ライフサイエンスコーパス: MSI

1 MSI and Ecc remained as significant after adjustment for

2 MSI had similar predictive accuracy to SEE for functiona

3 MSI tumors had increased frameshift mutations, showed ge

4 MSI/MMR testing reliably identifies LS probands, althoug

5 0.862]; OR, 1.05 [95% CI, 1.03-1.07] per +1% MSI for improvement and AUC, 0.844 [95% CI, 0.818-0.871]

6 0.872]; OR, 1.03 [95% CI, 1.02-1.03] per +1% MSI for improvement and AUC, 0.862 [0.832-0.891]; OR, 1.

7 Exome sequencing data of 24 MSI colorectal cancers revealed indels at 54 million mon

8 osatellite sequence in the TGFBR2 gene of 32 MSI-H colon cancer tissues and 6 cell lines (HCT116, LS1

9 for mutations in BRAF and KRAS); and type 5 (MSI-high, non-CIMP, negative for mutations in BRAF and K

10 Experimental results from 54 MSI sequences show that our spectral inconsistency measu

11 f 29 available LS CRCs demonstrated abnormal MSI/MMR results.

12 genes were further analyzed in 93 additional MSI colorectal cancers.

13 Although MSI has been studied for decades, large amounts of seque

14 Although MSI was similar between the 2 approaches, MSI3-slices pe

15 The association among MSI, MMRD, and survival was assessed.

16 OMAAT was evaluated by analyzing an MSI data set of a high-throughput glycoside hydrolase ac

17 mulation of basic drugs (like most ARVs), an MSI method to quantify the melanin biomarker pyrrole-2,3

18 Cs at age > 60 years, and one carrier had an MSI-positive tumor with no IHC defect.

19 nce data from seven anatomical regions of an MSI image of a coronal section of mouse brain were model

20 is limited to the RGB color space, while an MSI sequence contains typically more than ten spectra.

21 In multivariate analysis, MSI (hazard ratio [HR] for DFS: 1.10 [95% CI, 0.73-1.64]

22 platform for storing, sharing, and analyzing MSI data.

23 s") asymmetry dominating POLE-, APOBEC-, and MSI-associated mutations.

24 dMMR and MSI have been associated with responses of metastatic tu

25 Feature tracking-derived Ecc and MSI provide minimal incremental benefit to SEE in predic

26 However, the effect of MMRD and MSI in curatively resected gastric cancer treated with p

27 Interaction between MMRD and MSI status and overall survival (OS).

28 Polymerase e-mutated and MSI EC tumors may be excellent candidates for PD-1-targe

29 tended to be correlated with each other, and MSI and BRAF mutation functioned as key molecular charac

30 ctions between two peptides (cecropin P1 and MSI-78(C1)) and graphene in situ and in real-time using

31 The POLE and MSI ECs exhibited higher numbers of CD3+ (44.5 vs 21.8;

32 l immune cells and more frequent in POLE and MSI tumors (39% vs 13%; P = .02).

33 mphocytes (90% vs 28%; P < .001) of POLE and MSI tumors.

34 nish jujube cultivars, especially 'PSI' and 'MSI', may be selected to promote the growth of cultivars

35 sing tools for the analysis of large arrayed MSI sample sets.

36 pe-specific MSI loci will enable panel-based MSI testing to identify patients who are likely to benef

37 DBS that demonstrated good agreement between MSI-CE-MS and validated FIA-MS/MS methods within an accr

38 tes in human urine were reliably measured by MSI-CE-MS via serial injection of seven urine samples wi

39 trand cortex, allowing direct measurement by MSI without analyte extraction.

40 trol, pterostilbene, and piceids obtained by MSI.

41 ionally, nontargeted metabolite profiling by MSI-CE-MS with temporal signal pattern recognition revea

42 study of the mouse brain proteome sampled by MSI.

43 contrast agent mass spectrometry imaging (CA-MSI) that utilizes a magnetic resonance imaging (MRI) co

44 er tumors grown in mice were subjected to CA-MSI using Gadoteridol revealing tumor margins and vascul

45 tion mutations in microsatellites are called MSI target genes.

46 portunities for improved methods of clinical MSI diagnosis and cancer gene discovery.

