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1 elated protein, merozoite surface protein-1 (MSP-1).
2 n 1 (AMA-1) and merozoite surface protein 1 (MSP-1).
3 ional monoclonal antibodies against P. vivax MSP-1.
4 g peptide-specific T cells recognized native MSP-1.
5 rs against the immunogen as well as parasite MSP-1.
6 ctivation of the prometastatic growth factor MSP-1.
8 s showed that one highly conserved sequence (MSP-1#1, VTHESYQELVKKLEALEDAV; located at amino acid pos
9 e immunoassay with six different recombinant MSP-1(19) Ags did not correlate with protection from inf
11 is to change specific amino acid residues in MSP-1(19) and abolish antibody binding, and by using PEP
12 1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhib
13 fection primed the production of anti-native MSP-1(19) antibodies, which were boosted by vaccination
14 except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(1
16 detectable IgG and IgM Abs to MSP-1(42) and MSP-1(19) at 6 mo of age with no significant change by a
18 nvasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between an
20 of 5 of 86 (6%) newborns had cord blood anti-MSP-1(19) IgM Abs, an Ig isotype that does not cross the
21 showed the greatest age-related increase in MSP-1(19) IIA compared with infants with prenatal exposu
24 est that epitope-specific naturally acquired MSP-1(19) immune responses in endemic populations can be
25 mine the potential protective role of Abs to MSP-1(19) in individuals naturally exposed to malaria, w
27 ther of the two allelic forms of recombinant MSP-1(19) induced high levels of antigen-specific Th1 (g
29 nic P. falciparum expressing the P. chabaudi MSP-1(19) orthologue, individuals with high-level MSP-1(
30 fection, and suggest that the measurement of MSP-1(19) specific inhibitory Abs may serve as an accura
33 tein of the major merozoite surface protein (MSP-1(19)) fused to tetanus toxoid universal T-cell epit
34 dium falciparum merozoite surface protein-1 (MSP-1(19)) is a target of protective Abs against blood-s
35 to the C-terminal 19-kDa fragment of MSP-1 (MSP-1(19)) were detected in 24 of 92 (26%) newborns (4-1
36 f P. falciparum merozoite surface protein 1 (MSP-1(19)), a major blood stage vaccine candidate, is th
37 d 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory acti
39 pidermal growth factor domains that comprise MSP-1(19), and are classified as either inhibitory (inhi
41 pped onto the three-dimensional structure of MSP-1(19), it was apparent that the epitopes for the mAb
42 ts and recombinant circumsporozoite antigen, MSP-1(19), MSP-2, AMA-1, and Pf155 (also called ring-inf
43 onses were restricted to the Q-KNG allele of MSP-1(19), the major variant in this endemic area, where
45 s implicate an important protective role for MSP-1(19)-specific invasion inhibitory Abs in immunity t
46 (19) orthologue, individuals with high-level MSP-1(19)-specific invasion-inhibitory Abs (>75th percen
50 20 to 39) and one partly conserved sequence (MSP-1#23, GLFHKEKMILNEEEITTKGA; located at positions 44
55 as either inhibitory (inhibit processing of MSP-1(42) and erythrocyte invasion), blocking (block the
56 Infants had detectable IgG and IgM Abs to MSP-1(42) and MSP-1(19) at 6 mo of age with no significa
59 fragment of the merozoite surface protein 1 (MSP-1(42)) is a leading candidate for the development of
60 dium falciparum merozoite surface protein 1 (MSP-1(42)) is a prime candidate for a blood-stage malari
61 erythrocyte invasion one of these of 42 kDa (MSP-1(42)) is subjected to a second processing, producin
62 e P. falciparum merozoite surface protein 1 (MSP-1(42)) using the most frequently occurring codon in
63 minal region of merozoite surface protein 1 (MSP-1(42)), a B epitope of ring-infected erythrocyte sur
66 pon challenge with P. cynomolgi, none of the MSP-1(42)-vaccinated groups demonstrated sterile protect
69 lasmodium vivax merozoite surface protein 1 (MSP-1) 42-kDa fragment (PvMSP-1 p42) is a promising vacc
70 asmodium yoelii merozoite surface protein-1 (MSP-1), a leading vaccine candidate against erythrocytic
71 h correlates with infant development of anti-MSP-1 Abs acquired as a consequence of natural malaria i
72 work indicates that MT-SP1 is sufficient for MSP-1 activation and that MT-SP1, MSP-1, and the previou
77 trast, antibody levels to and frequencies of MSP-1 and EBA-175 were similar in adults in areas of sta
79 ody response and the concurrent targeting of MSP-1 and MSP-8 resulted in improved, nearly complete pr
80 ii MSRP-2 with the amino-terminal portion of MSP-1 and with each other on the surface of schizonts.
