ライフサイエンスコーパス: MSG

1 MSG consumption was positively, longitudinally associate

2 MSG contents ranged from 0.01g/100g to 15.39g/100g in fo

3 MSG is encoded by a multicopy gene family; in two specif

4 MSG treatments induced hypogonadism and obesity, retain-

5 MSG- and vehicle-treated hamsters given an exogenous nor

6 MSG-evoked neuronal activation in the nTS was measured b

7 MSG-treated hamsters exhibited normal entrainment to the

8 MSG/IMP+ conditions significantly reduced subsequent int

9 MSGs from pSS patients contain IL-17-expressing cells as

10 As adults, MSG-treated hamsters had significantly increased body ma

11 ed maximally during the initial 20 min after MSG administration.

12 e to detect the compound stimulus across all MSG (+amiloride) concentrations due, in part, to the tas

13 ch is present at the beginning of nearly all MSG mRNAs, and which is likely to be involved in regulat

14 ells infected with a baculovirus carrying an MSG gene lacking the UCS expressed a nonglycosylated 130

15 UCS peptide was ligated to the 5' end of an MSG gene and incorporated into a recombinant baculovirus

16 ssary and sufficient for transcription of an MSG gene.

17 ocus is required for the transcription of an MSG gene.

18 ER, Golgi, and MSG steady-state pH values were also dependent upon the

19 at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antig

20 Both the UCS and MSG genes were shown to be located at the ends of chromo

21 Golgi and MSGs required active H(+) v-ATPases for acidification.

22 MSGs, and proper acidification of Golgi and MSGs required gradual decreases in P(H+) and successive

23 2 from the trans-Golgi network into ISGs and MSGs, however, is not affected.

24 orm 1 showed strong reactivity with the anti-MSG MAb RA-C11.

25 Given that few if any MSG mRNAs lack the UCS, the correspondence between the U

26 examine the longitudinal association between MSG consumption and incidence of overweight.

27 there was no significant difference between MSG-obesity group and lyophilized monocomponent probioti

28 the ATP-dependent reactivation rate of bound MSG by preventing multiple cycles of its GroEL binding a

29 mal entrainment to the light-dark cycle, but MSG treatretain-->ment counteracted the circadian arrhyt

30 ies have shown that the sensation aroused by MSG is distinct from that of the other 4 taste qualities

31 T thermogenesis that could be compromised by MSG treatment.

32 Cold-exposed (18 h at 5 degrees C) MSG- and vehicle-treated hamsters initially maintained T

33 inii expresses a surface glycoprotein called MSG.

34 he major surface glycoprotein of P. carinii (MSG).

35 th a monoclonal antibody against a conserved MSG epitope.

36 (UCS), which is in frame with the contiguous MSG sequence.

37 P-A bound to purified rat P. carinii-derived MSG in a saturable and calcium-dependent manner, which w

38 no acid sequences of variants of rat-derived MSG.

39 tect IMP alone, yet some were able to detect MSG + amiloride + IMP, but only at the higher MSG concen

40 Messenger RNAs encoding different MSG isoforms start with the same sequence, called the up

41 m by which the UCS becomes part of different MSG mRNAs is not obvious because at least 15 loci, which

42 copy per haploid genome, but that different MSG genes were linked to the unique UCS locus in differe

43 Messenger RNAs encoding different MSGs each begin with the same 365-bp sequence, called th

44 e, whereas multiple copies of the downstream MSG gene were present.

45 re distributed throughout the genome, encode MSGs.

46 en or probable invasive candidiasis by EORTC/MSG criteria in patients who did not have disease at bas

47 024; 95% CI, 1.006-1.042; P = .009) by EORTC/MSG criteria, with response rates of 83% and 28% when bo

48 sible invasive mold disease defined by EORTC/MSG criteria.

49 te of Allergy and Infectious Diseases (EORTC/MSG) criteria.

50 fectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (11 probable cases and 36 con

51 fectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (19 proven/probable cases and

52 eatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria.