47 In contrast, MSI is not observed in Fancd2(-/-) mice but is prevalent

48 y ionization mass spectrometry imaging (DESI MSI), both as a novel diagnostic tool and as a method to

49 The constant-distance mode nano-DESI MSI enabled imaging of many metabolites, including nonri

50 ased on this effort, constant-mode nano-DESI MSI proved to be ideally suited for imaging biological s

51 ization mass spectrometry imaging (nano-DESI MSI) was used to characterize the molecular speciation o

52 eved with an accuracy of 98.2% based on DESI MSI data (PPV 0.96, NVP 1, specificity 0.96, sensitivity

53 ing surgical resections were subject to DESI MSI.

54 DESI-MSI has the potential to be a diagnostic tool for periop

55 s ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haematoxy

56 specimens were examined and analyzed by DESI-MSI.

57 t the molecular information obtained by DESI-MSI/Lasso from pancreatic tissue samples has the potenti

58 s, margins were found to be positive by DESI-MSI/Lasso, but negative by frozen section analysis.

59 electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profiles of

60 y ionization mass spectrometry imaging (DESI-MSI) on 54 banked human cancerous and normal prostate ti

61 y ionization-mass spectrometry imaging (DESI-MSI) was applied to latent fingerprints to obtain not on

62 y ionization mass spectrometry imaging (DESI-MSI) with the least absolute shrinkage and selection ope

63 ion electrospray ionization MS imaging (DESI-MSI), specific changes in lipogenesis and specific lipid

64 y ionization-mass spectrometry imaging (DESI-MSI).

65 term benefits to patients of the use of DESI-MSI for surgical margin evaluation is also needed to det

66 samples demonstrates the capability of DESI-MSI to characterise ovarian samples and to overcome exis

67 The results suggest that DESI-MSI imaging of fingerprints with GDBT analysis might off

68 and experimental conditions amenable to DESI-MSI, especially for analytes that are weakly attached to

69 lysis of adjacent tissue sections using DESI-MSI is also reported.

70 Despite their vast phenotypic differences, MSI proteins appear to have an analogous role in governi

71 o a synergistic combination of the different MSI platforms for high-throughput discovery and validati

72 Most on-tissue digestion MSI studies have focused on method development rather th

73 Two-dimensional MSI was also studied for embryos at different cell stage

74 over non-coding loci that frequently display MSI.

75 c colorectal cancer locally assessed as dMMR/MSI-H from 31 sites (academic centres and hospitals) in

76 se control in pre-treated patients with dMMR/MSI-H metastatic colorectal cancer, and could be a new t

77 checkpoint inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer.

78 d allows requisite C-trap inject time during MSI to be reduced to 30 ms.

79 n Control (AGC), which cannot be used during MSI analysis.

80 To explore MSI across malignancies, we examined 5,930 cancer exomes

81 We find MSI is highly dependent on the temporal interval between

82 This is the first MSI study at 12 mum spatial resolution of the malaria ve

83 d to makeS. mediterraneatissues amenable for MSI.

84 oci and constructed a genomic classifier for MSI.

85 irst cellular-level mechanisms described for MSI.

86 ory airways we have provided a guideline for MSI investigations of respiratory diseases involving the

87 cy measurement is potentially invaluable for MSI-based ocular disease diagnosis.

88 lopment and characterization of a method for MSI based on pulsed laser ablation via a scanning near-f

89 evelopmental period, the temporal window for MSI significantly narrows and is selectively tuned to sp

90 Our results open the door for matrix-free MSI of tissue sections and small cell populations by nan

91 Herein we demonstrate a new matrix-free MSI technique using nanophotonic ionization based on las

92 markers identified previously by MALDI-FTICR MSI.

93 rameters of dried jujube fruits (cv. "GAL", "MSI", and "PSI").

94 eport a new tool to perform histology guided MSI; instead of analyzing large parts of each tissue sec

95 23 patients suspected of having CMMRD, 6 had MSI and LC tolerance to methylation (CMMRD highly probab

96 A total of 254 patients had MSI and MMR results available.

97 In the MAGIC trial, MMRD and high MSI were associated with a positive prognostic effect in

98 hemotherapy plus surgery who had either high MSI or MMRD had a median OS of 9.6 months (95% CI, 0.1-2

99 ents treated with surgery alone who had high MSI or MMRD had a median OS that was not reached (95% CI

100 median OS among those who were neither high MSI nor MMRD of 19.5 months (95% CI, 15.4-35.2 months; h

101 a median OS among those who had neither high MSI nor MMRD of 20.5 months (95% CI, 16.7-27.8 months; h

102 2 years; 219 males (77.4%)] and 20 with high MSI [median age, 66 years; 14 males (70.0%)]).