81 manifests positive natural selection for the MSP-1 and, less strongly, MSP-3 polymorphisms; the McDon
82 n of the 3D7 Pf merozoite surface protein-1 (MSP-1), and tetanus toxoid were measured by indirect enz
83 tigenic genes of P. falciparum (such as Csp, Msp-1, and Msp-2) exhibit numerous polymorphisms that ha
85 ce parasitemic, stronger responses to AMA-1, MSP-1, and MSP-3 were associated with protection (odds r
87 icient for MSP-1 activation and that MT-SP1, MSP-1, and the previously shown MSP-1 tyrosine kinase re
89 dium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical m
91 est that fetal sensitization or tolerance to MSP-1, associated with maternal malaria infection during
92 f sequence diversity in genes encoding three MSP-1-associated surface antigens of P. falciparum, rang
93 ibitor blocked the proteolytic activation of MSP-1 at the cell surface of peritoneal macrophages.
94 dium falciparum merozoite surface protein-1 (MSP-1) at birth correlates with infant development of an
97 djuvants and delivery systems for AMA-1- and MSP-1-based vaccines can be selected for their ability t
101 t two sequences located in the N terminus of MSP-1 can induce T- and B-cell responses following immun
106 e leishmanolysin gene, Entamoeba histolytica MSP-1 (EhMSP-1) and EhMSP-2, while the commensal ameba E
107 n of photosystem II in Arabidopsis thaliana, MSP-1 (encoded by psbO-1, At5g66570), and MSP-2 (encoded
108 fragment of the merozoite surface protein 1 (MSP-1) from Plasmodium falciparum has been determined us
109 l region of the merozoite surface protein-1 (MSP-1) from the rodent malarial parasite Plasmodium yoel
111 dium falciparum merozoite surface protein 1 (MSP-1) has been evaluated in Aotus lemurinus griseimembr
114 ymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to P
116 otection induced by the carboxyl terminus of MSP-1 in vivo and illustrate the need to consider these
117 o P. falciparum merozoite surface protein-1 (MSP-1) in infants born in an area of stable malaria tran
119 port a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falc
123 t the structure of the C-terminal domains of MSP-1 (known as MSP-1(19)) from Plasmodium knowlesi.
125 sponses to the C-terminal 19-kDa fragment of MSP-1 (MSP-1(19)) were detected in 24 of 92 (26%) newbor
128 ntification of the helper T-cell epitopes on MSP-1, MSP-2, and MSP-3 that are needed to evoke anamnes
129 rozoite or the merozoite (AMA-1, CSP, LSA-1, MSP-1, MSP-2, and MSP-3) are more polymorphic than those
130 alves included major surface proteins (MSPs) MSP-1, MSP-2, and MSP-3, which were previously shown to
131 xpression decreased, while the expression of msp-1, msp-7, and several rhoptry protein genes increase
135 cted to the major merozoite surface protein (MSP-1) of this parasite enabled both BALB/cByJ mice and
138 onses to PHA, PPD, and Plasmodium falciparum MSP-1 peptides did not significantly differ by age.
141 dy responses to merozoite surface protein-1 (MSP-1), ribosomal phosphoprotein P0 (PfP0), and region I
143 ) and P. yoelii merozoite surface protein-1 (MSP-1) showed encouraging results when tested individual
144 cord blood lymphocyte cytokine responses to MSP-1) showed the greatest age-related increase in MSP-1
149 city of conserved and polymorphic regions of MSP-1, the specificity of Ab responses to a polymorphic
151 that MT-SP1, MSP-1, and the previously shown MSP-1 tyrosine kinase receptor RON are required for peri
153 ollowing an initial rise in parasitemia, all MSP-1-vaccinated animals had significantly lower parasit
154 and 19-kDa C-terminal processed fragments of MSP-1 were determined by serology and by a functional as
155 rom conserved or partly conserved regions of MSP-1 were evaluated for immunogenicity in B10 congenic
158 Ags from the polymorphic Block 2 region of MSP-1 were recognized by many, although not all individu
159 of the major polymorphic region (Block 2) of MSP-1 were used to determine the specificity and longitu
160 (EBA-175), and merozoite surface protein 1 (MSP-1) were compared in 243 Kenyans living in a highland
161 target for inhibitors of protein binding to MSP-1, which might prevent invasion of the merozoite int
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