53 erative Group and Mycoses Study Group (EORTC/MSG) criteria.

54 e Fungal Infections Cooperative Group (EORTC/MSG) definition.

55 fectious Diseases Mycoses Study Group (EORTC/MSG) definitions for fungal disease, commercially manufa

56 eatment of Cancer/Mycoses Study Group (EORTC/MSG) definitions of invasive fungal disease because of l

57 fectious Diseases Mycoses Study Group (EORTC/MSG) definitions, and 6-week survival.

58 fectious Diseases Mycoses Study Group (EORTC/MSG)-defined hematological population.

59 by LFD and qPCR to classify cases, the EORTC/MSG criteria had a sensitivity of 83.3%.

60 The diagnostic performance of the EORTC/MSG criteria was evaluated against the test(s) identifie

61 According to the EORTC/MSG criteria, IFD was classified as possible in 182 (34.

62 Using the EORTC/MSG criteria, the sensitivities of qPCR and LFD were 100

63 now mature enough for inclusion in the EORTC/MSG definitions.

64 GM in BAL had modest agreement with EORTC/MSG criteria for diagnosing IFD in immunocompromised pat

65 Every MSG mRNA begins with 380 nucleotides copied from the UCS

66 nt major surface glycoprotein (MSG) fragment MSG-14, a P. jiroveci-specific protein that includes a h

67 hat are closely related to but distinct from MSG.

68 Furthermore, MSG-evoked Fos-LI was significantly less in P2X-dblKO mi

69 kDa slow folding protein, malate synthase G (MSG), was investigated.

70 ta)-[(13)CHD(2)]}-labeled Malate Synthase G (MSG)--an 82-kDa monomeric enzyme that contains 73 Ala(be

71 Twelve metastasis suppressor genes (MSGs) have been identified that reduce the metastatic pr

72 Although >30 metastasis suppressor genes (MSGs) that negatively regulate metastasis have been iden

73 plants using multiplexed shotgun genotyping (MSG), and located MSG markers to the genome sequence.

74 Plasma and minor salivary glands (MSGs) from patients with pSS were therefore evaluated fo

75 strain consume more monosodium l-glutamate (MSG) than do mice from the 129P3/J (129) strain.

76 ted with a solution of monosodium glutamate (MSG) (4 mg/g) subcutaneously (s.c.) at 2nd,4th, 6th, 8th

77 Neonatal monosodium glutamate (MSG) administration increases adiposity, decreases energ

78 mic or oral ad libitum monosodium glutamate (MSG) administration on glutamate levels in plasma, and o

79 Monosodium glutamate (MSG) has been shown to increase satiety when combined wi

80 the aim of quantifying monosodium glutamate (MSG) in foodstuffs, such as chips, taste cubes, sauces a

81 vor paired with 150 mm monosodium glutamate (MSG) over a flavor paired with water.

82 reated neonatally with monosodium glutamate (MSG) that destroys ARC neurons were subjected in adultho

83 eurons or via neonatal monosodium glutamate (MSG) treatment.

84 been hypothesized that monosodium glutamate (MSG), a flavor enhancer, is positively associated with w

85 newborn male rats with monosodium glutamate (MSG), a total growth hormone (GH) blocker, and, using cu

86 ha-gustducin in umami [monosodium glutamate (MSG), monopotassium glutamate (MPG), and inosine monopho

87 ts, II-VII - rats with monosodium glutamate (MSG)-induced NAFLD.

88 sible for the taste of monosodium glutamate (MSG).

89 orm of the sodium salt monosodium glutamate (MSG)] and the nucleotide monophosphates 5'-inosinate and

90 nces specific to major surface glycoprotein (MSG) and dihydrofolate reductase (DHFR) were used to det

91 with recombinant major surface glycoprotein (MSG) fragment MSG-14, a P. jiroveci-specific protein tha

92 The major surface glycoprotein (MSG) is an abundant, immunodominant protein on the surfa

93 d to express the major surface glycoprotein (MSG) of human P. carinii, an important protein in host-p

94 The major surface glycoprotein (MSG) of P. carinii f. sp. carinii is a family of protein

95 The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii is a family

96 The major surface glycoprotein (MSG) of Pneumocystis carinii, a pathogen responsible for

97 response to the major surface glycoprotein (MSG) of Pneumocystis carinii.