103 ient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer has a poor prognosis after trea

104 We identified MSI-positive tumors in 14 of the 18 cancer types.

105 To identify MSI target genes, we developed a statistical model for t

106 analysis of mass spectrometry-based imaging (MSI) experiments of biological samples such as tissues.

107 Multispectral imaging (MSI) creates a series of en-face fundus spectral section

108 powerful tool in mass spectrometry imaging (MSI) and has been demonstrated to be capable of differen

109 Mass spectrometry imaging (MSI) at ambient pressures with submicrometer resolution

110 n is performed in mass spectrometry imaging (MSI) experiments to access larger proteins and to assign

111 al development of mass spectrometry imaging (MSI) for the detection of pituitary tumors during surger

112 mbient ionization mass spectrometry imaging (MSI) has been increasingly used to investigate the molec

113 Mass spectrometry imaging (MSI) has primarily been applied in localizing biomolecul

114 Mass spectrometry imaging (MSI) is a comprehensive tool for the analysis of a wide

115 Mass spectrometry imaging (MSI) is a powerful molecular imaging technique.

116 Mass spectrometry imaging (MSI) is a technique that is well suited to study the bio

117 onization (MALDI) Mass Spectrometry Imaging (MSI) is combined with an on-tissue chemical derivatizati

118 t of FFPE tissue, mass spectrometry imaging (MSI) is the most appropriate when morphological and hist

119 ritical aspect of mass spectrometry imaging (MSI) is the need to confidently identify detected analyt

120 onization (MALDI) mass spectrometry imaging (MSI) is used for the multiplex detection and characteriz

121 ant-distance mode mass spectrometry imaging (MSI) of biological samples using nanospray desorption el

122 a new matrix for mass spectrometry imaging (MSI) of mouse and rat brain tissue.

123 he feasibility of mass spectrometry imaging (MSI) of the distribution of a finish layer on the synthe

124 his site, we used mass spectrometry imaging (MSI) to analyse MLN tissue from a murine model of S. Typ

125 The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues, with

126 onization (MALDI)-mass spectrometry imaging (MSI) to map and visualize the three-dimensional spatial

127 he technique as a mass spectrometry imaging (MSI) tool, extracting points at 1 mm spatial resolution

128 Parallel mass spectrometry imaging (MSI) using desorption electrospray ionization (DESI) and

129 Mass spectrometry imaging (MSI) was used to elucidate host lipids involved in the i

130 tion (IR-MALDESI) mass spectrometry imaging (MSI) with 100 mum resolution.

131 Mass spectrometry imaging (MSI) with matrix-assisted laser desorption ionization (M

132 ng method such as mass spectrometry imaging (MSI), which can enablede novostudies of nervous system r

133 n preparation for mass spectrometry imaging (MSI).

134 of molecules and mass spectrometry imaging (MSI).

135 nalysis combining mass spectroscopy imaging (MSI) and fluorescence imaging was developed to localize

136 tified using commonly employed algorithms in MSI, and we validate our results on synthetic MSI data.

137 These changes in MSI correlate with developmental increases in evoked syn

138 e reverses observed developmental changes in MSI.

139 ated how TGFbeta signaling might continue in MSI-H CRC cells.

140 es of analyzing spatially defined samples in MSI data sets.

141 t for analyzing spatially defined samples in MSI.

142 Phosphorylation of SMAD2 in MSI-H cells required TGFBR2-even the form encoding a fra

143 Clustering is widely used in MSI to segment anatomical features and differentiate tis

144 estricted progenitor cell markers, including MSI-1, SOX9, and TUJ1.

145 tramyocardial hemorrhage, and salvage index (MSI) were assessed in 2624 segments.

