG-Ab-serostatus), multiple sclerosis (MS) (n=69), optic neuritis (n=5) and non-neurological co

210 patients with relapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual s

211 ayer (GCIPL) thinning in multiple sclerosis (MS) attributable to normal aging increased from 42.7% an

212 herapies for people with multiple sclerosis (MS) have recently gained marketing approval.

213 Multiple sclerosis (MS) is a heterogeneous inflammatory demyelinating diseas

214 Multiple sclerosis (MS) is a neurological disease with a substantial genetic

215 Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss.

216 genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS i

217 pathological features of multiple sclerosis (MS), the most common disabling neurological disease in y

218 susceptibility locus for multiple sclerosis (MS).

219 omyelitis (EAE) model of multiple sclerosis (MS).

220 eatment of patients with multiple sclerosis (MS).

221 autoimmunity that mimics multiple sclerosis (MS).

222 veral potential roles in multiple sclerosis (MS): secretors of proinflammatory cytokines and chemokin

223 Next, using SDCP-MS and AIDP-Wb, we rapidly identify multiple regulatory

224 fluid chromatography-mass spectrometry (SFC-MS).

225 We demonstrate for the first time the SFC-MS separation of a mixture of polypeptides carried out u

226 lected ion flow tube-mass spectrometry (SIFT-MS).

227 medium is eluted into the mass spectrometer (MS) and interfering with evaluation.

228 peptides using multistage mass spectrometry (MS(n)).

229 ived from high-resolution mass spectrometry (MS) and tandem-MS (MS(n)), the localization of C=C doubl

230 Recently, mass spectrometry (MS) based proteomics analysis has emerged as a promising

231 ng ribosome-profiling and mass spectrometry (MS) data.

232 ght scattering and native mass spectrometry (MS) for the biophysical characterization of complex form

233 though recent advances in mass spectrometry (MS) have enabled meaningful glycoproteomic undertakings,

234 e protein quantitation by mass spectrometry (MS) involve the digestion of target protein and employ i

235 Native mass spectrometry (MS) is a powerful means for studying macromolecular prot

236 ty spectrometry (IMS) and mass spectrometry (MS) measurements.

237 Native mass spectrometry (MS) provides the capacity to monitor membrane protein co

238 l" proteome has empowered mass spectrometry (MS)-based methods to delve more deeply and precisely int

239 ning this technology with mass spectrometry (MS)-based proteomics allows us to obtain snapshots of mo

240 ce (NMR) spectroscopy and mass spectrometry (MS).

241 er DMS separation, tandem mass spectrometry (MS/MS) analyses of the separated isomers also distinguis

242 nd high-resolution tandem mass spectrometry (MS/MS) for peptide quantification and then apply the met

243 of sphingolipids, tandem mass spectrometry (MS/MS) is the method of choice, offering sufficient sens

244 HS-SPME-MS-enose turned out to be a fast, cost-effective and obj

245 0 min compared to overnight), and subsequent MS-analysis following UV degradation.

246 ohort study, we linked data from the Swedish MS register to the Swedish Cancer Register and other nat

247 ate the influence of the metabolic syndrome (MS) (obesity, hypertension, elevated triglycerides, redu

248 g 2DMS contour plot contains abundant tandem MS information for each component in the sample and corr

249 compatible with native MS and improve tandem MS (MS/MS) approaches with respect to when and how energ

250 sured by an ultra-high-performance LC-tandem MS platform.

251 nd its precursors were measured by LC-tandem MS.

252 atographic separation, and multistage tandem MS, here we first demonstrate that human platelet-type 1

253 t N-glycan profiling and, upon use of tandem MS, for structure determination.

254 resolution mass spectrometry (MS) and tandem-MS (MS(n)), the localization of C=C double bonds (DBs) r

255 ange) in MOGAD of 24 (2-65) was younger than MS at 36 (16-65; p=0.046) and AQP4-IgG-NMOSD at 45 (6-72

256 fation and sialylation drastically alter the MS(2) fragmentation pattern of glycopeptides in negative

257 assay, NP-HPTLC-UV/vis/FLD-bioassay) and the MS.

258 ral rotor made up of two ring complexes, the MS-ring and the C-ring.

259 However, the MS detection of low-abundance proteins from blood remain

260 chemogenetic activation normalised it in the MS animals.

261 begins with selection of a parent ion in the MS scan, followed by tandem mass spectrometry (MS2) frag

262 nalysis highlights active deformation in the MS.

263 dy reactivity was evident in the sera of the MS cohort, and the antibodies bound a heterogeneous set

264 0.05) by plotting the measured ratios of the MS ion responses against the known spiked-in ratios (CVs

265 l least squares-discriminant analysis of the MS/MS(ALL) lipidomic dataset, identified lipids driving

266 entiation of oligodendrocytes similar to the MS pups, while chemogenetic activation normalised it in

267 Using the MS-cleavable cross-linker, disuccinimidyl sulfoxide, int

268 i-CiQA, were identified on the base of their MS fragmentation profile.

269 Ultimately, this MS(n) platform paired with ion/ion chemistry permitted i

270 We show that (1) tandem-TIMS/MS retains native-like avidin tetramers with deeply buri

271 ed to validate the approach in comparison to MS/MS spectra produced via data dependent acquisition (D

272 t our understanding of how it contributes to MS is limited.

273 narrow bore monolithic LC columns coupled to MS via a high-field asymmetric waveform ion mobility spe

274 fast fractionation module coupled online to MS.

275 e as a potent immunomodulatory supplement to MS drugs.

276 gets and may be used for different MALDI-TOF MS applications.

277 time of flight mass spectrometry (MALDI-TOF MS) with only 1 muL of sample in a fast (less than 1 min

278 R and multidimensional techniques, MALDI/ToF MS provides a straightforward technique that can be appl

279 and repeatability of the developed EESI-TOF-MS were tested under complex dynamic and periodic experi

280 time-of-flight mass spectrometry (MALDI-TOF-MS).

281 to develop antiviral strategies for treating MS are underway.

282 er PCI values in comparison to the other two MS severity groups (severe: p = 0.001, moderate: p = 0.0

283 quid chromatography-mass spectrometry (UHPLC-MS), we show results on the rate of particle growth/aggl

284 debranning) and flour/semolina, using UHPLC-MS/MS methods.

285 this issue has largely remained unaddressed; MS signal intensities are usually directly used to calcu

286 Using MS, we identified an ester bond formed between a thermol

287 onal fold-change calculations directly using MS signal intensities can be misleading.

288 The final diagnosis was MS in 57%, idiopathic in 29%, MOG-IgG-associated disorde

289 When MS alone is not capable of providing reliable quantitati

290 ributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance.

291 time window within neurodevelopment in which MS risk variants act upon the brain.

292 se liquid chromatography (RPLC) coupled with MS for protein characterization.

293 ng hydrogen-deuterium exchange kinetics with MS (HDX-MS) to interrogate the high-order structure of p

294 anding derived from studies of patients with MS and animal models of how specific cytokines produced

295 AE), substantial evidence from patients with MS points to a role for CD8+ T cells in disease pathogen

296 sonance imaging departments in patients with MS, which include new data and practical comments for el

297 rmal-appearing white matter in patients with MS.

298 mechanisms can develop early in people with MS and are closely related to disability.

299 To advance XL-MS studies, we have previously developed a series of sul

300 Quantitative XL-MS (qXL-MS) provides unique information on protein confo

301 ge-scale cross-linking mass spectrometry (XL-MS) can confirm and extend this interactome.