98 enes encodes the major surface glycoprotein (MSG) of Pneumocystis carinii.

99 antigen known as major surface glycoprotein (MSG), which is encoded by about 100 heterogeneous genes.

100 isoforms of the major surface glycoprotein (MSG).

101 nii, namely the major surface glycoproteins (MSGs) and HSP70 proteins; three of these putative famili

102 = 6.2 +/- 0.4) to mature secretory granules (MSGs) (pH(MSG) = 5.5 +/- 0.4).

103 o ISGs and not to mature secretory granules (MSGs), and Syt IV binds to syntaxin 6, a SNARE protein t

104 Gs) gives rise to mature secretory granules (MSGs), the storage compartment in endocrine and neuroend

105 cause GroES bound to the trans side of GroEL-MSG complex, it may be anticipated that confinement of t

106 nt addition of ATP or GroES/ATP to the GroEL-MSG complex led to the formation of the native state via

107 ced by the DPS protocol: only 6% of retain-->MSG-treated hamsters exhibited circadian arrhythmia, whe

108 SG + amiloride + IMP, but only at the higher MSG concentrations.

109 Rats with NAFLD were untreated (group II, MSG-obesity group) and treated with probiotics (groups I

110 In MSG-treated hamsters that retained circadian rhythmicity

111 differences between B6 mice and 129 mice in MSG consumption are unrelated to strain variation in con

112 Diet, including MSG and other condiments, was assessed with a weighed fo

113 identified non-metastatic 2 (NME2) as a key MSG from a pool of >30 metastasis suppressors.

114 Monosodium L-glutamate (L-MSG), a natural component of many foods, is an important

115 Like MSG, they are cysteine-rich.

116 ern blotting studies demonstrated that, like MSG, v1MSG and v2MSG are the products of multicopy gene

117 plexed shotgun genotyping (MSG), and located MSG markers to the genome sequence.

118 a; however, it did not react with the mature MSG protein, which migrates at 116 kDa.

119 he role of taste responsiveness, we measured MSG-evoked activity in gustatory nerves and showed that

120 hat induce GFP expression only in meristems, MSG (meristem-specific GFP), were used to monitor GFP mo

121 dium glutamate and inosine 5'-monophosphate (MSG/IMP) provided either alone or in a high-energy, high

122 dium glutamate and inosine 5'-monophosphate (MSG/IMP+) or without added monosodium glutamate and inos

123 dium glutamate and inosine 5'-monophosphate (MSG/IMP-) were consumed on 4 nonconsecutive days, and ch

124 The three-gene repeat PRT1-MSR-MSG was common, suggesting that duplications of these re

125 carinii pneumonia demonstrated that multiple MSG genes were expressed in a given host, and that diffe

126 ve fibers/cells were not altered by neonatal MSG treatment despite substantial Arc and PVH destructio

127 Lastly, neonatal MSG treatment had no adverse effect on postnatal and adu

128 Therefore, we tested the effects of neonatal MSG or vehicle administration in Siberian hamsters and,

129 rast, in more posterior, viscerosensory nTS, MSG-induced Fos-LI was similar in WT and P2X-dblKO mice.

130 (IBAT) in the cold is not due to any obvious MSG-induced deletions of central sympathetic outflow cir

131 The addition of MSG/IMP to a low-energy preload had a biphasic effect on

132 d that, after intragastric administration of MSG, the MSG is preferentially metabolized through gluco

133 dies that show the synergy of the binding of MSG and 5'-guanylate to tongue taste tissue mirror this

134 In the case of MSG, these applications include the measurement of (1)H-

135 most likely to modulate the conformation of MSG intermediates that can fold faster and thereby elimi

136 xplain why ad libitum dietary consumption of MSG apparently lacks neurotoxic potential.