146 In this work, multisegment injection (MSI)-CE-MS was used as multiplexed separation platform f

147 iency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many cancers and for

148 Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is dete

149 .0-75.0] years), microsatellite instability (MSI) phenotype, KRAS, and BRAF V600E mutations were dete

150 Microsatellite instability (MSI) refers to the hypermutability of short repetitive s

151 tal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including

152 ne whether tumor microsatellite instability (MSI) typing along with immunohistochemistry (IHC) and ML

153 ancer (CRC) with microsatellite instability (MSI), and promotes tumorigenesis.

154 agents and have microsatellite instability (MSI), due to accumulation of errors in repetitive DNA se

155 tational events, microsatellite instability (MSI), epigenetic features, protein expression status, an

156 ere assessed for microsatellite instability (MSI), MLH1 methylation, and MMR protein expression.

157 Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from r

158 le in preventing microsatellite instability (MSI), which is a hallmark of Lynch syndrome, activities

159 cancers exhibit microsatellite instability (MSI), which leads to accumulation of large numbers of sm

160 h high levels of microsatellite instability (MSI-H) accumulate mutations at a microsatellite sequence

161 or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is unknown.

162 markers: type 1 (microsatellite instability [MSI]-high, CpG island methylator phenotype [CIMP] -posit

163 ion was observed in microsatellite-instable (MSI) tumors, as well as in a subgroup of microsatellite-

164 Multisensory integration (MSI) is the process that allows the brain to bind togeth

165 a process known as multisensory integration (MSI).

166 Time to myocardial maximum signal intensity (MSI), MSI value, radiotracer retention index (RI, myocar

167 cies which were unseen by ambient ionization MSI alone.

168 matrix-assisted laser desorption/ionization MSI data sets.

169 f generating accurate segmentations of large MSI data sets acquired on the newest generation of MSI i

170 In light of the advent of larger MSI data sets based on either an increased spatial resol

171 LESA-MSI was used to effectively map the distribution of thes

172 ss spectrometry imaging (MALDI-MSI) and LESA-MSI.

173 aring quantitative results generated by LESA-MSI to LC-MS/MS.

174 ace analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling

175 Here, we expand the use of LESA-MSI beyond qualitative analysis to a quantitative analyt

176 tative studies in order to optimize the LESA-MSI method across several different chemical entities.

177 lity of mutations determined the most likely MSI target genes to be the aminoadipate-semialdehyde deh

178 ts (283 with microsatellite stability or low MSI [median age, 62 years; 219 males (77.4%)] and 20 wit

179 orption electrospray ionization (IR-MALDESI) MSI analyses, two laser pulses are used for analysis at

180 MALDI MSI of the hippocampal area allowed targeted fatty acid

181 relative quantification in 2D- and 3D- MALDI MSI data sets.

182 lized from rat cerebrum tissue using a MALDI MSI instrument operating in positive mode.

183 izable complexes that can be imaged by MALDI MSI.

184 ionization mass spectrometry imaging (MALDI MSI) was used to study the effects of liquid extraction

185 oof of concept study demonstrates that MALDI MSI could be used to directly detect excessive hormonal

186 However, analyte coverage with MALDI MSI is typically limited to the more abundant compounds,

187 a range of endogenous fatty acids with MALDI MSI.

188 assisted laser desorption/ionization (MALDI) MSI, no study has so far addressed the necessity of inst

189 assisted laser desorption/ionization (MALDI) MSI.

190 assisted laser desorption/ionization (MALDI)-MSI and liquid extraction surface analysis (LESA)-MS(2)I

191 MALDI-MSI identified endogenous molecular markers that illustr

192 A MALDI-MSI scan performed at the equivalent density of 495,000

193 which mass spectral peaks generated by MALDI-MSI could be assigned to unique N-glycan and peptide ide

194 monidazole metabolite can be imaged by MALDI-MSI in a breast tumor xenograft model.

195 In conclusion MALDI-MSI described specific lipid profiles that could be used

196 it is likely that the presented direct MALDI-MSI approach is also applicable to other tissues from pi

197 previously shown to be applicable for MALDI-MSI quantitation.

198 s categorizing the lipidome for future MALDI-MSI studies of pulmonary diseases.

199 ionization mass spectrometry imaging (MALDI-MSI) and complemented by quantitative measurement of dru

200 ionization mass spectrometry imaging (MALDI-MSI) and LESA-MSI.

201 /ionization mass spectrometry imaging (MALDI-MSI) can be used to record spatially correlated molecula

202 /ionization mass spectrometry imaging (MALDI-MSI) can be used to simultaneously visualize the lateral

203 ionization mass spectrometry imaging (MALDI-MSI) generally involves embedding the tissue followed by

204 ionization mass spectrometry imaging (MALDI-MSI) in order to characterize the lipid profiles and the

205 ionization-mass spectrometry imaging (MALDI-MSI) is a technique that allows the mapping of metabolit

206 ionization mass spectrometric imaging (MALDI-MSI) of agarose micro-beads randomly arrayed at high-den

207 /ionization mass spectrometry imaging (MALDI-MSI), which has been previously used to directly monitor

208 /ionization-mass spectrometry imaging (MALDI-MSI).

209 This study demonstrates the power of MALDI-MSI to reveal unprecedented insights on metabolic outcom

210 5- and 10 mum high spatial resolution MALDI-MSI to the asymmetric Kranz anatomy of Zea mays (maize)

211 This is the first time MALDI-MSI has been applied for three dimensional chemical imag

212 interferences that are detrimental to MALDI-MSI, while fixation is undesirable for the analysis of s

213 value as a complementary technique to MALDI-MSI.

214 ocedures are generally transferable to MALDI-MSI; however, there are various limitations.

215 We have used MALDI-MSI to study the spatial distribution of two major lipid

216 Data gathered using MALDI-MSI was verified through gas chromatography analysis of

217 eroid drug in human OA cartilage using MALDI-MSI.

218 -Tag are detected simultaneously using MALDI-MSI.

219 fixed and fresh tissue compatible with MALDI-MSI and histology is desirable to increase the breadth o

220 and small molecule distributions with MALDI-MSI.

221 The mammalian MSI family of RNA-binding proteins (RBPs) have important

222 The mean MSI was 0.426% +/- 0.092%.

223 In microprobe MSI, images are created through a grid-wise interrogatio

224 To examine the association among MMRD, MSI, and survival in patients with resectable gastroesop

225 The mainstream method for molecular MSI is matrix-assisted laser desorption ionization, howe

226 o myocardial maximum signal intensity (MSI), MSI value, radiotracer retention index (RI, myocardial a

227 es and MI sizefull LV resulted in 'negative' MSI in 7/48 patients.

228 tion (CMMRD highly probable), 15 had neither MSI nor LC tolerance to methylation (unlikely to have CM

229 Among patients with non-MSI-high cancer, BRAF mutation status emerged as a disti

230 wed by a discussion of the novel advances of MSI in three-dimensional (3D) cell cultures for accurate

231 Although well-suited, the application of MSI for comparing thousands of spatially defined spotted

232 gy is valuable in biomedical applications of MSI for detection of multiply charged lipids and protein

233 Here, we review the current applications of MSI for drug studies in animal models, followed by a dis

234 mediates development of temporal aspects of MSI in the tectum.

235 potentially immunogenic mutations because of MSI in coding repeat sequences.

236 A combination of MSI and multivariate statistics was used to differentiat

237 g of the genomic drivers and consequences of MSI, and our comprehensive catalogue of tumour-type-spec

238 y, we showed that the temporal dependence of MSI in the optic tectum of Xenopus laevis tadpoles is me

239 ellular mechanisms underlying development of MSI between visual and mechanosensory inputs in the opti

240 se effectiveness, another central feature of MSI stating that the amount of multisensory enhancement

241 us to examine the molecular fingerprints of MSI in greater detail.

242 Our analysis reveals that the frequency of MSI events is highly variable within and across tumour t

243 In this review, we focus on the function of MSI in the blood and the intestine, and discuss therapeu

244 ta sets acquired on the newest generation of MSI instruments and evaluate these results by comparison

245 for measuring the spectral inconsistency of MSI images without supervision, which yields quantitativ

246 An Ophthalmologist's interpretation of MSI images is commonly conducted by qualitatively analyz

247 used as a basis for statistical modeling of MSI data.

248 While the phenomenology of MSI in vertebrate brains is well described, relatively l

249 ts that are necessary for the progression of MSI toward routine clinical application.

250 conserved and cancer-specific properties of MSI and reveal opportunities for improved methods of cli

251 introduction to the capabilities and role of MSI in the clinical analysis of patient tissues and disc

252 ing a full cataloging of the true targets of MSI in colorectal cancer.