137 ive cues and that postingestive detection of MSG does not rely on the same purinergic signaling that

138 ed impaired, if not eliminated, detection of MSG in WT and T1R1, T1R2, T1R3, and T1R2 + T1R3 KO mice

139 elop a mathematical model of the dynamics of MSG inactivation and calculate the expected number of me

140 the attachment of the UCS to the 5' ends of MSG mRNAs.

141 Expression of MSG genes is not well understood.

142 s been implicated in selective expression of MSG genes.

143 ype, and second, which molecular function of MSG controls metastasis.

144 Thus, the inability of MSG-treated animals to sustain T(IBAT) in the cold is no

145 ndition also reduced intake independently of MSG/IMP.

146 oEL bound to the burst phase intermediate of MSG and accelerated the slowest kinetic phase associated

147 Introduction of MSG during the neonatal period leads to the NAFLD develo

148 Different isoforms of MSG are encoded by a gene family spread over at least 15

149 ding experiments, consumption of 2.3 g/kg of MSG by previously-trained rats during an 1-h period incr

150 ual organisms transcribe a limited number of MSG genes.

151 a given host, and that different patterns of MSG expression were seen among different patients.

152 samples reacted with the carboxyl portion of MSG-14; by ELISA, immunocompromised patients with Pneumo

153 h excess monosaccharides, or pretreatment of MSG with N-glycanase.

154 ocus, called UCS, supports the production of MSG mRNA.

155 ully for the detection and quantification of MSG in a wide variety of foodstuffs.

156 for participants in the highest quintile of MSG intake compared with those in the lowest quintile af

157 rms of rat-derived P. carinii, regulation of MSG expression uses a single expression site, termed the

158 ch is likely to be involved in regulation of MSG gene transcription.

159 P. carinii can express a broad repertoire of MSG variants.

160 howed that each contained a different set of MSG genes linked to the UCS, suggesting that UCS-MSG jun

161 o IMP but was involved in the umami taste of MSG and MPG.

162 the known higher sensitivity to the taste of MSG in juvenile rodents.

163 eptor responsible, in part, for the taste of MSG.

164 regulation of vMSG is different from that of MSG.

165 tional role of the UCS in the trafficking of MSG, the nucleotide sequence encoding the UCS peptide wa

166 To determine if translation of MSG mRNAs begins in the UCS, polyclonal antiserum was ra

167 imals showed that at least three variants of MSG were expressed in an individual lobe, that there was

168 era revealed that at least three variants of MSG were present in organisms isolated from an individua

169 SNARE molecules mediating the exocytosis of MSGs in neuroendocrine cells, syntaxin 1, SNAP-25, and V

170 0.4) to mature secretory granules (MSGs) (pH(MSG) = 5.5 +/- 0.4).

171 ential was small and not a determinant of pH(MSG).

172 However, neither steady-state pH(MSG) nor rates of passive H(+) leak were affected by Cl(

173 anslation begins in the UCS to produce a pre-MSG protein, which is subsequently directed to the endop

174 and supporting cytokines within diseased pSS MSGs without a compensatory increase in immunomodulatory

175 United States found that the flavor of pure MSG was difficult to describe.

176 The predicted proteins, like rat MSGs, were closely related but unique variants, with a h

177 t 380 nucleotides of P. carinii f. sp. ratti MSG mRNAs were 59% identical to the P. carinii f. sp. ca

178 This recombinant MSG fragment, which is the first human P. carinii antige

179 Thus, human-derived P. carinii regulates MSG expression in a manner similar to P. carinii f. sp.

180 The cumulative mean (+/-SD) MSG intake of 2.2 +/- 1.6 g/d was positively associated

181 Seven MSG genes were cloned from a single isolate by PCR or ge

182 of MPR, VAMP4, and syntaxin 6 in mature SGs (MSGs), suggesting that CCV budding from ISGs is inhibite