253 iver operator curves, was similar to that of MSI (AUC, 0.840 [95% CI, 0.809-0.872]; OR, 1.03 [95% CI,

254 ng a paradigm for a broader understanding of MSI function and oncogenic activities.

255 Here, we expand this cellular level view of MSI by focusing on the principle of inverse effectivenes

256 ning set, we identified parameters, based on MSI and LC tolerance to methylation, that detected patie

257 cule (PD-L1, 8/9) than PDACs without dMMR or MSI (4/10) (P = .05).

258 he invasive front than PDACs without dMMR or MSI (P = .08; Fisher exact test).

259 A higher proportion of PDACs with dMMR or MSI expressed the CD274 molecule (PD-L1, 8/9) than PDACs

260 PDACs with dMMR or MSI had a higher density of CD8+ T cells at the invasive

261 whether these features of PDACs with dMMR or MSI might serve as prognostic factors.

262 tly between patients with PDACs with dMMR or MSI vs without dMMR or MSI.

263 th PDACs with dMMR or MSI vs without dMMR or MSI.

264 ge at diagnosis, personal/family history, or MSI/MMR results.

265 ct not attributable to MLH1 methylation), or MSI-low.

266 ET1, DDM1, RNA-dependent DNA methylation, or MSI-dependent histone methylation.

267 negative for KRAS mutation); type 3 (MSS or MSI low, non-CIMP, negative for BRAF mutation, positive

268 positive for KRAS mutation); type 4 (MSS or MSI-low, non-CIMP, negative for mutations in BRAF and KR

269 ion); type 2 (microsatellite stable [MSS] or MSI-low, CIMP-positive, positive for BRAF mutation, nega

270 Of the 503 study participants, MSI results were available for 303 patients (283 with mi

271 In particular, MSI was a key hub, highly connected with other biomarker

272 Q-MSI confirmed previously reported RLR interactions and r

273 h quantitative microspectroscopic imaging (Q-MSI), a technique that determines FRET efficiency and su

274 ization of various phenomena in quantitative MSI, such as to study how the signal depends of the thic

275 scriminant analysis (PCA-LDA) on 3D rendered MSI volume data from MDA-MB-231-HRE-tdTomato breast tumo

276 DESI mass spectrometry imaging source (sDESI-MSI).

277 ization mass spectrometry imaging (AP-SMALDI MSI) has been employed to study the molecular anatomical

278 TGFbeta signaling remains active in some MSI-H CRC cells despite the presence of frameshift mutat

279 prehensive catalogue of tumour-type-specific MSI loci will enable panel-based MSI testing to identify

280 capillary electrophoresis-mass spectrometry (MSI-CE-MS) was developed to provide comparable sample th

281 capillary electrophoresis-mass spectrometry (MSI-CE-MS).

282 t are currently overlooked based on sporadic MSI+ screening.

283 This allows the generation of synthetic MSI data sets with known ground truth, providing a means

284 SI, and we validate our results on synthetic MSI data.

285 We demonstrate that MSI-CE-MS enables serial injections of 10 samples within

286 of unstable microsatellites, suggesting that MSI may be a continuous, rather than discrete, phenotype

287 By combining the MSI approach with extract analysis, we were also able to

288 ions, enabling them to be used to define the MSI measurement regions.

289 ccurate exome-based predictive model for the MSI phenotype.

290 ted and then automatically registered to the MSI-prepared tissue section; the registration transforma

291 The MSIs revealed consistent lipidomic profiles of individua

292 nd oncogenic pathways recurrently subject to MSI and uncover non-coding loci that frequently display

293 the specific PTP1B inhibitor trodusquemine (MSI-1436), is a potent, specific, and orally bioavailabl

294 response in both 2D and 3D renderings using MSI.

295 If independently validated, MSI or MMRD determined by preoperative biopsies could be

296 pproaches, MSI3-slices performed poorly when MSI was <0.50.

297 of planar and hydrophilic residues, whereas MSI-78(C1) lies down on graphene due to an even distribu

298 In patients with MSI tumors, KRAS status was not prognostic, whereas BRAF

299 llite-stable tumors but not in patients with MSI tumors.

300 elineating the AAR, especially in those with MSI < 0.50 and we would advocate full LV coverage in fut

301 tensities between regions of interest within MSI data sets, we propose the use of Conditional Autoreg