183 ced P. carinii populations in which a single MSG sequence resided at the UCS locus in 80 to 90% of th

184 Systemic MSG administration (0.25, 0.5, 1 or 2 g/kg, i.p.) to adu

185 sed during the initial 20 min after systemic MSG administration, and peaked during the second 20-min

186 MP+ carbohydrate and protein conditions than MSG/IMP- condition.

187 ally, behavioral studies have indicated that MSG and L-2-amino-4-phosphonobutyrate (L-AP4), a ligand

188 ee solutions or valinomycin, indicating that MSG membrane potential was small and not a determinant o

189 PCR result and hybridization signal for the MSG gene were used for the RT-PCR experiments.

190 from hypox rats, the cells derived from the MSG-treated rats were completely unresponsive.

191 Energy compensation was greater in the MSG/IMP+ carbohydrate and protein conditions than MSG/IM

192 fter intragastric administration of MSG, the MSG is preferentially metabolized through gluconeogenesi

193 In the current study, the UCS of the MSG from human-derived P. carinii was obtained using an

194 at includes a highly conserved region of the MSG protein family.

195 ed with the complete unresponsiveness of the MSG-derived hepatocytes, also associated with hypermethy

196 The addition of the MSG/IMP+ also increased the soup pleasantness and caused

197 ntly reduced subsequent intake more than the MSG/IMP- condition did irrespective of energy.

198 igh degrees of diversity with respect to the MSG genes attached to the UCS locus.

199 atosis score respectively as compared to the MSG-obesity group (2.3 +/- 0.21 %).

200 probiotic mixtures (VI, VII) compared to the MSG-obesity group.

201 ng of SP-A to mannose-Sepharose beads and to MSG.

202 ding of SP-A to oligosaccharides attached to MSG.

203 aculovirus vectors and tested for binding to MSG.

204 re evident from our finding that exposure to MSG increases its consumption in B6 mice and decreases i

205 and v2MSG proteins are highly homologous to MSG at the carboxyl, but not the amino, terminus.

206 The similarity of its properties to MSG taste suggests that this receptor is a taste recepto

207 nt increase in the proliferative response to MSG and in interleukin-4 secretion.

208 hat interferon-gamma secreted in response to MSG was also significantly less.

209 monia showed a predominately Th2 response to MSG.

210 ignificantly less proliferative responses to MSG than did healthy controls.

211 decreased progressively from ER to Golgi to MSGs, and proper acidification of Golgi and MSGs require

212 sorted away during the maturation of ISGs to MSGs.

213 eters of URs appeared normal, but in the two MSG-treated hamsters that became circadian arrhythmic af

214 somes, suggesting that the mechanism for UCS-MSG recombination is reciprocal exchange.

215 genes linked to the UCS, suggesting that UCS-MSG junctions are formed by recombination during populat

216 Insect cells infected with the UCS-MSG hybrid gene expressed a 160-kDa protein which was N-

217 To distinguish between these two models, UCS/MSG junctions in the genome were compared with UCS/MSG j

218 The UCS/MSG junctions in the mRNA matched those in the genome, a

219 the UCS, the correspondence between the UCS/MSG junctions in transcripts and those in the genome ind

220 nctions in the genome were compared with UCS/MSG junctions in mRNA.

221 However, unlike MSG, each vMSG gene encodes a signal peptide, suggesting

222 e current study identified two novel variant MSG (vMSG) gene families in rat P. carinii that are clos

223 observed in some T1R1 and T1R3 KO mice when MSG + amiloride + IMP was tested suggests that a T1R1 or

224 o issues are poorly understood: first, which MSGs oppose metastasis in a tumor type, and second, whic

225 PCR analysis with MSG primers with tissues obtained from both groups of ra

226 Compared with MSG, v1MSG is characterized by a deletion near the carbo

227 terleukin-4 levels following incubation with MSG between any of the groups; however, all the HIV-infe

228 e 5'-monophosphate acts synergistically with MSG when tasted, is present in high-protein sources, and